Articles tagged with Drug Studies
A new drug called CADD522 blocks a gene associated with driving bone cancer's spread, increasing survival rates by 50% in mice implanted with human bone cancer. The breakthrough treatment shows promise in all main bone cancer subtypes and has the potential to save lives and reduce disability.
A new study by Weill Cornell Medicine found that the FDA's mandate to limit opioid-acetaminophen combinations resulted in significant reductions in liver injuries. The mandate, implemented in 2014, limited the dosage of acetaminophen in these drugs, leading to a decline in hospitalizations and acute liver failure cases.
A study found that a commercial water purifier may have caused Mycobacterium abscessus infections in 4 cardiac surgery patients due to chlorine depletion. The hospital's water system was contaminated via municipal water, emphasizing the importance of monitoring and preventing mycobacteria.
Two compounds, A5 and C1, have shown promising results in inhibiting the growth of glioblastoma cells, a type of aggressive brain cancer. Further research is needed to confirm their effectiveness on normal nerve cells and to move towards clinical trials.
The HALP score, a novel immune-nutritional marker, has been linked to prognostic ability in different cancer types. It integrates indicators of immune status and nutritional status, showing promise as a cost-effective biomarker.
A new cutaquig study found that increasing infusion volume per site resulted in a reduction of injection sites, while increasing infusion rates decreased infusion duration. The research also showed that dosing every other week demonstrated equivalency to trough levels with weekly dosing.
High-dose anticoagulation reduces intubations and deaths by 30% in hospitalized COVID-19 patients, especially those with ARDS. The study found a significant reduction in mortality and need for ICU care among patients treated with therapeutic anticoagulation.
A virtual care team consisting of physicians and pharmacists improved the adoption of life-saving therapies in patients with heart failure, leading to increased use of evidence-based treatments and better patient outcomes. The strategy was safe and effective, with comparable length of stay and safety events between the groups.
Researchers have discovered a gene mutation that can block chronic pain and provide protection against other stimuli, including heart and brain cells. The TRPV1 receptor mutation, found in avian species, was successfully transplanted into mice, showing reduced pain sensitivity and improved protective effects.
A new study found that walking an additional 500 steps per day was associated with a 14% lower risk of heart disease, stroke or heart failure. This benefit is significant for older adults, as most studies have focused on early-to-midlife adults.
Two studies found that adults with high cardiovascular health scores tend to live longer lives free of major chronic diseases. The research highlights the importance of maintaining ideal cardiovascular health to delay onset of age-related diseases, allowing individuals to enjoy life in their years as well as their years in life.
Researchers found that adding immunotherapy before surgical removal of stage III-IV melanoma significantly improved event-free survival compared to standard-of-care treatment. The study showed that neoadjuvant therapy is superior to the same therapy given in the adjuvant setting.
A clinical study by Indiana University School of Medicine researchers found that oral verapamil can improve pancreatic beta cell function in children with new-onset type 1 diabetes, with a 30% increase in insulin secretion over the first year. The trial involved 88 participants and was published in JAMA.
The CALYPSO study assesses the efficacy of combined MET and PD-L1 inhibition in patients with MET-driven metastatic papillary renal cancer. Response rates were 29% for all patients and 53% for those with MET-driven tumors, with improved progression-free survival observed in MET-driven status.
The BIAL Award in Biomedicine is a prestigious international award that recognises outstanding biomedical research. The €300,000 prize is given to researchers whose work has shown exceptional quality and scientific relevance, published within the last ten years.
A study found that over 80% of American adults with type 2 diabetes meet the criteria to use GLP-1 RAs or SGLT2is, but only a small percentage are using them. The medications have a substantially higher cost than current first-line treatments, making it difficult for patients to access them.
A preliminary study by the American Academy of Neurology found that Black people with dementia are receiving dementia-related medications less often than white people. The study revealed significant disparities in access to treatments, with Black patients receiving fewer prescription types compared to their white counterparts.
A University of Minnesota-led study shows that verapamil can increase pancreatic insulin secretion by 30% in children with newly-diagnosed type 1 diabetes. The treatment was well-tolerated and had a favorable safety profile, making it an appealing option for children and adults with the condition.
A recent study by the University of Kentucky Markey Cancer Center validates a new radiopharmaceutical compound as a viable treatment option for patients with advanced cervical cancer. The radioactive drug, 212Pb-DOTAM-GRPR1, targets gastrin-releasing peptide receptor, a protein expressed by cancer cells.
Researchers found that dose escalation to 600mg of ME improved disease control in five patients, while stable disease was observed in another five patients with an average duration of 15 weeks. Additionally, patients reported overall improved quality of life via a questionnaire.
