Articles tagged with Cancer Medication
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at Texas A&M University found that breast cancer cells may evade treatment by consuming stem cells from bone marrow, making them difficult to kill. This mechanism could explain cancer recurrence and lead to new treatments, such as delivering toxic agents directly to cancer cells using stem cells as a delivery vehicle.
Researchers at Dana-Farber Cancer Institute found that cabozantinib exceeded sunitinib in progression-free survival and overall response rates for patients with metastatic kidney cancer. The study showed a 20% lower risk of death associated with cabozantinib treatment.
Researchers created a new cancer drug using gold nanoparticles to deliver paclitaxel directly to tumors, increasing effectiveness while reducing devastating side effects such as hair loss and nerve pain. Early lab tests showed the therapy to be nearly as effective as a high dose of paclitaxel alone.
Researchers at the University of Hawaii Cancer Center identified a protein called RSK2 as a driver of tumor cell invasion in glioblastoma. Inhibiting RSK2 stops the invasion and enhances chemotherapy effectiveness, offering new hope for patients with this aggressive brain cancer.
Research finds that tumor necrosis factor inhibitors used to treat juvenile idiopathic arthritis do not increase the risk of malignancy. The study, which analyzed data from over 27,000 children with JIA, concluded that TNFi are not associated with a significantly increased risk of incident malignancy.
Lung cancer is expected to result in an estimated 158,080 deaths in 2016 due to limited treatment options. Researchers are exploring signals within lung cancer cells that cause them to grow quickly and spread to other organs like the liver.
Researchers at Moffitt Cancer Center have developed a novel approach using mathematical modeling to accurately predict patient responses to cancer drugs in virtual clinical trials. This approach enables the identification of optimal treatment schedules that improve outcomes and reduce toxicities for melanoma patients.
A new study raises concerns about the effectiveness of expensive new cancer drugs in improving survival rates, citing limitations in clinical trials and high costs. Experts call for stricter approval criteria and improved patient consent processes to ensure fair and equitable treatment.
RK-33 reduces prostate cancer cell proliferation and increases sensitivity to radiation, offering a promising combination treatment for prostate cancer. The experimental drug has been shown to be effective in both laboratory cultures and animal models.
Researchers at Queen's University Belfast have identified a way to bypass bowel cancer's defence against the drug cetuximab by blocking the ADAM17 protein. This breakthrough could lead to a new combination therapy that delays or prevents cancer recurrence, improving patient outcomes.
An international team has developed a new method to analyze RNA structures linked to cancer. The research aims at understanding how four-stranded RNA structures called G-quadruplexes affect cellular processes such as RNA splicing, which is essential for producing proteins.
A new synthetic binding protein called NS1 monobody has been developed to block the activity of genetic mutations found in nearly 90% of pancreatic cancers. This breakthrough discovery provides insight into how RAS proteins function in cells, potentially leading to new therapeutic approaches for treating cancer.
Researchers use gold nanoparticles with radioactive tracers to target cancer cells' telomeres, shutting down telomerase and halting growth. The method holds promise for delivering a lethal payload to cancer cells, improving treatment outcomes.
The Lancet Commission estimates the monthly cost of a basic package of 201 essential medicines could be as low as $1-2 per person, addressing universal health coverage goals. However, many countries spend less than this amount on medicines, highlighting the need for additional financing to meet basic healthcare needs.
A new study from Massachusetts General Hospital finds that cigarette smoking significantly reduces the lifespan of people living with HIV in the U.S., potentially even more than HIV itself. Quitting smoking can greatly increase lifespan and is never too late to quit.
Researchers at Georgetown University Medical Center have developed a method to study cancer cell invasion and metastasis in real-time using zebrafish embryos. This approach allows for faster analysis of cancer questions, potentially leading to new treatments.
The SWOG and The Hope Foundation's efforts are paying off, with 13 NCTN trials now open to veterans at participating medical centers. Veterans like Jerry Valentino have successfully enrolled in trials, responding well to cutting-edge treatments.
A study published in The New England Journal of Medicine details two cases of acute and unexpected fatal myocarditis that occurred in melanoma patients following treatment with a combination of ipilimumab and nivolumab. High-dose corticosteroids were initially administered, but both patients died due to the severe immune reaction.
Researchers at The Wistar Institute have developed a combination therapy that improves chemoresistance in ovarian cancer. BET inhibitors can suppress ALDH activity, making treatment more effective when used with cisplatin. This approach has shown extended survival rates and delayed tumor growth in mice.
Researchers found that high levels of Manganese Superoxide Dismutase (MnSOD) trigger aggressive breast cancer cell behavior. By targeting MnSOD, scientists hope to develop effective therapeutic strategies against triple-negative breast cancer.
