Articles tagged with Bacterial Infections
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Bacterial infections are common and severe complications in patients with liver cirrhosis, with a global prevalence of 35.1% reported. The most common infection sites were the gastrointestinal tract, ascites fluid, and urinary tract, with gram-negative organisms more frequent than gram-positive organisms.
Researchers at the University of Arizona have developed a copper-based compound that can kill MRSA bacteria by disguising itself as iron. The compound, BMDC, works by delivering a toxic dose of copper to bacterial colonies, making it an effective treatment against drug-resistant infections.
Researchers at NTU Singapore have found that a common bacterium produces reactive oxygen species that impairs wound healing. Neutralizing this process with an antioxidant enzyme restores skin cells' ability to migrate and heal, offering a potential solution to tackle antibiotic-resistant strains.
A comprehensive genomic characterisation of E. coli strains isolated from diabetic foot ulcers reveals high diversity and antibiotic resistance. The study provides valuable insights into the specific pathogens involved in diabetic foot disease and suggests potential targets for improved treatment strategies.
Researchers have made a groundbreaking discovery about how bacteria swim upstream to cause infections, pointing to new designs for biomedical devices that can prevent contamination. The study found that wider channels with faster counterflows are more prone to invasion, but sharp corner designs can inhibit bacterial growth.
A high-protein diet rich in casein and wheat gluten can significantly reduce the amount of cholera bacteria able to infect the gut. The study found that these dietary components can suppress a key structure on the surface of cholera bacteria, making it difficult for the pathogen to colonize and cause harm.
A new study reveals that farmers in the Northeast are facing a growing threat of tick-borne diseases, which can be devastating to their livelihoods. The research found that farmers often experience multiple tick bites per month, with some contracting serious illnesses like Lyme carditis.
A systematic review and meta-analysis found that ceftazidime-avibactam is more effective than standard antibiotic therapy in managing drug-resistant Klebsiella pneumoniae infections. The treatment also showed a lower rate of adverse reactions and mortality. The results suggest that ceftazidime-avibactam is a more favorable choice for c...
A study published in the International Journal of Infectious Diseases found that delafloxacin inhibits Legionella replication more effectively than levofloxacin. The antibiotic demonstrates promising intracellular activity, which could support further clinical investigation as a potential treatment for Legionnaires' disease.
Public Health Alerts provide concise, data-driven information on disease outbreaks and urgent health events. The new series, launched by NEJM Evidence and CIDRAP, offers expert-reviewed reports to support public health evidence-based care.
Researchers at TUM developed a new method that allows for direct analysis of urine to determine antibiotic resistance in urinary tract infections. The test reduces the time to result by up to 24 hours compared to conventional testing, enabling healthcare providers to prescribe more targeted treatments.
A team of researchers has identified two proteins critical to the destruction of red blood cells by the Oroya fever pathogen. This discovery paves the way for a potential novel therapy against this deadly neglected tropical disease.
A new study from the University of Gothenburg has found that high teenage BMI and poor physical fitness are associated with a higher risk of developing severe bacterial infections in adulthood. The study, which followed over 44,000 men for three decades, shows that even at high normal weight, individuals are already at increased risk.
A SickKids-led study reveals how bile acids can bind to block C. diff's most dangerous toxin, leading to the development of a new compound that neutralizes the toxin directly in the gut. This approach preserves gut health and targets the toxin with precision, offering hope for safer treatments.
A study suggests that volcanic activity around 1345 CE led to crop failures and famine in southern Europe, prompting Italian city states to import grain shipments from the Black Sea region contaminated with Yersinia pestis. This grain trade may have exacerbated the spread of the plague across Europe.
Researchers from North Carolina State University have confirmed a new species of Rickettsia bacteria found in dogs, associated with symptoms similar to those of Rocky Mountain spotted fever. The new species, Rickettsia finnyi, has been cultured and sequenced, and its genome revealed a unique circular chromosome.
Researchers have developed a new molecular test to identify Lyme disease earlier and more accurately than traditional methods. The test can detect as few as five bacterial cells and has an estimated sensitivity of 90.9%, making it a potential new avenue for testing Lyme disease.
Researchers have discovered that manganese is both an armor and a weakness for the Lyme disease bacterium, Borrelia burgdorferi. Exploiting this vulnerability could lead to new therapeutic strategies for treating the disease.
The Phase 3 study demonstrated the safety and non-inferiority of EuTYPH-C Inj.® Multi-dose compared to a World Health Organization (WHO) prequalified comparator TCV, Typbar TCV®. The vaccine was shown to be well-tolerated across all age groups with no serious adverse events.
