Researchers combine Sabutoclax with viral gene therapy to prevent tumor growth in prostate-cancer-prone mice, offering a novel approach to treating advanced prostate cancer. The study's findings suggest that this combination therapy could be effective in other cancers and pave the way for personalized medicine.
SourceVirginia Commonwealth University·JournalProceedings of the National Academy of Sciences·DateMay 10, 2011
Recent research highlights exciting developments in ocular gene therapy, including potential treatments for age-related macular degeneration and retinal disease. Gene therapy strategies have shown promise in reducing cell death and slowing retinal degeneration.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalHuman Gene Therapy·DateMay 9, 2011
Researchers at Tufts University School of Medicine developed a gene therapy approach that significantly reduces uncontrolled blood vessel growth and cell death typical of AMD, slowing its progression. The treatment uses CD59 to block the formation of 'membrane attack complex' in cell membranes.
SourceTufts University, Health Sciences Campus·JournalPLOS ONE·DateApr 29, 2011
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers developed an effective gene therapy technique using induced pluripotent stem cells to correct chronic granulomatous disease in cell culture. The corrected neutrophils produced normal levels of hydrogen peroxide, potentially offering a cure for the rare disorder.
SourceAmerican Society of Hematology·JournalBlood·DateApr 28, 2011
Researchers at University of Michigan have developed a novel gene therapy, NP2, that shows promise in providing substantial pain relief for patients with unrelenting cancer-induced pain. The study demonstrates the safety and efficacy of NP2 in reducing pain by up to 80% over four weeks.
SourceMichigan Medicine - University of Michigan·JournalAnnals of Neurology·DateApr 11, 2011
Researchers have determined that correcting a genetic defect does not substantially increase the number of potentially cancer-causing mutations in induced pluripotent stem cells. This breakthrough suggests that human-induced pluripotent stem cells altered to correct a genetic defect may be cultured into subsequent generations of cells ...
SourceUniversity of Wisconsin-Madison·JournalProceedings of the National Academy of Sciences·DateApr 4, 2011
A study found that young adult patients with hypertrophic cardiomyopathy survived cardiac arrest after receiving therapeutic hypothermia. The treatment was successful despite marked left ventricular wall thickness and other risk factors.
SourceMinneapolis Heart Institute Foundation·DateApr 3, 2011
Researchers successfully reprogrammed diseased human hepatocytes into induced pluripotent stem cells, offering a potentially unlimited source for liver disease treatment. This breakthrough could enable the generation of genetically corrected liver cells via auto-transplantation, avoiding liver transplants and immunosuppression.
SourceEuropean Association for the Study of the Liver·DateApr 1, 2011
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
A gene therapy called NLX-P101 significantly reduces movement impairment in Parkinson's patients, with half achieving dramatic symptom improvements. The treatment introduces a gene to normalize chemical signaling, correcting dysfunction in brain circuitry responsible for coordinating movement.
SourceNewYork-Presbyterian·JournalThe Lancet Neurology·DateMar 16, 2011
A new study found that gene therapy NLX-P101 improved motor performance and control of Parkinsonism symptoms in half of patients, offering hope for the treatment of neurodegenerative disorders. The therapy has been safe and well-tolerated over a six-month period.
SourceHenry Ford Health·JournalThe Lancet Neurology·DateMar 16, 2011
A double-blind trial demonstrated a 23% improvement in motor symptoms among patients receiving gene therapy for advanced Parkinson's disease, compared to a 12% improvement in those receiving sham surgery. The study suggests a potential breakthrough in treating this progressive movement disorder.
SourceNorthwell Health·JournalThe Lancet Neurology·DateMar 16, 2011
A double-blind gene therapy trial has demonstrated safety and significant improvement in motor function for patients with Parkinson's disease. The study found that injecting the glutamic acid decarboxylase (GAD) gene directly into the brain improved motor scores by 23.1% compared to a placebo group.
SourceThe Lancet_DELETED·JournalThe Lancet Neurology·DateMar 16, 2011
A study at Cold Spring Harbor Laboratory has identified a therapeutic target for liver cancer using a monoclonal antibody that blocks the activity of the FGF19 gene. This approach shows promise in treating patients with FGF19 amplification, which can be used as a biomarker to predict treatment effectiveness.
SourceCold Spring Harbor Laboratory·JournalCancer Cell·DateMar 14, 2011
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers have identified 15 new genetic regions associated with an increased risk of developing primary biliary cirrhosis. The study used genome data from 2,500 patients and 7,500 healthy individuals, tripling the number of known genetic regions to 22.
SourceWellcome Trust Sanger Institute·JournalNature Genetics·DateMar 13, 2011
Researchers believe ADAM-12 gene could be important in fighting cancer, arthritis and cardiac hypertrophy. The gene's regulation pathway could lead to new treatment plans.
