Articles tagged with Cancer Medication
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Allopurinol, commonly used for gout, was found to significantly reduce the risk of colorectal cancer in patients taking the medication for at least five years. The study analyzed data from 1,781 patients and showed a notable reduction in risk.
Consuming three or more servings of vegetables daily lowered NHL risk by 40% in study participants. Higher intakes of selenium and zinc also showed protective effects, while vitamins A-C-E and carotenoids had no significant link.
The new Mayo Clinic research indicates that mycophenolate mofetil could help many more lupus patients, offering a potential alternative to existing treatments with fewer side effects. Currently, there is no curative treatment for SLE, and many medications used to treat this disease have considerable side effects.
Researchers found a significant increase in ischemic stroke risk with tamoxifen, but emphasized that the absolute risk is small. The study's findings suggest careful screening of women before prescribing tamoxifen therapy due to potential stroke risk.
Researchers at Vanderbilt University Medical Center discovered that lithium can protect brain cells involved in learning and memory from radiation damage. Clinical trials are expected to test whether the drug can prevent cognitive deficits in humans treated with cranial radiation therapy.
A recent study published by Fox Chase Cancer Center found that patients who used nonsteroidal anti-inflammatory drugs (NSAIDs) regularly before their diagnosis and treatment had improved overall survival rates. The research involved 1,206 men with localized prostate cancer and compared the outcomes of those who used NSAIDs regularly to...
Researchers have discovered a cottonseed-derived compound that enhances the effectiveness of radiotherapy and chemotherapy in treating various cancers, including prostate cancer. The study's findings suggest that the compound, (-)-gossypol, can increase induction of apoptosis and make tumours more sensitive to radiation therapy.
Researchers at the University of Michigan have found that a potential small molecule inhibitor, (-)-gossypol, can boost the effectiveness of radiation therapy and chemotherapy in human prostate tumors in mice. The study demonstrates increased induction of apoptosis, making cancer cells more sensitive to treatment.
The second-generation antisense cancer drug OGX-011 has shown promising results in a Phase I trial, inhibiting clusterin production in patients' cancers. The Phase II trials will investigate the effectiveness of OGX-011 combined with standard chemotherapy in patients with metastatic hormone refractory prostate, breast, and lung cancer.
A study surveyed 605 women aged 40-69 to assess eligibility for tamoxifen-based breast cancer prevention. Only a small proportion of white women and none of black women were found to be at high risk, highlighting challenges in targeting discussions about chemoprevention.
A new study found that tamoxifen would only prevent a maximum of 6-8% of breast tumors in eligible women, while its harmful side effects rule out 90% of potential beneficiaries. The researchers suggest that other chemopreventive agents without the same side effects could be more effective in saving lives.
Yale researchers have been awarded a $7.5 million grant to investigate the role of viruses in cancer development. The grant will support studies on human papillomaviruses, Epstein-Barr Virus, and Kaposi's Sarcoma Herpesvirus, focusing on viral genes and cellular pathways that lead to cancer.
A recent study published in Carcinogenesis found that specific DNA patterns enhance breast cancer protection from marine n-3 fatty acids. Women with low-activity versions of genes associated with GSTs have a lower risk of breast cancer, while high-activity versions show no benefit.
Researchers tested the oral compound PKC412 in patients with Myeloproliferative Disease (MPD) and saw symptoms improve. The drug targets a specific genetic mutation, blocking abnormal tyrosine kinases that cause uncontrolled cell division and growth.
Researchers found that PGE2 activates PPARd through a signaling pathway promoting cell survival and polyp formation. This effect was not observed in mice lacking PPARd, highlighting the role of PPARd as a critical downstream mediator in PGE2-stimulated colorectal tumor growth.
Scientists successfully eliminated leukemia in genetically modified mice by disrupting the BCL-2 protein. The study provides strong support for a new paradigm of cancer treatment involving targeted apoptosis regulation.
Researchers have identified a protein tag that is unique to cancer cells and can be targeted by a drug delivery system. The strategy showed effectiveness in laboratory tests and animal models, and the team plans to test it next in human tumors.
Researchers at St. Jude Children's Research Hospital have successfully treated medulloblastoma brain cancer in lab models by targeting a single protein in the hedgehog pathway, demonstrating potential for novel treatment approaches and improved outcomes for patients.
Researchers in The Netherlands and Belgium developed a new technique that uses genetically engineered rhTSH to stimulate thyroid cancer cells to absorb radioactive iodine, avoiding hypothyroidism and increasing safety. This approach may allow higher doses of radioiodine to be used when needed, improving treatment efficacy.
