Articles tagged with Antibiotics
Researchers discovered an unprecedentedly diverse collection of bodily bacteria in isolated Yanomami Indians, with a 40% lower diversity than those in industrialized countries. The study suggests a link between modern antibiotics and reduced microbiome diversity, potentially driving diseases like obesity and diabetes.
Researchers found antibiotic resistance genes in Yanomami tribespeople who had never been exposed to antibiotics, suggesting that bacteria have resisted antibiotics since long before their use. The study reveals a link between decreased bacterial diversity and increased diseases such as obesity and diabetes.
Researchers found that a concentrated maple syrup extract makes disease-causing bacteria more susceptible to antibiotics, leading to lower antibiotic usage. The extract also reduces biofilm formation of pathogenic bacteria, making it a potentially simple and effective approach for reducing antibiotic resistance.
Researchers discovered that alternating low doses of two antibiotics can kill bacteria while promoting the emergence of drug-resistance mutations. This sequential treatment approach, called 'sequential synergies,' may provide a way to sensitize bacteria to concentrations of antibiotics that would normally induce resistance.
A pioneering new technique using sequential treatments may help combat the rise of antibiotic-resistant bacteria by killing them at lower doses than usual. This approach reduces the risk of bacteria becoming resistant to antibiotics, maintaining long-term effectiveness.
Researchers found that simpler antibiotic regimens are as safe and effective as standard treatments, allowing more infants with severe infections to receive life-saving treatment at home. The study demonstrated that outpatient treatments with fewer injections can produce similar results to the traditional course of twice daily injections.
The American Academy of Otolaryngology-Head and Neck Surgery Foundation has updated its clinical practice guideline for adult sinusitis. The new guideline emphasizes the importance of shared decision-making between patients and clinicians, including deciding whether to use antibiotics for acute bacterial sinusitis. Key recommendations ...
Newborns and young infants with severe bacterial infections can be effectively treated outside hospital with simplified antibiotic regimens, reducing deaths and improving adherence. The Lancet study found that treatment failures were low in all three trials, and the risk of death was similar to infants who received hospital care.
The University of Texas at Austin researcher is working on developing small-molecule inhibitors that counter antibiotic resistance in Gram-negative bacteria. The goal is to create a suite of drugs for treating bacterial infections resistant to most antibiotics.
The article highlights the importance of antimicrobial resistance, citing its impact on human and animal health. Global collaboration and innovative approaches are necessary to tackle this complex issue.
A study published this week found that over 6.3 million people may be exposed to antibiotic-resistant bacteria while engaging in water sports, with surfers and swimmers at highest risk. The research highlights the importance of maintaining good water quality standards to minimize exposure to these harmful microbes.
Researchers warn that increased antibiotic use in livestock could lead to decreased effectiveness in humans. A study found that global demand for animal protein is rising dramatically, driving antimicrobial consumption.
The FDA approves new antibiotics with minimal evidence of efficacy against antimicrobial resistance. Despite this, industry and medical societies claim the drugs address the issue, sparking concerns over safety and efficacy standards.
A child with autism improved dramatically while taking an antibiotic for strep throat, prompting a quest by the parent to understand the phenomenon. The collaboration led to a scientific conference and special issue in a scientific journal featuring articles on the microbiome's involvement in autism.
ACS researcher Laura Kiessling has discovered a way to target bacterial carbohydrates, potentially leading to new antibiotic strategies. Her team found that human proteins can recognize unique microbial carbohydrates, opening up possibilities for delivering targeted treatments.
Scientists report preliminary studies suggesting chlorine treatment in wastewater plants may create new, stronger antibiotics. This could contribute to growing antibiotic resistance problem and harm aquatic life.
Antibiotics are widely used in lab experiments for microbiology, molecular biology, and genetic research. However, this practice contributes to the growing problem of antibiotic resistance, posing a catastrophic threat to modern medicine. Researchers must use antibiotics more responsibly and sparingly.
Researchers have found that clindamycin and TMP-SMX are equally effective in treating uncomplicated skin infections caused by community-associated MRSA. The study's findings suggest that these off-patent antibiotics can be used successfully to combat MRSA skin infections acquired outside of hospitals.
A multicenter clinical trial found that clindamycin and trimethoprim sulfamethoxazole (TMP-SMX) are similarly effective in treating uncomplicated skin infections, with cure rates of 80.3% and 77.7%, respectively. The study was conducted on 524 adults and children with cellulitis or abscesses.
Researchers have linked antibiotic resistance with poor governance and corruption around the world, citing alarming rates of 23,000 deaths annually in the US due to antibiotic-resistant infections. The study suggests that addressing corruption and control of antibiotics could help lower resistance levels and save lives.
