Articles tagged with Bleeding
A study using gadoxetate disodium-enhanced MRI found associations between imaging characteristics and hepatocellular adenoma (HCA) subtypes. The algorithm identified common HCA subtypes with high accuracy, including β-catenin exon 3 mutations.
A new CAPSTONE study aims to identify inflammatory biomarkers associated with positive and poor outcomes in patients after intracerebral hemorrhage (ICH) strokes. By analyzing patient blood and plasma samples, researchers hope to develop targeted treatments to prevent long-term brain degeneration.
A Swedish cohort study found that direct oral anticoagulants (DOACs) were associated with a lower risk of kidney function decline or kidney failure compared to vitamin K antagonists (VKA). DOACs also showed a lower risk of acute kidney injury.
COVID-19 vaccination during pregnancy was found to lower the risk of severe outcomes including preterm birth and postpartum hemorrhage. Vaccination during pregnancy is now recommended to protect against COVID-19 infection.
A new biomaterial has been developed to prevent bleeding complications after vascular surgeries, adhering to both human tissue and grafts, reinforcing suture lines, and withstanding high vascular pressures. The material outperforms existing products in terms of safety and efficacy, paving the way for clinical translation.
Researchers analyzed over 6,700 patients treated for blood clots and irregular heart rhythms. Stopping aspirin significantly reduced bleeding complications by 32.3% and prevented one major bleeding event per every 1,000 patients who stopped taking aspirin.
A clinical trial has shown that full-dose anticoagulation therapy is more effective than standard-dose prophylactic anticoagulation in preventing blood clotting complications in COVID-19 patients. The study found a significant reduction in venous or arterial clotting complications among patients who received full-dose treatment.
A new risk score can help predict mortality for patients with atrial fibrillation who have undergone successful TAVR and been discharged home. The risk score was developed using data from the ENVISAGE-TAVI AF trial, which found that patients with certain clinical risks were more likely to die within a year of discharge.
Researchers found that astrocytes can transfer their mitochondria to damaged neurons after a brain hemorrhage, stimulating the production of an enzyme that neutralizes free radicals. This treatment showed improved neurological recovery in mice, but not if the mitochondria were without the protective enzyme Mn-SOD.
The new guideline provides evidence-based recommendations for managing patients on warfarin, DOACs, and antiplatelet drugs before and after surgeries. It aims to minimize preventable bleeding and thrombotic events by standardizing approaches and protocols.
Researchers urge healthcare professionals to acknowledge changes in society around anal sex and have open conversations with young women to ensure they make informed choices about sex. Young women cite pleasure, curiosity, and coercion as factors for engaging in anal sex, which is associated with specific health concerns, including fae...
A new analysis shows that combining two anti-platelet drugs can reduce the risk of graft failure after coronary artery bypass surgery, but also increase the risk of bleeding. The study found a significant reduction in graft failure rates with dual therapy, but more bleeding events requiring medical attention.
A new study finds that COVID-19 infections may predispose individuals to developing irreversible neurological conditions, such as Alzheimer's and Parkinson's diseases. The research also suggests that the virus can cause long-term neurodegenerative diseases, particularly in the elderly and other vulnerable populations.
Researchers have created stem cell models that mimic the genetic disorder, revealing the role of WASP protein in regulating RNA splicing and finding potential therapeutic targets. These findings could lead to new treatments for Wiskott-Aldrich syndrome, a devastating immune deficiency disorder.
A water birth significantly reduces the use of epidurals, injected opioids, episiotomy, pain, and heavy bleeding after birth, while increasing mothers' satisfaction levels and the odds of an intact perineum. A water immersion also increases the likelihood of an intact perineum and reduces episodes of umbilical cord breakage.
Establishing complete trauma care programs accessible to all road injury victims could save 200,000 lives annually, according to a study. Clinical interventions such as early resuscitation and interventional radiology are the most effective measures to reduce deaths related to road traffic injuries.
The Mount Sinai Hospital will recruit eight postdoctoral trainees for a five-year fellowship program in emergency care research. The program aims to investigate complex medical questions and lead to studies transforming patient care.
Researchers at Keck School of Medicine of USC are testing the efficacy of 3K3A-APC as a cerebroprotectant to reduce brain bleeds in acute ischemic stroke patients. The experimental drug has shown promising results in Phase 2 clinical trials, reducing incidence of brain hemorrhage by nearly 20%.
A real-world study found that clopidogrel monotherapy was associated with reduced risk of net adverse clinical events and major cardiac events, compared to aspirin monotherapy. Clopidogrel also showed a lower incidence rate of clinically relevant bleeding events.
A new study by the London School of Hygiene & Tropical Medicine found that injured women are half as likely as men to receive the life-saving drug TXA, despite the treatment being equally effective regardless of sex. The study highlights a significant disparity in trauma care, with clinicians needing clearer guidance to reduce bias.