Researchers found that combining histone deacetylase inhibitors with anti-angiogenesis drugs reduced tumor growth in mice by up to 85% and controlled new blood vessel formation by 60%. This combination therapy may provide a greater impact on cancer development than using the drugs alone.
Researchers found no clear association between atrazine exposure and cancer in a large cohort study. Additionally, studies on alcohol consumption and gastric cancer incidence revealed mixed results, while an animal study demonstrated the potential of mammaglobin-A immunotherapy as breast cancer treatment.
Researchers found that zoledronic acid inhibits the growth of cervical cancer by targeting macrophages expressing matrix metalloproteinase-9 (MMP-9) and angiogenesis. This treatment approach offers new hope for cervical cancer patients.
Researchers from MIT and international collaborations found that different proportions of two key ingredients in ginseng promote or hinder blood vessel growth, with implications for wound healing and cancer treatment. The study highlights the need for stronger regulations on herbal drugs due to variable processing methods.
Paediatric research is crucial for disease prevention and treatment, yet data are lacking due to a lack of legislation requiring companies to conduct trials on children. The UK Government's new initiative aims to invest £100 million in research networks but falls short of centre stage for acquiring research-based evidence.
Researchers have created a group of rhodium-based compounds that can target and kill cancer cells, as well as deactivate viruses like West Nile and yellow fever viruses. These compounds work by binding to DNA in tumor cells and rendering them inert, and they offer a promising alternative to traditional chemotherapy drugs.
Stanford researcher Matthew Bogyo and colleagues discovered that cathepsin cysteine proteases help build blood vessels to tumors, increase tumor growth and invasiveness. A broad-spectrum inhibitor slowed tumor development in mice with no apparent side effects.
Scientists have determined the precise molecular structure of a potential new target for treating prostate cancer, driven by abnormal testosterone activity. The target is part of the androgen receptor, which drives prostate cancer at different stages.
Researchers have discovered a significant correlation between ABC transporter gene expression and decreased sensitivity to certain cancer drugs. This study provides valuable insights into the role of these proteins in multidrug resistance, potentially leading to the development of new therapeutic strategies.
Researchers have uncovered a powerful new cancer-fighting property of Herceptin, which targets HER-2 positive breast cancer cells. The study found that high levels of PTEN in tumor cells predict response to the drug, and offers potential combination therapy with PI3K inhibitors.
Researchers at Johns Hopkins University have developed a new class of nitroxyl-releasing compounds that seem to strengthen cardiac contractions and relaxation in dogs with heart failure. These compounds, which produce nitric oxide (HNO), have shown promising results in early studies.
A new compound called OSU 111 has been developed to target both cancer cells and the formation of new blood vessels that feed them. In laboratory experiments, it was found to be highly effective in killing prostate cancer tissue cells within three days.
Researchers developed first mouse embryos without D-type cyclins, which sparked hope for anti-cancer therapy. The triple-knockout mice followed a normal course of cell division until late stages, contradicting previous theory and experiments.
A national study led by UC Davis researchers found that surveillance colonoscopies are performed more frequently than necessary, with 24% of gastroenterologists recommending unnecessary procedures. The study suggests that implementation of clinical guidelines can help optimize patient care and reduce healthcare burden.
Emory researchers create three-dimensional, atomic-scale images of epothilone A binding site with key protein controlling cell division. The study's results pave the way for creating new compounds and a clinical tool for pharmacogenetic profiling.
MGH cancer specialists propose a new 'selective approval' mechanism to identify most suitable patients for targeted therapies. This approach could improve treatment outcomes and reduce waste of resources.
Researchers have developed a new approach to identify connections between genes and chemotherapy drugs, which may enable clinicians to customize treatment plans. By analyzing cell lines from large families, the team found potential links between genetic markers and increased sensitivity to two chemotherapy drugs.
A recent study found that combining EGFR inhibitors like Erbitux with Iressa or Tarceva hinders cancer cell growth more effectively than single drug treatments. The tandem application of these drugs amplified control of cancer cell signaling, leading to increased apoptosis and tumor development limitation.
Researchers have identified nearly 100 genes linked to cancer, shedding light on the processes driving disease progression. The study highlights the potential of targeted therapies and early detection methods to manage cancer.
The NIH has renewed funding for Giordano's Rb2 tumor suppressing gene research at Temple University, aiming to design therapies for cancer patients. Over the past decade, Giordano's work linked Rb2 with cancer regression and effectiveness of drug therapies against breast cancer.
The award honors an individual scientist for highly original research, with the winner receiving €75,000 and a commemorative plaque. Recent past recipients include Stanley J. Korsmeyer and Mario R. Capecchi.
