Articles tagged with Bleeding
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at Keck School of Medicine of USC are testing the efficacy of 3K3A-APC as a cerebroprotectant to reduce brain bleeds in acute ischemic stroke patients. The experimental drug has shown promising results in Phase 2 clinical trials, reducing incidence of brain hemorrhage by nearly 20%.
The Mount Sinai Hospital will recruit eight postdoctoral trainees for a five-year fellowship program in emergency care research. The program aims to investigate complex medical questions and lead to studies transforming patient care.
A real-world study found that clopidogrel monotherapy was associated with reduced risk of net adverse clinical events and major cardiac events, compared to aspirin monotherapy. Clopidogrel also showed a lower incidence rate of clinically relevant bleeding events.
A new study by the London School of Hygiene & Tropical Medicine found that injured women are half as likely as men to receive the life-saving drug TXA, despite the treatment being equally effective regardless of sex. The study highlights a significant disparity in trauma care, with clinicians needing clearer guidance to reduce bias.
A recent cohort study found that previous cardiovascular conditions, including heart surgery and heart failure, were associated with increased COVID-19 severity in US pediatric patients. The study highlights the importance of pre-existing medical conditions in determining COVID-19 outcomes in children.
The new American Heart Association/American Stroke Association guideline refines care for people with spontaneous intracerebral hemorrhages. The guideline recommends alternative treatments, such as intermittent pneumatic compression, and updates standard care practices.
A study found no increased mortality risk or serious adverse outcomes in high-risk patients receiving tranexamic acid during IT fracture surgery. The medication, which promotes blood clotting, was also associated with a small decrease in blood transfusion risk.
The USPSTF recommends against initiating low-dose aspirin use for primary prevention of CVD in adults 60+, but suggests its use for those with a 10% or greater 10-year CVD risk. The net benefit is small, and those willing to take daily aspirin are more likely to benefit.
Researchers investigated the use of intranasal human milk as a stem cell therapy for preterm infants with intraventricular hemorrhage. The study found that preterm infants could tolerate nasal milk therapy without major safety events, paving the way for further research on long-term outcomes.
Researchers have identified a biomarker that indicates high risk of impending stroke post-subarachnoid hemorrhage, enabling early treatment initiation in comatose patients. Electrodiagnostic monitoring detects 'spreading depolarizations' caused by toxic by-products of blood breakdown, allowing clinicians to intervene before it's too late.
A large study found that small to moderate-sized leaks after left atrial appendage occlusion (LAAO) procedures significantly increased the risk of adverse events such as clotting and bleeding in AFib patients. Researchers suggest optimizing device placement techniques and using newer devices may help minimize leaks and reduce stroke risk.
Researchers found that patients treated with tranexamic acid had significantly less serious bleeding and needed fewer blood transfusions compared to those who received a placebo. No significant difference in adverse events such as heart attacks or blood clots was observed.
A new study reports breakthrough bleeding and other period symptoms in non-menstruating individuals after COVID-19 vaccination, highlighting the need to include gender-diverse people in vaccine research. The study found that one-third of respondents reported breakthrough bleeding, with some experiencing significant mental health impacts.
A new study by University of Cincinnati researchers analyzed outcome data from a large cohort of patients and found correlations between different risk factors, including age, hemorrhage size, location, and cognitive impairment, which were associated with poor outcomes. The results also showed that Black and Hispanic populations were m...
Researchers at UVA Health System discovered a cluster of cells in the brainstem that controls the body's response to severe blood loss. The study found that re-activating these neurons can restore blood pressure and heart rate in lab rats, offering new hope for treating traumatic injuries.
A post-hoc subgroup analysis of the AFIRE trial found that reduced kidney function significantly influences bleeding events during antithrombotic therapy. Patients with healthy kidney function have a decreased risk of bleeding over time, while those with reduced kidney function remain at high risk.
A retrospective case-control study found no significant difference in traumatic intracranial hemorrhage frequency between adult patients on antithrombotic therapy and those not on the therapy. However, hematoma expansion occurred more frequently in patients on antithrombotic therapy.
Researchers assessed risk factors associated with mortality and neurologic disability three months after intracerebral hemorrhage, finding a link between certain comorbidities and poor outcomes. The study used a racially and ethnically diverse cohort to identify key risk factors for death and disability.
