Articles tagged with Tissue Transplantation
Researchers at the Medical University of South Carolina are developing a new therapy for Type 1 diabetes that combines stem cell biology, immunology, and transplantation science. The goal is to restore beta cell function and insulin production in people with T1D without using immunosuppressive drugs.
A new study reveals persistent inequalities in children's access to life-saving kidney transplants across the UK. Early disparities in ethnicity, socioeconomic status, and gender persist even after being placed on the waitlist.
A recent study found that blood cancer patients achieve good outcomes with a partial match drawn from the national public registry of donors when treated with cyclophosphamide. Survival rates at one year were comparable to those seen in other studies with fully matched donors.
New molecular testing methods are transforming post-transplant care by detecting potential heart injury or rejection earlier than traditional biopsies. This enables physicians to reduce immunosuppressive medicine dosage in low-risk patients, potentially improving patient outcomes beyond the first year post-heart transplant.
The study finds that the current transplant system is a net positive for patients, producing an additional 9.29 life-years from transplantation. However, the optimal structure of the matching system could potentially raise this figure to as high as 14.08 life-years.
Researchers from Emory University are using the International Space Station to study cardiac cells and accelerate the development of cell-based regenerative therapies. The team's findings have led to multiple peer-reviewed publications and could significantly advance methods to produce cardiac cells for heart disease treatment.
Researchers developed reprogrammed vascular endothelial cells that provide strong support for islets, allowing them to survive and reverse diabetes long-term. The study showed that mice transplanted with islet cells plus R-VECs regained normal blood glucose control after 20 weeks.
A new study published in the European Respiratory Journal found that extracorporeal photopheresis significantly reduces acute rejection episodes and chronic rejection risk in lung transplant patients. The treatment involves exposure to UV light, leading to apoptosis of immune cells and minimizing side effects.
Researchers found that brown adipose tissue enhances exercise endurance and supports healthy aging by improving blood circulation and reducing cellular stress. The study suggests that treatments mimicking BAT's benefits could lead to innovative therapies for improved energy levels and heart health.
A QUT-led study found that surgeons are slow to adopt newly developed biomaterials or tissue-engineered solutions for treating bone defects. The researchers surveyed 337 surgeons and 99 scientists, revealing a significant gap between their optimism about future advancements and the slow adoption of these innovations in clinical practice.
Researchers at the University of Montreal have successfully transplanted human retinal sheets into minipigs with damaged macula, resulting in signs of restored vision. The method uses hypoimmunogenic human retinal sheets and has shown promise in treating severe photoreceptor degeneration.
Scientists at UCSF have developed engineered T cells that act as immune referees to soothe overreacting immune responses and mope up inflammatory molecules. These cells could improve treatment for organ transplants, type 1 diabetes and other autoimmune conditions by reducing the need for harsh immunosuppressant drugs.
Researchers at Niigata University successfully generated rat offspring from ovarian oocytes transplanted into mice, overcame previous challenges in producing fertilized eggs and embryos.
The world's first combined face and whole-eye transplantation successfully used personalized surgical cutting guides and a novel 'shortcut' to maintain blood flow. Innovative techniques ensured optimal blood flow to the retina, safeguarding the viability of the transplanted eye during the procedure.
Researchers develop a technique called nanowarming using magnetic nanoparticles and alternating magnetic fields to thaw frozen tissues rapidly and safely. This method enables the successful rewarming of animal tissues without causing tissue damage or toxicity.
Researchers investigate organ donation practices after extracorporeal cardiopulmonary resuscitation (ECPR), finding delayed organ procurement intervals and lower lung graft survival rates in ECPR groups. The study suggests using ECPR may address the organ shortage crisis by increasing viable organs for transplantation.
A new study reveals specialized proteins can dramatically delay ice crystal formation in extreme cold, paving the way for impossible organ transplants. Cryogenic damage compromises cellular structures, leading to irreversible damage and organ failure.
A University of Houston researcher has made a breakthrough discovery about the development of the heart in the womb, revealing that a certain gene deletion can cause a common type of heart muscle disease called left ventricular non-compaction.
Researchers from Nagoya University have successfully treated rare genetic skin disorders epidermolytic ichthyosis (EI) and ichthyosis with confetti (IWC) by transplanting genetically healthy skin to inflamed areas. Transplantation of healthy skin has been used as a treatment option for severe burn injuries.
Scientists from Tokyo Medical and Dental University successfully generate autologous skin grafts by introducing mutations into mouse embryos, which then form sheets of epidermis containing hair follicles. These grafted skin patches survive up to 3 months and mimic mature epidermis structure.
