Articles tagged with Drug Safety
A study found that 15 out of 20 drug classes had inconsistent black box warnings, with some warnings missing from all drugs in the same class. The researchers argue for a more transparent and systematic approach to label design.
The study highlights the risk of dosing errors in pediatric medication, particularly with potent narcotics and sedatives. Researchers found that over a quarter of children studied experienced errors resulting from small volume stock solutions.
A recent study from the University of Texas Medical Branch at Galveston found that aggressively marketed drugs tend to offer less benefit and more harm to most patients. The 'inverse benefit law' highlights the need for physicians to critically evaluate commercial marketing and prioritize patient safety.
A commentary highlights the shortcomings of Canada's current drug surveillance system, citing the off-label use of recombinant activated factor 7 (rFVIIa) as a case in point. The authors emphasize the need for improved collaboration between payers, insurers, and manufacturers to ensure safe monitoring of high-risk drugs.
A new study by Stanford researchers found that many prescriptions for atypical antipsychotic medications lack strong evidence, yet these drugs can cause serious side effects like weight gain, diabetes, and heart disease. The study also identified a significant amount of off-label use, with $6 billion spent on such prescriptions in 2008.
Researchers created a model predicting a drug's likelihood of causing birth defects by analyzing genes targeted by the medication. The model showed 79% accuracy in classifying drugs as safe or known to be teratogenic.
A study using the MEADERS (Medication Error and Adverse Drug Event Reporting System) system found that communication problems and lack of knowledge are leading causes of medication errors, with cardiovascular medications being the most commonly associated. The system has been successful in reducing harm to patients, documenting 11% of ...
A new drug treatment, tribendimidine, has shown promising activity against Opisthorchis viverrini infection, with a cure rate of 70% and almost complete egg elimination. The study suggests that tribendimidine is as safe and effective as the current standard treatment, praziquantel.
Researchers at the University of Missouri have developed an intervention strategy that improves medication adherence by three times more than previously studied techniques. The Continuous Self-Improvement strategy involves counseling patients to understand how taking medications fits into their daily routines.
A study of medical records in Hong Kong found 66 cases of poisoning from natural slimming therapy, with one fatality. The researchers identified 12 agents used in 81 products as falling into categories that include undeclared weight-loss drugs and banned substances.
Dr. Noam Shomron's new method uses genetic expression of microRNAs to optimize individual patient care and predict adverse drug effects, leading to safer and more effective treatment options.
The use of bespoke drugs in primary care is associated with high costs, lack of transparency, and legal pitfalls. The review calls for a major overhaul to reduce unnecessary prescribing and improve patient safety.
Experts advocate for phasing out codeine due to its significant risks and unpredictable pharmacokinetics. Morphine, its active metabolite, is proposed as an alternative, offering more predictable metabolism and cost savings.
A phase II clinical trial found tanezumab to be effective in reducing osteoarthritis knee pain, with a 62% reduction in walking knee pain compared to placebo. The drug also showed promise in improving physical function and relieving stiffness.
A pilot study suggests pioglitazone is well-tolerated and may be a promising treatment for Alzheimer's disease. Peripheral edema was the main adverse event, but no significant treatment effect on clinical efficacy was observed.
The International Serious Adverse Events Consortium (SAEC) will collaborate with Newcastle University to research the genetics of drug-induced liver injury. The collaboration aims to develop larger and more diverse collections of subjects to better understand the genetic effects contributing to these diseases.
The NIH is expanding its Pharmacogenomics Knowledge Base (PharmGKB) to analyze genomes and identify genetic variations associated with disease risk and adverse drug reactions. The goal is to develop tools that automatically extract information from biomedical literature and databases to improve the safety and efficacy of medicines.
Researchers at Johns Hopkins have identified two drugs that can protect nerve cells in mice from the lethal effects of Parkinson's disease by blocking the overactive LRRK2 protein. This finding suggests a promising target for developing treatments against Parkinson's disease.
Icatibant blocks bradykinin, a protein that dilates blood vessels and produces HAE symptoms. The drug produced faster symptom relief than the comparison drug in two phase 3 trials.
A recent study found that men taking erectile dysfunction drugs have a higher rate of STDs, particularly HIV infection, compared to those who do not use ED drugs. However, the optimal timing for initiating surgery on rotator cuff injuries remains unclear, with experts debating whether early or delayed intervention is best.
A new study found that rosiglitazone, a medication for treating Type 2 diabetes, is associated with an increased risk of stroke, heart failure, and death compared to pioglitazone. The study analyzed data from over 227,000 patients aged 65 and older who took the medications from 2006 to 2009.
