Articles tagged with Bleeding
A new anti-clotting medication, abelacimab, has significantly reduced bleeding among people with atrial fibrillation who are at risk of stroke. The AZALEA-TIMI 71 trial found that abelacimab substantially reduced bleeding compared to the current standard of care use of direct-acting oral anticoagulants.
A global study found that apixaban reduced the risk of stroke and blood clotting by 37% in patients with device-detected atrial fibrillation, also known as sub-clinical atrial fibrillation (SCAF). The medication also reduced fatal or disabling stroke by 49%.
A phase 4 clinical trial found that apixaban, an anti-clotting medication, reduced the rate of stroke and blood clots in adults with implanted heart devices experiencing short bouts of asymptomatic, irregular heart rhythms. The study suggests that these individuals may benefit from receiving an anticoagulant.
Researchers found that abelacimab, a Factor XI inhibitor, reduced bleeding compared to rivaroxaban in patients with atrial fibrillation. The study showed significant reduction in hospitalization due to bleeding and almost eliminated gastrointestinal bleeding.
A randomized clinical trial found that avoiding aspirin as part of an antithrombotic regimen reduces bleeding events without increasing thromboembolism risk in patients with advanced heart failure treated with left ventricular assist devices. The study suggests that aspirin avoidance may be a viable option for these patients.
A recent study in JAMA Cardiology analyzed data from 15,000 patients and found that enteric coating on aspirin does not change its effectiveness or safety for secondary prevention of cardiovascular events. The study suggests that patients can choose the aspirin formulation that suits them best.
Postoperative wound infections in the head and neck region are common complications, with risk factors including age, smoking, and comorbidities. Aseptic operating conditions and peri/postoperative antibiotics can help minimize infection rates.
A new technique to control severe bleeding in injured patients has been found to increase the risk of death. The REBOA treatment was tested in a clinical trial involving 90 adult trauma patients, but it did not show the expected benefits.
Red blood cell transfusions were common in ICU patients globally, with overlapping reasons for use despite differing clinical contexts. The three most common triggers for transfusion (hypotension, tachycardia, hemodynamic instability) were largely consistent across regions.
A post hoc analysis of 10,678 participants with atherosclerotic cardiovascular disease found no significant difference in heart attack, stroke, or death risk between enteric-coated and uncoated aspirin. Enteric-coated aspirin may offer reduced bleeding risk, but more research is needed to confirm its benefits.
A wearable optical device using laser speckle imaging detects peripheral vasoconstriction caused by postpartum hemorrhage, providing an early warning system. The device shows promise in detecting heavy bleeding before it becomes severe, with a highly sensitive response to blood flow changes.
The Massive Transfusion in Children-II (MATIC-II) clinical trial will test multiple interventions for life-threatening bleeding in children. The trial aims to determine the most effective and safe bundle of care for pediatric trauma patients, with a focus on precision transfusion medicine.
A new intrauterine device successfully controlled postpartum hemorrhage in 93% of patients who delivered vaginally and 84% of those who delivered by cesarean. The device, which uses low-level suction to promote uterine contractions, showed rapid effectiveness and can be a valuable tool for managing the condition.
A meta-analysis found that direct oral anticoagulants (DOACs) reduced dementia risk in Asian atrial fibrillation (AFib) patients compared to traditional blood thinners like warfarin. The benefit may reverse with increased age, necessitating further study.
A new study published in Neurology found that people who take cholesterol-lowering drugs called statins after having a bleeding stroke may have a lower risk of having another stroke, especially ischemic stroke. The study also found no increased risk of bleeding stroke with statin use.
A nationwide study found that modern blood thinners (NOACs) reduce the risk of serious bleeding by up to 45 percent compared to traditional drug Waran. Apixaban, a NOAC substance, is associated with a lower risk of bleeding in both short and long-term treatment.
A new study reveals that Female Genital Mutilation (FGM) is a leading cause of death in African countries, resulting in estimated 44,320 excess deaths per year. The practice remains legal in five countries and requires cultural change to be effective.
Researchers compared absorbency of 21 menstrual hygiene products using human red blood cells, finding that menstrual discs held the most blood, while super-absorbency period pants held the least. The study highlights the need for more research on menstruation to improve diagnostic accuracy and care for women.
A secondary analysis of a randomized clinical trial found that daily low-dose aspirin increases the risk of intracranial bleeding in healthy older adults, but does not reduce ischemic stroke risk. The study's findings have particular relevance to individuals prone to developing intracranial bleeding after head trauma.
