Articles tagged with Drug Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
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Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A pooled data analysis of available research found that ADHD drugs may successfully treat key aspects of Alzheimer's disease. Noradrenergic drugs, which target the neurotransmitter noradrenaline, showed a small but significant positive effect on overall cognition and a large positive effect on apathy in patients with Alzheimer's disease.
A multicenter study found that traditional Chinese medicine Yupingfeng was as effective as allopathic drugs in treating recurrent respiratory tract infections in children. The study showed a substantially greater reduction in RRTI events and similar safety profiles across all three groups.
A multicenter prospective study shows that 88% of isolated LCH skull lesions in children resolve spontaneously without surgery. The study supports a nonsurgical approach, avoiding the risks associated with removal.
Researchers with the Calgary Stroke Program have made a breakthrough in treating acute ischemic stroke with Tenectepele, a safe and well-tolerated drug that can be administered as a single dose. The study shows that TNK works better than current recommended drug tPA, restoring blood flow faster and for a longer period.
Researchers have devised a way to deliver carbon monoxide to the body using stable foams that can be delivered to the digestive tract. The foams reduced inflammation of the colon and helped reverse acute liver failure in mice, offering a potential alternative to immunosuppressive treatments.
A study published by researchers at the University of Colorado Anschutz Medical Campus found that psychiatric drugs imipramine and olanzapine can improve symptoms of Alzheimer's disease, including boosting cognition and reversing clinical diagnoses.
A clinical trial found that interrupting treatment with methotrexate, a common immune-suppressing drug, doubles the antibody response to COVID-19 booster vaccinations in vulnerable individuals. This improvement is maintained over a 3-month period and has no adverse impact on quality of life.
A new UCLA study found that fixed vial sizes for the controversial Alzheimer's drug aducanumab could result in significant wasteful spending of up to $605 million per year on Medicare. The researchers suggest reducing vial sizes to contain costs and improve the value of future Medicare spending.
Researchers at Johns Hopkins Kimmel Cancer Center developed a targeted immunotoxin that delivers into breast ducts, eliminating visible and invisible precancerous lesions in laboratory studies. The treatment showed strong cancer-killing effects in all cell lines and was well-tolerated in mouse models.
A systematic review of 84 studies found insufficient evidence that multivitamins or supplements can prevent cardiovascular disease and cancer in healthy adults. In contrast, diet and exercise are key to maintaining health. Whole fruits and vegetables contain a mixture of vitamins, phytochemicals, fiber, and other nutrients that act syn...
A population-based study found that patients with estrogen receptor-positive breast cancer who experienced hot flashes while on adjuvant hormone therapy had worse outcomes and a higher risk of early treatment discontinuation. The study suggests that managing side effects may not be enough to prevent treatment discontinuation, highlight...
The WVU program trains next generation of toxicologists to collect, analyze air samples from mining, fracking sites, using the university's Inhalation Facility. Students will work with preceptors from various fields to investigate health effects of inhaling toxicants.
A Rutgers study reveals that racial and ethnic minority groups were less likely to obtain prescriptions to treat opioid addiction during the COVID-19 pandemic. This trend is particularly concerning, as minority groups face more barriers to healthcare and are already disproportionately affected by the pandemic.
A study found that a genetic variant associated with low white blood cell counts, common in people of African ancestry, is linked to discontinued or decreased azathioprine medication. This suggests considering genetic factors before altering treatments.
A new study found that women over 40, non-Hispanic Black women, and those with lower education levels are more likely to experience infertility. The US fertility rate has plateaued, but access to healthcare services is a significant factor in preventing infertility.
Researchers identified a three-gene signature in multiple myeloma tumors that predicts a positive response to selinexor-based therapy. The discovery could improve patient selection for targeted agents and expand the use of the drug into patients who haven't failed other therapies.
Youth substance use declined during the COVID-19 pandemic, as teens had limited access to peers and substances due to stay-at-home orders. This reduced risk of substance use is attributed to increased social isolation from peers, which may have a negative impact on mental health.
The COVID-19 pandemic caused a substantial disruption to cancer clinical trials in the US, with a 46% decrease in new patient accruals and a 24% decrease in newly activated trials between March and May 2020. However, both patient accruals and trial activations have gradually recovered since then.
A new study from Tel Aviv University developed a unique treatment for AIDS that may be developed into a vaccine or a one time treatment. The treatment involves engineering type B white blood cells to secrete anti-HIV antibodies in response to the virus.
Researchers at the University of Cincinnati are studying how lipids help fortify lung cancer cells and if targeting them can lead to better outcomes. The team discovered that lipids play a crucial role in cancer cell growth, membrane fortification, and energy production.
