Articles tagged with Gene Therapy
Dr. Roger E. Stevenson, a senior clinical and research geneticist at the Greenwood Genetic Center, has received the 2019 ACMG Foundation David L. Rimoin Lifetime Achievement Award. The award recognizes his vision in founding the center, groundbreaking research on X-linked intellectual disability, and leadership in establishing programs...
Researchers found that some patients' skin areas return to normal as they age, eliminating mutant loricrin genes through somatic recombination. This natural process could lead to a new treatment method for genetic diseases like loricin keratoderma.
Researchers from the CNIO Hereditary Endocrine Cancer Group have identified a new gene, DLST, involved in the development of paragangliomas and phaeochromocytomas. Mutations in this gene were found to be directly linked to the disease, providing a potential breakthrough in diagnosis and treatment.
Researchers have successfully targeted the tumor biomarker EpCAM with chimeric antigen receptor-modified T cells, significantly delaying tumor growth in mice. The study suggests that EpCAM could be a promising target for cancer immunotherapy in various tumor types.
Researchers have identified two new genes, ING3 and EPDR1, that affect bone-forming cells and may lead to stronger bone mineral density and fracture prevention. The study's innovative use of three-dimensional genomic geography analysis could also aid in the discovery of new treatments for other genetic diseases.
Researchers identified a common oncogene, KRAS, as a key player in immune checkpoint blockade therapy resistance in metastatic colorectal cancer. Restoring IRF2 expression or inhibiting MDSCs through CXCL3-CXCR2 signaling increased CRC sensitivity to ICB therapy.
Researchers at UC Berkeley have developed a therapy that can improve and prolong sight in those suffering from vision loss by dampening noise generated by nerve cells in the eye. The treatment has shown promising results in mice with a genetic condition, retinitis pigmentosa.
A multi-center study by MD Anderson Cancer Center reveals that a liquid biopsy test, Guardant360, is comparable to standard tissue biopsies in detecting guideline-recommended biomarkers for advanced NSCLC. The test identified four mutations for which FDA-approved drugs exist and offers faster turn-around time.
A new study found that many commercial cell lines used for laboratory studies are mislabeled as minority ancestry, leading to a lack of diversity and hindering the development of precision medicine for underrepresented populations. Researchers call for more diverse biospecimens to be used in scientific investigations.
The RESTORE Health initiative aims to develop advanced therapies for curative treatments, backed by an international and interdisciplinary community. The consortium plans to invest up to €1 billion in new research projects over the long term.
The partnership aims to advance genetic diagnosis and therapy for patients with muscle wasting neuromuscular diseases, including motor neurone disease and muscular dystrophy. AIIMS will launch its first patient trials, providing insight into the different genes present in India's populations.
Researchers identified a genetic mutation in the PKD1L1 gene linked to Biliary atresia, a devastating condition that affects many children. The study found five patients with two copies of mutations and three additional patients with one mutation, providing new insights into the cause of the disease.
Dr. Carl June is being honored by ACGT for his lifesaving CAR T-cell treatment, which was the first-ever FDA-approved gene therapy for cancer. The funding from ACGT sustained Dr. June's research, allowing it to continue and ultimately lead to promising treatments.
Scientists have successfully restored auditory synapse function and hearing thresholds to a near-normal level in adult mice with DFNB9 deafness. The breakthrough uses an AAV-based gene therapy approach that can be used to produce otoferlin and durably correct the profound deafness phenotype in mice.
A recent study by CU Anschutz researchers has implicated a complex unexamined gene family in autism severity, suggesting that this underexplored area of the human genome may hold key insights into the disorder and potentially lead to new clinical therapies.
Recent advances in understanding Parkinson's disease have identified promising developments to slow or stop its progression. Researchers explore new therapeutic targets, targeting non-motor features of the disease, and repurposing drugs for their potential disease-modifying properties.
Researchers found that silencing microRNA-132 improved insulin secretion and reduced blood glucose in mice and human islet cells. The study suggests antagomir-132 as a potential treatment approach for type 2 diabetes.
Newer versions of gene therapy cassettes deliver better performance, increasing muscle strength and protecting against contraction-induced injuries in animal models. The treatment, micro-dystrophin, has been restructured to enhance its functionality.
Researchers have discovered a method to 'turn off' mutated melanoma, developing a promising therapeutic option for NRAS mutant cancer. A specific inhibitor targeting the STK19 gene has been designed to prevent NRAS activation and development of NRAS mutant melanoma in an experimental model.
Researchers pinpointed the premelanosome protein (PMEL) gene as the cause of pigmentary glaucoma, a condition that affects 150,000 people in North America. The study found that mutations in this gene lead to vision loss and blindness if left untreated.
