Articles tagged with Tissue Transplantation
Researchers at the University of Oregon used CRISPR-Cas9 gene editing to target a specific mutation causing Fuchs' corneal dystrophy, preserving endothelial cell density and function. The study lays the groundwork for future research on using this technique to treat genetic disorders in post-mitotic cells.
Researchers identified protein patterns in lung tissue from patients with end-stage bronchiolitis obliterans syndrome, revealing an epithelial/mesenchymal imbalance and increased stiffness in remodeled airways. This breakthrough study may help develop therapies to improve long-term outcomes for lung transplantation patients.
The new system automates the organ donation process for hospital staff, saving time and improving patient care. The collaboration enables the referral of potential donors directly to the OPO without manual calls, enhancing the efficiency of the entire process.
The University of Minnesota will host a new Organ and Tissue Preservation Center, focusing on technologies to rapidly rewarm cryopreserved organs. This center is part of the Biostasis Research Institute's 'Apollo Program' to develop new preservation methods for human organs.
Researchers at UC Berkeley created a tiny wireless implant that can measure tissue oxygen levels in real-time, allowing doctors to monitor the health of transplanted organs and tissues. The device could also track other biochemical markers, such as pH or carbon dioxide, providing early warnings of potential issues.
Researchers identified a biomarker that predicts kidney transplant rejection risk by analyzing immune molecule ratios. Monitoring this ratio may help clinicians identify high-risk patients and intervene with new treatments to prevent long-term organ rejection.
Northwestern University researchers create novel biomaterial that enhances neuron growth, a crucial finding for regenerative medicine. The material's bioactive properties allow cells to penetrate and interact with bioactive signals, potentially treating neurodegenerative diseases such as Parkinson's and Alzheimer's disease.
Researchers from Carnegie Mellon University developed a new 3D-bioprinting approach, FRESH, which enables advanced tissue fabrication by holding bioinks in place until they are cured. This method solves the distortion problem of soft and liquid bioinks, enabling the creation of functional adult-sized tissues and organs.
A new liquid bandage sensor measures the amount of oxygen reaching transplanted tissue, a crucial measure of its viability, and detected tissue oxygenation as well as the gold standard of an oximeter. The technology eliminates restrictions on patient movements and provides a major advancement over existing methods.
A new study published in The American Journal of Pathology reports that neutralizing tumor necrosis factor (TNF) can prevent rejection and tissue injury after cell transplantation, improving graft survival and regenerative medicine outcomes. TNF is identified as a master switch for orchestrating cytokines and inflammatory signals.
Researchers have successfully bioprinted miniature human kidneys in a lab using cutting-edge technology. The study validates the use of 3D bioprinted human mini-kidneys for screening drug toxicity, paving the way for new treatments and potentially lab-grown transplants.
Researchers used cell-free DNA to monitor infectious and immune-related diseases, including COVID-19 infection, and identified tissue-of-origin through methylation markers. This technology has potential clinical applications in screening for tissue damage, detecting cancer early, and patient care.
Researchers have developed a device inspired by an octopus's sucker that can transfer thin, delicate tissue grafts and biosensors quickly and safely. The device uses a temperature-responsive hydrogel to create suction, allowing for rapid handling of fragile materials.
Researchers developed an 'cell-less' therapy that accelerates recovery from heart attack in pigs by injecting tiny membrane-bound sacs containing proteins and DNA into the heart. This approach avoids safety concerns associated with whole-cell transplants, which often fail to engraft and can cause severe health issues.
A newly developed oxygen-releasing bioink has been shown to enhance the ability of implanted cells to grow and regenerate new tissue. The bioink was tested extensively to optimize its properties, delivering oxygen to cells in tissue constructs for the necessary period for blood vessels to develop fully.
Testicular tissue transplantation combined with retinoic acid administration successfully produces healthy offspring in mice, offering a potential method for preserving/recovering male fertility. The researchers' findings suggest that this approach may be effective in humans without adverse effects on pregnant mothers.
Researchers at the University of Pittsburgh School of Medicine have made a groundbreaking discovery that could lead to a significant increase in long-term survival of transplanted organs. The study found that the innate immune system can specifically remember foreign cells, paving the way for new drugs that can prevent chronic rejection.
Researchers found that iPSC-derived thymic epithelium cells can regulate immune response to skin grafts, extending their survival. The introduction of Foxn1 gene helps efficient differentiation of such cells.
A study from Ann & Robert H. Lurie Children's Hospital of Chicago defines the safest laparoscopic technique for removing ovaries in girls, resulting in better quality ovarian tissue for future transplantation. This technique minimizes damage and maximizes fertility preservation, increasing pregnancy rates after transplantation.