Researchers from the University of Edinburgh have identified a new mechanism of resistance to common antibiotics, targeting a special repair system possessed by certain bacteria. This discovery could aid efforts to combat antimicrobial resistance, one of the world's most urgent health challenges.
A Phase 2a clinical trial demonstrated the efficacy of an intravenous bacteriophage therapy in treating complicated Staphylococcus aureus bacteremia. The treatment showed encouraging results and was safe for patients with this serious bacterial infection.
A recurring seasonal outbreak pattern of Salmonella Strathcona cases has been identified in Europe since 2011, with small tomatoes from Sicily being the likely source. The investigation found that almost all cases were genetically related, suggesting a common source and food vehicle.
The winners of the Applied Microbiology International Horizon Awards 2025 have been recognized for their groundbreaking contributions to global challenges through applied microbiology. The awards celebrate excellence across various domains, including drug discovery and sustainable agriculture.
Researchers create novel compounds that kill bacteria in a new way, reducing the risk of side effects and environmental harm. The compounds have been shown to be effective in preventing bovine mastitis without affecting milk quality.
A new study reveals rising rates of invasive SDSE infections across Australia, particularly among older Australians and those from remote regions. The research highlights disparities in health outcomes between regions and populations, emphasizing the need for improved surveillance and prevention strategies.
Researchers argue that AI can strengthen pandemic preparedness by detecting emerging diseases earlier. By combining data from humans, animals, and the environment, AI can reveal patterns and provide insights into potential pathogens.
Researchers from UCL and Imperial College London have discovered how life-saving antibiotics called polymyxins target the outer layer of Gram-negative bacteria. By triggering the production and shedding of this armor, polymyxins create gaps in the cell's defenses, allowing the antibiotic to enter and kill the bacteria.
Researchers at the University of Oregon have discovered a new treatment approach using a two-drug combination that is 10,000 times more effective than single-drug antibiotics in killing bacterial cells in lab tests. This promising method could help shorten treatment time and reduce toxicity in patients with chronic wound infections.
Yale researchers have developed a novel diagnostic method for detecting leptospiral virulence-modifying proteins in blood and urine, which could lead to early diagnosis and improved treatment options. The test has the potential to transform leptospirosis management globally by enabling timely treatments and mitigating disease severity.
The Gladstone Infectious Disease Institute is broadening its research scope to tackle pressing health challenges beyond viruses. Scientists are discovering new ways to combat antibiotic-resistant bacteria and explore the interconnectedness of viruses and bacteria in causing chronic diseases.
A cohort study reveals oral bacteria and fungi as significant risk factors for pancreatic cancer development. The findings suggest that oral microbiota may serve as biomarkers to identify individuals at high risk of pancreatic cancer, potentially contributing to personalized prevention strategies.
A new review article highlights the need for effective control and prevention strategies for sexually transmitted gut infections, which can persist longer and be harder to treat. The authors emphasize the importance of prompt diagnosis, appropriate treatment, and community-level education and testing.
Researchers at Auburn University have discovered the strongest natural protein bond ever recorded, revealing how Staphylococcus aureus clings tightly to human skin. The study found that calcium plays a key role in fortifying this grip, making it stronger and more resistant to breaking.
Researchers funded by the National Institutes of Health found that a single injection of benzathine penicillin G successfully treated early syphilis just as well as the three-injection regimen used by many clinicians. Biological markers showed that 76% of participants in the single-dose group had a serologic response to treatment, comp...
Engineered peptides form nanonets that trap and kill bacteria, while leaving healthy cells untouched. The technology could inspire next-generation biomaterials for treating bacterial infections.
A multicenter study in China found that patients with liver cirrhosis were prone to community-acquired pneumonia and spontaneous bacterial peritonitis, with Klebsiella pneumoniae and MDR organisms being major concerns. The study highlights the need for region-specific strategies to improve outcomes for this vulnerable population.
Scientists create a way to eliminate harmful bacteria from the gut to prevent infections by using beneficial bacteria as an alternative. The approach has shown promising results in laboratory tests and mouse models.
A review led by Oregon Health & Science University researchers suggests that the US could save $1 billion a year by dropping adult tetanus and diphtheria booster shots if childhood vaccination rates remain strong. The safety of this approach depends on maintaining high childhood vaccination coverage.
The European Centre for Disease Prevention and Control warns of an increased risk of Vibrio infections throughout the summer season due to rising sea surface temperatures. Several northern countries bordering the Baltic Sea have reported increases in recent years, with serious infections possible through foodborne or skin contact.
Researchers propose using chemical sensors to diagnose bacterial infections by detecting volatile organic compounds in bodily fluids, providing a rapid and affordable diagnostic test. The technology has the potential to improve treatment plans and combat antibiotic resistance.
