Articles tagged with Flu Vaccines
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Two studies identify specific HA mutations in H5N1 and H7N9 viruses that enhance infectivity in the human respiratory tract. These findings can inform monitoring and vaccine development for emerging bird flu strains.
A new study found that school-located vaccination clinics increased flu vaccination rates among children by 13.2 percentage points, despite higher initial costs. The program may be a cost-effective way to broaden access to flu vaccines for children, particularly in primary-care settings.
Researchers develop a gene therapy that gives mice complete protection against lethal strains of H5N1 and H1N1 flu virus, including the infamous 1918 flu. The treatment involves expressing a broadly neutralizing antibody in nasal epithelial cells, providing substantial reductions in flu replication and virus load.
A novel vaccine concept using HA-ferritin nanoparticles elicited a potent immune response and broad protection against H1N1 virus strains. The experimental vaccine was also active against a wider range of strains than the licensed seasonal influenza vaccine.
Researchers have developed a novel vaccine delivery system that mimics pathogens to stimulate the immune system without causing infection. The technology uses inulin acetate from plant fibers, showing promise for preventing viral diseases such as influenza, with an estimated cost of one or two dollars per dose.
A*STAR and Cytos have initiated a Phase 1 clinical trial for Singapore's first H1N1 influenza vaccine candidate based on Cytos' proprietary bacteriophage Qbeta virus-like particle (VLP) technology. The vaccine aims to provide an effective means of combating influenza epidemics and pandemics in Singapore and the ASEAN region.
A Johns Hopkins fellow argues that the US public health agency's message on influenza vaccines may be overstated, with limited evidence supporting the claim that vaccines save lives. He also questions the effectiveness of vaccines in reducing elderly deaths and highlights potential side effects.
The H5N1 vaccine candidate induced a solid immune response in all three configurations of adjuvant and route of administration, exceeding the CHMP immunogenicity criteria. The results demonstrate the potential for significant 'dose-sparing' with the intradermal delivery device.
IDRI and Medicago present data on their H5N1 Avian Influenza VLP vaccine candidate, combining IDRI's GLA adjuvant with Medicago's proprietary manufacturing technology. The trial shows promising results in evaluating the safety and immunogenicity of the vaccine.
Researchers at UBC and Israel discovered that compliant physicians lead to more patient adherence to screening and vaccination practices. The study found significant differences in patients of doctors who received flu shots and those who did not, highlighting the importance of healthcare professionals' health habits on their patients.
A study published in Canadian Medical Association Journal found that physicians who followed recommended screening and vaccination practices had more likely patients to also follow these practices. The research involved 1488 physicians and their adult patients in Israel's largest health maintenance organization, Clalit Health Services.
A study by Penn State University researchers found that exposure to negative sentiment on Twitter is contagious, while positive sentiments are not. Microbloggers with reciprocal relationships tend to be influenced differently depending on the vaccine sentiments of their connections, with negative sentiments being more socially contagious.
A 14-year study found the varicella vaccine to be approximately 90% effective in preventing chicken pox, with a significant decrease in breakthrough cases over time. The second dose of varicella vaccine was found to be unnecessary for prevention of moderate to severe disease.
A new vaccine has proven highly effective against the H5N1 avian influenza virus, when tested in mice and ferrets. The vaccine uses an attenuated version of the H9 virus with an added H5 gene, slowing viral replication and reducing the risk of successful reassortment.
Researchers identified a unique subset of helper T cells that stimulates protective antibody responses following seasonal influenza vaccinations. The study found that these T cells boost production of existing antibodies by stimulating memory B cells, but do not help produce new antibodies by naïve B cells.
A meta-analysis found a small excess risk of Guillain-Barré syndrome associated with H1N1 flu vaccination. However, the benefits of vaccination significantly outweighed the risks. The study analyzed data from 23 million people vaccinated in the USA during the 2009 pandemic.
A study found a 14-fold increased risk of narcolepsy after receiving the AS03 adjuvanted pandemic A/H1N1 2009 vaccine, with vaccination within six months associated with an even higher risk. The authors suggest that the true risk may be lower due to delayed diagnosis.
A UCLA study found a link between untreated depression and decreased effectiveness of the shingles vaccine in older adults. Patients with depression showed a weaker immune response to the varicella-zoster virus, making them less responsive to the vaccine.
The ACIP has updated its recommended 2013 adult immunization schedule to include new guidelines for the use of pneumococcal conjugate and influenza vaccines. The updated schedule also recommends routine Tdap vaccination for adults aged 65 or older, pregnant women, and all patients over 6 months old against influenza.
A study published in the New England Journal of Medicine found that H1N1 flu shots do not increase the risk of pregnancy loss. In fact, vaccination reduces the risk of fetal loss by up to twofold compared to influenza infection alone.