Researchers developed a synthetic conduit that bridges large nerve gaps, supporting recovery and accelerating neuronal healing. The device boosts nerve regeneration and improves motor skills in macaques, showing superior recruitment of cells that insulate nerves.
Recent advancements in 3D bioprinting have the potential to revolutionize organ transplantation by enabling customized organs for patients. However, significant technical challenges need to be overcome, including biomimicry, vascularization, and tissue maturation.
Scientists at Cincinnati Children's developed the world's first three-organoid system, growing a connected set of mini human organs including liver, pancreas, and biliary ducts. The breakthrough allows for studying organ function in concert, reducing animal-based medication studies and accelerating precision medicine.
Researchers at FAU's Schmidt College of Medicine are working on a novel project to identify the role of hypoxia in the formation of the eye lens and its potential as a therapeutic target for eye diseases such as cataracts. The grant will help advance regenerative medicine by developing ocular cells that can replace damaged tissues.
A team from Kyoto University found that collagen in the skin is organized in a mesh-like structure, with elastic fibers following the same orientation. This discovery has significant implications for understanding skin pliability and could lead to breakthroughs in skin grafts and transplantation.
Researchers at King's College London have identified a new type of cell called hepatobiliary hybrid progenitor (HHyP) that can regenerate liver tissue. HHyPs exhibit stem cell-like properties and may be able to repair liver damage, potentially bypassing the need for transplants.
Researchers discovered that giving antibiotics to mice and humans before a liver transplant led to improved liver function after surgery. The treatment inhibited bacteria causing inflammation, reducing organ rejection and accelerating cell removal, resulting in better outcomes for patients.
Ibrahim Tarik Ozbolat has received $1.5 million in grants to explore ways to bioprint biological tissues like bone, lungs and other organs for use as models in various studies. The projects will investigate current questions about bioprinting of cell spheroids and develop 3D printed models of the lung and upper respiratory environment.
Patients who underwent face transplants experienced significant improvements in motor function and sensory perception, with a notable trend towards enhanced quality of life. The study's findings support the potential benefits of this surgery for patients with severe facial injuries.
The study evaluated four chemical fixatives, including diisocyanate, carbodiimide, epoxy compound, and genipin, on bovine pericardium biomeshes. The results showed that three of the four tested agents significantly increased the resistance of biomeshes to collagenase.
Researchers have successfully transplanted adult spinal cord grafts into spinal cord transected rats to improve locomotor function, promoting the recovery of motor function and survival of neural cells.
A new screening method using sensor particles and a urine test can catch organ rejection earlier and more comprehensively than traditional biopsies. The test detects T cell attacks on transplanted organs through fluorescent signals in the urine, allowing for early detection and potential adjustments to immunosuppressant medications.
A team at the University of Delaware has pioneered methods to grow a self-assembling, functional network of blood vessels. The system works across centimeter scales, necessary for functional tissue replacement, and could someday be utilized for tissue and organ transplantation into humans.
A new study reveals that protein galectin-1 has anti-inflammatory properties capable of minimizing damage to kidney cells by hypoxia and reperfusion, common processes in transplants. Galectin-1 may provide an alternative to corticosteroids for ischemia-reperfusion injury.
Researchers at Peter the Great St. Petersburg Polytechnic University create three-dimensional porous material made of collagen and chitosan to restore bone tissue after trauma or illness. The material stimulates natural tissue growth, eliminating the need for lifelong medication.
A UCI researcher has received a $4.8 million CIRM grant to develop a stem cell-based retina therapy for treating retinitis pigmentosa and age-related macular degeneration. The therapy aims to transplant sheets of stem-cell derived retina into the back of the eye, potentially restoring vision.
Researchers analyzed blood and tissue samples from kidney transplant recipients to understand how immunosuppressive drug tacrolimus works. They found that it reduces the number of T follicular helper cells, a key player in antibody production.
A UCLA-led team developed a new 3D printer to create complex artificial tissues from multiple materials. The printer uses stereolithography and a custom-built microfluidic chip, enabling the creation of biocompatible structures with different properties.
Tissue-engineered human pancreatic islets developed a circulatory system and secreted hormones like insulin, resolving the disease in transplanted mice. The self-condensation cell culture process promotes vascularization, offering a potential curative strategy for type 1 diabetes.
Johns Hopkins surgeons develop a modified muscle transplant operation that restores wide and even smiles to selected patients with one-sided facial muscle paralysis. The procedure, published in JAMA Facial Plastic Surgery, shows improvements in smile function, gum exposure, and eye wrinkles.