SourceUniversity of Missouri-Columbia·JournalProceedings of the National Academy of Sciences·DateMar 8, 2011
A new patented therapy has been developed by WSU researcher Dr. Karli Rosner, which uses genetic constructs to target cancer cells and induce apoptosis, eliminating the need for external medications. The treatment shows promise in treating various types of cancers, including melanoma, prostate, lung, and breast cancers.
SourceWayne State University - Office of the Vice President for Research·JournalCancer Gene Therapy·DateFeb 28, 2011
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Researchers identified AEG-1 as a strong predictor of progression-free survival in patients with EGFR-mutant non-small cell lung cancer treated with erlotinib. Patients with low AEG-1 expression had longer progression-free survival compared to those with high expression.
SourceEuropean Society for Medical Oncology·JournalLung Cancer·DateFeb 25, 2011
Researchers discovered a rare gene mutation strongly linked to schizophrenia, which could be a new target for effective treatment. The mutation affects the VIPR2 gene, leading to increased signaling in the Vasoactive Intestinal Peptide pathway.
A team of investigators has identified a new candidate gene for primary open angle glaucoma (POAG), the most common form of eye disorder. The gene, ADAMTS10, is involved in processing extracellular matrix and may play a role in regulating aqueous humor outflow.
SourceVanderbilt University Medical Center·JournalPLOS Genetics·DateFeb 17, 2011
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
A new gene test has identified GFPT1 as a crucial cause of Congenital Myasthenic Syndrome (CMS), a rare genetic condition affecting signal transmission between the brain and muscles. The test allows for earlier treatment with cholinesterase inhibitors, offering an effective therapy that can be taken through life.
SourceNewcastle University·JournalAmerican Journal of Human Genetics·DateFeb 11, 2011
Researchers have developed a new method for treating genetic diseases using modified mRNAs, which can be administered repeatedly without increasing the risk of cancer or severe immune reactions. In mouse models, this technique successfully restored lung function in mice with a congenital lung defect.
SourceLudwig-Maximilians-Universität München·JournalNature Biotechnology·DateFeb 7, 2011
Researchers develop an innovative genetic strategy that transfers a bacterial gene into CD4+ T-cells, making them resistant to HIV infection. The MazF protein destroys gene transcripts, preventing protein synthesis and effectively blocking HIV replication.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalHuman Gene Therapy·DateJan 26, 2011
Researchers found that adding caffeine to lentiviral production protocols increases virus production by 3-8 times. This simple and inexpensive strategy may significantly decrease the cost of lentiviral production for research and clinical uses.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalHuman Gene Therapy·DateJan 25, 2011
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Two studies found that ITPA variants protect against treatment-related anemia in HCV patients, enabling safer use of antiviral therapy and reducing the need for erythropoietin treatment. The variants also help select patients who may tolerate higher doses of ribavirin, increasing the likelihood of viral clearance.
Researchers at Duke University Medical Center discovered how nanoparticles from diesel exhaust damage lung airway cells, a finding that could lead to new treatments for people susceptible to airway disease. The study showed that the severity of injury depends on an individual's genetic make-up.
SourceDuke University Medical Center·JournalEnvironmental Health Perspectives·DateJan 18, 2011
Dr. Sena-Esteves is investigating gene therapy techniques to replace the faulty gene causing Tay-Sachs Disease, a devastating neurological disorder. He's part of the Tay-Sachs Gene Therapy Consortium aiming to translate current results into a human clinical trial within three years.
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
Researchers have created a new type of nanoparticle called nanodisks, which can carry genetic material and enter cells quickly without losing its potency. These nanodisks offer a promising alternative to traditional gene therapy vectors, potentially improving therapeutic outcomes.
SourceUniversitat Autonoma de Barcelona·JournalBiomaterials·DateJan 11, 2011
Researchers developed a gene therapy strategy using parthenogenetic embryonic stem cells, which can differentiate into multiple tissue types and potentially reduce rejection problems. The approach shows promise for treating autosomal dominant diseases like Beta Thalassemia, tuberous sclerosis, or Huntington's disease
SourceNationwide Children's Hospital·JournalJournal of Clinical Investigation·DateJan 10, 2011
Researchers from the University of Leicester and international partners have identified potential new therapeutic targets for Huntington's disease using cutting-edge genetic techniques. The study found that flavonoids can prevent cell death in yeast, suggesting a possible new treatment approach.
SourceUniversity of Leicester·JournalJournal of Biological Chemistry·DateJan 10, 2011
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
A recent study published in the New England Journal of Medicine found that losing the NFKBIA gene promotes glioblastoma multiforme growth and reduces survival. Restoring this gene may improve survival for certain patients with glioblastoma, as it inhibits tumor cell growth and increases sensitivity to chemotherapy.
