Articles tagged with Drug Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
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Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
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Researchers from the University of Colorado found that Paxlovid significantly reduced rates of hospitalization and death among non-hospitalized patients infected with recent Omicron subvariants. The study used real-world data from 28,000 patients and suggested a benefit for Paxlovid in preventing severe disease.
A study by Johns Hopkins Medicine found that high doses of CBD may increase the adverse effects of THC in edible cannabis products. The study showed that CBD inhibits the metabolism of THC, resulting in stronger and longer drug effects.
A team of researchers from UNC and CDC developed an injectable implant that can release HIV PrEP medications for up to six months, providing full protection. The technology has shown promise in non-human primates and could potentially be adapted for human use.
The grant aims to eliminate barriers and facilitate access to early phase cancer clinical trials for medically underserved communities. Researchers will develop and implement a multilevel program to improve referrals and enrollment, exploring the impact of remote clinical trials on enhancing diversity in trials.
Research reveals that opioid tapering can lead to more hospitalizations and emergency department visits, while also reducing primary care visit rates. The study's findings suggest potential unintended consequences of opioid tapering for policymakers and clinicians.
A new study found that tailoring medication doses to a patient's DNA leads to a 30% reduction in serious side effects. The 'DNA medication pass' allows doctors and pharmacists to adjust prescriptions based on a patient's genetic profile, resulting in improved effectiveness and safety.
An updated Cochrane review found no effect of vitamin D supplements on reducing the risk of asthma attacks or improving control of asthma symptoms in children and adults. The review analyzed data from 20 randomized controlled trials involving over 2,200 people with mild to moderate asthma.
Two studies found that kisspeptin improves sexual responses in women and men with hypoactive sexual desire disorder, boosting attraction brain pathways. The researchers believe the results lay the foundation for kisspeptin-based treatments for millions of people worldwide.
Researchers found that patients treated with butylphthalide experienced milder neurological symptoms and better functioning at three months after a stroke compared to those who received a placebo. The study suggests potential benefits of this celery seed-derived medication in treating ischemic strokes.
Research highlights underuse of dual blood thinners in women after minor stroke or transient ischemic attack (TIA), with potential benefits for stroke prevention. A study analyzed electronic health records of 2,953 adults and found that women were less likely to receive the treatment regimen, despite evidence suggesting its effectiveness.
A large Dutch study found that the BCG vaccine does not protect elderly people with co-morbidities against COVID-19 symptoms. The study analyzed 6,112 participants and showed no difference in disease manifestations or hospitalizations between those who received the vaccine and those who received a placebo.
Researchers found that while some antidepressants are effective for certain pain conditions, most are either ineffective or the evidence is inconclusive. A more nuanced approach is needed when prescribing antidepressants for pain, say experts.
A new study found that sleep medications increase the risk of dementia in white adults. However, the relationship between sleep medications and dementia risk varies by medication type and socio-economic status. The study suggests that patients with poor sleep should consider alternative solutions before taking medications.
A new vaccine has shown efficacy in protecting against three common fungal pathogens responsible for fatal fungal infections. The experimental vaccine targets Aspergillus, Candida, and Pneumocystis, with broad, cross-protective antifungal immunity demonstrated in preclinical animal models.
The researchers aim to create a set of tools to help other chemists select and produce the right crystal structures for new drugs, potentially saving time and cost. By understanding how molecules crystallize, they hope to speed up the development process and lower costs.
Researchers used machine learning to analyze data sets for patterns and trends, identifying over 400 genes related to smoking behaviors. The study suggests that certain medications, such as dextromethorphan, could be repurposed for smoking cessation.
Research suggests that a new combination of drugs is needed to find an effective treatment for TB meningitis due to multidrug-resistant strains. The FDA-approved BPaL regimen is not effective in treating TB meningitis because bedaquiline and linezolid cannot penetrate the blood-brain barrier.
Scientists at MIT have designed a novel nanoparticle platform that can deliver optimal ratios of multiple cancer drugs, leading to enhanced efficacy and reduced side effects. The bottlebrush-shaped particles can be loaded with varying concentrations of drugs, enabling the precise delivery of synergistic combinations.
Researchers from UTSA and UT Health San Antonio are developing compounds that target the estrogen receptor-beta, which suppresses cancer growth. The goal is to identify a novel ER-beta agonist with potential as a therapeutic strategy for treating GBM in patients.
Researchers seek to reduce medical errors among patients with limited English proficiency by implementing three different translation approaches. The goal is to compare the effectiveness of telephone interpreter-based and in-person interpreter-assisted communication in reducing errors.