Researchers investigated the effectiveness of systemic thrombolysis for acute portal vein thrombosis (PVT) in liver cirrhosis patients. After a 7-day treatment period, 60% of patients achieved full recanalization of the portal vein, with no significant side effects.
Researchers analyzed cell changes before, during, and after xenotransplantation surgeries using single-cell RNA sequencing. The study found evidence of subtle immune reactions that could cause xenotransplants to fail over time, including antibody-mediated rejection and tissue repair mechanisms.
Researchers at University of Michigan Health have developed a normothermic perfusion system that can extend the life of organs waiting for transplant by up to 24 hours. This breakthrough allows for prolonged preservation without damage or edema, increasing the number of hearts considered for transplants.
Researchers created a proteomics-based imaging mass cytometry marker panel to categorize immune cells at single-cell resolution, identifying unique signatures of active T-cell-mediated rejection. The study aims to find personalized immunosuppression therapies with fewer side effects.
Researchers develop method to preserve donor hearts for more than 24 hours, a major improvement over current six-hour time window. The new approach uses normothermic ex-vivo heart perfusion and has shown strong improvements in extending the shelf-life of donor hearts.
Researchers at Johns Hopkins Medicine have reported promising results from a clinical trial testing a novel immunotherapy combination to target advanced, potentially lethal skin cancers in kidney transplant patients. Two out of six patients experienced complete tumor regression after adding a second checkpoint inhibitor to the regimen.
Researchers at Hokkaido University developed a technique to promote cardiac regeneration by activating mitochondrial function in transplanted cells. The study found that activated mitochondria improved cardiac function and suppressed myocardial fibrosis, suggesting a new approach for treating severe heart failure.
A pioneering study published in The American Journal of Pathology reveals the cytoprotective and proregenerative effects of neuropeptide α-MSH in promoting corneal healing after eye injury. The treatment has shown impressive therapeutic potential in reducing the need for corneal transplants.
Scientists at Niigata University successfully produced marmoset eggs and embryos from xenotransplanted ovaries, offering a new method for generating genetically modified marmosets. The novel egg production system is expected to facilitate research into human diseases and contribute to regenerative medicine.
Researchers at UC Irvine have identified a critical gene for muscle repair and regeneration, enabling the creation of muscle in the lab that can support human stem cells. The discovery has immense implications for treating various chronic muscle disorders and injuries, including rotator cuff tears and Duchenne Muscular Dystrophy.
Scientists from Central South University develop a novel approach to address bacterial infection in bone transplantation by enriching H2O2 and amplifying the Fenton reaction. The technique enhances biocompatibility and safety, promising reduced transplant failures and post-operative complications.
Researchers developed a new epigenetic clock that accurately measures biological aging in healthy and unhealthy tissue, outperforming current clocks. The Glasgow-Karolinska Clock showed promise in assessing the impact of chronic kidney disease on aging, even after dialysis treatment.
The Texas Heart Institute has received a five-year, $2 million grant from the National Institutes of Health to advance organ bioengineering. The project aims to develop transplantable bioartificial hearts to combat end-stage heart failure.
Researchers have found that mouse stem cells mimic their parent animals' cold resistance, generating energy differently at low temperatures. This discovery opens up new avenues for studying organ preservation and human hibernation using in vitro models.
Researchers have discovered a novel pathway that minimizes liver injury during transplantation by activating the protective CEACAM1-S version. This protective characteristic is regulated by HIF-1α and can be enhanced using molecular tools and alternative gene splicing, reducing organ injury and improving post-transplant outcomes.
Researchers at University of Technology Sydney have successfully created personalized 'bio-inks' from patients' own stem cells, which are then used to 3D-print cardiac tissues to repair areas of dead tissue. This technology shows promise in treating heart failure and may reduce the need for expensive and traumatic heart transplants.
Researchers successfully transplanted human brain organoids into adult rat brains and observed functional integration, including response to visual stimulation. The study demonstrates potential for neural tissues to rebuild injured brain areas.
A study involving three volunteers found that skin scars treated with hair follicle transplants exhibited profound architectural and genetic shifts towards healthy, uninjured skin. The findings suggest the potential for new therapies to rejuvenate mature scars and restore organ function.
Researchers at UCSF have developed a novel approach to prevent antibodies from triggering immune rejection of engineered therapeutic and transplant cells. By using a decoy receptor, they can capture the antibodies and take them out of circulation before they can kill the therapeutic cells.
A research team at Penn Vet identified p63 as a key factor in inappropriate tissue regrowth after infection, which may lead to new treatments. By removing p63, basal cells can differentiate into functional alveolar cells, promoting lung recovery.