A new study found that less than 45% of children were vaccinated against the flu during a five-year period, highlighting the need for increased vaccination efforts. The study also revealed that children under 6 months old had the highest hospitalization rates with flu, emphasizing the importance of protecting infants through vaccination.
Researchers led by Dr. Robert W. Finberg are working on a $12 million project to improve flu vaccine effectiveness by predicting the influenza virus's evolution in response to anti-viral drugs and human immune systems. The approach could potentially boost protection rates, reducing severe illness cases.
Researchers estimate naloxone distribution could prevent 6.5% of all overdose deaths by providing a cost-effective way to reverse opioid overdoses. Quadruple doses of seasonal flu vaccine may better protect HIV-infected patients from serious illness or death, but evidence for quality impact is limited.
Researchers at Georgia State University have developed a new process for creating a one-time, universal influenza vaccine using recombinant genetic engineering technology. This breakthrough aims to prevent the need for annual updates and shortages of flu vaccines.
According to a study by Wake Forest Baptist Medical Center, only one in five college students received the flu vaccine during the 2009-2010 season. The researchers suggest that colleges implement new or improved influenza vaccine strategies, such as giving flu shots at sporting events, to increase vaccination rates.
Researchers developed a microneedle technique to dry and stabilize the measles vaccine, showing it remained effective for at least 30 days. The method could provide a new tool for international immunization programs against measles, which killed nearly 140,000 children in 2010.
In an editorial published in CMAJ, Dr. Ken Flegel argues that a mandatory flu vaccine for healthcare workers is necessary due to the high risk of transmission and severe illness. With 55% of physicians not getting vaccinated, hospitals are at risk of outbreaks, emphasizing the need for compulsory vaccination rates above 90%.
The influenza vaccine has been shown to reduce the risk of major cardiac events such as strokes, heart attacks, and cardiac deaths by approximately 50 percent. A similar trend was seen for reducing death from any cause, with a reduction of around 40 percent.
Pediatric studies show that influenza can be fatal even in healthy children, with 43% of deaths occurring in those without underlying health conditions. School-based vaccination programs are effective in protecting student populations and preventing community spread.
A large study of nearly 200,000 females who received the HPV4 vaccine found that immunization was associated with same-day syncope and skin infections after vaccination. The findings support the general safety of routine vaccination with HPV4 in preventing cervical and other genital cancers.
Researchers analyzed DNA sequences of thousands of influenza strains to predict trends and understand the rules of flu virus evolution. This knowledge can help develop more effective vaccines against emerging strains.
Researchers at Stanford University School of Medicine discovered that blocking the action of a specific protein called DUSP6 can restore an important class of immune cells' response to vaccines. This finding holds long-term therapeutic ramifications and could potentially counter aging's effects on the immune system.
A study found that protection against whooping cough decreases by more than 40% each year after the fifth dose of DTaP vaccine. The decline in protection depends on the initial effectiveness of the fifth dose, with lower effectiveness leading to reduced protection.
A new study found that flu vaccination rates vary widely by ethnicity in Canada, with non-white Canadians having lower rates. The study analyzed data from 12 ethnic groups and found significantly higher vaccination rates among Filipino, Japanese, and Chinese Canadians compared to white and black Canadians.
Researchers have identified how immature immune cells respond to the influenza virus and traced the path to generate antibodies that can neutralize a wide range of strains. This understanding could aid in designing a universal flu vaccine that provides protection against most or all influenza virus strains.
The trial aims to evaluate the safety and immunogenicity of the H5N1 vaccine combined with IDRI's GLA adjuvant, which may result in a self-administered flu vaccine. The collaboration has the potential to expedite vaccination and simplify distribution during a pandemic.
Visits to retail medical clinics increased four-fold from 2007 to 2009, with a significant increase in younger patients seeking convenient care. The proportion of visits for preventive care, including vaccinations, rose to over 47% by 2009.
Researchers found that a prime-boost vaccine regimen can elicit broadly neutralizing antibodies in animals with pre-existing immunity, offering hope for developing vaccines giving long-lasting flu protection. The study's results suggest that a universal flu vaccine may be possible, potentially benefiting people of all ages.
Researchers at Scripps Research Institute describe three human antibodies protecting against a wide variety of flu viruses, including Influenza B strains. These broadly neutralizing antibodies may provide key clues to designing an active universal flu vaccine.
Two studies found that infants exposed to the H1N1 vaccine in utero did not have a significantly increased risk of major birth defects, preterm birth, or fetal growth restriction. However, adults exposed to the vaccine were at a small increased risk of Guillain-Barre syndrome during the 4-8 weeks after vaccination.
