Articles tagged with Bacterial Infections
Researchers have discovered a new immune disease that affects the innate immune system of children with a deficiency in the MyD88 gene. The study found that these children can see off other infections but still die from widespread infection by common bacteria like pneumococci and staphylococci.
A nationwide study found a sharp increase in skin infections, with abscesses and cellulitis rates nearly quadrupling in safety-net emergency departments and tripling among children. The study suggests community-acquired MRSA is the main cause of this rise, affecting all populations but those over 45 less severely.
Researchers have discovered two new β-Lactam antibiotics that target MRSA, a major global health threat responsible for approximately 20,000 US deaths annually. The novel compounds interact with the MRSA cell wall enzyme PBP 2a, inhibiting its function and leading to bacterial cell death.
Researchers at the Helmholtz Center for Infection Research discovered that biofilm bacteria use violacein, a pigment produced in response to threats, to neutralize attackers and trigger a suicide mechanism in phagocytes. This finding presents a new avenue for combating human parasites causing diseases like sleeping sickness and malaria.
A new study reveals that cranberry juice alters the thermodynamic properties of bacteria in the urinary tract, creating an energy barrier that prevents attachment. This effect occurs at concentrations comparable to those found in the urinary tract, suggesting regular consumption may prevent UTIs.
Researchers at A*STAR's IMCB have identified peptidoglycan as a factor that causes Candida albicans to become infectious. The discovery may lead to the development of novel treatments for immunocompromised patients infected by the fungus.
A new consortium aims to tackle healthcare-associated infections like MRSA and Clostridium difficile, exploring molecular makeup, hospital staff habits, and data analysis. The £4.2M project will create nine PhD fellows and develop new tools for detecting and controlling infections.
A new study has identified a molecular alarm system in which intracellular pathogens send signals to kick the immune response into gear. The findings shed light on how cells recognize and destroy pathogenic bugs living within their walls, potentially providing new targets for vaccine and drug research.
A three-dose pneumococcal vaccination program has shown a 70% reduction in serious infections among young children in Norway. The vaccine protects against seven serotypes of pneumococcus, responsible for 70% of severe cases.
Researchers have developed molecules that can mimic Yersinia pestis, a type of plague bacteria, to stimulate the innate immune response and protect against pneumonic plague. These synthetic modified lipid A compounds have been shown to be effective in treating infected animals, with up to 93% survival rate.
A new study published in Clinical Infectious Diseases found that patients harboring MRSA for long periods are at increased risk of developing infections, including pneumonia and bloodstream events. The study showed that nearly a quarter of MRSA-colonized patients developed infections within a year or more after colonization was confirmed.
Children with acute osteomyelitis are developing more severe MRSA infections, resulting in longer hospital stays and antibiotic therapy. Researchers found that MRSA infections were associated with higher rates of bone abscesses, muscle inflammation, and the need for surgical drainage.
Recent studies in Papua and New Guinea reveal P. vivax cases, particularly in young children, are more likely to develop severe disease and experience cerebral malaria.
Researchers found that misoprostol suppresses key immune responses and allows deadly infection to occur. The study has implications for understanding rare but life-threatening infections during pregnancy. More than a half-million women have taken the two-drug combination safely since its FDA approval in 2000.
Scientists have discovered a molecular trick used by Salmonella to evade the immune system, giving it crucial time to establish itself in the host before symptoms appear. The AvrA protein helps reduce inflammation, allowing the bacteria to avoid detection and spread more easily.
A study of 290 dental patients found bacteria in the blood after tooth brushing and extractions, but with lower incidence than expected. The researchers suggest that good oral hygiene can reduce the risk of heart valve infection by reducing gingival disease and bacterial species associated with IE.
Researchers suggest that increasing white blood cell count or enhancing infected cells' interaction with the immune system could be effective strategies for developing vaccines or treatments specifically for elderly TB patients. Aging affects the immune response, leading to a slower and less effective fight against the infection.
A study by Cardiff University found that current hospital protocols for antimicrobial wipes can spread pathogens like MRSA. Implementing a single-use, one-surface-per-wipe approach could reduce MRSA incidence in hospitals.
A new vaccine targeting more common pneumococcal strains is on the horizon to replace PCV7, which has seen a rise in non-vaccine strain IPD rates by 40%. The vaccine's effectiveness against resistant bacteria is currently being tested.
A new study by Cardiff University researchers found that antimicrobial-containing wipes used in hospitals can spread pathogens after first use. The study highlights concerns over the suitability of these wipes and the importance of regular surveillance programs to reduce infection risks.