A study of insurance claims data found that state laws governing opioid prescribing had a negligible effect on opioid prescribing trends. The authors suggest that shifting clinical guidelines, professional norms, or other factors may be driving the decline in opioid prescribing. In contrast, a post-hoc analysis of an ASPREE trial found...
A study of vaginal births in New York State hospitals found that labor neuraxial analgesia – having an epidural or combined spinal and epidural – was associated with a decreased risk of severe maternal morbidity. The use of epidural anesthesia was linked to a 14% reduction in the risk of severe maternal morbidity, with racial and ethni...
Researchers at MIT have performed a systematic study on how different-sized polymer nanoparticles circulate in the body and interact with platelets to stop bleeding. They found that intermediate-sized particles (150 nanometers) were the most effective, with less likelihood of accumulating in off-target sites.
Researchers found targeted DOAC medications to be as effective as warfarin in preventing future clots and reducing the risk of brain bleeds. The study's real-world data suggests that DOACs have a lower risk of major bleeding compared to warfarin.
A randomized study in Japan found that mechanical clot removal in addition to standard medical therapy can significantly improve functional recovery for patients with severe strokes. The study demonstrated the effectiveness of endovascular therapy in patients with large-vessel clots disrupting blood flow to more areas of the brain.
A comprehensive quality-improvement initiative in a NICU reduced death and severe brain bleeding in extremely preterm infants from 27.4% to 15%. The program introduced evidence-based practices, including electronic order sets, improved monitoring of blood carbon dioxide and pH levels, and standardized delivery room practices.
A study published in PLOS Medicine found associations between obesity and various female reproductive conditions. Researchers used Mendelian randomization to investigate causal links between body mass index, waist-to-hip ratio, and risk of conditions like uterine fibroids and pre-eclampsia.
A recent University at Buffalo-led study found that nearly 1 in 7 COVID patients in ICU experienced severe bleeding when given full-dose blood thinners. The research compared the safety and effectiveness of two blood clot treatment strategies, finding that a smaller dose was equally effective but carried less bleeding risk.
Proton pump inhibitors are underutilized in high-risk patients due to knowledge gaps and barriers among specialties. Multi-component interventions can improve guideline-based use to prevent upper gastrointestinal bleeding.
The American College of Physicians (ACP) has released two new clinical guidelines for the diagnosis and management of diverticulitis. The guidelines recommend that clinicians manage most patients with uncomplicated disease in outpatient settings without antibiotics, while patients with complicated disease should be referred for colonos...
Researchers developed a novel polymeric nanoparticle that selectively binds to fibrinogen in human plasma, offering a simpler and less expensive way to manufacture fibrinogen concentrate. This breakthrough could lead to the creation of more efficient fibrinogen-specific affinity reagents for drug development.
A new study published in the Canadian Journal of Cardiology found that frail patients with atrial fibrillation are under-prescribed for direct oral anticoagulants (DOACs), a safer alternative to traditional warfarin treatment. Despite needing DOACs most, these patients are less likely to receive them than non-frail patients.
A novel gene therapy has shown sustained expression of clotting factor VIII, leading to a reduction or complete elimination of bleeding events in patients with hemophilia A. The trial demonstrated improved production of coagulation factor VIII over prolonged periods.
Patients with stroke symptoms can be quickly assessed for traumatic injuries without delaying brain imaging and treatment. The novel STRAUMA activation enables rapid evaluation of both stroke and trauma to facilitate timely administration of life-saving interventions.
Researchers at the University at Buffalo have developed a new treatment that pairs essential proteins with lysophosphatidylserine to build immune tolerance and prevent antibody development, potentially treating autoimmune disorders and allergies.
A new Northwestern Medicine study found that over half of US women and people who menstruate experienced changes in their menstrual cycle due to COVID-19 pandemic stress. Individuals with higher levels of stress reported heavier bleeding and longer periods.
A recent study found that 26-45% of people with atrial fibrillation fail to adhere to their prescribed direct-acting oral anticoagulants due to cost and bleeding concerns. Researchers interviewed 42 adults who had stopped or reduced dosing, citing these reasons as major barriers to adherence.
A large-scale international study found that edoxaban is non-inferior to warfarin for efficacy in preventing adverse events, but led to higher bleeding complications. The trial suggests that treatment with edoxaban can be valuable in managing AF patients after TAVR, especially when a lower dose of edoxaban is used.