The CLOVERS trial demonstrated that large volume fluid administration and vasopressor therapy led to nearly identical survival rates in patients with septic shock. The findings suggest that rapidly achieving normal blood pressure and systemic perfusion may be more important than the method used to achieve it.
Despite relaxed regulations, buprenorphine overdose deaths remained low and often involved multiple substances. The study suggests that expanded access to treatment for opioid use disorder is crucial to reducing overdose rates.
Researchers from KAIST and Chungnam National University have developed a new equation to predict drug interactions, improving accuracy by 80% compared to the existing FDA formula. The new equation takes into account factors such as gut bioavailability and enzyme concentration.
Research reveals that commonly used antiretroviral drugs TAF and TDF directly impact mitochondria's energy production in immune cells. The study suggests a larger energy reduction when combined with other antiretrovirals, sparking concerns about potential long-term effects on human cells.
Researchers analyzed data from the VITAL trial and found that vitamin D supplementation increased biomarkers associated with vitamin D metabolism in people, regardless of their weight. However, these increases were significantly smaller in people with elevated BMIs, suggesting a blunted response to supplementation.
A large clinical trial supported by the National Institutes of Health found that two widely used diuretics, furosemide and torsemide, did not differ in improving patient survival when compared. The study suggests a need for better treatments for heart failure patients and highlights the importance of optimizing diuretic doses to improv...
Researchers found that a pro-oxidant mixture of resveratrol and copper can inactivate cell-free chromatin particles, reducing chemotherapy toxicity. The treatment also showed promise in preventing aging and sepsis.
A new study suggests that hormone replacement therapy (HRT) could help prevent Alzheimer's disease in women who are carriers of the APOE4 gene. The research found that HRT use is associated with improved memory and larger brain volumes among at-risk women. Early introduction of HRT during perimenopause may be particularly beneficial.
Researchers found a genetic alteration in the SARS-CoV-2 spike protein that redirects the virus into a storage compartment within cells, reducing its surface exposure. This change may affect the immune system's ability to identify and kill infected cells.
Researchers have developed a novel portable and low-cost macroscopic mapping system for all-optical cardiac electrophysiology using optogenetics and machine vision cameras. The system can stimulate and image engineered networks of human heart cells, providing insights into cardiac wave function and stability.
Researchers at the University of Minnesota Medical School conducted a large clinical trial comparing two commonly prescribed generic drugs, chlorthalidone and hydrochlorothiazide. The study found that both medications were equally effective in preventing cardiovascular disease and non-cancer death, contradicting current clinical guidel...
A study found that Black, Latino, and Native Hawaiian people with epilepsy are less likely to receive newer medications than white individuals. People who saw a neurologist had more than three times the odds of being prescribed newer drugs.
A study shows that pharmacies can offer a safe starting point for patients with opioid use disorder, leading to higher rates of retention in treatment. The pharmacy-based model increases access to buprenorphine, a lifesaving medication, for diverse patient populations and promotes racial and economic equity.
A study from Japan found that variations in psychiatric diagnoses across different cultures can affect the efficacy of antipsychotics in clinical trials. Researchers analyzed data from 28 double-blind randomized trials and found that psychotic features were associated with varying therapeutic responses to antipsychotic medications.
Researchers found that letters successfully encouraged clinicians to check patients' prescribing records, leading to increased PMP search rates and persistent effects. The findings suggest a cost-effective evidence-based strategy for promoting safer prescribing practices through simple letter interventions.
Researchers at EMBL Grenoble have discovered that THC inhibits the human enzyme autotaxin, which is involved in cancer, inflammation, and pulmonary fibrosis. This finding provides new molecular insights into the therapeutic effects of medical cannabis.
Researchers found that clonidine, a common blood pressure medication, can reduce the consolidation of traumatic memories in PTSD patients. By interacting with the adrenergic receptor axis, clonidine interferes with cofilin's ability to form mushroom-shaped dendritic spines, which are essential for memory formation. This suggests that c...
A comprehensive study of childhood leukemia's genetic diversity provides insights into personalized therapy. Researchers identified distinct groups based on drug sensitivity profiles, which significantly impact prognosis.
The procedure requires thorough pre-procedural evaluation and assessment of anatomical and hemodynamic data. Long-term results indicate that TPVR can effectively restore RVOT function, while improving survival rates and reducing the need for reintervention across age groups. Vigilant testing is recommended to avoid rare but serious com...
A randomised controlled trial found that molnupiravir treatment did not decrease hospital admissions or deaths in vaccinated adults with higher risk of mortality from COVID-19 infection. However, patients treated at home with molnupiravir recovered faster compared to the control group.
