Articles tagged with Opioids
A study suggests that two Florida laws, enacted to combat prescription drug abuse, led to a small but significant decrease in opioid prescriptions. The Prescription Drug Monitoring Program and 'pill mill' law measures reduced the volume of opioids prescribed by 2.5% and the dosage strength by 5.6%, equivalent to 750,000 pills per month.
Researchers at Stanford University have genetically engineered yeast to produce hydrocodone and other opioid painkillers, enabling a faster and potentially less expensive way to produce plant-based medicines. The breakthrough could lower costs and increase access to pain medications for 5.5 billion people worldwide.
Researchers successfully synthesized thebaine and hydrocodone in yeast, offering a novel microbial-based production process for opioids. The breakthrough could significantly reduce production time and potentially create a new source of pain relief worldwide.
A $1.3 million grant from AHRQ supports a demonstration project to track and analyze data on pharmacies' naloxone rescue kit distribution to develop best practices for a national program. The study aims to increase naloxone distribution in Massachusetts and Rhode Island to combat opioid addiction and overdose.
Patients with depression or anxiety experience 50% less pain improvement, 75% more opioid abuse when prescribed opioids. Identifying psychiatric disorders early can improve pain relief and reduce opioid abuse risk.
A study by WSU researchers found that an online program can help people with chronic non-cancer pain manage their symptoms and reduce opioid use. Participants who used the program reported increased confidence and positive thinking, and made progress towards reducing or eliminating pain.
New research finds that equipping law enforcement officers with naloxone does not raise their risk of legal liability. The study concludes that officers should be authorized to administer naloxone to reduce opioid-related deaths and increase overdose rescue times.
A new program at Johns Hopkins Hospital implemented consistent use of experienced medical teams, preemptive antibiotics, and early patient mobilization to reduce complications and accelerate recovery in colorectal surgery. The approach resulted in a significant reduction in hospital stays, surgical infections, blood clots, and costs.
A Kaiser Permanente study found that clinicians are hesitant to prescribe naloxone, a life-saving medication for opioid overdose, due to concerns about its effects and potential risks. Despite its promise as a tool to prevent deaths, logistical challenges and clinician reluctance hinder widespread adoption.
A study of US and international orthopaedic surgery patients found that despite receiving more pain medication, American patients reported higher worst pain scores than international patients. This suggests that the relationship between pain medication and pain perception may be complex.
Researchers found no significant differences in co-occurring substance use between medical cannabis patients using prescription pain medication and those who did not. Medical cannabis may be a safer alternative for chronic pain management, but communication between doctor and patient is key.
A literature review highlights the alarming rise of opioid use in the US, with orthopaedic surgeons as the third highest prescribers. The study emphasizes the need for comprehensive risk assessment and patient-physician relationship trust to avoid overprescribing opioids.
A randomized trial by Yale researchers found that patients given buprenorphine in the emergency department were more likely to engage in addiction treatment and reduce illicit opioid use. They also had fewer resources used, compared to those who received only referrals or brief interventions.
A study published in Cell Reports reveals that pain signaling pathways influence the sensitivity of opioid receptors on neuron surfaces. The findings may help develop non-addictive pain management drugs.
A new Penn Medicine study found that patients seen in emergency departments have misperceptions about opioid dependence and want more information about their pain management options. Patients desire better communication from physicians about their pain management options, along with discussion of the risks of opioid dependence.
A study published in PAIN journal reports that 20-30% of opioid analgesic drugs prescribed for chronic pain are misused, while the rate of opioid addiction is approximately 10%. The researchers note variability in rates across studies and question whether the benefits of opioids for chronic pain outweigh the consequences.
Researchers found altered opioid neurotransmission in obese individuals, with reduced opioid receptors in the brain. The study provides new insights into the mechanisms of overeating and obesity, but its findings do not indicate whether the changes are a cause or consequence of obesity.
A new study found that people with depression release less of a natural pain and stress-reducing chemical called natural opioids when rejected, prolonging the pain of social rejection. In contrast, they experience relatively better feelings when someone they're interested in likes them back, but only momentarily.
A study by Saint Louis University found that patients taking higher doses of opioids for chronic pain were more likely to experience an increase in depression. The researchers hope their findings will inform better pain management strategies and improve outcomes for patients.
A new study by UMass Chan Medical School found that opioids administered in the emergency room do not influence patient satisfaction scores. Factors such as wait time and communication play a greater role, according to the study's authors.