Despite pre-surgery antibiotics, bacterial clumps persist in joint fluid, forming protective mesh of proteins that slow growth and make them resistant to treatment. The study identified a key reason for the difficulty in curing joint infections: biofilm-like clumps of bacteria that harbor antibiotic-resistant superbugs.
Scientists have created nanoparticles loaded with clarithromycin, an antibiotic used in respiratory infections treatment, allowing better delivery of the drug to lung cells. This method enables direct access to bacterial biofilms or individual lung cells, reducing toxic effects and improving treatment efficacy.
Researchers develop novel approach to target bacterial lipids, labeling and sparing healthy cells. The new strategy exploits covalent chemistry of lipids, enabling selective recognition and labeling of bacterial cells.
Researchers have discovered a new mechanism of antibiotic resistance in bacterial cells, which could help develop solutions to the growing problem of antibiotic resistance. The study found that a mutation in the efflux pump makes it more efficient at pumping antibiotics out of bacterial cells.
Researchers developed bioactive filaments, chemotherapy beads, and catheters that can deliver antibiotics and chemotherapeutic agents in targeted areas. These devices have the potential to inhibit bacterial growth and cancer cell proliferation.
Researchers at the University of Maryland have developed chemical compounds that enhance conventional antibiotics' effectiveness and inhibit bacterial biofilms. The compounds block quorum sensing signals, preventing biofilm formation and alerting the immune system to their presence.
A study by Johns Hopkins researchers found that competition among healthcare providers, including physicians and retail clinics, leads to higher antibiotic prescribing rates in affluent areas. The analysis revealed a strong correlation between the number of clinics and increased antibiotic prescriptions in wealthy regions.
Researchers say treating human health as part of an ecosystem can resolve problems like antibiotic crisis and obesity epidemic. Professor Mark Wahlqvist advocates for integrative approaches to healthcare, emphasizing the importance of nature and varied diets.
Pediatric cancer patients who receive antibiotics within 60 minutes of reporting fever and neutropenia have decreased intensive care consultation rates and lower mortality. The study shows that timely antibiotic delivery can lead to significant reductions in hospitalization and fatalities among pediatric cancer patients.
A new study found that administering antibiotics within the first hour of injury can significantly reduce infection rates in trauma patients. The study, published in the Journal of Orthopaedic Trauma, included 137 patients with open fractures and found that those who received antibiotics early had much lower infection rates.
Researchers identify thiocillin as an antibiotic that activates biofilm formation in a way unrelated to its killing ability, suggesting that antibiotics may evolve to produce biofilms rather than kill other bacteria.
Scientists at Washington State University have discovered a probiotic toxin that can combat Coldwater Disease in rainbow trout, killing the bacteria with a toxic protein. The probiotics could be a game-changer for the global salmonid aquaculture industry, reducing disease losses and improving animal welfare.
Researchers discovered that C. difficile bacteria can wreak havoc on the gut within 24 hours of exposure, causing severe diarrhea and life-threatening disease. The study found that bile acids 'wake up' dormant spores, allowing them to grow into toxin-producing cells in the large intestine.
Researchers at Oregon State University have discovered that antibiotics have a profound impact on the microorganisms in an animal's gut, disrupting the natural balance of the microbiota. This can lead to damage to the intestinal epithelium, changes in mitochondrial function and other biological effects.
A new study found that Lyme disease costs the US healthcare system between $712 million and $1.3 billion a year, with patients experiencing persistent symptoms after completing antibiotics. The condition, also known as post-treatment Lyme disease syndrome, affects an estimated 240,000 to 440,000 people each year.
High school students Anya Dunaif and Nell Kirchberger collected bacteria from NYC subway stations that resisted two common antibiotics. The samples are part of a city-scale environmental DNA sampling effort to profile the microbiome and assess biological threats.
Researchers at MGH have identified characteristics, including gene expression differences, that indicate which patients recovering from severe burns are at greatest risk for repeat infections. The study could lead to personalized therapies and more effective prevention and treatment strategies.
A new study found that nearly half of patients with respiratory tract infections were inappropriately prescribed antibiotics in an outpatient setting. The study suggests implementing comprehensive education about antimicrobials and stewardship into medical school curricula to prevent establishment of poor prescribing practices.
A large Canadian Medical Association Journal study found that combining trimethoprim-sulfamethoxazole with spironolactone more than doubles the risk of sudden death in older patients. The study suggests that physicians should consider alternative antibiotics for patients on spironolactone to reduce this risk.