A new Boston University study found that COVID vaccines likely do not affect menstrual cycle regularity, bleed length, or pain. Menstrual cycles increased by 1.1 days after a first dose and 1.3 days after a second, but these changes resolved within one to two cycles.
A clinical trial has shown that desmopressin may reduce the risk of death or disability in stroke patients taking antiplatelet drugs. The results support the need for a large-scale trial to determine its effectiveness.
A new device combines rapid hemorrhage management, infection control, and sensing capabilities for long-term monitoring. The device features a tunable biodegradation rate and can detect bleeding in real-time using a nanowire-based capacitive sensor.
A post-hoc analysis of the ASPREE trial found that low-dose aspirin was associated with a 20% increased incidence of anemia and decline in ferritin levels in healthy older adults. The study recommends periodic monitoring of hemoglobin for patients taking aspirin.
Researchers at Tulane University have identified a synthetic compound called dimethyl malonate that can prevent coagulopathy during massive hemorrhages. The study found that this compound inhibits excessive cellular metabolism, preventing the glycocalyx from shedding and causing bleeding to stop.
A new study has found that the drug tranexamic acid significantly improves survival rates among severely injured patients, with approximately four extra survivors for every 100 treated with the medication. However, the long-term outcomes of care and quality of life remain a concern, highlighting the need for further research.
A University of Gothenburg study found that individuals who engaged in regular physical activity had smaller hemorrhages upon arrival at the hospital. Physically active patients experienced 50% less bleeding volume compared to inactive ones.
A study of 5302 patients found no significant difference in bleeding events between those temporarily discontinuing and maintaining antithrombotic therapy during image-guided breast biopsies. The findings support the safety of continuing antithrombotic therapy, but counsel patients on bruising risk.
A new E-MOTIVE solution dramatically improves outcomes for women experiencing postpartum haemorrhage (PPH), a leading cause of maternal mortality worldwide. The study found a 60% reduction in severe bleeding and fewer blood transfusions, potentially saving thousands of lives globally.
Researchers at UBC and the University of Michigan have discovered a new compound, MPI 8, that prevents blood clots without increasing bleeding risk. This breakthrough could lead to improved treatment options for patients affected by blood clots.
A multicenter international study found that medical management is a viable alternative to surgery for patients with pituitary apoplexy. The study compared outcomes in 97 patients with the condition and found no significant difference between surgical and nonsurgical treatment options.
A team of scientists has successfully used synthetic platelets to treat a genetic condition that prevents blood from clotting, known as Von Willebrand disease. This breakthrough treatment could provide new hope for millions of people affected by the disorder, which affects up to 1% of the US population.
A team of researchers at Aarhus University has discovered a protein that helps protect the body against blood clots in hibernating bears. The protein, HSP47, is found to be downregulated during winter months, allowing bears to avoid blood clots.
A recent study published in the New England Journal of Medicine found that tranexamic acid did not reduce the need for blood transfusions or prevent maternal death in patients with increased risk for excessive bleeding after cesarean delivery. However, patients who received tranexamic acid had less need for additional medical intervent...
Researchers from the London School of Hygiene & Tropical Medicine found that intramuscular administration of tranexamic acid (TXA) is safe and quickly reaches therapeutic concentrations in pregnant women. Oral TXA was also well-tolerated but took an hour to reach therapeutic blood concentrations.
A phase 3 randomised controlled trial found monthly injections of fitusiran effective in reducing bleeds in patients with severe haemophilia A or B. The study included 56 male patients with inhibitors, who experienced no bleeds after nine months on prophylactic treatment.
A University of Ottawa study found that almost two-thirds of Canadians with stroke experience disturbed sleep, and those affected are up to 7 times more likely to report multiple sleep problems. The study highlights the need for better awareness and guidance on managing sleep disorders in stroke patients.
Wilate prophylaxis showed an 84% reduction in bleeding episodes and improved quality of life in children and adults with all types of VWD. The treatment reduced the frequency of bleeding episodes by lowering the mean total annualized bleeding rate compared to on-demand treatment.
Researchers found that a combination of symptom and high-level viral rebound after untreated COVID-19 infection is rare, occurring in only 3 percent of study participants. This suggests that accounting for underlying rates of symptom relapse is crucial when evaluating antiviral treatment effects.
A new genetic test can identify dogs at risk of a potentially deadly disorder resulting in excessive bleeding and bruising after surgical procedures. The DEPOHGEN test will allow for preventative treatment by administering antifibrinolytic drugs to dogs with the mutation before surgery.
A new study of the FDA-cleared Jada System found that it successfully treated postpartum hemorrhage in 92.5% of vaginal births and 83.7% of cesarean births, with a mean indwelling time of 4.6 hours for vaginal births and 6.3 hours for cesarean births.