Nanoscope Technologies has received multiple NIH grants to further develop its gene delivery and optogenetics platforms for treating and monitoring retinal degenerative diseases, such as Age-related macular degeneration. The company aims to improve visual acuity in patients with these conditions through targeted retinal stimulation.
Researchers discovered that a muscle protein called LIM protein (MLP) can promote nerve healing by stabilizing structures in growth cones. Blocking or suppressing MLP's function reduces nerve cells' ability to grow axons.
Researchers are analyzing the genes of hundreds of females with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome to identify genetic causes. The study aims to improve genetic counseling and potential treatment for this condition, which affects about 7-10% of women.
Researchers identified specific genes associated with AMD using DNA methylation profiling of human donor eyes. The condition affects central vision and has no treatment for 85% of patients. New targets for therapy may help address the unmet clinical need for AMD treatments.
Researchers have made a breakthrough in treating nerve damage by combining neurosurgical repair with gene therapy, which stimulates the survival of nerve cells and regeneration of nerve fibers. The discovery is an important step towards developing a new treatment for people with nerve damage.
Scientists have developed a gene therapy that blocks axon destruction in mice, suggesting a therapeutic strategy to prevent the loss of peripheral nerves in multiple conditions. This breakthrough could help prevent peripheral neuropathy, a disease affecting 20 million people in the US, and other neurodegenerative disorders.
Recent review highlights latest advances in precise nanomedicine for intelligent cancer therapy, exploring metallofullerenol nanoparticles, supramolecular chemo-therapy, and DNA nanorobots. These strategies aim to improve cancer imaging and therapeutic applications while understanding nanotoxicity.
Scientists at Harvard University have identified a potential biomarker and drug target for amyotrophic lateral sclerosis (ALS), a neurological disease that is difficult to diagnose and treat. The gene STMN2 was found to be involved in the loss of motor neurons, which leads to progressive paralysis.
Researchers at WSU and PNNL developed biologically inspired materials that deliver therapeutic genes into tumor cells without causing toxic effects. The flower-like particle is about 150 nanometers in size and made of peptoids, which work well in biological systems.
Researchers have discovered a new population of immune cells that respond to immunotherapy treatment, as well as a critical molecular factor required for the therapy's success. The study highlights the importance of early-stage T cells and the need for further understanding of how checkpoint blockade therapies work.
A study published in Nature Neuroscience reveals that defective immune cells in the brain play a key role in Alzheimer's disease. Activating a specific gene, TREM2, can help prevent toxic deposits, but over-activation may have negative consequences.
Recent advancements in Parkinson's disease treatment hold promise for patients, with gene therapy approaches showing potential, and brain stimulation techniques also being explored. Despite progress, hurdles persist, and understanding the reasons for treatment failure is crucial to overcoming the disease.
A new study found that genes cause about 1 in 10 cases of chronic kidney disease in adults, and identifying the responsible gene has a direct impact on treatment. DNA testing reclassified the cause of kidney disease in 1 out of 5 individuals with a genetic diagnosis.
Researchers at Kiel University will develop next-generation gene therapies for cardiovascular disease using AAV vectors, aiming to improve treatment approaches and reduce vascular inflammation in conditions like atherosclerosis. The project aims to translate experimental treatments into clinical applications.
Researchers at the University of Birmingham have discovered a protein fragment called ?N-JARID2 that regulates skin cell differentiation. The finding holds promise for developing new gene therapies for psoriasis and other skin conditions caused by hyper-proliferation of skin cells.
A research group at FAU Erlangen-Nürnberg is developing procedures for monitoring the newly-developed therapies for neuroretinal degeneration. They are using a highly accurate method to measure perception thresholds, which can also be used to track disease progression and test new treatments.
Researchers at UCSF developed CRISPRa, a modified version of the gene-editing tool that activates appetite-suppressing genes without making cuts to the genome. This approach prevented severe obesity in genetically engineered mice with only one functional copy of certain genes.
Researchers at Aarhus University have made a breakthrough in understanding hereditary angioedema by identifying cellular defects leading to the rare disease. The study reveals that genetic mutations cause intracellular retention of C1-inhibitor, resulting in patients producing only 10-20% of normal levels.
A large-scale genetic study has identified 11 new genes associated with epilepsy, which may inform the development of new treatments. The research, led by RCSI researchers, compared DNA samples from over 15,000 people with and without epilepsy, tripling the number of known genetic associations.
Children's Hospital of Philadelphia celebrates European Commission approval of LUXTURNA, a one-time gene therapy treating vision loss due to inherited retinal dystrophy. The therapy has received regulatory approval in both the US and EU, offering new hope for patients with progressive blindness.
