Articles tagged with Medical Imaging
Researchers led by Atsuo Sasaki aim to identify mechanisms behind cell movement and energy allocation in cancer cells, with potential applications beyond cancer treatment. They will use scanning ion-conductance microscopy and machine learning technology to study the role of GTP in cellular migration.
Scientists create genetically engineered mouse model that changes color in response to light, allowing them to isolate background noise from blood flow and enhance imaging techniques. This breakthrough enables researchers to observe internal physiology with unprecedented accuracy, paving the way for new treatments and therapies.
A team from the Institute for X-ray Physics at the University of Göttingen has developed a new method for X-ray microscopy that uses imperfect lenses to achieve higher image quality and sharpness. The researchers used a lens consisting of finely structured layers deposited on a thin wire and adjusted it between the object to be imaged ...
Researchers validated a liquid biopsy test as a better predictor of immunotherapy response in lung cancer patients compared to traditional tumor biopsies. The test measures the PD-L1 biomarker in blood, showing improved accuracy in predicting treatment outcomes and survival.
Researchers have developed a new tool to visualize leukocytes in the brain vasculature during in vivo two-photon laser scanning microscopy. The tool uses a fluorescent antibody targeting CD45, a ubiquitously expressed protein on white blood cells, allowing for tracking of circulating leukocytes over time and space.
A new statistical method for brain mapping is proposed to improve accuracy by removing redundant associations. The study uses simulations to test the method's performance on fake diseases and scores, revealing its superiority over existing approaches. The next step is to apply this refined analysis to study Alzheimer's disease.
Researchers at Penn Medicine have developed an imaging agent that detects cancer cells in real-time during biopsies, offering promise for earlier and more accurate diagnoses. The technology, known as NIR-nCLE, uses a combination of near-infrared tracers and confocal laser endomicroscopy to identify microscopic cancer cells.
Researchers at the Beckman Institute found a direct link between high-fat diets and heightened nitric oxide levels, which can lead to increased risk of inflammation and cancer development. The study used a molecular probe to visualize changes in the tumor microenvironment.
A new method for creating key components of solar cells, X-ray detectors, and LEDs uses water to control the growth of phase-pure perovskite crystals. This approach allows for precise tuning of crystal structures at room temperature.
Researchers have developed a vertical matrix X-ray detector that can distinguish between substances of different densities, enhancing imaging contrast and identifying soft substances. The device uses a novel design to restore the X-ray spectrum in detail, enabling effective multi-energy discrimination under a single exposure.
A new device, consisting of a smart stent and printed soft sensors, can wirelessly monitor hemodynamics in real-time, detecting various vascular conditions. The system uses inductive coupling for wireless energy transfer and has the potential to replace existing clinical devices and angiograms.
Researchers at the University of Tsukuba developed a portable MRI system to identify wrist cartilage damage among athletes, providing a convenient means of early detection and treatment. The system enables quick screening at remote locations, eliminating the need for hospital visits.
A study found that higher levels of active brown adipose tissue are associated with early metabolic dysfunction and pre-cooling glucose, insulin, thyroid stimulating hormone, and triglyceride levels. Activated brown fat was recruited to counteract 'pre-prediabetic' states, potentially serving as a first-line protective mechanism.
A recent study presented at the 2022 ARRS Annual Meeting found that COVID-19 infection significantly impacted lung cancer screening in diverse inner-city populations. The research revealed that approximately 9% of participants developed COVID-19 during the pandemic, with mortality rates reaching 6.9%.
A retrospective study found high sensitivity and specificity for diagnosing coronary artery calcium on contrast-enhanced and non-contrast chest CT. The visual ordinal assessment of CAC has prognostic utility, identifying patients at higher risk of cardiovascular events.
Researchers have developed a new type of optical fiber that generates high-power supercontinuum light in the mid-infrared spectrum, expanding its applications for environmental monitoring and cancer diagnostics. The non-silica graded-index fiber provides a self-cleaning mechanism, enabling efficient generation of broadband sources.
Researchers found that video radiology reports improved patients' understanding of their results by using lay language and annotated images. The reports were also well-received by patients, with an average rating of 4.7 out of 5.
Conjunctival goblet cells play a crucial role in tear film stability, and their dysfunction is linked to various ocular surface diseases. A new microscopy system allows for non-invasive examination of CGCs in live animal models and humans, enabling precise diagnosis and treatment of ocular surface diseases.
A multicenter study found that only 42% of patients with a visualization score C on surveillance exams maintain the same score on follow-up exams. The study suggests that alternative surveillance strategies may be necessary for patients at risk for HCC, particularly those with severe steatosis and advanced cirrhosis.
