Articles tagged with Drug Studies
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A yearlong study found that patiromer can reduce elevated blood-potassium levels and prevent life-threatening adverse events in patients with chronic diabetic kidney disease. The drug consistently maintained normal serum potassium levels over 52 weeks, with minimal discontinuation due to adverse events.
University of Michigan researchers created a computer model that predicts the flow of liquid medication in human lungs, providing new insight into treating acute respiratory distress syndrome. The model suggests using a less concentrated version of the medication and optimizing its delivery based on individual patient characteristics.
The American College of Physicians recommends combined diet and physical activity promotion programs to prevent type 2 diabetes in at-risk patients. These interventions have been shown to be effective in reducing new onset diabetes and are also cost-effective.
A new trial by Cancer Research UK has shown that omitting doxorubicin from treatment for children with stage II-III, intermediate-risk Wilms' tumour can be done safely without affecting survival chances. This reduces the risk of irreversible heart problems in later life.
A new psoriasis drug called guselkumab has been shown to be more effective than the current standard of care in treating moderate-to-severe psoriasis. The study found that 81% of patients taking a 200-mg dose of guselkumab had cleared or minimal psoriasis after 40 weeks.
Ludwig Cancer Research and the Cancer Research Institute launched clinical trials to evaluate immunotherapeutic strategies for brain cancer and various solid tumors. The trials will test MedImmune's checkpoint blockade antibody durvalumab in patients with glioblastoma multiforme, a deadly form of adult brain cancer.
A new meta-analysis of 11,000 healthy volunteers in 394 phase I trials found that serious adverse events were rare, occurring in only 34 (0.31%) cases, and half of these were unrelated to the study drug or procedures. The majority of adverse events were mild, with nearly a quarter being judged as unrelated to the study.
A phase IIIb study has confirmed regorafenib's benefit in patients with previously treated metastatic colorectal cancer. The safety profile and progression-free survival were similar to phase III trial results, with a median duration of 2.5 months.
Healthy people given citalopram were willing to pay more to prevent harm to themselves or others than those on placebo drugs, highlighting the serotonin-enhancing antidepressant's effect on moral decision-making. In contrast, levodopa made healthy people more selfish and less altruistic.
Researchers found that afamelanotide significantly improves pain-free sun exposure and quality of life in patients with erythropoietic protoporphyria. The treatment reduced the number of phototoxic reactions and improved overall quality of life, offering patients increased daily functionality.
A recent weight loss study showed significant improvements with liraglutide treatment, resulting in an average weight loss of 8.4 kg. The Temple doctors emphasized that modest weight loss can be considerable and improve medical issues, but more research is needed for longer-term results.
A recent study found that antipsychotic medication use declined in children under 12 years old between 2006 and 2010, while increasing in adolescents and young adults. Boys are more likely than girls to receive antipsychotic prescriptions for conditions like ADHD.
The article highlights lessons learned from monitoring complex HIV clinical trials in Africa over 15 years, including the use of on-site and central monitoring, local monitor teams, and standardized processes. The authors encourage global trial teams to publish their practical observations to improve best practices.
The BMJ has introduced a new policy requiring data sharing for all clinical trials, building on initial policies for drug and device trials. This move aims to promote transparency and reproducibility in research, as encouraged by initiatives from the US Institute of Medicine and World Health Organization.
The University of Pittsburgh School of Medicine is leading a national trial to examine methods to reduce unnecessary use of antibiotics in post-acute and long-term care facilities. The trial aims to develop comprehensive guidelines and tools to help facilities better manage urinary tract infections.
A clinical trial is underway at the Royal Alexandra Hospital to test a new gene therapy treatment for choroideremia, a genetic disorder that causes inherited blindness. The treatment involves injecting a customized virus into the retina to transfer a healthy gene, with promising results already seen in early patients.
The ASPIRE Phase III trial tested the safety and effectiveness of a vaginal ring containing dapivirine for preventing HIV in women. The study found that women who used the ring experienced reduced risk of HIV infection, paving the way for potential long-acting protection against the disease.
A team of scientists at the University of Vermont has developed a new algorithm that can efficiently search millions of tweets on Twitter for drug names and build a map of their connections using hashtags. This approach can quickly identify clear evidence of drugs linked together via hashtags.
A new study suggests a genetic link between high blood pressure and reduced Alzheimer's disease risk, with antihypertensive drugs possibly playing a protective role. Researchers analyzed genetic data from over 17,000 individuals and found a significant association between higher systolic blood pressure and lower Alzheimer's risk.
A UCLA study found that long-acting injectable risperidone significantly reduces symptoms of schizophrenia, especially in recently diagnosed patients. The medication showed better adherence and efficacy compared to daily oral pills, with only 5% experiencing symptom return within a year.
