Articles tagged with Bleeding
A new simulation method predicts blood flow conditions that cause pathological behavior of the human blood protein vWF. This breakthrough has the potential to optimize the design of left ventricular assist devices used in heart failure patients and improve diagnosis and treatment of von Willebrand disease, a common inherited bleeding d...
The HOST-EXAM trial found that patients who received clopidogrel experienced a 30% reduced risk of adverse events compared to those on aspirin. This study confirms the effectiveness of long-term maintenance therapy with clopidogrel as an alternative to aspirin for patients who have completed dual antiplatelet therapy.
Switching from high-potency DAPT (ticagrelor) to less potent clopidogrel after 30 days reduced major cardiac events, including heart attacks and strokes. In a study of over 2,700 patients, de-escalation was shown to be safe and more effective than continuing on ticagrelor.
Researchers have identified a specific mechanism of von Willebrand Factor (vWF) that enables it to bind to platelets and initiate clotting. The discontinuous autoinhibitory module (AIM) is a prime site for new antithrombotic drug development.
The study confirms long-term DAPT as an optimal treatment option for ACS patients following PCI, reducing ischemic events without increasing bleeding. Extended DAPT was associated with a lower risk of major cardiovascular events without an increase in bleeding events in high-risk patients.
Increased tourniquet use in Los Angeles County has improved patient survival and reduced the need for blood transfusions. The study found that patients with prehospital tourniquets had lower mortality rates, fewer delayed amputations, and lessened blood transfusion requirements.
A new study found that Black and Hispanic stroke survivors are at higher risk of having changes in the brain's blood vessels that can lead to a second bleeding stroke. The research, published in Neurology, suggests that these differences may be due to disparities in healthcare access and severity of cerebral small vessel disease.
Among people critically ill with COVID-19 hospitalized in an intensive care unit (ICU), a large study found that only 2% experienced a stroke after admission. Hemorrhagic stroke was linked to a significantly higher risk of death, while ischemic stroke did not increase mortality.
A new study found that COVID-19 significantly increases the risk of in-hospital death among patients with hemorrhagic stroke, leading to longer hospital stays and more medical complications. Patients from racial and ethnic minorities, as well as those with obesity and diabetes, were particularly vulnerable.
The FDA has approved supplements to biological license applications for Octaplas and fibryga, strengthening Octapharma USA's pediatric critical care product portfolio. The new labels provide results from post-marketing studies evaluating the products' efficacy, safety, and tolerability in newborns through age 20. Fibryga's indication i...
A study of over 56,000 patients found that new users of direct oral anticoagulants (DOACs) had lower risks for ischemic stroke or systemic embolism and major bleeding events compared to warfarin. DOACs were associated with greater effectiveness and fewer major bleeding events in adults with valvular atrial fibrillation.
A new study found that hysterectomies are used more frequently to treat significant postpartum bleeding than uterine artery embolization, a minimally invasive procedure. The procedure resulted in longer hospital stays and higher costs.
A large study found that people taking antidepressants were no more likely to have an intracerebral hemorrhage than those who didn't take such medications. Researchers analyzed data from over 127,000 stroke patients and found a slight decrease in risk associated with antidepressant use.
Researchers found that CD14+ macrophages and neutrophils change rapidly in the brain after hemorrhage, with signatures consistent in patients with good recovery. Inhibiting inflammation may improve patient outcomes, and targeting specific molecular circuits could unlock new treatment options for ICH.
Researchers have developed a new tool to address disseminated intravascular coagulation (DIC) by targeting blood clots with nanogel spheres loaded with tissue-type plasminogen activator. In vivo studies show promising results in rat models and in vitro tests using DIC patient blood plasma.
Researchers develop hydrogel dressings that can promote wound healing, absorb excess fluid, and prevent infection. These biodegradable dressings are better suited for irregular and deep wounds than traditional bandages.
A new study published in Neurology found that the incidence of stroke is declining among people aged 70 and older. The researchers also discovered a steady rate of stroke incidence among younger adults, with fewer deaths from the disease overall.
A study of critically ill COVID-19 patients found that early therapeutic anticoagulation did not reduce the risk of death, but may increase the risk of major bleeding. The study analyzed data from over 3,200 patients and used simulation to estimate the effects of treatment on clinical outcomes.
A new study found that some COVID-19 patients have an unbalanced ability to break down clots, contributing to a high bleeding risk. This imbalance is linked to a potential clinical biomarker seen in later stages of the disease and may be consistent with recent trial pauses.
A new University of Washington study found that bleeding gums on gentle probing and retinal hemorrhaging are associated with low vitamin C levels in the bloodstream. Increasing daily vitamin C intake helped reverse these bleeding issues.