A new study identifies the Hedgehog signaling pathway as a central driver of gastrointestinal stromal tumors (GIST), which are often resistant to current treatments. Researchers have found that targeting this pathway with arsenic may offer a new approach to treatment, potentially killing multidrug-resistant cell lines.
A recent study found that hybrid structures composed of DNA and RNA play a crucial role in restoring genetic information after damage. The research also revealed that RNase H enzymes targeting these hybrids are vital for efficient DNA repair. This discovery offers potential for developing new cancer drugs targeting these enzymes.
The article explores the economic aspects of cancer care, highlighting the need to assess the value of healthcare innovation. It discusses the rising costs of new treatments and the potential impact on healthcare budgets. The Special Issue provides a review of health economics in cancer research and care.
Researchers at Boston University School of Medicine have discovered a potential treatment option for ovarian cancer by combining calpeptin with epigenetic inhibitors. The therapy shows promise in killing cancer cells and preventing their growth, offering new hope for women affected by the disease.
A new Penn Medicine study fails to find NLR reliable for predicting cancer progression and treatment response in bladder cancer patients. The researchers analyzed data from a prospective clinical trial, which showed that NLR was not effective as a prognostic or predictive biomarker.
Researchers developed a way to attach labels to cancer drugs packaged in liposomes, allowing for imaging with PET to see where they accumulate in the body. This method shows promise in predicting drug delivery to cancer tissues in specific patients, potentially leading to more effective treatments and reduced side effects.
A recent study published in JAMA Internal Medicine estimates that nearly 40% of cancer deaths in men are linked to smoking, with the South experiencing the highest rates. The research suggests that weaker tobacco control policies and lower socioeconomic status contribute to these disparities.
Researchers at Aarhus University combined two scanning technologies to create high-resolution images of cancer tumors in mice, providing detailed mapping of blood vessels. This method could lead to the development of more effective drugs and personalized treatment plans.
Researchers use fission yeast to discover new cancer drugs targeting active proteins involved in DNA replication. The unique "arched and snapped" appearance of treated cells suggests potential for accelerating drug development.
Researchers at MUSC Hollings Cancer Center discover a mechanism conferring resistance to AML drugs and develop a ceramide-based therapeutic that reactivates mitophagy, killing drug-resistant cancer cells. The treatment has clinical appeal due to its specificity towards cancer cells.
Scientists at TUM have discovered new mechanisms of action for Imiquimod, a medication used to treat viral skin infections and certain types of skin cancer. The study reveals that Imiquimod activates the NLRP3 inflammasome, which can lead to inflammation and potentially contribute to its efficacy or adverse side effects.
A new compound, S63845, has been shown to block a protein essential for the sustained growth of up to a quarter of all cancers. This research holds promise for treating blood and solid cancers, including acute myeloid leukaemia and melanoma.
Researchers at Johns Hopkins Medicine have developed a modified cancer drug that enhances its ability to reach the brain, improving delivery and reducing toxicity. The new compound shows promise in treating brain tumors by targeting tumor metabolism and evading immune cells.
Rural Appalachia faces alarming disparities in cancer care, including higher mortality rates, late diagnoses, and limited access to comprehensive treatment. The region has seen a decline in cancer incidence nationwide, but its cancer death rate has increased, with rural residents facing significantly worse outcomes.
Researchers at USC Fertility found modified natural cycle IVF to be a cost-effective fertility method, saving up to $7,000 per live birth compared to conventional IVF. This approach takes less time and is gentler on the body, making it more accessible to younger patients.
Eleven cancers causing most loss of healthy life years in the US are closely associated with preventable risk factors like smoking and alcohol. Lung cancer accounts for 24% of the burden, followed by breast, colorectal, pancreatic, prostate, leukemia, liver, brain, non-Hodgkin lymphoma, and ovarian cancers.
Researchers develop artificial cell-like spheres from natural proteins to study drug transport and variability. Variants in genes ABCB1 and CYP19A1 associated with anastrozole concentrations and joint pain in breast cancer patients.
Researchers at Weill Cornell Medicine found that chemotherapy kills urothelial cancer cells but shapes their genetic evolution, leading to drug-resistant cell clones. This study provides a framework for understanding the biological basis of chemotherapy resistance in bladder cancer and may lead to improved diagnostics and treatments.
Researchers at Hokkaido University discovered that a nonsteroid anti-inflammatory drug used for treating colds can suppress the spread of bladder cancers and reduce chemoresistance in mice. The study identified the metabolic enzyme aldo-keto reductase 1C1 (AKR1C1) as a key player in cancer progression.
A recent scandal in Brazil highlights the dangers of unproven compounds being sold to cancer patients. The authors argue that skipping clinical research phases puts patients at risk of false hopes and dangerous treatments. They emphasize the need for evidence-based medicine and the importance of testing novel drug candidates.