A recent study published in Research Involvement and Engagement found that research on treatments for health problems like diabetes and schizophrenia is not focused on the most important treatments considered by patients and clinicians. The study reveals marked differences between the types of treatments highlighted as priorities by pa...
A new study conducted at the University of Iowa's National Advanced Driving Simulator found that drivers who use both alcohol and marijuana together weaved more on a virtual roadway than those using either substance independently. The study, which analyzed the effects of inhaled cannabis on driving performance, also found no double eff...
Two randomised controlled trials found patient-controlled analgesia (PCA) to be statistically and clinically superior for patients with non-traumatic abdominal pain, with users reporting lower total pain scores. However, results were more equivocal for patients with traumatic injury, leaving room for further investigation.
A new study found that certain immune responses may play a role in blocking systemic HIV infection after exposure. T-cell responses against specific HIV-1 antigens were significantly higher and more frequent among those who remained uninfected compared to those who became infected, associated with reduced risk of infection.
Researchers found that serotonin receptor antagonists, commonly used to prevent nausea and vomiting after surgery, may also increase the risk of irregular heartbeats. The safest options were ondansetron plus dexamethasone for adults and dolasetron for all ages, with inconclusive findings for children.
The newly redesigned Oncology Central is now live, featuring a dedicated Pipelines and Trials section, webinars, and exclusive multimedia content. The platform offers easy navigation and access to peer-reviewed journal articles, regular cancer news updates, and exciting features.
A new study by USC's Valter Longo suggests that a periodic diet mimicking fasting can cut visceral belly fat, boost neural regeneration and improve learning and memory in old mice. In humans, the pilot study found evidence of reduced risk factors for aging, diabetes, cardiovascular disease and cancer with no major adverse side effects.
A new class of CGRP monoclonal antibodies is showing significant promise in treating high-frequency episodic migraine and chronic migraine. The drugs have been shown to reduce elevated levels of calcitonin gene-related peptide, a key driver of migraine pain.
A large study found no benefit in IVF from routinely freezing all embryos before transfer, even among normal responders. This challenges the move to adopt a freeze-all strategy in IVF.
Patients suffering from symptomatic vitreomacular adhesion experience improved vision after receiving ocriplasmin injections, without undergoing surgical treatment. The non-surgical approach avoids risks and costs associated with surgery, making it an attractive option for preventing blindness.
A study published in the Journal of the American Pharmacists Association found that having pharmacists on primary care teams improved the treatment of blood pressure in patients with Type 2 diabetes. The addition of pharmacists led to substantial improvements in patient health, including a significant impact on blood pressure control.
A study by the University of Sydney found that an ABC TV program questioning the link between cholesterol and heart disease resulted in 14,000 fewer people taking statins per week. The program's impact was seen in those at high risk of cardiovascular disease, potentially leading to preventable heart attacks and strokes.
A new trial design, called a two-by-two trial, can account for behavior-treatment interactions and provide more accurate efficacy results. By randomizing both treatment and probability of treatment, researchers can quantify the effects of treatment, behavior, and their interaction.
A study by the University of Arizona's BIO5 Institute has identified potential protective compounds in dust samples from Amish farming communities. The findings suggest that these natural environmental products could be transformed into medicines to promote lung health and prevent asthma. The research aims to understand the biological ...
Researchers have developed a new drug that stimulates tissue stem cells to repair damaged tissues more quickly, showing promise in treating diseases such as ulcerative colitis and bone marrow transplants. The drug, known as SW033291, increases prostaglandin E2 levels and promotes tissue healing without adverse side effects.
Researchers at Karolinska Institutet found that cardiopulmonary resuscitation performed before ambulance arrival increases survival rate by over two-fold. A new SMS Lifesavers system has also caused a 30% increase in CPR, highlighting the effectiveness of mobile technology in emergency response.
A large data-mining study by Stanford University School of Medicine has linked proton-pump inhibitors (PPIs) to an elevated risk of heart attack. The study found a 20% increase in the rate of subsequent heart-attack risk among all adult PPI users, even when excluding those also taking clopidogrel.
A new study proposes a two-by-two blind trial design that considers interactions between behavior and treatment. The researchers found that participants who felt confident about receiving treatment changed their behaviors in ways that improved health outcomes and made the drug more effective.
A new psoriasis drug, ixekizumab, has shown significant improvement in treating the condition, with 40% of patients clearing all symptoms within 12 weeks. The treatment was found to be more effective than a placebo or widely used drug etanercept.