A new 90-day dual-purpose vaginal ring containing dapivirine and levonorgestrel has shown promising results in preventing both HIV and unintended pregnancy. The study found that the ring delivered sustained levels of each drug, likely sufficient for protection against both, with minimal bleeding concerns.
The American Society of Hematology, International Society on Thrombosis and Haemostasis, National Hemophilia Foundation, and World Federation of Hemophilia have developed joint clinical practice guidelines for von Willebrand Disease (VWD). The guidelines provide recommendations for diagnosis and management, including the use of injecta...
Researchers found that laypeople underestimate blood loss in female victims more than male victims, regardless of volume, and perceive it as less life-threatening. This knowledge can inform the design of training programs to teach people how to respond effectively in emergency situations.
Researchers have created a new composite hydrogel with tantalum particles that can effectively seal off damaged blood vessels, providing rapid and stable bleeding control. The gel exhibits shear-thinning capabilities, allowing for easy deployment using standard catheters.
A USF Health-Tampa General Hospital study found that obese women experience worse outcomes after postpartum hemorrhage, even with the same medical treatment. The researchers suggest that certain groups of high-risk obstetric patients, such as obese women, may need additional support or a different treatment protocol.
Researchers at Sungkyunkwan University found that stem cell-derived extracellular vesicles can reduce severe intraventricular hemorrhage-induced brain injuries in newborn rats. The neuroprotection is primarily mediated by BDNF transfer via EVs, providing a promising potential treatment for bleeding in the brain.
A National Eye Institute-supported clinical study found that surgical and injectable drug approaches are equally effective in treating bleeding inside the eye from proliferative diabetic retinopathy. Most participants needed both treatments to improve vision over two years. The findings provide useful guidance for clinicians managing p...
Researchers evaluated the efficacy and safety of fibryga, Octaplas, and Octaplex in treating congenital and acquired bleeding disorders. Fibryga demonstrated efficacy in on-demand treatment and perioperative prophylaxis for patients with rare congenital fibrinogen deficiency.
Two new posters will present investigative treatment options using NUWIQ and WILATE for rare bleeding disorders. The research focuses on long-term prophylaxis with Simoctocog Alfa for hemophilia A, as well as the use of a von Willebrand Factor/Coagulation Factor VIII Complex for treatment of inherited platelet disorders.
Researchers at Children's Hospital of Philadelphia (CHOP) resolved a severe lymphatic disorder in a girl with Noonan Syndrome by targeting the SOS1 gene pathway. The treatment, an MEK inhibitor, led to a resolution of symptoms within three months and complete remodeling of her lymphatic system.
A one-month treatment of dual anti-platelet therapy is safe and as effective as a longer duration of therapy at preventing cardiac events in patients one year after stent placement. This study evaluated the safety and effectiveness of two durations of dual anti-platelet therapy in patients who had drug-eluting stent placement or polyme...
A recent Finnish study found that subarachnoid hemorrhage is the 12th most common cause of death in middle-aged women and exceeds deaths from car crashes or cerebral infarctions. The disease can be largely prevented through healthy lifestyles, including not smoking and preventing high blood pressure.
A follow-up study of infants found that those with asymptomatic subdural hemorrhages as newborns had normal neurodevelopmental scores and gray matter volumes at age two. The research suggests that small brain bleeds may not have a significant impact on cognitive development.
A new study suggests that aspirin use is most beneficial for individuals with high coronary calcium scores and a low risk of bleeding. The research found that for patients with CAC scores above 100, aspirin's benefits outweigh its risks, but this effect only applies to those with inherent low bleeding risks.
Engineers at Monash University developed a portable and cheap diagnostic that measures fibrinogen concentration in blood. This simple test can diagnose hypofibrinogenemia in critically bleeding patients anywhere in the world, reducing treatment time by up to five times.
A randomized trial comparing a nano-coated coronary stent with shorter dual anti-platelet therapy (DAPT) to a drug-eluting stent (DES) with guideline-recommended DAPT duration found no reduction in bleeding or thrombotic events. The study included 996 patients and found the rate of bleeding in the test group was 7.5% compared to 8.9% i...
A meta-analysis of bivalirudin versus heparin in patients with myocardial infarction (MI) found that bivalirudin was associated with similar overall rates of 30-day mortality but lower rates of serious bleeding. In STEMI patients, bivalirudin use reduced all-cause mortality and serious bleeding.
A 10-year study from Flinders University has found that removing only a portion of the tonsil can significantly reduce pain and bleeding after surgery. Children who underwent this partial removal procedure returned to normal activities in under half the time compared to those who had their entire tonsil removed.
Researchers identify key risk factors for acute kidney injury (AKI) in patients with intracerebral hemorrhage (ICH), including higher baseline serum creatinine levels and higher doses of nicardipine, which increase the risk of AKI and death within three months
Researchers at the University of Pittsburgh School of Medicine have developed a blood-clotting agent that can improve survival rates for severely injured trauma patients. The drug, tranexamic acid, was found to be safe and beneficial in certain subgroups of patients who received it early.