A recent cohort study found that previous cardiovascular conditions, including heart surgery and heart failure, were associated with increased COVID-19 severity in US pediatric patients. The study highlights the importance of pre-existing medical conditions in determining COVID-19 outcomes in children.
The new American Heart Association/American Stroke Association guideline refines care for people with spontaneous intracerebral hemorrhages. The guideline recommends alternative treatments, such as intermittent pneumatic compression, and updates standard care practices.
A study found no increased mortality risk or serious adverse outcomes in high-risk patients receiving tranexamic acid during IT fracture surgery. The medication, which promotes blood clotting, was also associated with a small decrease in blood transfusion risk.
The USPSTF recommends against initiating low-dose aspirin use for primary prevention of CVD in adults 60+, but suggests its use for those with a 10% or greater 10-year CVD risk. The net benefit is small, and those willing to take daily aspirin are more likely to benefit.
Researchers investigated the use of intranasal human milk as a stem cell therapy for preterm infants with intraventricular hemorrhage. The study found that preterm infants could tolerate nasal milk therapy without major safety events, paving the way for further research on long-term outcomes.
Researchers have identified a biomarker that indicates high risk of impending stroke post-subarachnoid hemorrhage, enabling early treatment initiation in comatose patients. Electrodiagnostic monitoring detects 'spreading depolarizations' caused by toxic by-products of blood breakdown, allowing clinicians to intervene before it's too late.
A large study found that small to moderate-sized leaks after left atrial appendage occlusion (LAAO) procedures significantly increased the risk of adverse events such as clotting and bleeding in AFib patients. Researchers suggest optimizing device placement techniques and using newer devices may help minimize leaks and reduce stroke risk.
Researchers found that patients treated with tranexamic acid had significantly less serious bleeding and needed fewer blood transfusions compared to those who received a placebo. No significant difference in adverse events such as heart attacks or blood clots was observed.
A new study reports breakthrough bleeding and other period symptoms in non-menstruating individuals after COVID-19 vaccination, highlighting the need to include gender-diverse people in vaccine research. The study found that one-third of respondents reported breakthrough bleeding, with some experiencing significant mental health impacts.
A new study by University of Cincinnati researchers analyzed outcome data from a large cohort of patients and found correlations between different risk factors, including age, hemorrhage size, location, and cognitive impairment, which were associated with poor outcomes. The results also showed that Black and Hispanic populations were m...
Researchers at UVA Health System discovered a cluster of cells in the brainstem that controls the body's response to severe blood loss. The study found that re-activating these neurons can restore blood pressure and heart rate in lab rats, offering new hope for treating traumatic injuries.
A retrospective case-control study found no significant difference in traumatic intracranial hemorrhage frequency between adult patients on antithrombotic therapy and those not on the therapy. However, hematoma expansion occurred more frequently in patients on antithrombotic therapy.
A post-hoc subgroup analysis of the AFIRE trial found that reduced kidney function significantly influences bleeding events during antithrombotic therapy. Patients with healthy kidney function have a decreased risk of bleeding over time, while those with reduced kidney function remain at high risk.
Researchers assessed risk factors associated with mortality and neurologic disability three months after intracerebral hemorrhage, finding a link between certain comorbidities and poor outcomes. The study used a racially and ethnically diverse cohort to identify key risk factors for death and disability.
A study of insurance claims data found that state laws governing opioid prescribing had a negligible effect on opioid prescribing trends. The authors suggest that shifting clinical guidelines, professional norms, or other factors may be driving the decline in opioid prescribing. In contrast, a post-hoc analysis of an ASPREE trial found...
A study of vaginal births in New York State hospitals found that labor neuraxial analgesia – having an epidural or combined spinal and epidural – was associated with a decreased risk of severe maternal morbidity. The use of epidural anesthesia was linked to a 14% reduction in the risk of severe maternal morbidity, with racial and ethni...
Researchers at MIT have performed a systematic study on how different-sized polymer nanoparticles circulate in the body and interact with platelets to stop bleeding. They found that intermediate-sized particles (150 nanometers) were the most effective, with less likelihood of accumulating in off-target sites.
Researchers found targeted DOAC medications to be as effective as warfarin in preventing future clots and reducing the risk of brain bleeds. The study's real-world data suggests that DOACs have a lower risk of major bleeding compared to warfarin.
A randomized study in Japan found that mechanical clot removal in addition to standard medical therapy can significantly improve functional recovery for patients with severe strokes. The study demonstrated the effectiveness of endovascular therapy in patients with large-vessel clots disrupting blood flow to more areas of the brain.
A comprehensive quality-improvement initiative in a NICU reduced death and severe brain bleeding in extremely preterm infants from 27.4% to 15%. The program introduced evidence-based practices, including electronic order sets, improved monitoring of blood carbon dioxide and pH levels, and standardized delivery room practices.