The ELIXA study found no increased risk of cardiovascular death, heart attack, stroke, or heart failure in patients with type 2 diabetes taking lixisenatide. Lixisenatide also showed a modest benefit for weight control and no increase in hypoglycemia or pancreatic injury risk.
A five-year phase II clinical trial testing the ability of BCG to clinically improve type 1 diabetes in adults will be conducted at Massachusetts General Hospital. The trial aims to create a lasting therapeutic response and has received $19 million out of $25 million needed for the study.
A new study published in Anesthesiology found that resuming angiotensin receptor blockers within two days after surgery decreases death rates in the first month following surgery. Resuming these medications also reduced rates of infection, pneumonia, heart failure and kidney failure.
A review of 10 studies found no human data to support claims that eating placenta reduces postpartum depression or pain. Unknown risks to women and babies are also a concern due to lack of regulation and inconsistent dosing.
A new study found that keeping blood sugar levels under good control for many years can reduce the risk of heart attack, stroke, or amputation. The researchers conclude that a long-term average A1C level of around 8 is enough to achieve most cardiovascular benefits.
A RAND Corporation study found that implementing CDS tools led to a small reduction in inappropriate advanced imaging studies, increasing the proportion of tests rated as appropriate. However, challenges persist due to limited criteria availability and tool limitations.
A two-year clinical trial will study whether human growth hormone can safely improve recovery and prevent long-term osteoarthritis after an ACL tear. The trial aims to help professional athletes recover more easily and maintain their quality of life.
In the ATREUS trial, 41.2% of patients treated with trabectedin in second line showed improved survival and median progression-free survival at 12 weeks. The study adds to scarce evidence-based science in this disease, warranting further investigation.
Research found that preoperative statin use significantly reduces the risk of death after coronary artery bypass graft (CABG) surgery. The study, published recently, evaluated data from over 16,000 patients and showed a protective effect of statins on perioperative mortality.
Researchers found that a lower dose of modified poliovirus therapy is more effective in treating glioblastoma brain tumors, resulting in fewer side effects. The therapy has been shown to be safe with minimal side effects related to localized brain inflammation.
A groundbreaking Alzheimer's disease prevention trial is supported by $10 million in new funding, focusing on therapies targeting amyloid proteins. The trial will test two investigational anti-amyloid therapies to prevent or delay Alzheimer's symptoms in people at high genetic risk.
A new study reveals that clinical and genetic factors affecting warfarin dose vary by race, highlighting the need for race-specific dosing equations to improve anticoagulation control. The research team found that gene variants may have different effects on dose across racial groups, particularly among African Americans.
Researchers at the University of Louisville have successfully treated stage IIIb to IV melanoma patients with a modified cold sore virus, resulting in improved survival rates. The therapy, talimogene laherparepvec (T-VEC), stimulates the immune system to fight cancer cells and has been shown to extend patient survival by 20 months.
A new trial shows that inmates who were allowed to continue methadone maintenance treatment while incarcerated were more than twice as likely to engage in treatment after release. The study suggests that interrupting treatment during incarceration may make people with addiction more vulnerable to relapse and overdoses.
A major international trial found that starting antiretroviral drugs earlier reduces the risk of developing AIDS and other serious illnesses. The study supported treating everyone with HIV, regardless of CD4+ T-cell count.
Researchers analyzed data from major company-sponsored studies on SSRIs and found a significant difference favoring the active drug. The conventional measure of efficacy was only 44% effective, but analyzing the effect on depressed mood showed 91% superiority over placebo.,
Researchers have discovered a novel biomarker that tracks Parkinson's progression in the brain, providing a new tool for diagnosis and treatment. The study uses MRI-based diffusion imaging to measure changes in brain tissue fluid levels, which can inform treatment decisions and identify promising new therapies.
A psychiatrist advocates for the reclassification of psychedelic drugs as Schedule 2 compounds, citing their potential benefits in treating various psychiatric disorders. He notes that these substances were extensively used and researched before prohibition in 1967, but are now subject to strict regulations that hinder further research.
Researchers found that almost 83% of participants regained mobility after six months with home exercise and support, compared to 36.4%. Home-based walking programs can help prevent mobility loss in patients with clogged leg arteries.
UCLA researchers have identified a potentially effective treatment for methamphetamine addiction, with Naltrexone significantly reducing craving and arousal. The study found that Naltrexone blocks opioid receptors in the brain, making the drug less pleasurable, and had minimal side effects.
Researchers from Concordia University and UC Berkeley have developed a new method to produce alkaloids, including codeine and morphine, using engineered yeast. This breakthrough enables the synthesis of valuable pharmaceuticals, paving the way for the creation of new complex compounds with therapeutic effects.