A drug targeting IDH1 mutations in select cancers also inhibits wild-type form under certain conditions, making it a promising therapeutic option. Laboratory experiments and mouse models demonstrate the efficacy of Ivosidenib against various cancer types, including pancreatic, colorectal, ovarian, and lung cancer.
A new study published in JAMA Internal Medicine suggests that COVID-19 vaccination during pregnancy can provide protection to newborns against SARS-CoV-2 infection. The study found a lower incidence of confirmed SARS-CoV-2 infection in infants born to vaccinated mothers compared to unvaccinated mothers.
A phase 3 randomized study showed that momelotinib significantly improved outcomes for patients with myelofibrosis, a rare and fatal bone marrow cancer. The oral pill met all primary and secondary endpoints, showing a trend toward overall survival benefit within six months.
A long-term study found that cigarette smoking significantly increases the risk of developing both reduced ejection fraction and preserved ejection fraction heart failure. Former smokers retained a higher risk of heart failure for decades after quitting, with the risk decreasing only after 30 years without smoking.
The proposed ban on menthol cigarettes aims to address health inequities in the Black community. The Rutgers Center for Tobacco Studies has found a strong link between menthol use and higher smoking rates among young people and reduced success in quitting.
A secondary analysis of the MOVe-OUT trial found molnupiravir-treated participants had a decreased need for respiratory interventions and fewer COVID-19-related acute care visits. Additionally, they showed faster normalization of biomarkers and were discharged earlier than placebo-treated patients.
A review of 25 trials found that synthetic cannabis products with high THC-to-CBD ratios improved chronic pain, but were associated with higher risks of adverse events. In contrast, products with comparable THC-to-CBD ratios showed few benefits in overall functioning.
A recent study published in the New England Journal of Medicine found that dostarlimab was effective in treating a subtype of rectal cancer, showing remarkable responses and resolving difficult symptoms. The treatment offers a more effective and less toxic alternative to traditional chemotherapy and radiation.
A new study found that patients with multiple myeloma who received a three-drug combination therapy had improved progression-free survival if they underwent an autologous stem cell transplant soon after treatment. The use of maintenance lenalidomide also conferred substantial clinical benefit.
A Phase 3 clinical trial is investigating the effectiveness of a combination of two immunotherapy drugs, nemvaluekin alfa and pembrolizumab, compared to standard chemotherapy for patients with platinum-resistant ovarian cancer. The trial aims to provide a novel treatment option with better efficacy and safety profiles.
A study of patients with high-risk renal cell carcinoma found that those taking everolimus daily after surgery lived longer without disease recurrence. The results, although narrowly missed statistical significance, showed improvement primarily in very high-risk disease, with a 21% improvement in RFS for those with the highest risk.
A study of over 3,000 adults found that RAAS inhibitors lowered aneurysm rupture risk by 18%. Using proper antihypertensive medications can decrease the risk of a ruptured aneurysm. The study suggests that nearly 18% of ruptured aneurysms may be prevented with RAAS inhibitors.
A new drug combination of ramucirumab and pembrolizumab significantly extended overall survival in advanced non-small cell lung cancer patients who had progressed on prior immunotherapy. The study found a 31% reduction in risk of death compared to standard therapy, with median overall survival times of 14.5 months.
A Mayo Clinic study found that disparities in opioid treatment access persist among women, Black and Hispanic populations. Despite increased access, these groups continue to face systemic barriers, including racism, mistrust of healthcare professionals, and lack of clinicians able to prescribe buprenorphine.
A combination of ramucirumab and pembrolizumab reduced the risk of death by 31% compared to standard care in advanced non-small cell lung cancer patients who had previously failed immunotherapy. The study found that these patients lived significantly longer, with a mean overall survival time of 14.6 months.
The NIH has launched a clinical trial testing dupilumab, an approved treatment for moderate-to-severe asthma, in children with poorly controlled allergic asthma living in low-income urban neighborhoods. The study aims to define the activity levels of gene networks associated with asthma attacks and improve lung function.
A team of MIT researchers has developed drug-carrying nanoparticles that can efficiently penetrate the brain and kill glioblastoma cells. Using a human tissue model, they showed that the particles could get into tumors and deliver chemotherapy drugs, including cisplatin, which effectively killed tumor cells.
A global black market for COVID-19 antiviral drugs is emerging, putting patients' health in jeopardy due to unequal distribution and substandard products. The investigation found that patients are buying pills online without medical supervision, increasing the risk of birth defects and viral resistance.
Researchers created oil-based gels that can deliver a variety of medications, including those for infectious diseases, in a stable and palatable form. The gels can be used to administer drugs to children and adults with difficulty swallowing pills, and could have a significant impact on improving medication adherence.
