Articles tagged with Drug Studies
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Researchers identified GERD, female gender, and higher total SGRQ scores as significant predictors of COPD exacerbation risk in patients using inhaled medications. Tiotropium showed a trend towards lower rates of exacerbations in subjects without asthma, suggesting it may be beneficial for these patients.
The 'Radial Paradox' reveals that radial access may offset vascular complications when used as a backup method for femoral access. A study found that non-culprit vessels with significant stenosis are not functionally important, increasing debate on intervention strategy. Meanwhile, elderly patients benefit from drug-eluting stents with...
A study at Brigham and Women's Hospital discovered a genetic variant, SLC9A9, associated with patients' likelihood of responding to interferon-beta treatment. The variant may also play a role in regulating immune cells involved in inflammatory diseases like MS.
Researchers found that a medical marijuana pill was safe and well-tolerated, but did not show significant improvement in behavioral symptoms of dementia. The study suggests further research is needed to test the effectiveness of higher doses.
Research suggests that psychiatric drugs may be harming more people than helping them, with experts arguing that the benefits are minimal and the risks are immense. The BMJ says that more than half a million people die from psychiatric drug use every year in Western countries.
Scientists at Northwestern University have synthesized four new chemical compounds with antipsychotic properties using natural products from plant species used in traditional healing practices in Nigeria. These compounds show promise in improving cognitive impairment in animal models, a partially effective treatment for schizophrenia.
A large study of Tricare patients found that statin users were 87% more likely to develop diabetes and had a higher risk of complications. The study confirms past findings on the link between statins and diabetes risk, but is among the first to show this connection in a relatively healthy population.
Studies found that daclatasvir, asunaprevir, and beclabuvir regimens achieved high sustained virologic response (SVR) rates in patients with HCV genotype 1 infection. The UNITY-1 study reported an SVR rate of 91.3% among treatment-naive patients, while the UNITY-2 study showed a similar success rate for treatment-experienced patients. ...
A 12-week dose of an investigational three-drug combination cleared the virus in 93 percent of patients with liver cirrhosis who hadn't previously been treated. The addition of ribavirin to the regimen enhanced results, eliminating the virus in 93 percent of previously treated patients.
A new study suggests pharmacies can reduce asthma-related illnesses by dispensing more asthma controller medications. Pharmacies located in high utilization census tracts dispense more rescue medications than controller medications.
Sudden cardiac death accounts for 42% of deaths in on-duty firefighters over the past 5 years, exceeding traditional risks like burns and trauma. Researchers examine heat stress impact on firefighter hearts and blood vessels.
Researchers from Mount Sinai presented a first successful 3D printed trachea, as well as studies on increased mortality in black patients after esophageal cancer surgery and the potential benefits of surgical resection for myasthenia gravis. These findings highlight the importance of personalized medicine and access to specialized care.
A new experimental drug increases HIF-1α levels in human bladder cells, making them resistant to UTI-causing bacteria. The treatment also protects mice against UPEC infection and reduces colonization rates.
A randomized trial by Yale researchers found that patients given buprenorphine in the emergency department were more likely to engage in addiction treatment and reduce illicit opioid use. They also had fewer resources used, compared to those who received only referrals or brief interventions.
A clinical trial by Joslin Diabetes Center found that adjustable gastric band surgery and intensive group-based medical diabetes and weight management program achieved similar improvements in controlling blood sugar levels after one year. Participants experienced significant weight loss and better quality of life with both approaches.
A new study published in the International Journal of Clinical Pharmacy found that diphenhydramine, an active ingredient in Dr. Cocoa's Nighttime formula, significantly inhibits cough reflex sensitivity in adults with acute pathological cough, commonly known as a cold.
A new Veterans Affairs study found that the high-dose flu vaccine provides stronger protection against flu-related hospitalizations and deaths for those 85 and older, while standard vaccines may be effective for younger seniors. The study included over 165,000 patients and tracked hospitalization and death rates.
BLU-554, a small molecule inhibitor of FGFR4, has been identified as a potential treatment option for up to 30% of HCC patients. The investigational drug was shown to be potent and 'exquisitely selective' for FGFR4 compared to other kinases targeting the FGFR family.
A six-year, $40 million trial aims to investigate the effectiveness of statin therapy in reducing HIV-associated cardiovascular risk. The REPRIEVE study is the largest clinical trial to focus on cardiovascular disease in HIV patients, targeting those with no known heart disease and low traditional risk factors.
A randomized controlled trial demonstrated liraglutide met the primary endpoint of histological clearance of non-alcoholic steatohepatitis, and a reduction in fibrosis progression. The study also showed significant weight loss, BMI reduction, and fasting glucose decrease with liraglutide treatment.