SourceOhio State University Wexner Medical Center·JournalNew England Journal of Medicine·DateJan 6, 2011
A new, simplified method for producing large amounts of viral vector cassettes has been developed, overcoming previous limitations. This approach enables efficient packaging of single- or double-stranded AAV vectors and large AAV cassettes, paving the way for commercial production.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalHuman Gene Therapy·DateJan 5, 2011
Researchers have developed a novel virus-based gene therapy for renal cell carcinoma, killing cancer cells both locally and distantly. The therapy combines Sorafenib with Ad.5/3-mda-7 adenovirus, which activates the MDA-7/IL-24 protein to stop tumor growth.
SourceVirginia Commonwealth University·JournalCancer Biology & Therapy·DateDec 15, 2010
Scientists at Johns Hopkins and VCU have developed a nanoparticle-based gene 'ignition switch' to detect and treat cancer. The promoter-based system activates specific genes only in cancer cells, showing a 30-fold difference in identification.
SourceJohns Hopkins Medicine·JournalNature Medicine·DateDec 15, 2010
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
A new $2.1 million NIH grant will help MU scientist Dongsheng Duan develop a treatment that prevents heart muscles from weakening due to Duchenne muscular dystrophy. Tests have shown that treating skeletal muscle alone can lead to complications, highlighting the need for comprehensive treatment targeting both skeletal and cardiac muscle.
SourceUniversity of Missouri School of Medicine·DateDec 6, 2010
Researchers at the University of Cincinnati found a potential genetic target, miR765, which can down-regulate protein phosphatase 1 inhibitor-1 and reduce cardiac muscle contractility. This micro-RNA may play a role in heart disease development by decreasing or deactivating proteins that help the heart function at full capacity.
A new study found significant changes in targeted genes in patients' tumors, suggesting existing therapies may benefit more cancer patients. The research identified potential targets for treatment with existing targeted therapies.
SourceECCO-the European CanCer Organisation·DateNov 16, 2010
Researchers achieved marked clinical improvements in two young children with Wiskott-Aldrich syndrome through gene therapy, correcting immunodeficiency and reducing complications. The treatment is a promising step forward for patients with this rare and severe disorder.
SourceChildren's Hospital of Philadelphia·JournalNew England Journal of Medicine·DateNov 15, 2010
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers have developed a faster-growing E. coli strain suitable for mass production of high-quality DNA for vaccines and gene therapy. The modified strain retains useful traits while growing as quickly as other industrial strains.
SourceUniversity of Illinois College of Agricultural, Consumer and Environmental Sciences·JournalApplied and Environmental Microbiology·DateNov 11, 2010
Dr Ross Dickins, a leading cancer researcher at Walter and Eliza Hall Institute, has been awarded a $975,000 fellowship from the Sylvia and Charles Viertel Charitable Foundation. The fellowship will support his work on identifying the normal function of genes recently implicated in leukemia.
A recent review reveals that antibiotics can alter normal gut bacteria composition and leave resistance genes present for extended periods. This increases the risk of pathogenic bacteria survival and multi-drug resistance.
SourceMicrobiology Society·JournalMicrobiology·DateNov 1, 2010
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Antigene therapy utilizes a DNA-based drug that attaches directly to specific DNA sequences and is activated by light energy, effectively silencing targeted genes. This approach may offer new hope for treating diseases currently incurable or having limited success.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalOligonucleotides·DateOct 21, 2010
Researchers at NewYork-Presbyterian/Weill Cornell report that gene therapy to the brain reverses depression-like behavior in mice, with human data backing up the promise of such therapy. Autopsy studies reveal significantly reduced levels of p11 protein in patients with severe depression.
SourceNewYork-Presbyterian·JournalScience Translational Medicine·DateOct 20, 2010
Recent advances in neurogenetics research have shed light on the genetic basis of human brain disorders, including Parkinson's and Alzheimer's diseases. Genetic discoveries have transformed clinical practice and provided new hope for patients and families affected by these devastating disorders.
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Scientists at the University of Michigan have identified four new DNA hotspots that may aid in developing new treatments for psoriasis. The study, published in Nature Genetics, builds on past work by U-M researchers and provides a better understanding of the hereditary factors of the disease.
SourceMichigan Medicine - University of Michigan·JournalNature Genetics·DateOct 18, 2010
Researchers studied genetic risk factors for age-related macular degeneration (AMD) and found that patients carrying specific genes were more likely to respond to anti-VEGF therapy. Genetic screening may improve glaucoma care by identifying markers for congenital and primary open angle glaucoma.