A new multimodal eye scanner combining optical coherence tomography (OCT) and Raman spectroscopy enables the detection of molecular information in the internal structure of the eye. This technology aims to detect neurodegenerative diseases, such as Alzheimer's and Parkinson's, at an early stage, improving treatment options.
Researchers at Boston University have developed optoacoustic neurostimulation with single neuron and subcellular level precision. Optoacoustic neuromodulation may offer advantages over ultrasonic neuromodulation, including higher spatial temporal resolution.
A retrospective case-control study found no significant difference in traumatic intracranial hemorrhage frequency between adult patients on antithrombotic therapy and those not on the therapy. However, hematoma expansion occurred more frequently in patients on antithrombotic therapy.
Researchers have developed miniaturized reflectors that enlarge the uses of remote infrared spectroscopy, allowing for field-ready devices with minimal size, weight, and power requirements. The devices utilize Ge-BaF2 thin films for surface micromachined mid-wave and long-wave infrared reflectors.
Researchers found a nearly 16-fold higher prevalence of olfactory cleft abnormalities in patients with COVID-19 and olfactory dysfunction compared to controls. The blockages are expected to resolve with time, but nerve damage may be more difficult to recover from.
The new center aims to develop quantitative imaging markers to reduce subjectivity in medical image diagnosis and improve consistency. Researchers will explore cutting-edge imaging modalities and extract effective image features from existing clinical imaging modalities to aid in cancer detection and treatment.
A new phenomenon was discovered where increased pressure leads to a sudden burst of rapid and coordinated cellular motion, spraying outwards from the tumour. This fluid-like pushing mechanism can kill cancer cells but also enables them to survive and multiply in new environments.
Researchers at KTH Royal Institute of Technology developed a technique to study lung disease in living mice without using mechanical ventilation. The method uses phase-contrast X-ray tomography to produce high-resolution images of the lungs, including even the smallest airways, with low radiation doses.
Researchers have developed a new approach to micro-computed tomography using phase contrast and high-brilliance x-ray radiation, enabling detailed analysis of microstructures and broad applications in medicine, biology, and material sciences.
The KAUST team has created a flexible and efficient scintillation film using lead-free metal halides, detecting X-rays at levels 113 times lower than standard medical imaging doses. This breakthrough enhances medical, industrial and security X-ray imaging, offering significant improvements in spatial resolution.
Researchers at University of Cincinnati develop a new probe and imaging technique to study lysosomes, aiding in cancer and neurodegenerative disease research. The probe, known as EC Green, enables multidimensional analysis of lysosome dynamics and provides stable tracking capabilities.
A team of Penn State researchers developed a transparent, biocompatible ultrasound transducer chip for easy cell culture and stimulation. The chip enables high-resolution imaging and reproducible results in stem cell, cancer, and neuroscience research.
A retrospective study found that online patient experience ratings improved radiologists' performance, with scores increasing over time. The results showed that radiologists' performance was comparable to that of non-radiologist physicians, suggesting the value of implementing patient experience surveys in radiology.
A research team has proposed a new approach to achieve background-suppressed tumor-targeted photoacoustic imaging, enabling deep-tissue tumor-specific imaging in vivo. The approach uses genetically engineered bacteria to deliver a photoswitchable chromoprotein to the tumor site, eliminating interference from blood background signals.
A study published in American Journal of Roentgenology found that digital breast tomosynthesis (DBT) spot compression views increased both intrareader and interreader agreement, as well as diagnostic accuracy, for equivocal findings. This improvement was primarily due to increased specificity.
Researchers used energy dispersive diffraction to create high-resolution 3D maps of bioapatite arrangements within shark centra, revealing key structures and their functions. The study provides insights into the structure-function relationship of the shark skeleton and could be applied to other organisms.
A new diagnostic tool combines grayscale B-mode and strain elastography ultrasound imaging to detect breast cancer with high accuracy. The model achieved a detection rate of 90% in the study, surpassing individual models trained on either B-mode or SE imaging alone.
A retrospective study found that dual-energy CT examinations performed in 2019 had a significantly lower frequency of equivocal interpretations compared to those in 2013. Joint aspirations were also less likely to be performed after negative DECT interpretations in 2019.
A new AI-based method has been developed to evaluate patients with Stargardt disease, a leading cause of childhood blindness. The study found that the severity of vision loss can be classified into different phenotypes based on genetic variants, and provided sensitive structural outcome measures for therapeutic trials.
Researchers used optical imaging to study the metabolic interactions between pancreatic cancer cells and surrounding non-cancer cells. They found that cancer cells can hijack the metabolic activity of these non-cancer cells to fuel tumor growth. This discovery could lead to new therapies targeting the tumor microenvironment.
The new BD CellView Image Technology enables high-speed sorting of individual cells based on detailed microscopic analysis, accelerating discovery research in immunology, cell biology, and genomics. This technology has the potential to unlock new cell-based therapeutic discoveries and transform various fields of biomedical research.