The use of 3D-patient tumor avatars (3D-PTAs) is crucial for guiding treatment decisions in precision oncology. These avatars, including patient-derived organoids, 3D bioprinting, and microscale models, can accurately depict a tumor with its microenvironment, enabling the testing and prediction of therapeutic drug efficacy.
Research found that common anti-inflammatory drugs taken by children can alter the formation of dental enamel, leading to defects. The study's authors suggest potential harm from widespread use of these medications and plan to conduct a clinical trial to confirm findings in humans.
Researchers at Thomas Jefferson University have identified a new compound that can be added to existing asthma medications to make them more potent and longer-lasting. This approach could lead to improved symptom relief and reduced side effects for patients who require frequent doses.
A study by MIT economists found that doctors and their families are less likely to adhere to medication guidelines than the general population. Despite having better access to medical expertise, they lag behind in following guidelines 3.8 percentage points, with significant differences in 41 cases.
A new study has identified a potential therapy for metastatic colon cancer by targeting the molecule hyaluronan, which accumulates in tumors and shuts down immune cells that can kill tumor cells. The experimental therapy, hyaluronidase, shrinks tumors and allows immune cells to attack tumor cells.
Researchers found dapagliflozin reduces primary composite outcome in patients with heart failure and improved ejection fraction. The SGLT2 inhibitor may benefit this growing patient population with high risk for adverse outcomes.
Researchers found reduced serotonin release capacity in individuals with depression, suggesting a blunted serotonin system. The study used novel imaging techniques to measure serotonin levels in the brain, providing crucial insights into the pathology of depression.
Researchers investigate how lung cancers evade the immune system to develop more effective immunotherapy treatments. The study aims to uncover a new way lung cancers disguise themselves from the immune system, potentially leading to improved treatment outcomes.
A large VA clinical trial found that chlorthalidone (CTD) was not superior to hydrochlorothiazide (HCTZ) for preventing cardiovascular disease or non-cancer death. The study enrolled over 13,500 Veterans with high blood pressure and showed no difference between the two drugs in terms of effectiveness.
The E1910 trial found that adding blinatumomab to standard front-line consolidation chemotherapy improved overall survival and kept most patients in remission. The treatment, which targets malignant B cells, demonstrated its effectiveness in patients with a good prognosis after an initial round of chemotherapy.
Researchers at Baylor College of Medicine have identified a potential new treatment for endometriosis, oleuropein, which selectively inhibits ER-beta activity. This natural compound effectively suppresses the growth of endometriosis lesions in mouse models and improves fertility in mice with endometriosis.
A new study published in JAMA Network Open found that patients with depression are less likely to adhere to essential medical therapies following percutaneous coronary intervention (PCI). The study examined over 124,000 patients who underwent PCI and were diagnosed with depression, revealing a significant proportion of individuals with...
A large observational study found that Paxlovid is associated with a 44% reduction in hospitalization or death among highly vaccinated adults over 50. Even among patients with lower levels of prior immunity, Paxlovid showed an 81% reduction in hospitalization rates.
A randomized controlled trial found that a low-carbohydrate, high-fat diet helped patients with type 2 diabetes achieve better weight loss and glucose control over a 6-month intervention compared to a high-carb, low-fat diet. However, changes were not sustained 3 months after the intervention.
A new American Heart Association scientific statement highlights the potential benefits and risks of complementary and alternative therapies for heart failure. The statement advises healthcare professionals to discuss CAM use with patients, monitor medication interactions, and consider pharmacists' consultations.
A new study has shed light on how the most commonly used ADHD medication, methylphenidate, works in the brain. The research found that methylphenidate increases dopamine levels in the nucleus accumbens and improves coordinated brain network activity, resulting in more stable sustained attention in children with ADHD.
Researchers found that activating the non-mutated form of P53 can change the fundamental makeup of cancer stem cells in mouse models of mucoepidermoid carcinoma. This new therapy approach shows promise for treating this lethal form of salivary gland cancer.
A new study allows people with type 2 diabetes to choose their own medication after trying three different drugs in succession. The approach resulted in better glucose control and fewer side effects compared to other methods. Researchers conclude that patients should try before choosing a treatment for optimal results.
The phase 1 and phase 2 studies showed that ARV-471 was well-tolerated and could promote substantial estrogen receptor degradation in patients with advanced disease. The study has led to a randomized phase 3 trial comparing ARV-471 with a SERD in patients with ER-positive/HER2-negative advanced breast cancer.
A study published in the Hypertension journal suggests that bromocriptine, a Parkinson's disease medication, may help prevent heart disease in youth with Type 1 diabetes. The research found that teens with Type 1 diabetes who took bromocriptine had lower blood pressure and less stiff arteries after one month of treatment.