Researchers have discovered a way to eradicate cancer stem cells using antibiotics, opening up the possibility of a new treatment for cancer. The study found that four types of antibiotics eradicated cancer stem cells in every test, including glioblastoma and other aggressive forms of cancer.
A Finnish study found that travelers who used antibiotics to treat diarrhea were more likely to carry drug-resistant intestinal bacteria, such as ESBL, upon return. Carriers can spread the bacteria to others, even without symptoms.
A SLU scientist has discovered an evolutionary mechanism used by bacteria to evade antibiotics like azithromycin. The discovery reveals a universal stalling mechanism, suggesting a way to improve existing drugs' effectiveness against antibiotic-resistant strains.
A study found that taking antibiotics for diarrhea while traveling increases the risk of colonizing drug-resistant bacteria, such as ESBL-producing Enterobacteriaceae. Travelers returning home with these bacteria can unknowingly spread them to their own countries, posing a serious public health threat.
Researchers analyzed soils from five continents to discover potential antibiotic and anticancer drugs. They identified unique gene clusters in these samples that could lead to new medicines, including ones used to combat tuberculosis and cancer.
Researchers found that antibiotics can help prevent norovirus infections by eliminating a bacterial collaborator. They also identified an immune system molecule that can cure persistent norovirus infections even in mice with partially disabled immune systems.
Researchers at Northeastern University have discovered a novel antibiotic called teixobactin that eliminates pathogens without developing detectable resistance. This breakthrough presents a promising new opportunity to treat chronic infections caused by staphylococcus aureus and tuberculosis, two highly resistant bacterial strains.
Researchers at Stanford University School of Medicine have developed a modified version of an aminoglycoside that works effectively in mice without causing deafness or kidney damage. The new antibiotic, N1MS, was created by modifying the drug molecule to prevent it from entering the inner-ear cell's ion channels.
Researchers found that combining clarithromycin with certain statins increases the risk of acute kidney injury or high potassium levels, potentially leading to hospital admission. The study suggests that alternative antibiotics like azithromycin may help prevent these adverse events.
Researchers at UCL discovered how a protein, RcsF, triggers an alarm system in bacteria to defend against antibiotics. This discovery provides a new target for developing new antibiotics and could help combat the growing problem of antibiotic resistance.
A study published in Nature Communications reveals that mutations can converge on similar physical changes in bacteria, leading to resistance to multiple antibiotics. The researchers found a common set of features responsible for the development of resistance, which could help combat this growing problem.
Gut bacteria produce cephalosporinases that protect themselves and beneficial bacteria from antibiotics, while also giving protection to harmful bacteria. The researchers found genes in Bacteroides bacteria that produce an enzyme destroying certain antibiotics.
A study published in JAMA Pediatrics found that children treated with oral antibiotics did not experience more treatment failures than those treated with PICC-delivered antibiotics. Oral medication offers a safer alternative to IV therapy, reducing the risk of serious complications like infections and blood clots.
A study found that patients often believe taking antibiotics can't hurt and might make them better, even if they have a viral infection. Researchers are calling for new education tactics to address these misconceptions and reduce overprescription of antibiotics.
Researchers have identified bacterial genes that help UTIs spread, providing a potential new target for treating UTIs. The study reveals the specific genes expressed by E. coli bacteria in human urinary tract infections, which can be attacked to promote survival of the bacteria.
A treatment pioneered at the University of Pittsburgh Center for Vaccine Research is far more effective than traditional antibiotics in inhibiting the growth of drug-resistant bacteria. The new drug, called engineered cationic antimicrobial peptides (eCAPs), inhibited growth in about 90% of test bacterial strains.
Researchers discover penicillin works by setting in motion a toxic malfunctioning of the cell's wall-building machinery, which depletes cells of resources. This finding could lead to new ways to thwart drug resistance.
Researchers at the University of Houston are using a patented equation to assess the effects of antibiotics on bacteria and develop more effective treatments. They plan to use image analysis technology to automatically record data, reducing the need for physicians to run excessive tests.
Researchers at Karolinska Institutet have found no causal link between antibiotics and childhood asthma, contradicting previous studies. The study of half a million children suggests that respiratory infections may increase the risk of asthma, regardless of antibiotic treatment.
Researchers at Brigham Young University have identified a potentially life-saving antibiotic produced by good bacteria found in turkeys. The MP1 antibiotic has shown promise in targeting staph infections, strep throat, and severe gastrointestinal diseases.
A global study found that rheumatic heart disease is being neglected in many countries, resulting in inadequate treatment with antibiotics and oral anti-coagulants. This leads to increased maternal mortality rates, particularly in low- and middle-income countries.