A new clinical trial has shown safety and tolerability of oral GABA and reduced serum glucagon levels in children with recent onset Type 1 diabetes. The study focused on the potential of GABA and GAD to preserve insulin-secreting beta cells and attenuate excessive glucagon release.
Researchers from the University of Oxford-affiliated researchers found that high doses of ivermectin are ineffective in treating COVID-19. The study used the PLATCOV trial to compare the rates at which different drugs reduced the viral load of SARS-CoV-2, and the results suggest that ivermectin does not have measurable antiviral activity.
Researchers identified apremilast as an incredibly promising treatment for alcohol use disorder, reducing consumption by more than half in a clinical trial. The medication, approved for psoriasis and psoriatic arthritis, triggers increased activity in the brain's nucleus accumbens to control alcohol intake.
Researchers found that a combination of symptom and high-level viral rebound after untreated COVID-19 infection is rare, occurring in only 3 percent of study participants. This suggests that accounting for underlying rates of symptom relapse is crucial when evaluating antiviral treatment effects.
Researchers found that doxycycline postexposure prophylaxis did not prevent chlamydia or gonorrhea among cisgender women in a clinical trial. The lack of efficacy was attributed to differences in anatomy and antibiotic resistance.
A groundbreaking study found that a new TB treatment strategy can shorten treatment duration while maintaining effectiveness. The TRUNCATE-TB trial showed that an initial 8-week treatment period followed by retreatment for those not cured was as effective as the standard 6-month treatment but halved the average total time on treatment.
Researchers at the Paul Scherrer Institute have developed a film that demonstrates the potential of photopharmacology in treating diseases such as cancer. The new approach uses light to switch on and off a molecular photoswitch, allowing for targeted and reversible drug action.
Researchers at Washington State University found that CBD inhibits a key enzyme for nicotine metabolism, slowing down its effects and allowing smokers to wait before feeling the urge to smoke. The study suggests that CBD could be a useful tool in reducing harm from smoking and quitting nicotine addiction.
Patients with resectable NSCLC treated with neoadjuvant nivolumab show improved five-year recurrence-free and overall survival rates compared to historical outcomes. Major pathological responses after neoadjuvant nivolumab may be associated with lower risk of disease recurrence and death.
A new experimental contraceptive drug has been developed by Weill Cornell Medicine investigators, demonstrating the possibility of an on-demand male contraceptive. The study found that a single dose of the sAC inhibitor TDI-11861 temporarily stops sperm movement and prevents pregnancies in preclinical models.
Studies elucidate key aspects of traditional Chinese compounds and modern cancer therapeutics, highlighting the efficacy of R. serra in treating colitis and identifying active components of Gan Cao in treating pneumonia. A new radiolabeled antibody-based probe for detecting PD-L1 expression in cancers also provides a novel approach to ...
Researchers at the University of Texas M. D. Anderson Cancer Center have identified CD70 as a novel therapeutic target for eliminating drug-resistant cancer cells in EGFR-mutant non-small cell lung cancer. CD70 targeting strategies showed significant anti-tumor activity, eliminating resistant cells in laboratory models.
Researchers have created a tiny pill-like electromagnetic device that can provide medical professionals with diagnostic information about the inner workings of the gastrointestinal tract. The device, when swallowed, delivers data to a smartphone as it passes through the body using electromagnetic technology similar to MRI machines.
Researchers found Paxlovid to be effective in preventing severe COVID-19 and reducing all-cause mortality in adults over 70 years old with mild disease. The study concluded that testing for SARS-CoV-2 and access to Paxlovid are crucial for those at risk of severe infection.
A new neuroprotectant medication called ApTOLL has been shown to improve survival and reduce long-term disability among patients with stroke. The study found that ApTOLL, when used in conjunction with standard treatments, reduced death and brain damage, suggesting a promising new approach to treating stroke.
Researchers found no significant evidence of harm in lowering blood pressure targets after endovascular treatment, but trends suggested marginal benefit and potential worsening of long-term disability. Clinicians should consider auto-regulation of blood pressure unless above 180 mm Hg.
A study of over 350 patients with small vessel stroke found that the medications were well-tolerated and safe, suggesting potential benefits in improving patient outcomes. The results indicate that cilostazol and isosorbide mononitrate may help reduce recurrent stroke, cognitive impairment, and improve quality of life.
Researchers from the University of Colorado found that Paxlovid significantly reduced rates of hospitalization and death among non-hospitalized patients infected with recent Omicron subvariants. The study used real-world data from 28,000 patients and suggested a benefit for Paxlovid in preventing severe disease.
A study by Johns Hopkins Medicine found that high doses of CBD may increase the adverse effects of THC in edible cannabis products. The study showed that CBD inhibits the metabolism of THC, resulting in stronger and longer drug effects.