A Johns Hopkins-led committee, sponsored by the FDA, will examine drug safety studies' scientific and ethical issues. The committee aims to deliver a report on July 1 outlining key considerations for clinical trials evaluating post-market drug safety.
A Phase II clinical trial of eliglustat tartrate, an oral therapy, demonstrates significant improvements in spleen volume, hemoglobin level, and platelet count. The treatment also normalizes glucosylceramide plasma levels and improves bone mineral density.
A new study warns of the dramatic rise in psychotropic medications for children, with up to eight million children taking one or more drugs. The authors caution that there is little evidence available to warrant the widespread use of these medications for children.
Researchers have discovered two compounds that allow cells to survive attacks from ricin and Shiga-like toxins, rendering them immune to these deadly threats. These compounds work by blocking the toxins' escape via cellular components, providing potential countermeasures against bioterrorism.
A Saint Louis University doctor found no evidence supporting the use of natural treatments like St. John's wort for anxiety, instead recommending selective serotonin reuptake inhibitors (SSRIs) as a safe and effective first-line treatment option.
Researchers at Cedars-Sinai Heart Institute conclude that dronedarone is only moderately effective and lacks clear safety benefits. The review assesses data from the FDA approval process and compares dronedarone to amiodarone, a commonly used treatment for atrial fibrillation.
A recent study published in the Journal of General Internal Medicine found that e-prescribing significantly improves ambulatory medication safety. The research discovered a nearly seven-fold decrease in prescribing errors among doctors who adopted e-prescribing compared to those using traditional paper-based prescriptions.
A hospitalist at the University of Rochester Medical Center, Dr. Alec B. O'Connor, is calling for more rigorous standards for drugs up for FDA approval. He argues that current guidelines do not require studies comparing a new drug's effectiveness and safety to an established first-line drug.
Comparative effectiveness studies rarely examine the effects of nonpharmacologic interventions, cost-effectiveness, or safety. Most studies (87%) were funded by noncommercial entities, but only 10 included non-pharmacologic therapies in medication comparisons. Increased funding is necessary to support these studies.
A study published in Canadian Medical Association Journal found that collaborative care plans involving physicians and pharmacists have little clinical impact on managing lipid control in patients with high cholesterol. The study suggests that this approach may be effective for lifestyle changes, but not for significant clinical outcomes.
Researchers found more-aggressive ESA treatment practices among severely anemic patients led to better outcomes, while aggressive treatment of mildly anemic patients was associated with increased mortality. The study analyzed data from 4,500 U.S. dialysis units and supported guidelines for safer ESA use in end-stage renal disease patie...
A new review of scientific literature found that only a few anti-spasticity medications used for children with cerebral palsy have sufficient research backing their use. The American Academy of Neurology has released a new practice guideline on effective treatments, highlighting the need for more research on commonly used drugs.
A study examines the effect of FDA safety warnings on atypical antipsychotics prescribed to patients with dementia, revealing a decline in usage among the elderly population. The findings highlight the need for improved risk communication between physicians and patients.
A new UCLA study has found that metformin is safe for use in treating patients with both diabetes and advanced heart failure, suggesting improved survival rates. The study involved 401 patients who were followed for 14 years and showed a lower risk of death among those taking metformin.
A new ALS drug, talampanel, has shown some ability to slow the loss of major daily life activities such as speaking, walking and dressing. The study found that talampanel slowed progression of ALS by 30 percent, according to the ALS Functional Rating Scale.
A study found that 44% of patients believe they are receiving a medication they don't need, and 96% cannot recall at least one prescribed medication. The study highlights the importance of patient knowledge in preventing medication errors.
A new study by McMaster researcher Sam Schulman found that an oral drug called dabigatran etexilate is as safe and effective as warfarin for treating venous thromboembolism (VTE), a common clotting disorder affecting millions annually. The drug does not require frequent monitoring or dose adjustments, making it a convenient alternative.
A statistical analysis found that FDA review intervals for new drugs remained unchanged from 1997 to 2006, despite increased investment in information technology. The study analyzed data on three main categories of new drugs and found no statistically significant reduction in review times.
The University of Rochester Medical Center has launched a new center to improve cardiac safety and understand cardiac arrhythmias. The center will utilize a vast database of ECG data to develop novel methods and technologies to predict cardiac arrhythmias.
A CDC investigation found that contaminated pre-filled heparin and saline syringes from a single company led to 162 S. marcescens bloodstream infections in nine states. The company failed to comply with FDA's Good Manufacturing Practices, leading to the voluntary recall of affected syringes.
