Articles tagged with Bleeding
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A new reversal agent, andexanet alfa, effectively stopped acute life-threatening bleeding in patients taking factor Xa inhibitor blood thinners. Researchers found that good or excellent hemostasis occurred in 81.7% of patients after administering the reversal agent.
Researchers found that intensive blood pressure lowering reduces the risk of bleeding in the brain after 'clot-busting' treatments for acute ischaemic stroke, making thrombolysis safer. However, this didn't translate to improved overall outcomes for patients.
Researchers found that removing 70% or more of the blood via minimally invasive surgery can lead to better functional outcomes and milder disability one year later. The study also suggests that the amount of residual blood left at the end of treatment plays a crucial role in determining the success of the procedure.
A large international clinical trial found that intensive blood pressure lowering safely reduces the risk of brain bleeding in ischemic stroke patients being treated with clot-busting drugs, but did not improve post-stroke recovery. The study also showed no harm identified for intensive blood pressure management.
Patients on SSRIs are 40% more likely to develop severe GI bleeding when taking NSAIDs, according to a review in the Journal of the American Osteopathic Association. Physicians should educate patients on recognizing symptoms and monitor for bleeding risks during SSRI therapy.
A new study published in JAMA found that frequent aspirin use can lead to a 50% increase in major bleeding episodes. While aspirin reduces cardiovascular event risks, it increases the risk of major bleeding, making its use for initial prevention uncertain.
A meta-analysis of 13 clinical trials involving over 164,000 participants found that aspirin use was associated with a lower risk of cardiovascular events, including death, heart attack, and stroke. However, it also increased the risk of major bleeding in people without pre-existing cardiovascular disease.
Researchers at Rutgers University developed a way to reduce bleeding in patients after bariatric surgery. They found that endogenous thrombin potential (ETP) measurement provides a more accurate assessment of the best dosage for blood thinners, reducing the risk of minor and major bleeding.
Recent updates in stroke research focus on understanding cellular death mechanisms triggered by neuronal damage and astrocyte loss. Novel treatment alternatives, including restoration of blood flow control, are discussed as potential alternatives to existing therapies.
A Massachusetts General Hospital team developed an AI system to diagnose and classify brain hemorrhages using CT scan images. The system can provide the basis for its decisions by highlighting key features of each subtype.
A new study reveals that short-term stress in surgeons can lead to a 66% increase in mistakes during operations, which can cause bleeding, torn tissue, or burns. The research, published in the British Journal of Surgery, could lead to protocols aiming to reduce acute stress on surgeons.
A Vanderbilt University Medical Center study shows that combining PPIs with oral anticoagulants reduces the risk of gastrointestinal bleeding by 34% among high-risk patients. This protection is most significant for those taking warfarin, with a hospitalization rate reduced from 4% to 2.8% per year.
A new study published in Circulation found that fish oil did not increase perioperative bleeding in surgery patients. Higher blood omega-3 levels were associated with a lower risk of bleeding.
A new oral drug significantly reduced menstrual bleeding in over 90% of premenopausal women with fibroid tumors. Elagolix also prevented estrogen-deficiency induced side effects like hot flashes and bone loss when prescribed with hormone therapy.
Researchers discover plant-based compound rutin reduces bleeding and inflammation caused by snake venom, offers potential co-treatment with antivenom for snakebite patients in countries without access to antivenom. The study's findings indicate a great potential for rutin as an ancillary drug in conjunction with antivenom therapy.
A multicenter study involving over 2,400 first-time pregnant women found that delaying pushing during labor increases the risk of severe postpartum bleeding, infections, and sepsis. In contrast, immediate pushing is associated with lower rates of infection and excessive bleeding.
A randomized clinical trial examined the timing of pushing during delivery, finding no significant difference between immediate and delayed pushing in rates of natural delivery or adverse outcomes among newborns. However, rates of hemorrhage and infection were higher among women who delayed pushing.
A recent NIH-funded study calls into question common practice of delaying pushing during the second stage of labor. Women who pushed immediately had a shorter average duration of labor and lower rates of infection and bleeding compared to those who delayed pushing.
Researchers discuss bivalirudin's role in reducing bleeding complications and its potential for increased acute stent thrombosis risk. The study aims to clarify the optimal anticoagulation strategy for interventional cardiovascular procedures.
A new protein called emicizumab, administered via subcutaneous injection, has shown significant reductions in bleeding episodes in patients with haemophilia A. Weekly and fortnightly dosing regimens have been found to reduce bleed rates by 96% and 97%, respectively.