Researchers found that glutaminase inhibitor BPTES selectively eliminates senescent dermal fibroblasts, improving skin aging phenotype by increasing collagen density and cell proliferation. The study suggests BPTES as a potential therapeutic agent for skin aging, offering new treatment options.
A University of Colorado Anschutz Medical Campus faculty member has received a DOD grant to study noninvasive biomarkers for vascularized composite allograft rejection. The goal is to develop a simple saliva test to monitor patients for signs of graft rejection, reducing the need for frequent biopsies.
A bioengineered cornea made from collagen protein can restore vision in people with diseased corneas, offering an alternative to donated human corneas. The implant has been shown to be safe and effective in a pilot study, with patients regaining perfect vision after two years.
A study by researchers from the University of Chicago reveals that bacteria in donated organs complicate the immune response after transplantation. The findings show that immune responses against commensal bacteria add to the rejection of the organ, reducing the effectiveness of immunosuppressive drugs and causing damage to the graft.
A team of scientists has developed a complex tissue platform that can restore damaged rotator cuffs through 3D-bioprinting. The platform, which includes stem cells and tissue-specific extracellular matrix bioink, regenerates tissues and improves shoulder function in animal models.
Researchers have developed a novel biomaterial that promotes immune tolerance and allows islets to survive after transplant without the need for long-term immunosuppression. This breakthrough enables patients with type 1 diabetes to control their blood sugar levels without lifelong medication.
Scientists at Johns Hopkins Medicine have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice. The self-renewing stem cells were created by reprogramming laboratory-grown human skin cells, which then differentiated into specific cell types using a nutrient-rich broth.
Researchers successfully used composite tissue transfer techniques from face transplant surgery for 'autotransplantation' of avulsed facial tissues. The technique involves re reconnecting the patient's own blood vessels to restore circulation, allowing for successful replantation without postoperative complications.
Researchers have discovered a genetic difference in the meniscus that makes about 50% of females more prone to developing knee osteoarthritis than males or other females. The study suggests potential for a blood test to identify high-risk individuals, allowing for early interventions and prevention strategies.
A team of researchers at Kumamoto University successfully created complex 3D kidney tissue in the lab using mouse embryonic stem cells. The breakthrough could lead to advances in kidney research and potentially even transplantable organs.
Researchers at Johns Hopkins Medicine have successfully transplanted a kidney from a COVID-19 donor, demonstrating that healthy kidneys from such donors can be safely transplanted. The recipient has shown no signs or symptoms of the virus and has excellent kidney function since the transplant.
A recent study found that the number of stage 3 AKI kidneys transplanted in the US has increased significantly over the last decade, yet 44% are still discarded. This highlights the need for further efforts to optimize the use of these organs and reduce waste.
Researchers have developed a method to store 3D-bioprinted tissues in a frozen state, allowing for long-term preservation and rapid thawing. The technique, known as cryobioprinting, has been shown to retain tissue functionality, enabling potential applications in drug testing and tissue replacement.
Researchers at UC Davis Health developed a new treatment that simultaneously blocks IL-6 and TNF cytokines, providing superior protection against acute graft-versus-host-disease severity and mortality. The dual-cytokine blockade approach did not impair beneficial graft-versus-tumor effects.
A study in mice suggests that transplanted brown fat can reduce type 2 diabetes risk factors after a heart attack by dampening gene activation linked to negative effects. The transplantation method could help researchers understand the mechanisms behind this protective effect and potentially lead to therapeutic applications.
A new computer model developed by researchers at Oregon State University predicts the optimal vitrification method for preserving 3D tissues and organs at low temperatures. The model, which takes into account tissue size changes, could enable the cryopreservation of brain slices, pancreatic cells, and even whole organs.
Children who receive living donor liver tissue for transplants have nearly twice the survival rate and reduced risk of organ rejection compared to those receiving deceased donor livers. Living donation also shortens wait times for pediatric patients.
Researchers at the University of Oregon used CRISPR-Cas9 gene editing to target a specific mutation causing Fuchs' corneal dystrophy, preserving endothelial cell density and function. The study lays the groundwork for future research on using this technique to treat genetic disorders in post-mitotic cells.
Researchers identified protein patterns in lung tissue from patients with end-stage bronchiolitis obliterans syndrome, revealing an epithelial/mesenchymal imbalance and increased stiffness in remodeled airways. This breakthrough study may help develop therapies to improve long-term outcomes for lung transplantation patients.
The new system automates the organ donation process for hospital staff, saving time and improving patient care. The collaboration enables the referral of potential donors directly to the OPO without manual calls, enhancing the efficiency of the entire process.