A new study finds that Salmonella Dublin causes increased calf mortality, lower milk yield, and higher medication costs in dairy farms. The disease leads to hidden financial losses due to gradual infection without visible symptoms.
Researchers have identified genetic bottlenecks that explain the emergence of pandemic cholera strains. These specific combinations of genes and allelic variants grant an advantage in human intestinal colonization, allowing a small subset of Vibrio cholerae to become deadly pathogens.
The American College of Chest Physicians (CHEST) has launched a critical care APP education and certification program, covering 11 topic areas including patient-centered care and pharmacology. The CCAPP Certification Exam is now available, with an August 5 deadline to apply for the 2025 exam.
Researchers discovered how urban rat migration spreads leptospirosis, a deadly disease, and developed a novel technique for testing rat kidneys. The study used advanced molecular techniques to analyze DNA from 328 rat kidney samples collected from 17 sites in Boston, finding that 59 rats were positive for Leptospira bacteria.
A new study found that many home washing machines are insufficient for decontaminating healthcare worker uniforms, allowing antibiotic-resistant bacteria to survive. The researchers propose revising laundering guidelines or using on-site industrial machines to improve patient safety.
Scientists have discovered a novel immune signaling pathway in bacteria that turns viral infection machinery against the virus, potentially informing future biotech tools and phage therapy. This discovery reveals an ancient defense strategy that could help fight superbugs.
Researchers at Amsterdam UMC have developed a new diagnostic test that measures CRP protein in cerebrospinal fluid to quickly diagnose bacterial meningitis. The test has been shown to be very reliable and can start treatment within half an hour of diagnosis.
A hospital-based outbreak detection system has been shown to prevent infections, save lives and cut costs. The Enhanced Detection System for Healthcare-Associated Transmission (EDS-HAT) uses genomic sequencing to analyze infectious disease samples from patients, identifying near-identical strains that flag potential outbreaks.
Researchers at the University of Oregon have discovered a molecule produced by yeast living on human skin that shows potent antimicrobial properties against Staphylococcus aureus. The fungus, Malassezia sympodialis, transforms host lipids into antibacterial hydroxy fatty acids that can kill the bacteria in as little as 15 minutes.
Researchers at UMass Amherst's New England Center of Excellence in Vector-borne Diseases have identified a new strain of Rickettsia bacteria that causes spotted fever infections in humans. The discovery in Maine suggests rabbit ticks could be a zoonotic vector for serious infections, contradicting the usual dog tick vector.
Researchers discovered that CsrA gathers in droplet-like structures inside cells to control bacterial gene activation. These compartments help bacteria adapt to environments and switch between harmless and virulent states.
The ERA4TB project aims to develop new antibiotics against TB, while TAINT-TB focuses on contrast agents for precise diagnosis. The TCOLF-TC312 project uses humanized mice to study TB and its interactions with the immune system.
A study found that patients who experienced vision impairment due to microbial keratitis had poorer treatment outcomes if they delayed seeking medical attention or had more extensive eye damage. In contrast, patients in the US who wore contact lenses had better outcomes, possibly due to earlier treatment by their physicians.
Adding an experimental cancer drug to standard TB treatment reduces lung damage and prevents post-TB lung disease in mice. Researchers found that the drug doubled pulmonary apoptosis and reduced lung scarring by 40% compared to standard treatments.
Researchers developed a chemical probe to study Mycobacterium tuberculosis outer envelope component mycolic acid, revealing its role in evading immune responses. The probe provides insight into the pathogen's survival mechanisms and may inform new treatment strategies.
A new study by Hokkaido University found that colder temperatures significantly increase the risk of gastroenteritis among Rohingya refugees in Bangladesh's Kutupalong and Nayapara camps. The study reveals a link between temperature changes and gastroenteritis risk, with both extreme cold and heat contributing to higher numbers of cases.
A new study from the University of Oxford reveals that a molecule called glycosyrin, produced by the bacterium Pseudomonas syringae, mimics galactose to suppress plant immune responses. This finding has potential medicinal applications and highlights the complex strategies used by bacteria to manipulate host plants.
The study found that mitochondrial membrane potential (MMP) of CD8+ T cells is a significant predictor of bacterial infection (BI) and acute-on-chronic liver failure (ACLF) in cirrhotic patients. Low MMP levels were associated with increased risk of BI and ACLF.
Researchers detected widespread contamination of retail chicken meat in Bangladesh with antibiotic-resistant E. albertii, a lesser-known but deadly pathogen. The study highlights the need for improved hygiene measures and stricter regulations to prevent foodborne infections.
A new breath test has been developed to diagnose and monitor bacterial infections. The test is non-invasive and can detect various types of bacteria, making it a promising tool for early detection and treatment.