The ARRIVE study found that daily aspirin use did not reduce cardiovascular events, but participants who took aspirin had fewer heart attacks. Aspirin reduced the risk of total and nonfatal myocardial infarction in certain age groups, but increased gastrointestinal bleeding rates.
Patients with cardiovascular disease who experience major internal bleeding are more likely to be diagnosed with cancer, particularly gastrointestinal and genitourinary tract cancers. The study, which involved over 27,000 patients in 33 countries, suggests that bleeding may serve as an early warning sign for occult cancers.
The COMPASS trial found a significant link between major bleeding events and new cancer diagnoses in patients treated with anticoagulants. Patients who experienced bleeding were more than 20% likely to receive a new cancer diagnosis.
Research identified four simple checks on brain scans that can help doctors predict patients at risk of further bleeding after a brain hemorrhage. These checks can be applied during routine care to monitor patients and improve survival rates, especially in low- or middle-income countries where access to advanced CT angiography is limited.
RCSI and Bayer are working together to create new, tailored treatments for people with severe haemophilia. The goal is to promote blood clotting with increased precision, improving the quality of life for those affected by this condition.
Endometrial cancer is found in most cases of postmenopausal bleeding but the risk is relatively low at 9%. Early detection strategies for postmenopausal bleeding are needed to improve survival rates.
A California-based bariatric center reduced postoperative complications, including rehospitalization and infections, despite increasing its surgical volume. The center's quality improvement project involved implementing standardized processes and educating staff to reduce bleeding and urinary tract infections.
Researchers at UMBC developed nanoparticles that increase blast trauma survival rates and reduce anxiety. The nanoparticles also protect the brain from damage by reducing signs of inflammatory cells and neural cell death.
A study found that direct oral anticoagulants increase the risk of bleeding in patients with chronic kidney disease, highlighting the need for caution in their prescription. The findings suggest a higher risk of bleeding events compared to conventional anticoagulant warfarin use.
A study published in The BMJ found that direct oral anticoagulants (DOACs) are associated with reduced risks of major bleeding compared to warfarin. Apixaban was shown to have the lowest numbers needed to treat over six months to avoid one extra major bleed.
A recent study published in Neurology found that black and Hispanic people are at higher risk of having another intracerebral hemorrhage, or bleeding stroke, compared to white people. The study, which analyzed data from over 2,200 patients, also found significant racial differences in blood pressure and its impact on stroke risk.
A new study categorizes GI bleeding outcomes by cause, revealing high readmission rates and significant differences in length of stay and mortality. The findings suggest grouping patients by type of MS-DRG and clinical conditions could provide a more accurate assessment of quality metrics.
Dr. Alfonso Iorio has been appointed the inaugural holder of the Bayer Chair for Clinical Epidemiology Research and Bleeding Disorders at McMaster University. He will focus primarily on inherited blood disorders such as hemophilia A, hemophilia B, and von Willebrand disease to optimize treatment strategies.
Subarachnoid hemorrhage can disrupt brain signaling, leading to extreme constriction of blood vessels and energy deprivation. The 'negative ultraslow potential' is an electrophysiological correlate of infarction and tissue death due to inadequate blood supply.
MIT researchers have developed an ingestible sensor equipped with genetically engineered bacteria that can diagnose bleeding in the stomach or other gastrointestinal problems. The sensor, powered by ultra-low-power electronics, can detect biological signals in near real-time and transmit data to a smartphone.
A clinical trial involving over 4880 participants found that combining clopidogrel and aspirin reduces the risk of secondary stroke within 90 days. However, it also increases the risk of major bleeding, with most episodes being non-fatal and not brain-related.
A new study published in The New England Journal of Medicine found that combining clopidogrel and aspirin reduces the risk of major stroke within 90 days after a minor stroke or transient ischemic attack (TIA) by 25%. However, this combination also increases the risk of bleeding complications.
A recent study found that giving tranexamic acid to people with intracerebral hemorrhage reduced early deaths and bleeding in the brain. However, further research is needed to fully understand its potential benefits.
Women experiencing vaginal bleeding for more than one day during the first trimester may have smaller babies. Infants born to these women are at twice the risk of being small for gestational age.
Researchers found that hands-on instruction and retention testing are critical to proper bleeding control. In-person training resulted in an 88% correct tourniquet application rate, compared to 16% for those with no training.
The AVIATOR 2 international registry found significant discrepancies between physician-perceived risks and calculated scores for stroke, ischemic risk, and bleeding in patients with AF undergoing PCI. The study used a novel smartphone-based survey to capture physician and patient perspectives on antithrombotic therapies after PCI.