A National Institutes of Health white paper found little to no evidence for the effectiveness of opioid drugs in treating long-term chronic pain, despite their widespread use. The study's findings suggest that many studies used to justify prescription were poorly conducted or of insufficient duration.
The NIH panel recommends a more tailored approach to treating the estimated 100 million Americans with chronic pain. A combination of evidence-based and multidisciplinary approaches is needed to balance patient perspectives, desired outcomes, and safety.
A recent NIH report warns of dose-dependent risks of long-term opioid therapy, while an ACP policy paper tackles clinical documentation in electronic health records. These guidelines aim to improve care and documentation practices among healthcare professionals.
Researchers have discovered that individuals in opioid recovery exhibit signs of re-regulation of their brain's reward system within several weeks of medical-assisted opioid withdrawal. This finding suggests that the natural reward system may return to normal, making it easier for patients to remain drug-free outside treatment.
Researchers at McGill University found that tramadol use is associated with a two-fold increased risk of hospitalization for severe hypoglycemia. The study also suggests that this risk is particularly high in the first 30 days of tramadol use.
Most primary care physicians believe prescription drug abuse is a significant problem in their communities and that opioids are often overused to treat pain. As a result, many have decreased their prescribing of these products over the past year.
A survey of primary care physicians suggests a decrease in opioid prescriptions, with 58% reporting reduced prescribing habits. The study highlights the growing concern among doctors about the risks of prescription opioid use, including addiction and death by overdose.
Researchers found that tramadol use was associated with an increased risk of hospitalization for hypoglycemia, especially in the first 30 days. The study analyzed data from over 334,000 patients and found that tramadol was linked to a higher risk of severe hypoglycemia compared to codeine.
A new study published in the Journal of Behavioral Medicine found that Mindfulness-Oriented Recovery Enhancement (MORE) increases brain activation to natural healthy pleasures, reducing opioid cravings. Participants who received eight weeks of MORE instruction exhibited increased brain activity in response to enjoyable experiences.
Young adults who don't attend college are at high risk for non-medical prescription opioid use and disorder, while college-educated peers are more likely to misuse stimulants. The study analyzed data from 36,781 young adults aged 18-22, revealing a significant gap in substance abuse patterns between college graduates and non-graduates.
A new study published in PAIN found that chronic pain patients without opioid treatment have an increased risk of death compared to those with pain but without opioid use. Long-term opioid users had a higher risk of death due to causes other than cardiovascular and cancer mortality, as well as a four times higher risk of toxicity poiso...
A new study in the European Journal of Neuroscience found that oxycodone increases dopamine levels more significantly than morphine, potentially making it more addictive. The study aims to better understand addiction and inform treatment for pain relief.
The NIH/NCCAM initiative aims to enhance options for managing pain and associated problems in US military personnel, veterans, and their families. The research will focus on nondrug approaches to address chronic pain, PTSD, drug abuse, and sleep issues.
The study aims to test a collaborative care intervention to improve chronic opioid therapy management and reduce prescription opioid misuse among HIV-infected patients. Researchers at Boston University School of Medicine hope to develop an effective model that can be adopted nationwide.
A new study by Indiana University researchers found that combining an epilepsy medication with morphine can effectively treat neuropathic pain. The combination of the two drugs resulted in improved pain management and reduced need for opioids, offering a potential solution to the difficult-to-treat condition.
Rates of high-dose opioid dispensing increased across provinces, with Ontario having the highest rates and Quebec the lowest. Provincial differences may be attributed to varying coverage, training, and marketing strategies.
A new study found that states allowing medical marijuana have lower rates of opioid overdose deaths, with a 24.8% lower annual mortality rate after laws were enacted. The alternative treatment may provide relief for some individuals and reduce the risk of overdose.
A new drug, naloxegol, has shown promising results in relieving constipation caused by opioid painkillers. The once-a-day pill maintains opioids' pain-killing effect and blocks their effects in the bowels without diminishing pain relief, offering relief to millions of patients experiencing chronic severe pain.
A telephone-delivered telecare intervention improved chronic musculoskeletal pain compared to usual care, with nearly twice as many patients experiencing a 30% reduction in pain score. The intervention was associated with clinically meaningful improvements in pain and treatment satisfaction.
A study found that nearly half of deployed soldiers reported combat injuries, with 44% experiencing chronic pain and 15.1% using opioids in the past month. The researchers emphasized the urgent need to address chronic pain and opioid misuse among military personnel.
A new study links opioid pain relievers to less improvement and higher levels of dissatisfaction following spine surgery. Patients who used opioids before surgery had worse health outcomes at 3 and 12 months post-op, according to a study published in the Journal of Bone and Joint Surgery.