A study published in PLOS Medicine found associations between obesity and various female reproductive conditions. Researchers used Mendelian randomization to investigate causal links between body mass index, waist-to-hip ratio, and risk of conditions like uterine fibroids and pre-eclampsia.
A recent University at Buffalo-led study found that nearly 1 in 7 COVID patients in ICU experienced severe bleeding when given full-dose blood thinners. The research compared the safety and effectiveness of two blood clot treatment strategies, finding that a smaller dose was equally effective but carried less bleeding risk.
Proton pump inhibitors are underutilized in high-risk patients due to knowledge gaps and barriers among specialties. Multi-component interventions can improve guideline-based use to prevent upper gastrointestinal bleeding.
The American College of Physicians (ACP) has released two new clinical guidelines for the diagnosis and management of diverticulitis. The guidelines recommend that clinicians manage most patients with uncomplicated disease in outpatient settings without antibiotics, while patients with complicated disease should be referred for colonos...
Researchers developed a novel polymeric nanoparticle that selectively binds to fibrinogen in human plasma, offering a simpler and less expensive way to manufacture fibrinogen concentrate. This breakthrough could lead to the creation of more efficient fibrinogen-specific affinity reagents for drug development.
A new study published in the Canadian Journal of Cardiology found that frail patients with atrial fibrillation are under-prescribed for direct oral anticoagulants (DOACs), a safer alternative to traditional warfarin treatment. Despite needing DOACs most, these patients are less likely to receive them than non-frail patients.
A novel gene therapy has shown sustained expression of clotting factor VIII, leading to a reduction or complete elimination of bleeding events in patients with hemophilia A. The trial demonstrated improved production of coagulation factor VIII over prolonged periods.
Patients with stroke symptoms can be quickly assessed for traumatic injuries without delaying brain imaging and treatment. The novel STRAUMA activation enables rapid evaluation of both stroke and trauma to facilitate timely administration of life-saving interventions.
Researchers at the University at Buffalo have developed a new treatment that pairs essential proteins with lysophosphatidylserine to build immune tolerance and prevent antibody development, potentially treating autoimmune disorders and allergies.
A new Northwestern Medicine study found that over half of US women and people who menstruate experienced changes in their menstrual cycle due to COVID-19 pandemic stress. Individuals with higher levels of stress reported heavier bleeding and longer periods.
A recent study found that 26-45% of people with atrial fibrillation fail to adhere to their prescribed direct-acting oral anticoagulants due to cost and bleeding concerns. Researchers interviewed 42 adults who had stopped or reduced dosing, citing these reasons as major barriers to adherence.
A large-scale international study found that edoxaban is non-inferior to warfarin for efficacy in preventing adverse events, but led to higher bleeding complications. The trial suggests that treatment with edoxaban can be valuable in managing AF patients after TAVR, especially when a lower dose of edoxaban is used.
Researchers at Karolinska Institutet have identified eight primary factors that increase the risk of upper gastrointestinal bleeding after heart attack. The study, published in European Heart Journal - Cardiovascular Pharmacotherapy, found that smoking, blood pressure, and blood glucose are among the new predictors.
A new NIH-funded study found that certain patterns on CT scans after mild traumatic brain injury can predict outcomes and guide treatment. The research identified three distinct sets of patterns, including bleeding into brain tissue and cerebrospinal fluid, associated with various short- and long-term outcomes.
A novel body tissue adhesive incorporating snake venom has been developed to stop life-threatening bleeding in seconds. The 'super glue' works with visible light and offers 10 times the strength of existing fibrin glue, cutting blood clotting time in half.
A new study found that intensive blood pressure-lowering therapy may harm patients with decreased kidney function after a stroke, whereas those with normal kidney function showed similar outcomes. The study suggests considering renal function when deciding optimal blood pressure ranges for each patient.
A nationwide study in Scotland found a slight increased risk of idiopathic thrombocytopenic purpura (ITP) after receiving the Oxford-AstraZeneca vaccine. The risk is estimated at 11 per million doses, similar to other vaccines for flu and MMR.
Researchers at Georgia Institute of Technology and Emory University have made a significant discovery in the physics of blood clotting. By modeling the dynamics of clot contraction, they found that platelets work best when not in total sync with each other, leading to a 90% decrease in clot volume.
The study found that rivaroxaban is safe for patients with luminal gastrointestinal cancer, while apixaban should be used cautiously due to higher bleeding risk. DOACs can also be used in non-luminal GI cancers like pancreatic and hepatobiliary cancers.
A recent study found that tens of thousands of women visited the emergency room for fibroid symptoms, with only 1 in 10 leading to hospital admission. The study suggests that many cases could have been managed in an alternative non-urgent health setting.