Drug resistance is making many diseases increasingly difficult--and sometimes impossible--to treat, according to Anthony S. Fauci, M.D., director of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. “Extensively drug-resistant tuberculosis and invasive methicillin-resistant Staphylococcus aureus (MRSA) infections are just two recent examples of this problem that pose serious threats to domestic and global health,” he adds. In a new report in the Journal of Infectious Diseases, now available online, Dr. Fauci outlines NIAID’s commitment to addressing this urgent public health issue.
The innate ability of microbes to evade containment and destruction by drugs through rapid reproduction and genetic mutation is exacerbated by the overuse and misuse of existing antimicrobial drugs, Dr. Fauci and his coauthors note. Other factors contributing to the upswing in drug resistance include a dearth of rapid diagnostic tests that would allow physicians to better gauge whether a given infection is drug-susceptible or drug-resistant, and a paucity of clinical trial data to guide therapeutic strategies.
NIAID is meeting the complex challenge of antimicrobial resistance through a multifaceted research approach that includes partnerships with other federal agencies, academia, industry and non-governmental organizations, the authors report. In fiscal year 2007, NIAID invested more than $800 million to support basic and translational research on antimicrobials, more than $200 million of which was devoted to understanding the causes, consequences and treatments of antimicrobial drug resistance.
Basic research projects under way at NIAID or in NIAID-supported labs across the country include the following:
Facilitating the translation of basic research findings into better diagnostics, new therapies and novel strategies to slow the emergence of antimicrobial resistance is also an area of emphasis for the Institute, write the authors. The following are examples of the many applied and translational research programs supported by NIAID:
Finally, the authors outline several new and established NIAID partnerships addressing antimicrobial resistance, including
“With antimicrobial resistance, we face the perpetual challenge of maintaining a favorable balance between microbes and humans,” says Dr. Fauci. “The efforts of NIAID and all our partners from the public health, research and pharmaceutical sectors are critical to addressing this challenge and thus keeping us at least one step ahead of our microbial foes.”
In addition to Dr. Fauci, the other authors are N. Kent Peters, Ph.D., program officer for antibacterial resistance, NIAID Division of Microbiology and Infectious Diseases (DMID); Dennis M. Dixon, Ph.D., chief, Bacteriology and Mycology Branch, DMID; and Steven M. Holland, M.D., chief, Laboratory of Clinical Infectious Diseases, NIAID Division of Intramural Research.
NIAID is a component of the National Institutes of Health. NIAID supports basic and applied research to prevent, diagnose and treat infectious diseases such as HIV/AIDS and other sexually transmitted infections, influenza, tuberculosis, malaria and illness from potential agents of bioterrorism. NIAID also supports research on basic immunology, transplantation and immune-related disorders, including autoimmune diseases, asthma and allergies.
The National Institutes of Health (NIH)--The Nation's Medical Research Agency--includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov .
Reference: NK Peters et al. The research agenda of the National Institute of Allergy and Infectious Diseases in antimicrobial resistance. The Journal of Infectious Diseases DOI: 10.1086/533451. (Published online March 2008.)
News releases, fact sheets and other NIAID-related materials are available on the NIAID Web site at http://www.niaid.nih.gov .
The Journal of Infectious Diseases