A new UK study has found that only one in three patients with gout were prescribed preventative medication within a year of diagnosis, indicating poor care quality. The study also revealed that just one in six patients achieved the target blood urate level recommended by the British Society for Rheumatology.
Research reveals pridopidine enhances autophagy in ALS model, reducing toxic protein aggregation and promoting neuronal health. The study supports pridopidine's potential as a treatment for neurodegenerative diseases like Huntington's disease and Alzheimer's.
A new study found that Medicare spent $1.2 billion on 36 drugs with no confirmed clinical benefits, mainly for cancer-related indications. The study suggests reforming the FDA's accelerated approval program to reduce waste and ensure patients receive effective treatments.
Researchers at West Virginia University are studying the mechanisms behind Alzheimer's disease and PTSD, using animal models to investigate how stressful events affect brain cells. They aim to understand the role of estrogen and high-cholesterol diet in developing the disease.
A study led by Tel Aviv University researchers reveals a common mechanism underlying genetic mutations associated with autism, schizophrenia, and other neurological disorders. The discovery points to an experimental drug developed by the team as a potential treatment for these conditions.
A landmark trial found that a widely used diabetes drug, metformin, is not effective against the most common forms of early-stage breast cancer. However, researchers discovered a potential benefit for individuals with HER2-positive breast cancer, which accounts for about 20% of all breast cancers.
A review of 38 randomized controlled trials found that counseling patients about contraceptive use and providing contraceptives increases use without increasing STI risk or reducing condom use. The interventions also decrease unintended pregnancy in trials designed to evaluate this outcome.
Research found that e-cigarette users spent more on healthcare services, including hospital stays, ER visits, and doctor appointments. The study estimated $15.1 billion in annual healthcare expenditures attributable to e-cigarette use in the US.
Researchers at University of Utah Health have found a natural chemical in soft corals that shows promise in treating cancer. The discovery allows for the first steps of re-creating the chemical in the laboratory, opening up possibilities for producing it on a large scale.
A lifestyle intervention program of increased physical activity and healthy eating, or taking the medication metformin, were found to be effective long-term in delaying or preventing Type 2 diabetes in adults with prediabetes. However, neither approach reduced the risk of cardiovascular disease over a 21-year follow-up period.
A study published in Human Reproduction found that men with obesity who lost weight saw a 50% increase in sperm concentration and a 40% increase in sperm count over an 8-week period. This improvement was sustained for up to 52 weeks and even doubled for those who maintained weight loss after a year
A Johns Hopkins Medicine study found that a protein called STING responds to clean-up signals in brain cells damaged by Parkinson’s disease by creating a cycle of inflammation that accelerates the disease’s progression. In mice with deactivated STING proteins, there was less microglial activity and brain cell death.
This study analyzed supportive evidence for FDA approvals of 49 novel drugs in 2020. The study's findings provide insight into the key design characteristics of pivotal trials supporting these drug approvals.
A recent study found that 70% of adults with stage 3 or 4 cancer were at risk of drug-drug interactions, highlighting the importance of deprescribing medications to avoid harm. The study's results emphasize the need for education and problem-solving to address polypharmacy in older adults with cancer.
Research on experimental drug NU-9 invents by Northwestern University scientists reveals it is more effective than existing FDA-approved drugs for ALS treatment. NU-9 also repairs the axons of diseased upper motor neurons in ALS mouse model, offering a potential new approach to treating the devastating disease.
A global study found a combination of two drugs dramatically reduces the chances of suffering an asthma attack. The combination of albuterol and budesonide lowers the number of sudden episodes of shortness of breath, wheezing, and coughing in patients.
A Rutgers study found that individuals with opioid-use disorder who used non-prescribed buprenorphine before entering treatment were twice as likely to remain in care. Those who used the medication also had significantly lower rates of opioid use during the first six months in treatment.
A new lymphoma treatment, zanubrutinib, has been found to be effective in 80% of patients with marginal zone lymphoma, resulting in significant cancer shrinkage. However, its impact on follicular lymphoma is less pronounced.
The Cardiovascular Research Foundation (CRF) announced that TVT: The Structural Heart Summit will feature 12 studies as Late-Breaking Clinical Science and Featured Clinical Research. These studies highlight advances in transcatheter aortic valve replacement, mitral, tricuspid, and left atrial appendage occlusion therapies.
Researchers developed an algorithm to quickly identify two cancer drugs that work well together, reducing testing time from three years to eight weeks. The new method uses gene expression data to prioritize potential combinations and has been confirmed in lab tests.
Researchers found that targeting both tumor and lymph node microenvironments with nanomedicine improves treatment response for metastatic triple negative breast cancer. Long-term tumor remission was achieved in mice models using nanoparticles to deliver immune-modulating drugs.