A large cohort study found no significant risks of major congenital malformations associated with H2 blocker exposure during pregnancy. The study involved 1,148 infants exposed to H2 blockers and 84,823 unexposed infants, showing no increased risk of perinatal mortality or birth complications.
Abatacept, a new biologic drug, is effective in treating rheumatoid arthritis by blocking immune cell actions, reducing pain and swelling. The review of seven trials found significant improvements in patients' symptoms and joint health, with no progression of joint damage at 12-month follow-up
Scientists have developed micrometer-sized capsules that can safely deliver drugs inside living cells. These 'micro shuttles' can be loaded with specific doses and released by biological triggers or light activation, offering a promising solution for managing chronic conditions.
The increasing use of smart drugs to boost academic performance may necessitate routine doping tests for exam students, suggests Vince Cakic. Despite the illegitimacy of chemically enhanced academic success, nootropics are near impossible to ban due to their ready availability for therapeutic use.
The USP's Annual Scientific Meeting highlighted efforts to combat counterfeit and adulterated food and drugs, with a focus on measurement science and international cooperation. Experts discussed sophisticated quality measurement techniques and technologies, as well as the need for consumer education and vigilance.
A new once-daily medication has shown to be as effective as multiple dosings for treating the most common mouth infection in HIV/AIDS patients. The treatment, a small tablet applied daily, provides relief from oral candidiasis (OC) with few or no side effects.
Recent observational studies show no overall safety issue with drug eluting stents compared to bare metal stents, with lower risks of death or myocardial infarction. However, late stent thrombosis remains higher and uniquely associated with drug eluting stents, necessitating improved patient selection and treatment strategies.
A recent national survey found that physicians inaccurately believed in the FDA approval status of 22 drug-indication pairs, including lorazepam for chronic anxiety and quetiapine for dementia with agitation. The study highlights the need for better methods to inform physicians about the level of evidence supporting off-label drug use.
Researchers link high blood pressure to multiple sclerosis and suggest a safe, inexpensive drug lisinopril could be an effective treatment option. The study found that lisinopril controls blood pressure by blocking an enzyme that converts angiotensin's precursor into the active hormone.
A new study reveals that 95% of older drivers (ages 55+) have medical conditions and take medications, yet only 28% are aware of the potential impact on their driving ability. The researchers emphasize the need for increased education and awareness among health professionals and patients to address this critical issue.
A study found that clozapine, restricted due to safety concerns, is associated with lower mortality compared to other antipsychotics. Long-term use of any antipsychotic reduces mortality by around 20%, indicating restrictions may have caused thousands of extra deaths worldwide.
Researchers have discovered that two commercially available drugs used for Parkinson's treatment, entacapone and tolcapone, have potential to treat multi-drug resistant tuberculosis. The study, published in PLOS Computational Biology, uses a novel computational strategy and experimental validation to support this repositioning.
A new study in CMAJ reports that oseltamivir and zanamivir are relatively safe for use in pregnant and breast-feeding women during the H1N1 pandemic. Pregnant women, especially those in the third trimester, are at high risk of serious complications from the flu virus.
A large cohort study found that metoclopramide poses no significant risks for fetal development when used to relieve morning sickness nausea, supporting its safe use during pregnancy. The study analyzed data from over 80,000 infants born to mothers who received the medication during the first trimester.
Researchers have found that humans are likely exposed to a daily dose of bisphenol A (BPA) that far exceeds the current estimated safe daily intake dose. The study, which involved five female adult monkeys, suggests that BPA exposure comes from multiple unknown sources beyond food and beverage containers.
A legal loophole in Canada's advertising regulations has exposed Canadians to more than $90 million worth of drug ads, including those for life-threatening medications. The study found that four out of eight heavily advertised drugs had black box warnings and five had been subject to Health Canada safety advisories.
A pooled analysis of two studies found significant improvements in pulmonary function, dyspnea, and rescue medication use when Perforomist Inhalation Solution was added to maintenance tiotropium. Patient satisfaction also increased with twice-daily Perforomist Inhalation Solution compared to ipratropium/albuterol metered-dose inhaler.
The SCAAR registry study analyzed 47,967 patients who received drug eluting stents (DES) between 2003 and 2006. The results found no significant difference in late mortality between DES and bare metal stent (BMS) groups.
A University of Rochester Medical Center survey found teens lack knowledge about over-the-counter pain medications, with only 35% correctly identifying acetaminophen and Tylenol. Chronic misuse can lead to liver damage and accidental overdose