Researchers from the Repurposing Drugs in Oncology project found that propranolol has significant anti-cancer properties, particularly in angiosarcoma. The study highlights the potential of propranolol to act on multiple points of the metastatic cascade, reducing metastatic spread and saving lives.
Changes in protein modifications generate biological diversity needed for evolution, allowing species to adapt to environments. Most phosphorylation sites arose relatively recently in evolution, contributing significantly to evolutionary diversity and highlighting potential avenues for therapeutic research.
A team of researchers at the Salk Institute has found a way to obstruct the creation of fat molecules in cancer cells, stalling their growth. This approach involves inhibiting an enzyme called Acetyl-CoA Carboxylase, which is crucial for lipid synthesis activity.
Researchers aim to learn about physical parameters limiting drug delivery into brain tumors to improve treatment selection for unique tumors.
A team of international scientists has outlined 14 recommendations to improve the adoption of new cancer scans in clinics. The guidelines aim to address challenges such as variability in methodologies and lack of reproducibility across laboratories.
Scientists at Harvard's Wyss Institute have developed a way to analyze the effect of mechanical stiffness on chemotherapy treatment. The new method uses alginate hydrogels to mimic tumor and normal tissue environments, revealing that softer matrix conditions lead to increased resistance.
A new study suggests that combining an experimental PARP inhibitor with an epigenetic drug can strengthen treatment effectiveness against breast cancer cells without BRCA mutations, as well as leukemia cells. The combination therapy resulted in a strong antitumor response and halted tumor growth.
Researchers discovered a novel mechanism in a combination drug therapy that disrupts cancer cells' ability to survive DNA damage. The therapy combines DNA methyltransferase inhibitors with poly-ADP-ribose polymerase inhibitors, causing massive DNA damage that leads to cancer cell death.
Researchers at MIT and Dana-Farber Cancer Institute developed a novel way to test tumors for drug susceptibility using a device that measures single-cell masses. They successfully tested this approach with glioblastoma and acute lymphocytic leukemia, finding that susceptible cells reduce growth rates while resistant cells continue unaf...
Single-arm trials can provide valuable opportunities for speeding up cancer drug development and approval, particularly in small populations with high unmet medical need. Regulatory guidance is being developed to define evidence requirements for SATs, and initial approvals based on SATs have similar success rates to RCTs.
A genetic signature related to metabolism has been identified as a predictor of poor patient prognosis in cancer. The discovery could lead to the development of targeted treatments and personalized therapy approaches. Further validation is needed to confirm the link between mitochondrial function and cancer survival.
A survey by Dr Lidija Kandolf-Sekulovic found that over 5000 European melanoma patients are denied access to innovative treatments each year. In Eastern Europe, only 42% of countries have registered the treatment, and only 18% have full reimbursement coverage.
A survey found that over 5,000 metastatic melanoma patients in Europe are denied access to innovative treatments annually. The inequality affects Eastern and South-Eastern European countries more severely, where only 10% of patients have access to the latest treatment recommended by current guidelines.
Researchers discovered that certain proteins associated with Alzheimer's disease are stored in dormant cancer cells as amyloid bodies. Disaggregation of these bodies can reactivate the cancer cells. The study identified ribosomal intergenic noncoding RNA as a target for drug discovery to prevent amyloid body disaggregation.
Researchers discovered a nuclear protein, EYA1, that contributes to neuroblastoma's aggression. The protein migrates to the nucleus in more aggressive forms of the disease, and its structure can be altered by inhibiting an enzyme called PRMT1.
A new study identifies a previously unknown 'off-switch' for cancer based on the protein TMX1, which can slow down tumor growth and promote resistance to cell death mechanisms. This breakthrough offers hope for developing new therapeutic approaches and improving chemotherapy efficiency.
Researchers at the University of Bradford have discovered a way to prevent chemotherapy resistance in lung cancer by blocking a protein called Ran-GTP. Suppressing this protein also causes cancer cells resistant to gefitinib to become re-sensitized, offering new hope for treatment.
Researchers have identified a strategy to selectively sensitize certain cancer cells to radiation therapy using antibody drug conjugates (ADCs), which could improve tumor control and reduce treatment-related side effects in HER2-positive tumors. The study shows promise in sensitizing these cancers to radiation and chemotherapy.
A new study by University of Connecticut researchers reveals that larger particles, approximately 2 microns in size, are most effective for delivering cancer drugs to tumor sites. Smaller particles, however, tend to skip through blood cells and reach the target site less frequently.
Researchers identify two gut bacteria that activate cancer-fighting T cell immune responses, enhancing the effects of cyclophosphamide. These microbial-driven immune responses predicted longer progression-free survival in advanced lung and ovarian cancer patients treated with chemo-immunotherapy.