Researchers found that patients treated with butylphthalide experienced milder neurological symptoms and better functioning at three months after a stroke compared to those who received a placebo. The study suggests potential benefits of this celery seed-derived medication in treating ischemic strokes.
A novel microneedle patch can immediately stop bleeding after injury, reducing clotting time from 11.5 minutes to 1.3 minutes and bleeding by over 90%. The biocompatible and biodegradable technology promotes rapid blood coagulation and wound closure.
A nationwide registry of AVM patients from 52 hospitals in mainland China investigated the efficacy of different treatments on patient groups. The study found that categorizing treatment strategies based on disease severity is an ideal approach, and a multidisciplinary comprehensive assessment promotes individualized treatment protocols.
Researchers developed a blood test using circulating microparticle proteins to predict placenta accreta spectrum (PAS) cases as early as the second trimester. The study found five unique proteins that can distinguish PAS patients from control patients, enabling safe predication before delivery.
A new injectable hydrogel has been developed to rapidly stop bleeding from traumatic wounds. The material becomes solid when injected into the body and can be easily washed away with a cold saline solution.
Researchers have created a hydrogel-based material that can absorb up to three times more water-based liquid than traditional paper towels. The gel sheets also show promise in absorbing thick liquids, such as blood and syrup, with high efficiency and stability.
Researchers found that 'The Secret', a centuries-old folk medicine remedy, does not prevent bleeding after invasive coronary procedures. However, the study suggests that it may have therapeutic value due to its placebo effect, potentially providing stress relief for its believers.
A new study published in Neurology found that people taking cholesterol-lowering drugs called statins may have a lower risk of having a type of stroke called an intracerebral hemorrhage. Longer use of statins was associated with a lower risk of stroke in both lobe and non-lobe areas of the brain.
A trial found that extending anti-clotting treatment after a blood clot in the lower leg reduced further clot risk up to two years. Rivaroxaban administered for three months effectively and safely reduced venous thromboembolism compared to six weeks of treatment.
Researchers at the University of Gothenburg found that using warmer brain irrigation fluid can halve the number of repeat operations needed to remedy bleeding under the cranium. This method involves replacing room temperature irrigation fluid with body temperature fluid, resulting in a significant reduction in surgical interventions.
Researchers at UVA Cancer Center have identified interleukin-1 as a crucial contributor to the development of myelofibrosis, a potentially deadly bone marrow cancer. Targeting this cytokine could prevent myelofibrosis from progressing and spare bone marrow scarring.
A new study has shown that bivalirudin is a safer and more effective anticoagulant than heparin for treating heart attack patients. The trial found that bivalirudin significantly reduced death, major bleeding, and thrombosis in patients undergoing percutaneous coronary intervention.
A major clinical trial found that a short course of antibiotics can significantly reduce the risk of stomach bleeding caused by regular aspirin use, potentially improving its safety. The study involved 30,166 patients taking aspirin and showed rapid protection from hospital admissions for ulcer bleeding.
A new daily anti-clotting pill, edoxaban, shows promise in preventing bleeding and clotting instances rare in children with heart conditions. The study's findings indicate edoxaban is a viable alternative to current treatments, eliminating injections and reducing frequent blood tests.
A study found subarachnoid hemorrhage rates disproportionately higher in Black people, increasing by 1.8% per year. Incidence also increased with age and was higher in women than men, with an average of 13 cases per 100,000 people among women.
Patients taking apixaban had a 43% lower risk of stroke or systemic embolism compared to those taking rivaroxaban. Apixaban also reduced the risk of bleeding events by 49% in patients with atrial fibrillation and valvular heart disease.
A study found that 16.5% of American adults with diabetes ration their insulin, with younger adults and the uninsured being most affected. Insulin rationing is often linked to cost concerns, with many patients delaying purchases or taking less insulin than needed.
Researchers from McGill University developed a medical adhesive inspired by flatworms that uses suction to absorb blood and promote blood coagulation. The adhesive can be removed without causing re-bleeding, making it a potential replacement for wound sutures or delivering drugs.
A study using gadoxetate disodium-enhanced MRI found associations between imaging characteristics and hepatocellular adenoma (HCA) subtypes. The algorithm identified common HCA subtypes with high accuracy, including β-catenin exon 3 mutations.
A new CAPSTONE study aims to identify inflammatory biomarkers associated with positive and poor outcomes in patients after intracerebral hemorrhage (ICH) strokes. By analyzing patient blood and plasma samples, researchers hope to develop targeted treatments to prevent long-term brain degeneration.