Researchers found that only two strains of Salmonella are common in garden birds, which are sensitive to antibiotics. This contrasts with the more resistant strains found in livestock and humans, highlighting the need for alternative approaches to infection control.
A randomized controlled trial involving 285 students found that disinfecting surfaces and using hand sanitizer reduced gastrointestinal illness-related absences by nine percent. The study suggests that elementary schools consider simple infection control practices to help keep students healthier.
A recent study highlights the importance of understanding C. difficile's toxins and virulence factors, which can cause severe hospital-acquired infections. The research also explores the bacteria's transmission, symptoms, and treatment options, including the development of a potential 'designer' probiotic.
A study found high levels of Staphylococcus aureus and Escherichia coli bacteria in infant deaths that couldn't be explained. The researchers suggest these infections may be associated with unexplained cases of SUDI.
Researchers at Caltech identified a sugar molecule produced by beneficial gut bacteria that induces immune cells to produce anti-inflammatory molecules, potentially treating inflammatory bowel diseases. The discovery suggests a new approach to treating human diseases linked to the loss of beneficial microbial interactions with our bodies.
Surgical antibiotic prophylaxis has increased the risk of Clostridium difficile infection by 21 times, with severe consequences for patients. Researchers suggest minimizing antibiotic duration to reduce risks and benefits.
Researchers at the University of Illinois have identified a novel toxin receptor for H. pylori, allowing the bacterium to survive in the human stomach. The discovery provides valuable insights into the mechanisms of H. pylori's survival and may lead to new therapeutic strategies.
A study found that using silver-coated endotracheal tubes reduced ventilator-associated pneumonia (VAP) rates by nearly 40% and highly resistant infection rates by less than half. The average costs associated with VAP treatment were also significantly reduced due to the impact on length of stay in ICU.
The Burroughs Wellcome Fund has awarded $11.2 million to 15 physician-scientists in recognition of their outstanding contributions to medical research. The Career Awards for Medical Scientists program supports early-career investigators as they transition from mentored positions to independent research careers.
A new study found that swimming pools in remote Aboriginal communities significantly reduced skin, ear, and chest infections. Infections were more than halved in both Jigalong and Mugarinya communities. The pools also provided social hubs and employment opportunities while reducing clinic visits and antibiotic prescriptions.
A study found that doripenem treatment reduced hospital length of stay and time on mechanical ventilation for patients with ventilator-associated pneumonia. Clinical cure rates were similar to those treated with imipenem-cilastatin.
Researchers at the University of British Columbia have discovered how tuberculosis bacteria hide and multiply in human bodies. By identifying a key protein involved in this process, they are working towards therapies that can block its activity, leading to a more effective treatment for TB.
The American Society for Gastrointestinal Endoscopy has updated its guidelines on antibiotic prophylaxis for gastrointestinal (GI) endoscopy, citing a lack of data supporting the use of prophylactic antibiotics solely to prevent infective endocarditis. Clinically significant infections after endoscopic procedures are extremely rare.
A Brazilian study found that urban slums are a source of leptospirosis transmission due to poor sanitation and rodent-borne disease. The study identified households with Leptospira antibodies clustering in squatter areas, highlighting the need for social factors-based prevention strategies alongside improved sanitation.
Researchers have discovered that Type IV pili on bacteria can bundle together and pull with forces far stronger than previously thought possible. This discovery sheds light on the role of pili in initiating infectious diseases such as tuberculosis.
Researchers used a transgenic fruit fly model to study how Salmonella evades immune defenses, finding that the protein AvrA shuts down key signaling pathways. This allows the bacteria to cause severe intestinal infections. The study's results suggest that other pathogens may target similar biochemical networks to avoid elimination.
New research reveals that nicotine reduces neutrophil ability to seek and destroy bacteria, contributing to increased susceptibility to infection in chronic tobacco users. The study also found that nicotine suppresses oxidative burst and increases matrix metalloproteinase-9 release, leading to impaired neutrophil function.
Patients with cystic fibrosis who develop life-threatening lung infections pose significant challenges for lung transplantation. The success rate of lung transplants in these patients is lower compared to those without such infections, sparking debate about whether to allocate donor lungs to them.
A team of scientists has solved the mystery of how proteins control bacterial cell division, a crucial process that can be targeted by new antibiotics. By understanding the role of protein MinC, they have identified a potential target for drug development.
Researchers have identified at least three clays that kill or significantly reduce the growth of MRSA, Mycobacterium ulcerans, E. coli, and Salmonella bacteria. The clays' antibacterial activity is believed to be due to specific compounds within them.
