Research on antibiotics and the bacteria they target. Covers antibiotic resistance, gut pathogens, persistent strep throat, and water-source contamination.
Researchers identified two synthetic compounds that can restore the effectiveness of antibiotics against MRSA by blocking an enzyme involved in bacterial cell wall production. When paired with existing antibiotics, these compounds significantly improved survival rates and reduced infection severity in mice infected with MRSA.
A team of researchers is using computational models and data from actual patients to understand C. difficile colonization and infection. They aim to develop tools to prevent and treat infections that kill thousands annually.
Researchers from KU Leuven found that frequent antibiotic use leads to the development of persister cells, which are dormant and tolerant to antibiotics. This phenomenon can lead to the recurrence of infections despite successful treatment.
A randomized controlled trial found that electronic consultations improved access to cardiac care, with nearly two-thirds of patients not requiring a face-to-face visit. Additionally, e-consultations were completed on average almost a month sooner than traditional consultations.
A long-term study found a correlation between the use of animal manure and an increase in antibiotic-resistant genes in soil. Phasing out antibiotics led to a rapid decrease in resistant gene abundance, suggesting that stopping antibiotic use can help reduce resistance levels.
A recent publication by Journal of Environmental Quality highlights the science behind antibiotic resistance in agroecosystems. Key findings include the widespread use of large quantities of antibiotics and animal waste leading to environmental contamination.
A new method of treating abscesses has been discovered, which involves adding an antibiotic to the conventional approach, resulting in improved recovery rates and reduced risk of MRSA infection spread. The study found that 93% of patients who took the antibiotic were cured, compared to 86% who received a placebo.
Engineered fabrics effective against superbugs like MRSA could reduce impact of super-bacterial infections. Researchers have successfully produced anti-super-bacterial masks using violacein-based dye, blocking growth by 99.9%.
Duke University researchers have engineered microbes that can't run away from home; those that do will quickly die without protective proteins produced by their peers. The system could be used to reliably program colonies of bacteria to respond to changes in their surrounding environment, such as releasing specific molecules on cue.
The VA has robustly implemented antibiotic stewardship practices across its facilities, with over 80% having an Infectious Disease specialist on staff. Formal policies and staffing patterns promoting appropriate antibiotic use were also widespread.
Newborns may develop severe infections from exposure to vaginal bacteria, experts warn. Encouraging breast feeding and avoiding unnecessary antibiotics may be more important than vaginal seeding for infant health.
A study of over 600,000 adults found that macrolide antibiotics were associated with a similar 30-day risk of ventricular arrhythmia as nonmacrolide antibiotics, and slightly lower risk of all-cause mortality. The findings are reassuring for healthcare providers who prescribe these antibiotics to patients at low risk of adverse events.
A nationwide trial found that providing GPs with tailored feedback on their antibiotic prescribing habits reduced prescriptions by an average of 3.3% over 6 months. The intervention resulted in over 73,000 fewer prescriptions and direct savings of £92,000.
A study published in Neurology found that certain antibiotics are associated with delirium, a condition characterized by mental confusion and hallucinations. Researchers identified three types of brain problems related to antibiotics, including seizures, psychosis, and impaired muscle coordination.
New research reveals a clear parallel between antibiotic resistance in medicine and similar genes detected in agricultural soils treated with animal manure. The study found that repeated use of antibiotics in agriculture can increase soil bacteria's capacity to acquire new resistance genes.
A distinctive gene signature discovered in white blood cells of patients infected with Lyme disease could lead to a new way of diagnosing the tick-borne illness. The study found that this signature persisted even after antibiotic treatment, suggesting potential long-term symptoms.
Researchers at the John Innes Centre have identified DNA gyrase as a key enzyme in plants that can be targeted for the development of new, more effective herbicides. This discovery holds promise for reducing the risk of antibiotic resistance and ensuring the safety of farmers and gardeners.
Researchers found that dairy farm waste treated with an advanced anaerobic digestion system still contained high levels of estrogens and antibiotics, which can harm wildlife and contribute to antibiotic resistance. The study highlights the need for improved treatment techniques to remove these chemicals from waste.
Researchers found that 56% of elective resections for uncomplicated diverticulitis occurred after fewer than 3 episodes, suggesting a need for further investigation into appropriate care guidelines. The study included 87,461 patients and analyzed inpatient, outpatient, and antibiotic claims.
A study found that accountable justification and peer comparison behavioral interventions significantly reduced inappropriate antibiotic prescribing. The interventions resulted in modest changes to the practice environment without restricting clinicians' choice of treatment.
