Articles tagged with Drug Studies
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
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Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
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The ANRS 162-4D trial found that patients on a 4-day a week regimen had undetectable viral loads for most of the study period. The innovative strategy aims to improve adherence and reduce drug burden, but more research is needed to confirm its efficacy.
Researchers found that subdermal buprenorphine implants maintained low to no illicit opioid use among currently stable opioid-dependent patients. The study showed that 72% of participants who received buprenorphine implants and 64% of those who received sublingual buprenorphine maintained opioid abstinence over six months.
UAB will receive $200,000 per year in base funds for the next five years through the NICHD Maternal-Fetal Medicine Units Network. The network focuses on addressing preterm birth through translational research, genetics, and new technologies.
A large clinical trial has found that estrogen therapy does not impact cognitive function in postmenopausal women, contradicting previous theories. The study suggests that healthy women at any stage after menopause should not take hormone supplements to improve memory.
A systematic review with network meta-analysis found no significant differences in the associations between glucose-lowering drugs and cardiovascular or all-cause mortality. The study included nearly 120,000 adults with type 2 diabetes and estimated that diabetes accounted for approximately 1.5 million deaths in 2012.
The HOPE study will build on the ASPIRE trial results, gathering more information on the dapivirine ring's safety and effectiveness in reducing HIV risk. The study aims to understand why the ring works for some women but not others.
The HPTN 052 study found that antiretroviral therapy (ART) provides durable protection against HIV transmission from infected individuals to their uninfected partners. The trial showed a 93% reduction in HIV transmission when ART was started early, with no observed transmission when viral replication was stably suppressed.
Using a drug-infused vaginal ring most of the time significantly reduced HIV infection risk in women by at least 56 percent, according to an exploratory analysis of data from the ASPIRE study. High adherence was associated with a risk reduction of potentially 75 percent or more.
A study published in PNAS highlights two protective mechanisms compromised in macular degeneration. Drugs that target immune abnormalities and cholesterol levels may slow or prevent the condition, which affects 2 million Americans.
Researchers found that using the dapivirine ring consistently provided significant protection against HIV, with high adherence associated with better HIV protection. The study's results coincide with the start of the HOPE open-label study, which will gather additional information on the ring's safety and effectiveness.
A study found that over half of elderly adults take five or more chronic medications daily, with underuse occurring in 67% and misuse in 56%. This can lead to increased risks of mortality and hospitalization.
A CCNY-led study reveals differing treatment options for women smokers, finding varenicline significantly improves quit rates compared to nicotine patch and bupropion. The research highlights the importance of considering sex differences in smoking cessation pharmacotherapy.
The FDA has approved the ExAblate focused-ultrasound device to treat essential tremor in patients who do not respond to medication. The procedure shows promise as a less invasive alternative to deep-brain stimulation, with significant reductions in tremor symptoms after three months and one year.
The study found that SAPIEN 3 TAVR resulted in an over 85% one-year survival rate for high-risk and inoperable patients, significantly higher than previous studies. Patients also experienced improved quality of life and no significant increase in moderate leaking around the prosthetic valve.
A new transparent skull implant developed by UCR researchers allows for minimally invasive laser-based treatments for patients with brain disorders. The implant's biocompatibility and ability to endure bacterial infections make it a promising alternative to currently available cranial implants.
A new clinical trial funded by the National Institute for Health Research (NIHR) aims to transform early detection of diabetic eye disease by introducing a novel screening method. The trial will enable patients at lower risk to undergo tests only every two years, while those at higher risk can be checked up to twice a year.
Two groundbreaking studies published in New England Journal of Medicine found that patients with specific subtypes of breast cancer responded better to neratinib and veliparib combinations before surgery. These findings have led to the fast-tracking of experimental drugs for large-scale phase 3 trials.
A study by Jennifer Estall and Aurèle Besse-Patin explores how female mice respond to FGF21, a hormone that improves metabolism and insulin sensitivity. The researchers aim to provide a more comprehensive understanding of the effect of sex on drug treatment for metabolic diseases.
Researchers have identified the key cellular mechanism behind antipsychotic-induced parkinsonism, which includes involuntary movements and tremors. By targeting dopamine D2 receptor blockade in specialized neurons, a new approach to designing novel antipsychotics without side effects may be possible.
A Phase 3 clinical trial found deutetrabenazine significantly decreased chorea in HD patients, with improvements also seen in quality of life measures. The drug was well-tolerated and effective in treating chorea associated with Huntington disease.
