Research on opioids, addiction, and treatment. Covers traditional care practices, opioid treatment in pregnancy, illicit fentanyl, and treatment disparities.
Researchers at UNC School of Medicine have created a new drug-like compound that activates only the kappa opioid receptor, a key step in developing better pain medications. This breakthrough could lead to safer and more effective opioids with reduced side effects.
A recent study found that opioid prescribing for disabled adults is higher outside of large central metro counties, even after accounting for local economic factors. County-level factors such as household income, unemployment rate, and income inequality also play a significant role in determining opioid prescribing rates.
A recent study found that patients who received gabapentin before and after surgery were more likely to stop using opioids. The nonopioid pain medication may promote opioid cessation and prevent chronic opioid use.
A novel genetic study aims to identify unique genetic signatures of patients at risk for opioid addiction, enabling tailored treatment approaches. The research will also inform the development of an 'addiction risk score' to guide clinicians in prescription decisions.
Living in a household with a prescription opioid user may increase the risk of prescription opioid use by other household members. According to a study published in JAMA Network, the one-year risk of prescription opioid use was an absolute 0.71 percent higher among people in households where another person had an opioid prescription.
A new guideline based on patient data and education has been shown to effectively reduce opioid prescribing in surgery patients by up to 66%, while maintaining similar levels of pain control. The study's findings have the potential to significantly impact the national opioid crisis, with estimates suggesting over 13,000 excess pills ha...
A new study published in PLOS ONE reveals that medications like opioids and antidepressants for chronic pain management increase the risk of obesity and poor sleep. The research found that these medications double the risk of obesity and are associated with poor sleep, highlighting the need to reduce their use.
A new study from Washington State University found that frequent marijuana use can strengthen the relationship between pain and depression and anxiety in patients with opioid addiction. This suggests that marijuana may not be an effective treatment for managing these symptoms.
A new clinical trial aims to test a novel treatment protocol that combines medication with follow-up support to prevent opioid relapse after recovery from an overdose. The trial, led by F. Gerard Moeller and Warren Bickel, involves patients receiving the investigational treatment in emergency rooms followed by outpatient care.
A new guideline for discharge opioid prescriptions after inpatient general surgical procedures could significantly reduce opioid prescriptions. The guideline, developed by researchers at Dartmouth Hitchcock Medical Center, recommends prescribing a certain number of opioids based on the patient's usage the day before discharge.
A California survey found that physicians and pharmacists significantly increased their use of the state's prescription drug monitoring program, CURES, following a law mandate update and registration requirement. The study suggests that education and outreach efforts can drive greater compliance with the law.
A multi-disciplinary team of researchers is exploring natural compounds from marine organisms to develop non-opioid drugs for chronic pain management. The team aims to identify novel drugs with the beneficial effects of opioids but lack the adverse actions, such as addiction and respiratory depression.
A study of over 13,000 opioid overdose deaths found that individuals with chronic pain conditions were at the highest risk of death. The study also reveals that many who died had been diagnosed with depression and anxiety, highlighting the importance of early intervention for those at high risk of fatal overdose.
Naloxone administered in the field by EMS personnel is safe and effective for reversing opioid overdose symptoms, according to a systematic evidence review. Research is needed to determine the optimal dose and route of administration.
Acupuncture has strongest evidence for effectiveness in reducing chronic pain, while yoga and other therapies also show positive preliminary evidence. These integrative medicine approaches can help improve pain and reduce opioid use, according to a review of current evidence.
A pilot study of 15 individuals using oxycodone digital pills found that patients self-administered opioids for only a brief period and took a fraction of the prescribed dose. The technology may enable physicians to monitor adherence and identify escalating opioid use patterns, potentially reducing the risk of addiction.
A new study found that 1 in 20 children received codeine after tonsil and adenoid removal surgeries, despite the FDA warning on significant safety risks. The researchers recommend increasing efforts to eliminate inappropriate prescribing and encouraging non-opioid medications.
A recent study published in Addiction has found that a concentrated 2mg intranasal naloxone spray delivers naloxone as effectively as the standard 0.4mg intramuscular injection over the critical first 15 minutes. The nasal spray maintains blood levels of naloxone more than twice as high as the IM levels for two hours after administration.
Researchers separate pain relief and breathing effects in opioids, revealing a 'biased signaling' mechanism with a 'therapeutic window' of safer alternatives. This finding could lead to new opioid medications without the risk of respiratory failure.
