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Bird flu risk to Danish cattle – new tool can warn farmers before infection spreads

Researchers developed a tool that combines wild bird abundance and cattle density data to predict where and when the risk of infection is highest in Denmark. The study warns that Danish cattle are particularly vulnerable due to their location along migratory bird routes, with the risk of infection highest from December to March.

SourceUniversity of Copenhagen·JournalPreventive Veterinary Medicine·DateMar 19, 2026

Building immunity against avian flu risks

A team from UNIGE has shown that certain antibodies to seasonal flu can also target avian flu. Stimulating these antibodies could strengthen protection in the event of a pandemic. Vaccinated individuals show increased levels of cross-reactive antibodies capable of neutralizing the H5N1 virus, which may result in milder symptoms.

SourceUniversité de Genève·JournalNature Communications·TypeNews article·DateFeb 10, 2026

Nasal vaccine combats bird flu infection in rodents

Researchers developed an intranasal vaccine that elicited strong immune responses and prevented infections in exposed animals, providing protection against upper respiratory infection and severe disease. The nasal vaccine was effective regardless of prior flu exposure, making it a promising tool in the fight against H5N1 bird flu.

SourceWashU Medicine·JournalCell Reports Medicine·TypeExperimental study·DateJan 30, 2026

Early-stage clinical trial demonstrates promise of intranasal influenza vaccine in generating broad immunity

Researchers at the University of Maryland School of Medicine have reported encouraging results from an early phase clinical trial of an intranasal influenza vaccine. The study found that the vaccine triggered a broad immune response, including higher levels of protective antibodies and better ability to kill infected cells.

SourceUniversity of Maryland School of Medicine·JournalNature Communications·TypeRandomized controlled/clinical trial·DateNov 6, 2025

The H5N1 influenza outbreaks in the US dairy cattle likely triggered by the "milk-stealing" behavior of lactating cows

Researchers found that the H5N1 virus enters the mammary glands through the teat, not via respiratory infection. Lactating cows' self-nursing or mutual-nursing behaviors may facilitate this transmission. Vaccination with two different vaccines showed complete protection against H5N1 infection in cattle.

SourceScience China Press·JournalNational Science Review·TypeExperimental study·DateJul 14, 2025

Map of genetic regulation in chickens could help fight against bird flu

A comprehensive atlas of gene activity in chickens has been created, revealing how millions of genetic variants affect gene regulation and giving researchers tools to understand agriculturally important traits. This knowledge could lead to healthier flocks, more resilient farming systems, and fewer economic losses for poultry producers.

SourceUniversity of California - Davis·JournalNature Genetics·TypeExperimental study·DateApr 9, 2025

HKU State Key Laboratory for Emerging Infectious Diseases and InnoHK Centre for Virology, Vaccinology and Therapeutics successfully develop nasal spray H5N1 avian influenza vaccine

Researchers at HKU and CVVT create a nasal spray vaccine offering single-dose protection against H5N1 infection, inducing comprehensive immunity in the upper respiratory tract. The vaccine's high safety profile and ability to curb viral transmission make it a critical reserve for future outbreaks.

SourceThe University of Hong Kong·JournalNature Communications·TypeExperimental study·DateApr 8, 2025

Current antivirals likely less effective against severe infection caused by bird flu virus in cows’ milk

Scientists at St. Jude Children's Research Hospital found that frequently used flu antivirals do not work well against the H5N1 avian influenza virus in cows' milk. The study showed that reducing infection risk through methods like avoiding raw milk and minimizing dairy farm workers' exposures may be more effective interventions.

SourceSt. Jude Children's Research Hospital·JournalNature Microbiology·TypeExperimental study·DateMar 17, 2025

Older adults might be more resistant to bird flu infections than children, Penn research finds

Researchers found that older adults exposed to seasonal flu viruses before 1968 have higher antibodies against the H5N1 avian flu virus. In contrast, young children who were not exposed had low levels of antibodies that could fight H5N1. The study suggests that younger adults and children would benefit more from H5N1 vaccinations.

SourceUniversity of Pennsylvania School of Medicine·JournalNature Medicine·TypeExperimental study·DateMar 13, 2025

An aerosol test for airborne bird flu

Researchers developed a prototype sensor that detects H5N1 viruses in air samples, detecting the virus at levels below an infectious dose. The sensor produced results within 5 minutes and showed over 90% accuracy compared to traditional methods, offering promise for noninvasive air monitoring.

SourceAmerican Chemical Society·JournalACS Sensors·DateMar 7, 2025

Could microRNAs help us understand why different birds react differently to being infected with bird flu?

A recent study found that different birds react differently to being infected with bird flu, and microRNAs may play a key role in this variation. The researchers analyzed blood samples from ruddy turnstones and found 163 different forms of microRNA, including two unique to birds.

SourceNorwegian University of Science and Technology·JournalJournal of Avian Biology·TypeSurvey·DateFeb 18, 2025

New discovery could help protect against influenza

A preclinical trial has uncovered how beta-glucan can 'reprogram' immune cells to prevent lung inflammation and reduce the risk of illness and death from influenza. The study's findings highlight beta-glucan as a promising therapy for influenza and other emerging viral pathogens.

SourceMcGill University·JournalNature Immunology·TypeExperimental study·DateFeb 17, 2025

Update: T cells may offer some protection in an H5N1 ‘spillover’ scenario

A new study by La Jolla Institute for Immunology researchers suggests that many people may already have immune cells on standby to combat the H5N1 virus. The study found similarities between H5N1 and seasonal influenza viruses, allowing scientists to predict cross-reactive T cell responses that could help decrease disease severity.

SourceLa Jolla Institute for Immunology·JournalmBio·TypeData/statistical analysis·DateJan 2, 2025

Single mutation in H5N1 influenza surface protein could enable easier human infection

Researchers discovered a single mutation in the H5N1 virus that improves its ability to attach to human cells, potentially making it easier for humans to become infected. The study's findings stress the importance of continued genomic surveillance and public health preparedness to monitor potential genetic changes.

Preparing for the worst: Healthcare can check readiness for bird flu spread

Infectious disease experts suggest that hospitals closely monitor local and national cases of bird flu and screen patients with flu-like symptoms for contact with farm animals. Effective communication is essential for fostering trust and reducing anxiety among healthcare personnel, patients, and the public.

SourceSociety for Healthcare Epidemiology of America·JournalInfection Control and Hospital Epidemiology·TypeCommentary/editorial·DateDec 5, 2024