Cincinnati Children's Hospital Medical Center has been named a national Center of Excellence for Molecular Hematology to accelerate the discovery of new therapeutic approaches for conditions like sickle cell anemia and leukemia. The center will also help speed the transition of new therapies from research to clinical trials.
SourceCincinnati Children's Hospital Medical Center·DateOct 7, 2010
A clinical trial of gene therapy for muscular dystrophy has uncovered an unexpected aspect of the disease, revealing that some patients mount an immune response to the dystrophin protein even before receiving treatment. The study suggests that tailoring treatment approaches to suit individual patient needs could lead to better outcomes.
SourceUniversity of North Carolina Health Care·JournalNew England Journal of Medicine·DateOct 6, 2010
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers studying gene therapy for Duchenne muscular dystrophy discovered a natural immunity to dystrophin, complicating experimental therapies. The immune response triggered by T cells may target muscle cells, resembling autoimmunity.
SourceNationwide Children's Hospital·JournalNew England Journal of Medicine·DateOct 6, 2010
A new, fully characterized viral vector is introduced as a reference material to standardize gene therapy protocols in research applications and human clinical trials. The availability of this reference standard allows vector parameters to be expressed in common units, enabling comparison and normalization across laboratories.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalHuman Gene Therapy·DateOct 6, 2010
The NIH Director's Transformative Research Projects (T-R01) award program provides funding for exceptionally innovative research ideas that have the potential for extraordinary impact. The program allows investigators to sidestep conventional stumbling blocks and propose daring ideas.
A new study has found prenatal cardiac defects in mice with Spinal Muscular Atrophy (SMA), a leading genetic cause of infantile death. The discovery has significant implications for treatment, suggesting that the disease may be multisystemic and requiring therapies beyond just motor neurons.
SourceUniversity of Missouri-Columbia·JournalHuman Molecular Genetics·DateSep 28, 2010
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Research at OHSU's Vaccine and Gene Therapy Institute suggests that G-CSF, a hormone stimulating stem cell growth, can reactivate human cytomegalovirus in bone marrow recipients, increasing their risk of infection. The study highlights the need for factoring in the risks associated with G-CSF use during transplants.
SourceOregon Health & Science University·JournalCell Host & Microbe·DateSep 21, 2010
Scientists at the University of Granada have developed a new therapy for skin and lung cancer using a suicide coliphage-gene, demonstrating effectiveness in vitro and in vivo. The treatment involves inducing cell death in tumour cells, potentially reducing the need for chemotherapy.
SourceUniversity of Granada·JournalJournal of Molecular Medicine·DateSep 21, 2010
A Phase 1/2 study of LentiGlobin gene therapy has demonstrated positive results in a young adult with severe beta-thalassemia, achieving transfusion independence for over two years. The treatment also identified cells with the corrected beta-globin gene that overexpressed HMGA2.
SourcePure Communications Inc.·JournalNature·DateSep 15, 2010
Researchers found that inhibiting GRK2 protects heart cells from destruction after a heart attack, while excess GRK2 leads to more damage. The discovery suggests that anti-GRK2 gene therapy may help prevent permanent heart damage.
SourceThomas Jefferson University·JournalCirculation Research·DateSep 15, 2010
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers are calling for a new focus on hypertrophic cardiomyopathy (HCM), a genetic disorder causing sudden death in young people. A task force of cardiologists and cardiac biologists recommends studying the natural history of HCM, defining all genetic causes, supporting clinical trials, and preventing mutant gene expression.
SourceThomas Jefferson University·JournalCirculation·DateSep 14, 2010
Scientists at Duke University Medical Center have identified a gene associated with myopia in Caucasian people, providing new hope for gene therapies. The RASGRF1 gene plays a crucial role in retinal function and visual memory consolidation, making it a promising target for treatment.
SourceDuke University Medical Center·JournalNature Genetics·DateSep 12, 2010
A new study reveals that CEP290 is crucial for maintaining the structural integrity of the ciliary gate, a key component of cilia. This discovery could lead to targeted gene therapy for cilia-related disorders, including Meckel syndrome and Joubert syndrome.
SourceRockefeller University Press·JournalJournal of Cell Biology·DateSep 6, 2010
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
A multidisciplinary team at UCLA has successfully visualized a virus using cryo-electron microscopy, enabling the adaptation of the adenovirus for use in gene-therapy treatments for prostate and breast cancers. The breakthrough provides critical structural information for researchers attempting to modify the adenovirus.
SourceUniversity of California - Los Angeles·JournalScience·DateAug 31, 2010
A team of 64 international researchers has identified 27 new MiniPromoters, greatly expanding the current limited pool of these vital tools. The Pleiades Promoter Project enables research worldwide with bioinformatics, genomics, and neuroimaging expertise.
SourceUniversity of British Columbia·JournalProceedings of the National Academy of Sciences·DateAug 30, 2010