Researchers found that mindfulness-based cognitive therapy (MBCT) is not more effective than maintenance antidepressant medication in preventing depression relapse. However, MBCT may offer similar protection against depressive relapse for people with a history of multiple episodes, with no significant cost difference.
A new study suggests that cloth masks used by healthcare workers in Vietnam increased their risk of contracting respiratory illnesses. The trial found that cloth masks allowed almost 97% of particles to pass through, compared to medical masks with 44%. Experts warn against the use of cloth masks in healthcare settings.
The article highlights the importance of clinical phenotyping in precision medicine, with Penn researcher Garret FitzGerald advocating for translational med hubs to be equipped with the necessary resources. The NIH's Clinical and Translational Science Awards (CTSAs) program is seen as a key driver of this effort.
A new study found that nearly 40% of multiple sclerosis patients who stopped taking their medication experienced some level of disease activity. Patients who stopped taking their medication were more likely to experience relapses and disability progression than those who continued treatment.
A global pandemic of fake medicines threatens decades of progress in combating HIV/AIDS, malaria, and tuberculosis. Up to 41% of drug samples studied failed to meet quality standards, highlighting the urgent need for improved surveillance and detection methods.
Researchers analyzed 2,028 antimalarials from Cambodia and Tanzania, finding no evidence of fake medicines, but substandard drugs were present in 31% of samples in Cambodia and 12% in Tanzania. The study highlights the importance of surveillance to protect patients and prevent drug resistance.
Researchers discovered two drugs, miconazole and clobetasol, that stimulate stem cells to repair white matter and reverse paralysis in multiple sclerosis. The study found that these compounds activate oligodendrocyte progenitor cells to increase myelination, potentially leading to new treatments for the disease.
A large study found that mindfulness-based cognitive therapy (MBCT) is comparable in preventing depression relapse to maintenance antidepressant medication. The therapy may offer a cost-effective and low-cost option for individuals with recurrent depression.
A new report from UC San Diego highlights the scope of the problem, finding that only 1,510 counterfeit incidents were reported between 2009 and 2011, despite an estimated 100,000-1 million deaths per year. The study calls for improved detection, data collection, and analysis to combat falsified medicines.
A recent EORTC trial found that adjuvant Ipilimumab significantly improves recurrence-free survival in patients with completely resected stage III melanoma at high risk of disease recurrence. However, the treatment was also associated with a high rate of immune-related adverse events.
A subset of lung cancer patients with BRAF-mutant cancers may derive significant clinical benefits from treatment with BRAF inhibitors, according to a European study. The trial found an overall response rate of 53% and progression-free survival time of 5 months among patients treated with vemurafenib or dabrafenib.
Randomized clinical trials demonstrate endovascular therapy is highly beneficial in treating acute ischemic strokes. The new studies, published simultaneously in NEJM, attribute the improved results to superior surgical technology and improved neuroimaging criteria.
A study found that removing clots in severe strokes, combined with medication, improves blood flow and may lead to better long-term outcomes. The treatment shows promise as a game-changer for certain types of stroke patients.
A new endovascular therapy procedure for ischemic stroke has been shown to improve patient outcomes, increasing positive results from 35% to 60%. The study, SWIFT-PRIME, randomized 196 patients and found a significant reduction in mortality rates, with an overall decrease of 50% compared to standard treatment.
A trial conducted in Catalonia, Spain, found that removing blood clots from large brain blood vessels improved function and reduced disability after stroke. The technique, called endovascular therapy or stent retriever thrombectomy, showed a 1.7 fold reduction in disability compared to medical intervention alone.
The NIH has launched a multicenter, international clinical trial to investigate the use of statins in reducing major adverse cardiovascular events among people with HIV. The trial aims to inform the best approach to preventing cardiovascular disease in HIV-infected individuals.
A study found that appropriate patient selection and pharmacist-led monitoring are associated with higher adherence rates to dabigatran. Modifiable site-level practices, such as collaboration between pharmacists and clinicians for nonadherent patients, also improved adherence rates.
A European study involving over 7,000 participants provides new insight into public interest in medicines research and development. The survey found that those with previous experience were almost five times more likely to have good knowledge of medicines R&D.
A pilot study published in Addiction journal found that extended-release naltrexone significantly reduced opioid relapse rates among mostly heroin-dependent men released from New York City jails. After one month, 88% of participants in the control group relapsed, compared to 38% in the treatment group.
In a deadly, rapidly spreading infectious disease like Ebola, traditional randomized clinical trials may be inadequate. Alternative trial designs can provide useful information and are morally justifiable, says a new article in the American Journal of Bioethics.