A team of researchers from UNC and CDC developed an injectable implant that can release HIV PrEP medications for up to six months, providing full protection. The technology has shown promise in non-human primates and could potentially be adapted for human use.
The grant aims to eliminate barriers and facilitate access to early phase cancer clinical trials for medically underserved communities. Researchers will develop and implement a multilevel program to improve referrals and enrollment, exploring the impact of remote clinical trials on enhancing diversity in trials.
Research reveals that opioid tapering can lead to more hospitalizations and emergency department visits, while also reducing primary care visit rates. The study's findings suggest potential unintended consequences of opioid tapering for policymakers and clinicians.
A new study found that tailoring medication doses to a patient's DNA leads to a 30% reduction in serious side effects. The 'DNA medication pass' allows doctors and pharmacists to adjust prescriptions based on a patient's genetic profile, resulting in improved effectiveness and safety.
An updated Cochrane review found no effect of vitamin D supplements on reducing the risk of asthma attacks or improving control of asthma symptoms in children and adults. The review analyzed data from 20 randomized controlled trials involving over 2,200 people with mild to moderate asthma.
Two studies found that kisspeptin improves sexual responses in women and men with hypoactive sexual desire disorder, boosting attraction brain pathways. The researchers believe the results lay the foundation for kisspeptin-based treatments for millions of people worldwide.
Researchers found that patients treated with butylphthalide experienced milder neurological symptoms and better functioning at three months after a stroke compared to those who received a placebo. The study suggests potential benefits of this celery seed-derived medication in treating ischemic strokes.
Research highlights underuse of dual blood thinners in women after minor stroke or transient ischemic attack (TIA), with potential benefits for stroke prevention. A study analyzed electronic health records of 2,953 adults and found that women were less likely to receive the treatment regimen, despite evidence suggesting its effectiveness.
A large Dutch study found that the BCG vaccine does not protect elderly people with co-morbidities against COVID-19 symptoms. The study analyzed 6,112 participants and showed no difference in disease manifestations or hospitalizations between those who received the vaccine and those who received a placebo.
Researchers found that while some antidepressants are effective for certain pain conditions, most are either ineffective or the evidence is inconclusive. A more nuanced approach is needed when prescribing antidepressants for pain, say experts.
A new study found that sleep medications increase the risk of dementia in white adults. However, the relationship between sleep medications and dementia risk varies by medication type and socio-economic status. The study suggests that patients with poor sleep should consider alternative solutions before taking medications.
A new vaccine has shown efficacy in protecting against three common fungal pathogens responsible for fatal fungal infections. The experimental vaccine targets Aspergillus, Candida, and Pneumocystis, with broad, cross-protective antifungal immunity demonstrated in preclinical animal models.
The researchers aim to create a set of tools to help other chemists select and produce the right crystal structures for new drugs, potentially saving time and cost. By understanding how molecules crystallize, they hope to speed up the development process and lower costs.
Researchers used machine learning to analyze data sets for patterns and trends, identifying over 400 genes related to smoking behaviors. The study suggests that certain medications, such as dextromethorphan, could be repurposed for smoking cessation.
Research suggests that a new combination of drugs is needed to find an effective treatment for TB meningitis due to multidrug-resistant strains. The FDA-approved BPaL regimen is not effective in treating TB meningitis because bedaquiline and linezolid cannot penetrate the blood-brain barrier.
Scientists at MIT have designed a novel nanoparticle platform that can deliver optimal ratios of multiple cancer drugs, leading to enhanced efficacy and reduced side effects. The bottlebrush-shaped particles can be loaded with varying concentrations of drugs, enabling the precise delivery of synergistic combinations.
Researchers from UTSA and UT Health San Antonio are developing compounds that target the estrogen receptor-beta, which suppresses cancer growth. The goal is to identify a novel ER-beta agonist with potential as a therapeutic strategy for treating GBM in patients.
Researchers seek to reduce medical errors among patients with limited English proficiency by implementing three different translation approaches. The goal is to compare the effectiveness of telephone interpreter-based and in-person interpreter-assisted communication in reducing errors.
The CLOVERS trial demonstrated that large volume fluid administration and vasopressor therapy led to nearly identical survival rates in patients with septic shock. The findings suggest that rapidly achieving normal blood pressure and systemic perfusion may be more important than the method used to achieve it.
Despite relaxed regulations, buprenorphine overdose deaths remained low and often involved multiple substances. The study suggests that expanded access to treatment for opioid use disorder is crucial to reducing overdose rates.
Researchers from KAIST and Chungnam National University have developed a new equation to predict drug interactions, improving accuracy by 80% compared to the existing FDA formula. The new equation takes into account factors such as gut bioavailability and enzyme concentration.