A new study found that behavioral interventions, such as peer comparison and accountable justification, significantly reduced unnecessary antibiotic prescriptions for acute respiratory infections. The study built upon prior research and resulted in a 16 percentage point reduction in prescription rates.
Exposure to specific antibiotics is linked to the development of antibiotic-resistant C. difficile , one of the fastest growing bacteria superbugs. The study found that fluoroquinolone and macrolide exposure was more frequent in patients with a highly resistant strain, supporting targeted antibiotic stewardship monitoring programs.
Researchers at Princeton University discovered the mode of action of antibiotic tropodithietic acid (TDA), revealing its ability to kill cancer cells. TDA's unique mechanism involves disrupting cell membrane function, rendering it a potential anticancer agent.
A new study suggests that routine antibiotics do not increase the likelihood of nutritional recovery in uncomplicated cases of severe acute malnutrition. Reducing antibiotic use would be prudent given global concern over antibiotic resistance.
Researchers found that adding azithromycin to standard antibiotics reduced post-C-section delivery infections and severe adverse events in high-risk women. The study used a multicenter double-blind randomized controlled trial involving over 17,000 women.
A new review suggests that targeted antibiotic therapy before prostate biopsy may lower sepsis rates. The study found 27 men need to receive antibiotics to prevent one infection, paving the way for safer procedures.
Bacteria use specific mechanisms to avoid toxic substances like antibiotics during colonization, driven by the action of flagella and chemoreceptors. The discovery reveals a crucial molecular balance between RecA and CheW proteins that enables bacteria to stop swarming movement in areas with high antibiotic concentrations.
The study found that antibiotic use in early childhood alters the composition of intestinal microbiota, reducing biodiversity and affecting age-driven development. Macrolide antibiotics were particularly associated with changes in microbiota features linked to obesity and metabolic diseases.
A team of biologists at UC San Diego has developed a new method to determine if bacteria are susceptible to antibiotics within a few hours. The approach allows doctors to rapidly identify the appropriate treatment for patients with life-threatening bacterial infections, potentially slowing the emergence of drug resistance.
Researchers at Duke University Medical Center have developed a gene signature test that accurately determines whether a respiratory illness is caused by infection from a virus or bacteria. The test shows high accuracy in classifying patients with flu viruses and other common infections.
The American College of Physicians (ACP) and Centers for Disease Control and Prevention (CDC) issued advice for prescribing antibiotics for acute respiratory tract infections in adults. Inappropriate antibiotic use contributes to antibiotic-resistant infections, posing a public health threat. Guidelines recommend symptomatic therapy fo...
The American College of Physicians (ACP) and Centers for Disease Control and Prevention (CDC) issue advice on prescribing antibiotics for acute respiratory tract infections, citing unnecessary use that can lead to $3 billion in excess costs. The guidelines recommend reserving antibiotics for serious illnesses only.
McGill researchers have taken 3D images of a large section from a medicine-synthesizing enzyme in action. The images reveal the intricate way these proteins function and could lead to the development of new antibiotics. This breakthrough may bring scientists closer to understanding how many antibiotics are made.
Researchers have discovered that lasers can improve the penetration of antibiotic treatments into citrus leaves, potentially offering a new approach to treating the deadly citrus greening disease. The method uses laser etching to create microscopic indentations in the leaf tissue, allowing for more effective delivery of substances.
Researchers at the University of Vermont discovered a new strategy for bacteria to become resistant to antibiotics by adopting an 'all-for-one' approach. This allows individual cells to assume high levels of resistance while others avoid extra work, enabling colonies to hedge their bets and persist in infections like cystic fibrosis.
Researchers have discovered that Bacillus cereus can form small colony variants in response to aminoglycoside antibiotics, making it resistant to these therapies. This alternative lifestyle allows the bacteria to survive harsh conditions and evade traditional diagnostic methods.
A new study by UGA ecologist J. Vaun McArthur reveals high levels of antibiotic resistance in streams near the Savannah River Site due to environmental contaminants like metals. The contaminated streams have no known input from antibiotics and show that industrial legacy waste can contribute to antibiotic resistance.
Researchers discover FDA-approved medications with dual-action against bacterial energy production and specific enzymes, potentially reducing resistance. Such multitarget drugs could treat a range of infections, including tuberculosis and Staphylococcus aureus.
Researchers discovered a unique antibiotic molecule that triggers a bacteria's adaptation strategy, enabling it to resist the drug. The resistant bacteria undergoes morphological changes and can move away from the antibiotic, allowing it to survive and spread.
Researchers at Rice University have developed time-released gel-filled implants that deliver antibiotics to the face, reducing the risk of infection during facial reconstruction. The innovative material protects tissue from bacterial invasion for several weeks.