Researchers found that delirium and spatial neglect are associated with widespread dysfunction of brain networks, including arousal, attention, and spatial orientation. This imbalance may contribute to chronic cognitive decline after stroke.
Researchers developed a new fluorescence lifetime imaging (FLIM) technique to study DNA compaction and gene activities in live cells. The method enables fine measurements of DNA compaction, revealing differences in compaction between gene-rich and gene-poor chromatin domains.
Researchers discover that lipid droplets can be used as endogenous intracellular microlenses to enhance fluorescence imaging in living cells. This technique reduces the required excitation power by up to 73% and enables efficient detection of fluorescent signals from extracellular environments.
Researchers have developed a new laser speckle imaging technique that can monitor blood flow velocity in thick tissue without the need for surgical windows or optical clearing. This non-invasive method uses transmission detection to improve signal-to-background ratio and enables individual-vessel resolution in human subjects.
Researchers from Göttingen University and Hannover Medical School have detected changes in heart muscle tissue of people who died from Covid-19. The study used innovative X-ray imaging to visualize the affected tissue in three dimensions, revealing a network of chaotic vessel formations.
A new imaging technique can detect early signs of blood trauma in red blood cells, which could aid in the development of markers to prevent damage. The technique, developed by researchers at Shibaura Institute of Technology and Griffith University, uses high-speed cameras to visualize changes in RBC shape under stress.
A new class of faster and more powerful semiconductors is being developed by UMass Lowell scientists to enhance wireless communication and digital imaging. The $1.7M NSF project aims to improve infrared optoelectronic devices, enabling better intracellular imaging, night vision, and quantum and 5G communication.
Researchers at KAUST have developed a nanocomposite that absorbs X-rays with near-perfect efficiency and re-emits the energy as light. This innovation improves high-resolution medical imaging and security screening, with detection limits up to 142 times lower than traditional methods.
Researchers developed a detachable head-mounted photoacoustic microscope for imaging brain activity in freely moving mice. The probe captures neurovascular dynamics and can be removed after imaging, enabling long-term studies that could reveal new insights into neurodegenerative diseases.
Scientists have created a new imaging method that can detect microscopic soft tissue damage in animal spines, which may lead to improved treatments for lower back pain. The technique uses fluorescent molecules to target denatured collagen and produce precise 3D maps of spinal damage.
Researchers developed photoswitchable label proteins to visualize small numbers of cells in live organisms, enabling improved understanding of diseases like the immune system or tumor development. They also created sensors for optoacoustic and super-resolution imaging to visualize small molecules or ions at nanometer resolution.
Researchers have developed microbubbles that can acoustically detect blood oxygen levels, showing a strong correlation between oxygen concentration and acoustic bubble response. This innovation has the potential to benefit medicine and imaging by evaluating oxygen-deprived regions of tumors and in the brain.
Researchers from Doshisha University developed a new imaging technique to measure oxygen concentration in osteoclasts, revealing key molecular mechanisms involved in bone resorption. The study found that hypoxia interferes with TET enzyme activity, limiting osteoclastogenesis.
Researchers developed an AI method to correct speed of sound aberrations in photoacoustic images, resulting in improved image quality and resolution. The technique reduced streak artifacts by up to 5% and increased signal-to-noise ratio by about 25 decibels.
Convolutional neural networks trained to identify abnormalities on upper extremity radiographs are susceptible to a ubiquitous confounding image feature: radiograph labels. Covering these labels increases accuracy, while using them alone leads to decreased performance.
A retrospective study found that Lung-RADS performed well in assessing lung cancer risk on follow-up CT scans, with a weighted cancer risk of 5% for new nodules. Strict application of Lung-RADS criteria downgraded some malignant nodules, highlighting the need for category 4X for suspicious features.
A new imaging technique called single-shot photoluminescence lifetime imaging thermometry (SPLIT) measures temperature in 2D, without contact, and in real-time. This technology could improve photothermal therapy and help detect skin cancers.
Researchers have developed the world's thinnest X-ray detector, made from tin mono-sulfide nanosheets, which could enable real-time imaging of cellular processes. The detectors possess high photon absorption coefficients and rapid response times, making them suitable for studying soft X-rays.
A study of 5.9 million radiological examinations found no significant difference in major and minor discrepancy rates for acute community setting exams between concordant and discordant with radiologists' fellowship training. However, advanced examination discrepancies were higher when concordant with radiologists' fellowship training.
Researchers from Tokyo Medical and Dental University have developed a non-invasive imaging technique using blue light to identify areas affected by diabetic retinopathy. The study found that blue images obtained through multicolor widefield scanning laser ophthalmoscopy (SLO) can reveal hyporeflective areas indicative of damage associa...