A University of British Columbia bioengineer has created platelets with extra powers to aid in the coagulation process, potentially rescuing blood from massive bleeding. The modified platelets showed improved clotting times and stronger clots in various blood samples.
A study published in the Journal of the American College of Surgeons found that tourniquet use improves survival rates for civilian trauma victims with vascular injuries of the arms or legs. The study involved 1,026 patients and showed that those who received a tourniquet had significantly lower mortality rates than those who did not.
A novel protein derived from a parasite has been identified as a therapeutic molecule to reduce bleeding and pain associated with chemotherapy-induced hemorrhagic cystitis. The protein, IPSE, was found to be equally potent as the current standard of care in suppressing bladder hemorrhaging and pain.
A team of researchers from Texas A&M University has developed an injectable bandage using a gelling agent commonly used in pastries, which can stop bleeding and promote wound healing. The injectable hydrogels are made with kappa-carrageenan and nanosilicates to form a controlled release of therapeutics.
The experimental drug andexanet has been shown to control serious bleeding in patients taking Factor Xa inhibitors. The study found that andexanet rapidly reversed the anticoagulant effect of these drugs without significant safety problems, achieving clinical hemostasis in 83% of patients.
Patients treated with dabigatran had a 28% lower risk of major cardiovascular complications compared to those receiving a placebo. Dabigatran also showed significant benefits in reducing the risk of specific events such as heart attack, stroke and blood clots.
A new study found that using genetic information to inform drug choice reduced adverse events by 42 percent in patients with acute coronary syndrome. Genetic testing led to different prescribing patterns, including more frequent use of prasugrel and ticagrelor.
In a trial of over 3,800 patients treated for STEMI at more than 180 centers, researchers found that ticagrelor is safe to use in combination with clot busters in patients younger than 75. The study met its primary endpoint indicating no difference in major bleeding rates between ticagrelor and clopidogrel.
Scientists from ITMO University have developed a new treatment for internal bleeding using magnetically-driven nanoparticles containing thrombin. The treatment reduces overall blood loss by 15 times and accelerates local clot formation.
A study presented at the ARRS 2018 Annual Meeting found that emergency patients are often given unnecessary head CT scans, leading to radiation exposure and healthcare costs. Motor vehicle accidents were associated with a higher rate of non-indicated CT examinations.
A Phase 2 clinical trial shows that patients with acute ischemic stroke can safely tolerate high doses of 3K3A-APC, a promising anti-stroke drug. The treatment also substantially reduced cerebral hemorrhage in patients.
Biomedical engineers developed a miniaturized system mimicking blood vessel injury, allowing for the study of bleeding and clotting. The device replicates all aspects of blood vessel injury, including clot formation and repair, and responds to drugs and other alterations.
A review of clinical data from trials and observational studies suggests that prasugrel and ticagrelor reduce major adverse cardiac events compared to clopidogrel, but with increased bleeding risk. Prasugrel shows superior benefits in STEMI patients
A study published in Mayo Clinic Proceedings reports significant improvements in HHT patients with severe bleeding treated with intravenous bevacizumab. The treatment reduced nose and gastrointestinal bleeds, allowing patients to stop or reduce blood transfusions, improving quality of life.
More than 2,000 maternal-fetal medicine specialists will present research on preventing postpartum hemorrhage, reducing cesarean births, and treating opioid misuse during pregnancy. The Society for Maternal-Fetal Medicine's annual meeting in Dallas aims to reduce high-risk pregnancy complications and promote public policy advancements.
Researchers found that tranexamic acid prevents blood loss after vaginal births and postpartum hemorrhage among women with operative vaginal deliveries or episiotomies. The study, presented at the Society for Maternal-Fetal Medicine's annual meeting, suggests TXA should be considered for women at risk of PPH.
Spontaneous subarachnoid hemorrhage is a rare type of stroke occurring in 6% of pregnant women, with better outcomes compared to non-pregnant women. Pregnant women with sSAH have lower mortality rates and are more likely to be discharged home.
Researchers at the University of Edinburgh identified a key protein driving repair of the womb lining during menstruation, which is reduced in women with heavy periods. Boosting levels of this protein shows promise as a novel, non-hormonal treatment to reduce blood loss and improve tissue repair.
Researchers have measured and mapped the key molecular forces on platelets that trigger blood clotting. The findings suggest that platelets care about the direction of forces applied to them, requiring a lateral force signal to prevent unnecessary clotting.