Two new studies demonstrate the lifesaving impact of STOP THE BLEED training in low-to-middle income countries. In Sierra Leone, nearly all patients survived life-threatening bleeding emergencies after receiving training, and participants retained knowledge for over a year. In Connecticut, course attendees showed strong proficiency in ...
A preliminary study has identified several genetic mutations associated with a reduced risk for postpartum hemorrhage. The common theme among these mutations is their proximity to genes linked to the immune system.
Intramuscular tranexamic acid injection can rapidly absorb and reach lifesaving levels within 15 minutes, expanding access to urgent treatment for trauma victims. The new method requires less training and takes less time than traditional intravenous injections.
A new study published in Stroke Journal Report found a significant link between smoking and subarachnoid hemorrhage (SAH), a type of bleeding stroke. Heavy and moderate smokers had three times the risk of fatal SAH, while light smokers had slightly less risk.
Researchers found that prophylactic treatment with direct-acting antivirals prevented chronic hepatitis C virus infection in patients receiving kidneys from HCV-positive deceased donors. The approach has potential to shorten waiting times on the organ waitlist.
A new wearable device could accurately assess blood loss due to hemorrhage using seismic vibrations and electrical signals from the heart. The device would provide a numerical score indicating the severity of cardiovascular system performance, helping first responders make life-saving decisions.
The POPular TAVI trial found that aspirin alone significantly reduced bleeding rates compared to aspirin with clopidogrel after TAVI. Aspirin therapy was also superior for secondary outcomes, including non-procedural bleeding and thromboembolic events.
Healthcare providers can empower adolescents by addressing concerns and educating them on effective contraception options. The etonogestrel implant is a highly effective and reversible method that can be tailored to individual needs.
A new study found that follow-up calls made the evening after Mohs micrographic surgery best identified patients with active pain. However, no single group was able to identify bleeding complications or highest pain levels. The study suggests that standard phone calls may not strongly contribute to overall patient satisfaction.
Researchers at EPFL have developed a synthetic inhibitor of coagulation factor XII that efficiently blocks blood clotting without causing bleeding side-effects. The inhibitor has high potency and selectivity, but its short retention time requires constant infusion to achieve sustained thrompobrotection.
Researchers developed an injectable clotting agent called HAPPI that slows internal bleeding by 97 percent in mice. The agent can be stored at room temperature and reconstituted before injection, making it a potential game-changer for trauma care.
A nationwide Korean study confirms NSAID use increases cardiovascular and bleeding risks post-heart attack. The study suggests celecoxib and meloxicam may be alternative choices for patients where NSAID prescription is inevitable.
A new study shows that IUDs significantly reduce menstrual symptoms in adolescents with disabilities, including heavy bleeding and cramping. The research found that 65% of young women reported less bleeding and 95% kept their IUD after one year.
Researchers aim to reduce bleeding time for soldiers on the battlefield by developing synthetic platelet substitutes that can be easily transported and stored. The technology, which involves freeze-drying artificial platelets into a powder, could potentially address blood shortages and improve treatment outcomes in emergency situations.
A Vanderbilt University Medical Center study found that post-surgical bleeding is associated with a higher mortality rate compared to blood clots. The researchers analyzed nearly 15 years of data on millions of patients and found that bleeding had a consistent signal for mortality, while blood clots did not.
A reduced dose of prasugrel was found to be as effective as a standard dose of ticagrelor in reducing the risk of bleeding without increasing it, particularly in elderly or low-weight patients with acute coronary syndrome. This finding is based on a randomized trial that assessed efficacy and safety in nearly 4,000 patients.
A new AI-enabled gut-imaging device called SmartCap is being developed by the University of Saskatchewan to diagnose gastrointestinal cancers and bleeding. With its ability to generate location-specific data, SmartCap aims to improve diagnostic accuracy and potentially double cancer survival rates globally.
A 10-year follow-up study found that premature babies treated with a 'brain washing' technique called Drainage, Irrigation and Fibrinolytic Therapy (DRIFT) were almost twice as likely to survive without severe cognitive disability. The treatment, pioneered by University of Bristol researchers, has been shown to reduce secondary severe ...
A novel, portable device called iCoagLab has been developed to measure blood clotting ability in minutes, reducing time and accuracy of traditional tests. The test was compared to a conventional test on 270 patients and found to be as sensitive at detecting bleeding risk with higher accuracy.
RCSI researchers have found a potential new way to promote blood clotting that could be used to treat the most common genetic bleeding disorder, Von Willebrand Disease. A modified molecule has been shown to extend the life of the clotting protein within the body's circulation, significantly increasing its half-life fivefold.