Saint Louis University researcher Jeffrey Scherrer is investigating the link between chronic opioid use and depression risk. He will analyze medical records of 1 million patients, including those with VA and private sector prescriptions, to understand the impact of opioid exposure on mental health.
Researchers found a dramatic rise in opioid analgesic prescriptions during US emergency department visits from 2001 to 2010, with some opioids increasing by 668.2 percent. Despite modest increases in painful conditions, the findings suggest a concerning trend that may lead to misuse and addiction.
A new approach to breast reconstruction surgery, known as an enhanced recovery pathway, has been shown to reduce opioid painkiller use in patients by 50% and decrease hospital stays by a day on average. The method includes preoperative analgesics, nonsteroidal anti-inflammatories, and resuming food and walking soon after surgery.
Research examining opioid painkiller use reveals that individuals initially obtain medications from friends and relatives, but as usage increases, prescriptions from physicians become a common source. The study emphasizes the importance of judicious prescribing practices to curb serious health issues.
New research reveals that opioid use changes the activity of a specific protein needed for normal brain function, affecting both pain relief and tolerance. The study found that blocking this protein can reduce addiction-related behaviors, but increasing its activity lowers pain relief response and leads to faster morphine tolerance.
Researchers at University of Utah developed Mindfulness-Oriented Recovery Enhancement, reducing opioid misuse and pain-related impairment in chronic pain patients. The new treatment combines mindfulness training, reappraisal, and savoring to address underlying processes involved in chronic pain and opioid misuse.
Studies in animal models reveal that mTOR activation contributes to morphine tolerance and hyperalgesia, while mitochondrial iron accumulation promotes doxorubicin-associated cardiotoxicity. These findings suggest potential therapeutic targets for improving pain management and limiting cardiotoxicity.
Research finds mTOR activation in neurons of dorsal horn contributes to morphine tolerance and hyperalgesia; rapamycin treatment improves opioid tolerance and hyperalgesia in rats. Targeting the mTOR pathway may enhance pain management.
The proportion of opioid treatment programs offering on-site testing for human immunodeficiency virus (HIV) and sexually transmitted infections (STIs) decreased substantially between 2000 and 2011, despite guidelines recommending routine opt-out HIV testing. For-profit opioid treatment programs were more likely to experience this decline.
A study examining incidence and trend of substance use disorder among medical residents found that 0.86% had a confirmed SUD during training, with increasing rates over the study period.
Researchers found that oxycodone is the most popular drug due to its high quality, while hydrocodone remains a favorite despite lower euphoric qualities. Hydrocodone's popularity stems from its affordability, ease of access, and perceived safety, making it an attractive option for risk-averse users.
A study analyzing over 1 million hospital admissions found that over 50% of nonsurgical patients were prescribed opioids, with high doses and late discharge increasing the risk of adverse events. Regional variation in prescribing rates was also observed, with a 37% difference between the highest and lowest regions.
A systematic review found multivitamin supplements lack effectiveness in preventing cardiovascular disease, cancer, and mortality. Guidelines for opioid prescribing also need improvement to mitigate overdose deaths among patients with chronic pain.
A new study by Indiana University researchers found that access to healthcare in counties with more dentists and pharmacists is associated with higher rates of opioid abuse. The study concludes that the structure of local healthcare systems plays a key role in determining community-level access to opioids.
A recent study published in Annals of Internal Medicine found that women who adhered to a Mediterranean-type diet in midlife had greater physical and mental function in old age. Researchers also developed a scoring system to identify low-risk patients for strep throat, which could potentially save hundreds of thousands of doctor visits...
A study published in Journal of General Internal Medicine found that long-term opioid use is linked to a higher risk of developing major depression. Patients who used opioids for 180 days or longer were at a 53% increased risk, while those using them for 90-180 days had a 25% increased risk.
Researchers analyzed conversations between chronic pain patients and their physicians about opioid treatment, revealing three patterns of physician responses: reassurance, avoidance, and gathering information. The study emphasizes the crucial role of a strong therapeutic alliance in discussing risks and benefits of opioid treatment.
A University of Michigan study found that the brain's natural painkiller system responds to social rejection, releasing chemicals called opioids to ease social pain. Individuals with high resilience scores exhibited greater opioid release during social rejection, suggesting a protective or adaptive response.
A study found that bariatric surgery led to greater chronic opioid use in patients with chronic pain, regardless of pre-surgery depression or chronic pain diagnoses. Weight loss after surgery did not reduce opioid use for these patients.