PharmaMar is presenting data on its anticancer candidates PM1183 and plitidepsin, showing synergistic effects against breast cancer cell lines and SCLC mouse tumor models. The company's studies also highlight the potential of plitidepsin as a novel therapeutic target in multiple myeloma.
A clinical trial found that zoledronic acid improved bone mineral density and reduced bone turnover in frail elderly women with osteoporosis. The treatment group showed significant increases in hip and spine bone mineral density at 12 and 24 months, while the placebo group showed decreases.
Researchers explore whether genetic variations can modify the placebo effect, potentially leading to better patient selection for clinical trials. Genetic tests could help identify individuals who are unlikely to benefit from treatment, allowing for more efficient and effective medical care.
A recent study published in The Lancet Neurology has found that a clot-busting drug called alteplase can benefit stroke patients without increasing the risk of bleeding. Researchers analyzed over 3,000 people and discovered that patients with early tissue damage from strokes still benefit from receiving the drug.
A study found that individuals on insulin experienced significantly higher levels of inflammation compared to those living in lower traffic areas. People taking oral diabetes medications did not show the same increase in inflammation, suggesting a potential protective effect.
A National Institutes of Health study found that an over-the-counter allergy medication, chlorcyclizine HCl (CCZ), limits hepatitis C virus activity in infected mice. The results suggest CCZ could be used to treat the virus in people, potentially providing an affordable alternative to costly options.
The TOAST classification system is widely employed in stroke studies worldwide, categorizing ischemic strokes into five broad causes. While useful for real-world research, it has limitations when determining treatment for individual patients.
A University of Missouri researcher found that behavioral interventions for patients are more effective than those targeting healthcare providers in improving medication adherence. The study analyzed 29 interventions and concluded that patient-centered approaches can help identify the root causes of non-adherence.
A Northwestern University study found that clinical trials for finasteride, a common hair loss treatment, inadequately reported sexual dysfunction, which may persist. The study analyzed 34 clinical trials and found no adequate information on the severity, frequency, or reversibility of sexual adverse effects.
A new investigation by The BMJ reveals that NHS doctors could prescribe the affordable and effective sight loss drug Avastin for patients with wet age-related macular degeneration. If allowed, this could release £102 million annually to reinvest in other frontline patient services.
A new study found that children who get a taste of their parents' wine are more likely to start drinking by high school. Of the 561 students surveyed, those who'd 'sipped' alcohol by sixth grade were five times more likely to down a full drink and four times more likely to binge or get drunk.
Researchers at Yale University have successfully restored memory and synaptic connections in Alzheimer's mice using the experimental cancer drug AZD05030. The treatment blocks damage caused by amyloid-beta plaques, a hallmark of Alzheimer's disease, and has led to the launch of human trials.
Researchers from Scripps Research Institute have discovered a unique mechanism of borrelidin, a natural product with wide-ranging antifungal, antibacterial, anti-malaria and anti-cancer effects. The study sheds light on the compound's inhibition of protein synthesis by occupying four distinct subsites on tRNA synthetase.
A new analysis found that studies supporting the value of second-generation antidepressant drugs for anxiety disorders have been distorted by publication bias, outcome reporting bias, and 'spin'. The researchers concluded that these medications may not be significantly more useful than a placebo in treating anxiety disorders.
A new oral drug, ZS-9, has been shown to normalize high potassium levels in 98% of patients with chronic kidney disease treated with Renin Angiotensin Aldosterone System inhibitors (RAASI's). This effective treatment reduces the risk of fatal cardiac arrhythmias associated with hyperkalemia.
A new study suggests that fasting combined with a class of cancer-inhibiting drugs can starve colorectal, breast and lung cancer cells, potentially replacing chemotherapy. The research found that this combination is equally effective in killing cancer cells.
Two studies show that midwives can safely treat failed abortions and miscarriages in rural districts of Uganda, and that home pregnancy tests can replace clinical follow-up examinations. These findings may lead to new international recommendations for medical abortion treatment.
Two experimental Ebola vaccines have proven safe in a phase 2 clinical trial involving over 600 participants in Liberia. The trial may now advance to Phase 3 testing if the results are confirmed, with the ultimate goal of determining whether these vaccines can protect against Ebola virus disease.
Existing health information exchange studies show little to no correlation between their use and improved patient care outcomes. Researchers found that high-quality evidence linking HIE adoption to clear benefits is scarce, with most studies having methodological limitations.
A two-year clinical trial using low doses of ketamine may hold promise for reversing the devastating symptoms of Rett Syndrome, a neurodevelopmental disorder found almost exclusively in females. The trial aims to measure changes in breathing patterns and overall clinical severity among up to 35 participants.