Prebiotic sugars have been shown to reduce Salmonella infection severity in animals, improving health and reducing economic losses. The study's findings suggest a potential solution to the growing problem of antibiotic resistance and foodborne illnesses.
A new species of bacteria, Leptospira licerasiae, has been identified as a cause of severe leptospirosis in the Peruvian Amazon region. The pathogen was found to have novel biological features and is significantly different from other forms of the bacteria.
Infections caused by PVL-Staphylococcus aureus can lead to necrotising haemorrhagic pneumonia with high mortality rates. The UK has seen an increase in PVL-related disease, with around 2% of Staphylococcus aureus strains producing the toxin.
Researchers develop materials impregnated with bacteria-killing viruses to prevent MRSA infection spread in hospitals. The technique allows the viruses to stay active for over 3 weeks, killing bacteria on surfaces and in wounds.
Researchers at the University of Leicester have discovered that TB bacteria accumulate body fat to aid survival during transmission, increasing resistance to anti-TB drugs. This finding challenges established views on bacterial transmission and offers new insights into developing targeted treatments.
Scientists warn of an impending crisis due to superbugs like Acinetobacter that have become resistant to all available antibiotics, including those thought safe. The bacteria cause severe infections, pneumonia, skin, and wound infections, and even meningitis, leading to significant patient mortality.
MRSA cases have increased 10 times in Denmark over the last decade, with community-acquired strains spreading through family and social networks, says Professor Robert Skov. The Danish health system has introduced guidelines to prevent MRSA transmission, but the rising epidemic remains a concern for public health.
Researchers have discovered how HIV evades the immune system by altering a key defence mechanism. The Nef protein interferes with the recognition of infected cells, making it difficult for the body to target and eliminate the virus.
A standard sampling regime is being developed to identify superbug genes in intensive care unit environments. The technique uses polymerase chain reaction (PCR) to characterise micro-organism genes and spot antibiotic resistance, allowing for the detection of MRSA and other drug-resistant bacteria.
Researchers found that Staph aureus produces lactic acid in the presence of nitric oxide, allowing it to thrive. This mechanism makes it difficult for our bodies to defend against the bacteria, making traditional antibiotics less effective.
UC Davis scientists discovered how salmonella becomes lethal for AIDS patients by finding the defect in immune response that allows it to cross the gut barrier and infect other organs. The study suggests Th17 cells play a crucial role in the inflammatory response, recruiting immune system cells to the site of infection.
The APIC Research Foundation's first national C. difficile prevalence study aims to gain a better understanding of the spread of this virulent pathogen, which causes diarrhea and serious intestinal conditions. The study will provide the first national estimate of C. difficile infection in U.S. healthcare facilities.
Researchers report a significant decline in invasive pneumococcal disease rates in all age groups post-PCV7 introduction. Disease caused by non-PCV7 serotypes, especially 19A, is emerging and accounts for nearly all IPD cases.
Researchers at University of Toronto have identified compounds that block the activity of a key protein (ExoS) in cystic fibrosis patients. These compounds may also serve as a model for future therapies against the HIV virus, according to a new study published in PLoS Genetics.
A study found that about 1 in 200 facelift patients developed methicillin-resistant Staphylococcus aureus (MRSA) infections, highlighting the need for screening protocols to identify high-risk patients. The authors recommend considering MRSA colonization and infection risk factors during preoperative evaluation.
Job's syndrome sufferers lack Th17 cells, a type of infection-fighting white blood cell, leading to recurrent and severe infections. The study reveals the importance of Th17 cells in protecting against Staphylococcus bacteria and certain fungal infections.
Research using ERIC-PCR method found that aerobe and facultative aerobes, such as Escherichia coli and Salmonella, become prominent in ducklings' intestines after S. enteritidis infection. The study aims to understand the pathogenesis of S. enteritidis infection.
The National Institute of Allergy and Infectious Diseases (NIAID) is addressing the growing challenge of antimicrobial resistance through a multifaceted research approach. The institute is investing over $800 million annually in basic and translational research to understand the causes, consequences, and treatments of antimicrobial dru...
A £285,000 grant from The Wellcome Trust will support the development of new infection-control methods that do not rely on conventional antibiotics. The team will focus on understanding how Streptococcus bacteria interact with host tissues and proteins to identify targets for prevention.
Researchers have demonstrated that immunization with a stabilized version of M protein found on Streptococcus bacteria can provide protection against Strep infections. The modified M1 protein stimulates the immune system in mice without serious side effects.