The American Association for Cancer Research (AACR) is honoring outstanding scientists and physicians who have made significant contributions to cancer research. The AACR recognizes researchers in various fields, including basic cancer research, clinical cancer research, and medical chemistry.
A new phase 2 study shows that combining cetuximab with irinotecan can resensitize tumors resistant to irinotecan, offering patients a new treatment option. The study's modest benefits in stopping cancer growth and improving patient response are seen as a step forward in treating colorectal cancer.
A study published in Cancer Cell reveals that mouse cells lacking LKB1 and PJS mouse polyps show activation of molecules downstream of the mTOR protein. Researchers suggest that using mTOR inhibitors like rapamycin may be useful for treating PJS patients' polyps and potentially other tumors resulting from LKB1 loss.
Researchers have discovered that N-acetylcysteine (NAC) can prevent cisplatin-induced ototoxicity, a type of progressive and irreversible hearing loss in patients undergoing chemotherapy for head and neck cancer. The study found that NAC was most effective when given 15 minutes before chemotherapy.
A study published in Science reports the effectiveness of a new compound, BMS-354825, against Gleevec-resistant Chronic Myeloid Leukemia (CML) cells. The compound targets secondary mutations that allow cancer to evade therapy, offering hope for patients who have relapsed on Gleevec.
Researchers find that combining discodermolide and paclitaxel inhibits human lung cancer cell growth by 41 percent, while alone the drugs exert only 9.6% or 16% growth inhibition. The combination also induces programmed cell death in cancer cells, suggesting a potential therapeutic approach for reducing undesirable side effects.
Researchers have identified a new compound, BMS-354825, that successfully sidesteps the problem of Gleevec resistance in some patients. The compound prolongs survival of mice with chronic myeloid leukemia (CML) and inhibits the proliferation of bone marrow progenitor cells resistant to Gleevec.
Researchers at Ohio State University developed a new anti-cancer agent, OSU-03012, which inhibits Akt and induces programmed cell death in cancer cells. The agent has shown potent activity against various types of cancer, including leukemia and breast and lung cancers.
A new HPV vaccine study is underway in women aged 24-45 to prevent cervical cancer and genital warts. The quadrivalent vaccine protects against four common strains of human papillomavirus virus, including two that cause cervical cancer and two that cause genital warts.
Researchers found that combining doxorubicin with dexrazoxane reduced heart damage in high-risk ALL survivors by 25 percent compared to doxorubicin alone. The study, published in the New England Journal of Medicine, used blood tests to detect heart damage before it could be seen on echocardiograms.
A new study by The Wistar Institute suggests that the MYC protein binds to a large percentage of genes without activating them. This discovery raises questions about MYC's other functions and potential tissue-specific controls.
Researchers at Thomas Jefferson University have developed a microarray chip that can track the genetic signature of cancer and normal tissue by analyzing miRNA gene expression patterns. This technology has the potential to provide new targets for drug development and improve our understanding of cancer phenotypes.
A study using FMISO-PET scans found that high uptake of the tracer correlates with a greater risk of tumor recurrence, while low uptake is associated with a longer survival rate. The technique may enable more precise prediction of therapeutic outcomes and improved patient treatment.
A new combined PET/CT scanner has shown significant improvement in tumor staging accuracy compared to traditional CT and PET imaging methods. The study involved 260 patients with various oncological diseases, yielding accurate staging results in 84% of cases.
Researchers at UC Davis are developing a new cancer treatment that uses ultrasound to steer tiny capsules carrying cancer-fighting drugs to tumors. This approach aims to reduce the toxic side effects of current cancer treatments by concentrating the drug directly in the tumor.
Researchers found that Cox-2 inhibitors slowed disease progression in men with recurrent prostate cancer by inhibiting tumor growth and increasing programmed cell death. The study showed significant results in 22 of 24 patients, with a 92% reduction in PSA levels after three months.
A small clinical trial showed that 22 out of 27 patients experienced improvement in symptoms such as weakness and pain after taking pentoxifylline for eight weeks. Researchers believe the drug may help reduce inflammation and improve quality of life for those with radiation fibrosis.
The study found that 85% of cancer patients use prayer as a common non-medical therapy for healing, while 25% change their diets or use mega-vitamins to improve their health. Patients often don't discuss these therapies with their doctors due to communication gaps.
Researchers found that approximately 50% of gemcitabine dose was converted to an active form, while the remaining 50% remained inactive. This discovery highlights the need for alternative treatment schedules for cancer patients undergoing gemcitabine infusions.
Researchers found Veglin to be safe and effective in lowering blood levels of key enzymes, showing promise in blocking tumor growth and metastasis. The phase I trial has shown encouraging results in patients with diverse disease types, paving the way for future phase II clinical trials.