The PREVAIL IV trial is a six-month study enrolling 60-120 EVD survivors with evidence of Ebola virus RNA in their semen. Participants will receive either investigational drug GS-5734 or a placebo to see if it can eliminate the viral RNA from semen.
Research from the University of East Anglia found that people switching to pill organizers are more likely to become unwell than those not using them. Patients should consult their GP or pharmacist before making the switch.
A new study found that nearly 70% of elderly patients taking antihypertensives also have low blood pressure, leading to increased mortality rates and hospital admissions. Regular review of treatment is crucial to balance risks and benefits.
A woman was admitted to intensive care due to a rare infection believed to be transmitted by her Italian greyhound, while a teenage girl had pinworms in her appendix. A 26-year-old student also developed lead poisoning from taking Indian Ayurvedic herbal medicines.
A global trial of midostaurin reveals that the drug can produce partial or complete resolution of organ damage in 60% of patients with advanced systemic mastocytosis. Patients treated with midostaurin experienced improved liver function, fewer signs of malabsorption, and increased survival rates.
A new neuroendovascular technique called ADAPT has shown impressive 90-day outcomes for stroke patients with large-vessel clots. Approximately 58% of patients achieved a good outcome after thrombectomy using the direct-aspiration, first pass technique.
Patients with asthma who use illicit drugs and have low socioeconomic status are at higher risk of requiring intensive care. Not adhering to prescribed asthma medication also increases this risk.
A team of experts has proposed a standard list of essential diagnostic tests to support the use of medicines listed on the Model List of Essential Medicines. The list includes 147 critical laboratory tests across 57 categories, which can guide the use of many different EML drugs and improve healthcare quality in developing nations.
Volanesorsen, a novel lipid-lowering medication, significantly improved insulin sensitivity and glucose control in patients with type 2 diabetes and high triglycerides. The study found a 69% reduction in triglycerides and improved hemoglobin A1c levels, suggesting that lowering triglycerides can improve insulin sensitivity.
A study found that only 53% of industry-funded clinical trials were listed on a data sharing website, despite the companies' commitment to share data. The proportion of shared data varied significantly between sponsors, with GlaxoSmithKline reporting 66% and Boehringer Ingelheim reporting 24%.
Researchers propose using small amounts of efavirenz to increase CYP46A1 enzyme activity, leading to improved memory and reduced plaque development. Studies suggest a 40% increase in cholesterol breakdown in mouse models, with potential benefits for human Alzheimer's patients.
The European Medicines Agency has revised its trial design guidelines for acute coronary syndromes, emphasizing the use of troponin to diagnose myocardial infarction. The new guidelines also recommend a more nuanced approach to risk analysis, including subgroup analysis according to risk levels. This updated framework aims to promote t...
Researchers at Johns Hopkins Medicine discovered that blocking the enzyme c-Abl prevents Parkinson's disease symptoms in specially bred mice. The study also found that a chemical tag on the protein α-synuclein may signal the disorder's presence and progression. The findings suggest both a promising target for drug research and a potent...
A systematic review of over 68,000 elderly people found no association between 'bad cholesterol' and cardiovascular deaths. High levels of low-density lipoprotein (LDL-C) were often linked to longer life, contradicting the long-held cholesterol hypothesis.
A pilot study published in The Journal of the American Osteopathic Association found an adjustable foot wrap to be significantly more effective than standard pharmaceutical treatment for restless legs syndrome. The device caused a 1.4 times increase in sleep for those with moderate to severe symptoms.
Studies show that e-consults can decrease wait times, improve clinical care, and reduce the need for face-to-face appointments. The use of electronic consultations increases access to specialists' care for patients who often have difficulty getting a specialist, including the uninsured and underinsured.
A recent study found that depression decreases adherence to COPD maintenance medications in older adults, with average monthly adherence peaking at 57% and decreasing to 25% within six months. Clinicians should be aware of the development of depression in newly-diagnosed patients with COPD.
Stent retrievers effectively reverse strokes by removing gelatinous blood clots, outperforming intravenous drug tPA in reducing disability. The devices will impact stroke systems of care and treatment location, routing higher severity patients to centers capable of neuroendovascular procedures.
The federal government restricts externally valid scientific research on Cannabis sativa due to its Schedule I classification. This limits the potency and variability of THC in approved products, hindering studies on its therapeutic benefits and risks.
A new study published in Science Translational Medicine found that the experimental drug CX546 counters the negative effects of general anesthesia on nerve signaling and learning ability in young mice. This research holds promise for preventing long-term neurocognitive deficits in children who undergo multiple surgeries requiring anest...