In 2018, the biotech industry saw significant investment from venture capital firms and a surge in initial public offerings. Promising developments include the approval of the first RNA interference drug, Onpattro, for treating rare genetic disorders, as well as advancements in CRISPR technology and cannabis-based therapeutics.
Researchers developed niosomes, a type of non-viral vector, to transfer genetic material into the brain. The innovative formulation uses lycopene as a helper lipid, improving transfection efficiency in neuronal and glial cells.
Researchers at the University of Delaware have developed a novel approach to gene therapy using microparticles that deliver gene-regulating material to hematopoietic stem and progenitor cells. This technology could potentially treat inherited blood disorders such as sickle cell anemia and thalassemia by altering the genetic defect in t...
The precision medicine initiative is shifting healthcare from population-based approaches to individualized care focusing on each patient's genetic makeup. This shift raises new legal, policy, and ethical issues, including liability, trust, governance, and data access and quality.
Researchers have developed a gene therapy treatment that is reversing disease symptoms in two adults with Sickle Cell Anemia. The treatment, which uses reduced-intensity preconditioning, shows promise for transportability to resource-challenged parts of the world where SCA is most common.
Scientists have discovered that an emerging Parkinson's gene therapy called AAV2-GAD creates new brain circuits associated with improved motor movement. The therapy has shown therapeutic effects for patients by forming new neural pathways in the brain, connecting the subthalamic nucleus to other motor regions.
Researchers identified a set of genetic variants associated with poorer stroke recovery in patients. The study, involving over 2,000 patients, found that certain variants of the PATJ gene predispose individuals to worse outcomes after a stroke, resulting in significant disability and dependence.
A newly published mouse model of Facioscapulohumeral muscular dystrophy (FSHD) has been developed to test potential therapeutics. The TIC-DUX4 mice express DUX4 only when exposed to the drug Tamoxifen, allowing researchers to control gene expression and study its effects on muscle weakness.
A study published in Human Gene Therapy found that urocortin 3 gene therapy significantly improved left ventricular function and ejection fractions in mice with induced heart failure. The therapy resulted in a 1.9-fold increase in left ventricular function and a 32% relative increase in ejection fractions.
Researchers developed a combinatorial gene therapy approach that inhibits inflammation and promotes pro-anabolic cartilage genes, preserving articular cartilage better than each approach alone. This strategy was shown to be effective in both moderate and severe post-traumatic osteoarthritis models.
Researchers have discovered a gene signature biomarker that can predict which patients will respond to immune therapy based on the extracellular matrix's stiffness around cancer cells. The study suggests that stiffening of the ECM barrier may physically block the immune system.
A machine-learning algorithm, inDelphi, predicts the precise correction of broken genes by analyzing data from CRISPR-induced breaks. Researchers successfully corrected nearly 200 disease-associated genetic variants, restoring gene function to healthy states.
A genetic study led by University of Helsinki researchers has uncovered the underlying causes of severe heart muscle diseases in children, revealing a unique genetic profile for each family. The study's findings have significant implications for predicting disease course and treatment decisions, paving the way for personalized medicine.
New research presents promising results from preclinical studies using gene therapy to treat amyotrophic lateral sclerosis, Parkinson's disease, and other neurological disorders. Gene therapy has been successfully used to slow disease progression and improve symptoms in mouse models.
The SQZ Biotechnologies platform has been shown to preserve key biological functions essential for cell therapies, unlike electroporation technology. This study highlights the superiority of SQZ in delivering target-specific immune responses and enabling scalable cell therapy development.
Researchers developed an antisense oligonucleotide therapy to halt or reverse SCA7-induced vision loss. Studies in mice and humans show promise for treating the rare condition with fewer side effects than existing medications.
A new study by UMass Medical School researchers successfully delivers RNAi-based gene therapy to silence SOD1 protein mutations linked to ALS without adverse effects. The therapy, delivered via a viral vector, achieved silencing of over 90% in some motor neurons, suggesting a safe and potentially one-time treatment for humans.
Children's hospitals will use electronic health records and DNA samples to identify genetic markers for severe pediatric growth disorders, enabling early diagnosis and targeted treatments.
Researchers found that patients with a non-functional IDO2 gene had more favorable outcomes when receiving radiotherapy, living cancer-free for almost twice as long. The discovery could lead to personalized treatment recommendations and improve patient survival rates.
Researchers have found associations between addiction-related phenotypes and variants in the PTPRD gene, a neuronal cell adhesion molecule. A chemical compound, 7-BIA, has been shown to selectively inhibit phosphatase activity of PTPRD in mice, reducing cocaine self-administration rates.