A new study reveals that codeine was still being prescribed to one in 20 children undergoing tonsil and adenoid surgery two years after the FDA issued a warning about its risks. The research suggests safer alternatives like acetaminophen and ibuprofen can be effective for managing post-surgical pain.
A study published in Anesthesiology found that most women do not require opioids to manage pain after hospital discharge. Researchers observed a significant reduction in opioid use for both vaginal and cesarean deliveries, with most pain resolving within 14 days.
A study of 62 rhinoplasty patients found that they used an average of nine hydrocodone-acetaminophen tablets, with 46 patients using 15 or fewer tablets. The most common adverse effects were drowsiness, nausea, and constipation.
Cognitive behavioral therapy (CBT) is an effective treatment for chronic pain that can reduce reliance on opioids and improve quality of life. By teaching patients coping strategies, CBT helps them manage their pain and behaviors associated with it.
A study found that patients with spine osteoarthritis and those under 65 are more likely to use opioids for pain management. The study also showed a significant association between opioid use and greater depressive symptoms, as well as higher levels of pain.
A new $9 million study will compare two approaches to relieving noncancer chronic pain and reducing opioid use. The study will assess which approach leads to lower or discontinued opioid use and greater pain relief among people who have been using opioids over the long term.
Researchers used machine learning technology to identify entities illegally selling prescription opioids online. The study found 1,778 tweets marketing controlled substances, with 90% including hyperlinks to purchase sites.
A study finds that while HCV screening is common among young adults who use prescription opioids recreationally, the follow-up measures needed to stop the spread of the virus are significantly less so. Only a small percentage received confirmatory testing, specialty care, or education on how not to transmit the virus.
A new study found that patients undergoing urological surgery are at risk of opioid dependence or overdose, with younger age, depression, and tobacco use being key risk factors. Urologists urge a balanced approach to prescribing opioids to minimize risks and maximize patient safety.
Researchers at the University of Eastern Finland found no association between long-term opioid use and Alzheimer's disease. Despite this, they highlight potential adverse effects such as drowsiness and addiction, suggesting restricted use for severe pain conditions.
A new study found that nearly 9% of bariatric surgical patients continue to use prescription opioids one year postoperatively, compared to 6% in general surgical populations. Surgeons must identify high-risk patients and adjust prescribing practices to prevent addiction.
The opioid epidemic has reached crisis proportions, with nearly 90 opioid overdose deaths per day in the US. Anesthesiologists and pain medicine physicians can take a leading role in identifying and solving the issues by using non-opioid drugs and emerging treatments.
A national analysis shows that opioid abuse remains disturbingly high, with nearly 1 in 7 Americans abusing prescription opioids. Experts urge caution and education to combat the epidemic.
The study found that opioid use decreased from 1 in 4 to 1 in 12 among hip and knee replacement patients between 2006 and 2014. Multimodal therapy increased, especially in small and medium-sized hospitals, leading to reduced opioid use and improved pain management.
A study published in Neurology found that prochlorperazine was more effective than hydromorphone in treating acute migraine, with 60% of patients experiencing sustained headache relief. The study also found no significant difference in opioid addiction rates between the two groups.
A new report from The Lancet estimates that 61 million people globally need palliative care and pain relief, with most in low- and middle-income countries lacking access to essential medicines. Immediate-release morphine costs just pennies but is inaccessible to over 90% of those who need it.
A new study found that gabapentin co-use with opioids increases the risk of fatal opioid overdose. The study analyzed data from Ontario, Canada and found that patients prescribed both gabapentin and opioids were more likely to die from an opioid overdose.
A new NIH-funded study aims to develop evidence-based treatments for neonatal opioid withdrawal syndrome, a condition affecting newborns exposed to opioids during pregnancy. The Advancing Clinical Trials in Neonatal Opioid Withdrawal Syndrome (ACT NOW) project will evaluate treatment options and develop research protocols.
The article highlights the risks of opioid addiction after plastic surgery, citing a study that found 4.7% of US population aberrantly used prescription opioids in 2015. Plastic surgeons are advised to screen patients for risk factors and refer them to addiction specialists or transitional pain services.
A study analyzing over 200,000 patients undergoing common surgical procedures found varying optimal opioid pain prescription lengths, with general surgery at 4-9 days, women's health at 4-13 days, and musculoskeletal at 6-15 days. The findings aim to balance adequate pain treatment with minimizing medication complications.
Researchers analyzed opioid prescription data from the Department of Defense Military Health System Data Repository to identify optimal opioid pain medication prescription length following surgery. The findings suggest that prescription lengths may need to be extended beyond seven days for certain procedures, recognizing that up to 40%...