Researchers identified elevated tissue iron as a critical factor in fungal infection risks for lung transplant recipients. Elevated iron levels prompted Aspergillus invasion into transplanted tissue, suggesting a potential new approach to curb these life-threatening infections.
Researchers from Cincinnati Children's Hospital Medical Center and Yokohama City University report a high-volume production method for bioengineered human gut and liver tissues that avoids tumor risks. The new approach uses genetically stable posterior gut endodermal progenitor cells, which can be programmed to form different tissue ty...
A randomized clinical trial of bortezomib in late antibody-mediated kidney transplant rejection found no improvement in transplanted kidney function or prevention of immunologic tissue injury. The treatment was also linked with adverse effects, ruling out its potential as a therapeutic option for this condition.
Belgian researchers have created a new artificial ovary prototype that resembles human ovarian tissue in terms of architecture and rigidity. The fibrin-based design could be used for ovary transplant, providing alternatives for women with infertility or cancer patients unable to conceive after treatment.
A study found that corneal donor tissue can be preserved for up to 11 days without affecting graft success rates. The researchers analyzed data from over 1,000 individuals and found that longer preservation times did not significantly impact the success of corneal transplantation.
A new nuclear medicine test can identify kidney transplant infection in non-invasive procedures, using positron emission tomography/magnetic resonance imaging (PET/MRI). The test has the potential to refine characterization of infectious and inflammatory kidney diseases.
The National Institutes of Health has completed a detailed atlas documenting the stretches of human DNA that influence gene expression across various tissues and cell types. This resource will aid researchers in understanding how individual genomic variation leads to biological differences, such as healthy and diseased states.
Prellis Biologics has received $1.8 million in funding to develop patent-pending technologies for creating viable human organs using 3D printing. The company aims to solve the challenge of creating microvasculature, a crucial component of functional organs.
Researchers at UBC Okanagan campus have created a new bio-ink made from cold-soluble gelatin, which shows promise for creating artificial organs. The hydrogel is thermally stable at room temperature, making it suitable for use in 3D bio-printing.
Researchers at eGenesis have successfully produced the first PERV-free piglets using CRISPR technology, addressing safety concerns in xenotransplantation. The breakthrough demonstrates the potential of gene editing to prevent cross-species viral transmission and pave the way for safe human transplantable cells, tissues, and organs.
A molecular analysis of tissue mismatch between donors and recipients predicted which recipients needed high doses of immune modulating drugs. The study found a strong correlation between low medication levels and low molecular mismatch scores, allowing physicians to tailor treatment to individual patients.
Researchers from Rice University and Baylor College of Medicine have demonstrated a key step in generating implantable tissues with functioning capillaries. They used human endothelial cells and mesenchymal stem cells to initiate tubulogenesis, crucial for blood-transporting capillary formation.
Experts at the University of Pittsburgh School of Medicine have identified a key molecule, SIRP-alpha, that triggers innate immune system activation and leads to organ rejection. Sequencing this gene could lead to better donor-recipient matches and new ways to prevent transplant rejection.
Scientists have successfully grown human embryonic colons in a laboratory using pluripotent stem cells, providing unprecedented detail for studying GI diseases. The technology also holds potential for generating human gastrointestinal tract tissues for transplantation into patients.
A South African team has successfully performed the second penis transplant, a procedure that aims to address penile mutilation caused by traditional circumcisions. The recipient is expected to regain full urinary and reproductive functions within six months, paving the way for cost-effective solutions to help affected men.
Researchers developed a technique using multimodal autofluorescence and light scattering to evaluate kidney function after ischemic injury. The study suggests that variations in tissue microstructure, fluorophore emission, and blood absorption spectral characteristics contribute to the behavior of recorded signals.
Researchers developed a novel strategy using cytokines TGF-β and IL-10 to promote tolerance in high-risk corneal transplant patients. Treating donor tissue with this combination improved graft survival rates by 68.7%, offering a promising approach for reducing rejection.
Activating innate immunity enhances nuclear reprogramming, leading to induced pluripotent stem cells that can regenerate into various tissues. This discovery could revolutionize transplantation and improve wound healing or recovery after a heart attack.
A new study reveals that nanotechnology can be used to rapidly rewarm cryogenically treated samples without damaging delicate frozen tissues. This technology may help make organ cryopreservation a reality, eliminating transplant waiting lists and reducing rejection rates.
Researchers successfully rewarmed large-scale animal heart valves and blood vessels preserved at low temperatures using a revolutionary new method. The discovery has the potential to increase organ availability for transplantation, potentially eliminating transplant waiting lists within two years.
Researchers have discovered a new pathway that likely plays an important role in rejection following kidney transplantation. The findings suggest that targeting specific immune cells or signaling pathways may help prevent tissue scarring.