A recent study found a small but significant risk of Guillain-Barre syndrome following H1N1 vaccination, primarily in individuals over 50 years old. The risk was estimated to be approximately 2 cases per 1 million doses, with most cases occurring within 4 weeks of vaccination.
A University of Louisville study reviewed medical literature to debunk fears about drive-thru flu clinics. The researchers found no evidence of fainting episodes or related auto accidents among over 50,000 vaccine recipients since the program's inception in 1995.
A successful swine flu vaccination program in Scotland showed 77% protection against the H1N1 virus, while also reducing hospital admissions by 20% due to related disorders. The program's effectiveness was demonstrated through detailed data analysis, which took into account multiple conditions such as pneumonia and COPD.
Researchers have made a significant discovery that the pandemic 2009 H1N1 vaccine can produce antibodies against not only the H1N1 virus but also other influenza virus strains including H5N1 and H3N2. This breakthrough brings the team closer to developing a pan-influenza vaccine that can reliably induce broadly cross-reactive antibodies.
Researchers have developed a new approach to speed up vaccine development by identifying immunomodulators like B2, which enhance immune response and even shrink cancerous tumors. This method uses expression library immunization to rapidly screen entire genomes for desired biological functions.
Researchers found that the 2009 H1N1 pandemic vaccine triggers antibodies protecting against many influenza viruses, including deadly avian H5N1 strain. This discovery could lead to universal flu vaccines eliminating seasonal vaccination needs.
A randomized controlled trial found that targeted text messages increased influenza vaccination coverage among low-income, urban children and adolescents. The study showed a higher proportion of vaccinated individuals in the intervention group, with 93.9% receiving vaccines outside of Saturday clinics compared to 97.2% in usual care.
Researchers at Columbia University's Mailman School of Public Health found that text message reminders to parents increased the proportion of children and adolescents vaccinated against flu. The study, published in JAMA, showed a higher vaccination rate among those receiving text messages compared to traditional reminders.
A new potential vaccine carrier, a microemulsion, has been developed by US Army Maj. Jean M. Muderhwa that is both stable and effective for delivering antigens. The microemulsion, composed of five components, has been found to be transparent and liquid, with no degradation after six months.
A new intranasal flu vaccine with four weakened influenza strains shows promise in protecting children from the flu. The vaccine demonstrates a robust immune response and is well-tolerated, offering improved protection against the flu.
A Finnish study found that the Pandemrix vaccine used during the 2009 H1N1 pandemic was associated with a significant increase in childhood narcolepsy. The vaccine's AS03 adjuvant was linked to an abrupt rise in incidence rates, especially among vaccinated children under 19.
Healthcare professionals are more likely to get vaccinated if they believe the flu jab really works, according to a descriptive meta-analysis of 85,000 healthcare workers. Convenient access and willingness to prevent spread also play significant roles in increasing vaccination rates.
Research found microneedle vaccine patches are more effective than traditional inoculation methods against influenza virus in mice. The patches trigger a local increase of cytokines and activate dendritic cells, leading to a strong innate immune response.
Researchers have developed long-lasting flu vaccines that target more constant proteins with less evolutionary flair, reducing the virus' ability to spread and mutate. These universal vaccines could make a bout with influenza less severe, making it easier to control the virus' spread.
A randomized controlled trial found that vaccinating pregnant women against influenza increased mean birth weight and reduced small-for-gestational-age births. The study, conducted in Bangladesh, involved 340 healthy pregnant women who received either the influenza vaccine or a control vaccine.
Researchers are developing a norovirus vaccine using Virus-Like Particles, which mimic actual noroviruses to stimulate a robust immune response. The vaccine aims to combat the highly contagious and often severe gastrointestinal illness caused by noroviruses.
A new study on the administration of a multicomponent serogroup B meningococcal vaccine (4CMenB) with routine infant vaccines found it to be immunogenic and generally well-tolerated. The vaccine produced minimal interference with routine vaccines, allowing for potential inclusion in early infancy vaccination schedules.
The CDC's Advisory Committee on Immunization Practices recommends routine HPV vaccination for males aged 11-12 years, catch-up vaccination for males aged 13-21. For adults with diabetes, Hepatitis B vaccinations are now recommended for those under 60 and over 60 based on specific conditions.
Scientists have identified peptides on internal structures of influenza viruses that could provide immunity against all strains, including seasonal and pandemic flu. This breakthrough could lead to the development of a universal vaccine that activates T-cell immune responses.
Michael Deem, a computational theorist, is being honored with the engineering award for fundamental theoretical work on vaccine design, mathematical biology, and nanoporous materials structure. His research has led to breakthroughs in understanding immunology, evolution, and materials science.