A study published in JAMA Surgery found that nonoperative management with antibiotics was an effective treatment strategy for children with uncomplicated appendicitis, resulting in fewer disability days and lower healthcare costs. The study also showed no difference in health-related quality of life at one year.
A new study from Nationwide Children's Hospital found that antibiotics alone can be a safe and effective treatment for children with uncomplicated acute appendicitis. The non-operative management was associated with less recovery time, lower health costs, and no difference in complications at one year.
A four-year study found that uninsured patients who self-administered long-term IV antibiotics had a 47% lower rate of 30-day readmission rates and similar mortality rates compared to those with insurance. The practice saves hospitals millions of dollars and allows patients to return to their normal lives.
Researchers use antibiotic resistance to identify chemicals blocking amyloid formation, providing a new approach to combat these intractable diseases. The study identifies a chemical that blocks amyloid deposits forming from sequences associated with type II diabetes.
A new method developed by UC San Diego biologists can quickly identify and characterize compounds capable of controlling antibiotic-resistant bacteria in natural product extracts. This breakthrough could shave years off screening efforts and lead to the discovery of new antibiotics, addressing a growing global crisis.
Children with childhood leukemia benefit from prophylactic antibiotics, reducing serious bacterial infections during the first month of treatment by approximately 60 percent. The use of antibacterial prophylaxis appears to have made a profound difference for patients.
A new study by King's College London found that reduced antibiotic prescribing is associated with lower GP satisfaction scores. The study, which analyzed records from 7,800 general practices, found a 25% lower rate of antibiotic prescribing corresponded to a 5-6 point reduction in GP satisfaction rankings.
A new study suggests that antibiotic use during the third trimester of pregnancy is associated with an increased risk of childhood wheeze. However, when confounding factors such as maternal infections and respiratory conditions are accounted for, the link between antibiotic use and childhood wheeze becomes less clear.
Researchers at Georgia State University developed novel antimicrobials targeting SecA, a key disease-causing component of bacteria. The study found that these inhibitors can overcome drug resistance and reduce toxin secretion, offering a promising alternative to existing antibiotics for treating MRSA infections.
A computer model of tuberculosis has shown that daily antibiotic regimens are more effective than once or twice a week in preventing drug-resistant strains. The study suggests that increasing the number of doses and improving drug properties can lead to significant improvements in treatment success rates.
Researchers found that giving common antibiotic azithromycin at the first sign of cold symptoms can reduce the risk of severe lower respiratory tract illness in children. The study tested azithromycin against placebo in 607 children and showed a significant difference in the severity of infections between the two groups.
The Centers for Disease Control and Prevention (CDC) emphasizes the importance of antibiotic stewardship in reducing Clostridium difficile infection rates. Key components include careful prescribing, early diagnosis, isolation of infected patients, and adequate cleaning of the patient care environment.
A new study promoted better prescribing practices for urinary tract infections (UTIs), but unexpectedly saw an increase in antibiotic prescriptions. Patients were twice as likely to receive a first-line antibiotic, with nitrofurantoin being the preferred option.
Researchers have gained a deeper understanding of the biosynthesis process, enabling them to manipulate nature's machinery to produce more effective compounds. This knowledge will help scientists engineer enzymes to create new treatments for diseases.
Researchers at Cedars-Sinai Medical Center found that certain antibiotics used to treat MRSA can worsen the infection in mice. The study suggests that these antibiotics may induce inflammation and damage tissues, making patients sicker.
A pre-clinical study reveals that treatment with first-line antibiotics can make MRSA skin infections worse by inducing a harmful inflammatory response. Newer tests are being developed to quickly diagnose and treat these infections, but caution is needed before extending the findings to humans.
A meta-analysis of 33 studies involving over 20 million patients found a statistically significant increased risk of sudden cardiac death and ventricular tachyarrhythmias associated with macrolide antibiotics. Macrolides were also linked to an increased risk of cardiovascular death, especially with clarithromycin.
Researchers created a synthetic model of E. coli's outer membrane, providing unprecedented access to its structure and dynamics. The model was used to test how antibiotic molecules can cross the critical barrier, which is highly impermeable to incoming molecules.
A study by American College of Allergy, Asthma, and Immunology (ACAAI) found that patients who were told they had a penicillin allergy but tested negative could safely take the drug. Researchers examined records of 15 patients who received intravenous penicillin without adverse reactions.
Recent gonorrhea susceptibility trends indicate a worsening of susceptibility to third-generation cephalosporin antibiotics, particularly cefixime. The CDC's Gonococcal Isolate Surveillance Project found that the percentage of resistant isolates increased from 0.1% in 2006 to 0.8% in 2014.