Emergency room patients prescribed opioids are less likely to become long-term users, with prescriptions exceeding 7 days decreasing by 84-91% in ER settings. This study suggests that adherence to CDC guidelines may contribute to reduced opioid misuse.
Researchers found ED opioid prescriptions were 44% less likely to exceed a three-day supply and 46% less likely to progress to long-term use. Patients in non-ED settings received higher doses, with one in five exceeding CDC guidelines, leading to a higher risk of long-term use.
A new analysis reveals that US dialysis patients are at high risk of early death, discontinuation of dialysis, and hospitalization due to excessive opioid use. The study found that more than 20% of dialysis patients received chronic opioid prescriptions, three times the rate in the general Medicare population.
Opioid-related problems in hospitalized children increased significantly over nine years, with white children being most affected. Adverse events included opioid withdrawal, constipation, altered mental status, and cardiac arrest.
The PCORI Board has approved $97.9 million to fund 11 studies comparing different approaches to improving care for conditions like opioid misuse, multiple sclerosis, and sickle cell disease. These studies aim to provide evidence-based information to inform healthcare decisions.
A study published in Annals of Internal Medicine found that excessive sedentary time, regardless of exercise habits, significantly increases the risk of death. Taking regular movement breaks can help mitigate this effect.
Patients in a collaborative care model received more substance abuse treatment and reported higher abstinence rates compared to those receiving usual primary care services. The study suggests that integrating treatment into primary medical care can increase access to evidence-based substance use treatment.
A new study found a significant association between opioid use and non-adherence to hormone therapy among breast cancer patients. The study highlights the challenges of managing chronic pain in cancer survivors, who often face 10 years of treatment.
A study found that tweets about opioid misuse on Twitter were strongly correlated with state-by-state information from the National Surveys on Drug Usage and Health. The research used a list of keywords to extract relevant tweets, which were then clustered based on semantic distance and verified by medical toxicologists.
The American Chemical Society has unveiled its annual 'Talented 12' list, showcasing young scientists working on world-changing projects. The researchers are developing alternative fuel sources, novel cancer treatments and innovative materials for everyday products.
Researchers found that patients of all races receive opioids at similar rates as evidence-based medications, despite concerns about medication overuse and comorbidities. The study suggests that clinicians can improve treating migraine patients by adopting better prescribing practices.
Most events leading to sustained prescription opioid use were nonspecific diagnoses, such as lumbago, rather than hospital procedures. Spine and orthopedic disorders were common conditions associated with the initial opioid prescription.
Researchers have discovered a potent pain reliever, UKH-1114, that targets the sigma 2 receptor to alleviate neuropathic pain. The compound is as effective as gabapentin but works at a lower dose and longer duration, offering a potential alternative to opioids.
A study published in JAMA Network found that acupuncture and electrotherapy can potentially reduce and delay opioid use after total knee replacement. The analysis of drug-free interventions revealed moderate evidence supporting the effectiveness of these non-pharmacological treatments.
A Yale University study found that ED-initiated buprenorphine treatment was the most cost-effective approach for individuals screening positive for opioid addiction. The treatment resulted in lower healthcare costs and better patient outcomes compared to referral alone or brief intervention with facilitated referral.
The PCORI Board approved $10 million for two studies to compare strategies for reducing unsafe opioid prescribing and improving pain management. The studies will focus on Medicaid payer strategies and healthcare provider interventions to expand non-opioid approaches, with the goal of providing evidence-based information to improve pati...
Researchers found that first-time buyers care only about finding trustworthy sellers, with trust remaining their primary concern. The core group of repeat buyers and sellers is harder to shut down, and disrupting it may be the best way to interrupt the cycle.
A new study reveals a 34% increase in overdose-related ICU admissions between 2009 and 2015, with average cost of care rising by 58%. The opioid epidemic has made patients sicker and killed more people despite intensive care, researchers say.
A new study by Drexel University found that opioid users are 50% more likely to receive treatment and have it paid for by insurance under Obamacare. The study analyzed data from the National Survey on Drug Use and Health, showing a significant increase in access to care and insurance coverage since the ACA's implementation.
A new study found that nearly one in five family medicine physicians accepted payments from pharmaceutical companies related to opioids, while anesthesiologists received the most total annual payments. The study suggests that pharmaceutical companies may have a stronger hold on how doctors prescribe opioids than previously known.