A novel combination of sorafenib and pemetrexed showed promise in a phase 1 clinical trial, with 61% of patients experiencing tumor growth delay. The therapy was particularly active in breast cancer patients, with one complete response and multiple partial responses.
A new study found that older adults who need help taking medications often have poor vision, hearing, or diagnosed conditions like stroke, diabetes, hypertension, heart attack, or cancer. The study also identified age and gender as predictors of medication assistance needs, with men and those aged 80+ being more likely to require help.
The study found that patients who received the LINKAGE intervention had greater involvement in managing their health and healthcare than those receiving standard care. Participants showed significant increases in patient portal use and rates of abstinence from alcohol and drugs.
A three-year clinical trial found that pioglitazone reduced fatty liver disease activity in 58% of participants and halted fibrosis that leads to cirrhosis. The study also highlights the importance of early diagnosis and treatment for NASH, a leading cause of liver transplants.
A review of 60 studies found that plant-based therapies like phytoestrogens and herbal remedies may improve menopausal symptoms, such as hot flashes and vaginal dryness. However, the evidence is limited by quality and more rigorous studies are needed to confirm these findings.
Researchers compared ClinicalTrials.gov and Drugs@FDA for results reporting accuracy, finding that while Drugs@FDA was useful for primary outcomes, it lacked validity for secondary outcomes and adverse events. Integration between the two sites could lead to better health information.
A new study by Yale researchers suggests that a catheter-delivered device called the Watchman may be a more cost-effective treatment option for patients with atrial fibrillation. The device, which is permanently implanted in the opening of the left atrial appendage, prevents blood clots from forming and reducing the risk of stroke.
A new study published in the International Journal of Epidemiology found that genetic research in large-scale biobank studies can significantly improve the drug development pipeline and reduce costs. The study used a genetic variant linked to cardiovascular disease to demonstrate the value of Mendelian randomization.
Researchers at the Babraham Institute have developed a technique to replicate early changes in Alzheimer's disease in a lab-dish model. This breakthrough allows for the study of the disease's progression and potential treatments without animal testing.
Penn State College of Medicine faculty define health systems science and its curriculum, complementing basic and clinical sciences. They identified 12 core domains and cross-cutting domains to be included in medical school curricula.
A new study found that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) can reduce the risk of strokes, heart attacks, and death in patients with end-stage renal disease undergoing peritoneal dialysis. The study involved 4,879 patients and showed a 16% lower risk of cardiovascular events with...
PharmaMar announces the start of a multicenter study evaluating plitidepsin's efficacy in patients with relapsed and refractory angioimmunoblastic T-cell lymphoma. The primary endpoint is overall response rate, while secondary endpoints include duration of response, progression-free survival, and pharmacokinetic characteristics.
A large clinical trial showed liraglutide safely and effectively decreases the overall risk of heart attack, stroke, or cardiovascular death for people with type 2 diabetes. The study also found a reduction in kidney disease and death from all causes.
A study found that opioid prescribing at hospital discharge is common among Medicare patients without prior opioid use, with substantial variation across hospitals. Another study revealed that many adults with recent opioid medication use share or keep leftover medication for future use, highlighting the need for safer practices.
Researchers found that at least one in five elderly nursing home residents experienced resident-to-resident mistreatment, with verbal aggression being the most common form. The study's findings highlight a need for better understanding and prevention strategies for this type of abuse.
A global study found that patients with type 2 diabetes admitted to the hospital for congestive heart failure face a high risk of mortality, highlighting the need for increased attention to this critical condition. The study suggests that heart failure outcomes should receive equal scrutiny as other cardiovascular events in future rese...
A new drug called ixekizumab has shown significant promise in treating moderate to severe psoriasis, with 80 percent of patients experiencing complete or near-complete clearance of their symptoms. The long-term efficacy and safety of the treatment will be monitored closely.
Researchers found that expensive drugs like aflibercept are not cost-effective for treating diabetic macular edema compared to cheaper alternatives. To reach a threshold of $100,000 per quality-adjusted life-year, treatment costs would need to decrease by 69% for aflibercept and 80% for ranibizumab.
A clinical trial shows that an intensive procedure replacing the diseased immune system with a new one using blood stem cells can eliminate all signs of brain inflammation in people with early, aggressive multiple sclerosis. The treatment resulted in zero clinical relapses and no new active inflammatory lesions over 4-13 year follow-up.
A recent NIH-funded study found that standard and intensive blood pressure treatments were equally effective in the emergency treatment of acute intracerebral hemorrhage, a type of stroke caused by bleeding into the brain. After 90 days, the rate of death or severe disability was equal for both groups, at around 38 percent.