Researchers at Karolinska Institutet have identified eight primary factors that increase the risk of upper gastrointestinal bleeding after heart attack. The study, published in European Heart Journal - Cardiovascular Pharmacotherapy, found that smoking, blood pressure, and blood glucose are among the new predictors.
A new NIH-funded study found that certain patterns on CT scans after mild traumatic brain injury can predict outcomes and guide treatment. The research identified three distinct sets of patterns, including bleeding into brain tissue and cerebrospinal fluid, associated with various short- and long-term outcomes.
A novel body tissue adhesive incorporating snake venom has been developed to stop life-threatening bleeding in seconds. The 'super glue' works with visible light and offers 10 times the strength of existing fibrin glue, cutting blood clotting time in half.
A new study found that intensive blood pressure-lowering therapy may harm patients with decreased kidney function after a stroke, whereas those with normal kidney function showed similar outcomes. The study suggests considering renal function when deciding optimal blood pressure ranges for each patient.
A nationwide study in Scotland found a slight increased risk of idiopathic thrombocytopenic purpura (ITP) after receiving the Oxford-AstraZeneca vaccine. The risk is estimated at 11 per million doses, similar to other vaccines for flu and MMR.
Researchers at Georgia Institute of Technology and Emory University have made a significant discovery in the physics of blood clotting. By modeling the dynamics of clot contraction, they found that platelets work best when not in total sync with each other, leading to a 90% decrease in clot volume.
The study found that rivaroxaban is safe for patients with luminal gastrointestinal cancer, while apixaban should be used cautiously due to higher bleeding risk. DOACs can also be used in non-luminal GI cancers like pancreatic and hepatobiliary cancers.
A recent study found that tens of thousands of women visited the emergency room for fibroid symptoms, with only 1 in 10 leading to hospital admission. The study suggests that many cases could have been managed in an alternative non-urgent health setting.
A new simulation method predicts blood flow conditions that cause pathological behavior of the human blood protein vWF. This breakthrough has the potential to optimize the design of left ventricular assist devices used in heart failure patients and improve diagnosis and treatment of von Willebrand disease, a common inherited bleeding d...
The HOST-EXAM trial found that patients who received clopidogrel experienced a 30% reduced risk of adverse events compared to those on aspirin. This study confirms the effectiveness of long-term maintenance therapy with clopidogrel as an alternative to aspirin for patients who have completed dual antiplatelet therapy.
Switching from high-potency DAPT (ticagrelor) to less potent clopidogrel after 30 days reduced major cardiac events, including heart attacks and strokes. In a study of over 2,700 patients, de-escalation was shown to be safe and more effective than continuing on ticagrelor.
Researchers have identified a specific mechanism of von Willebrand Factor (vWF) that enables it to bind to platelets and initiate clotting. The discontinuous autoinhibitory module (AIM) is a prime site for new antithrombotic drug development.
The study confirms long-term DAPT as an optimal treatment option for ACS patients following PCI, reducing ischemic events without increasing bleeding. Extended DAPT was associated with a lower risk of major cardiovascular events without an increase in bleeding events in high-risk patients.
Increased tourniquet use in Los Angeles County has improved patient survival and reduced the need for blood transfusions. The study found that patients with prehospital tourniquets had lower mortality rates, fewer delayed amputations, and lessened blood transfusion requirements.
A new study found that Black and Hispanic stroke survivors are at higher risk of having changes in the brain's blood vessels that can lead to a second bleeding stroke. The research, published in Neurology, suggests that these differences may be due to disparities in healthcare access and severity of cerebral small vessel disease.
Among people critically ill with COVID-19 hospitalized in an intensive care unit (ICU), a large study found that only 2% experienced a stroke after admission. Hemorrhagic stroke was linked to a significantly higher risk of death, while ischemic stroke did not increase mortality.
A new study found that COVID-19 significantly increases the risk of in-hospital death among patients with hemorrhagic stroke, leading to longer hospital stays and more medical complications. Patients from racial and ethnic minorities, as well as those with obesity and diabetes, were particularly vulnerable.
The FDA has approved supplements to biological license applications for Octaplas and fibryga, strengthening Octapharma USA's pediatric critical care product portfolio. The new labels provide results from post-marketing studies evaluating the products' efficacy, safety, and tolerability in newborns through age 20. Fibryga's indication i...
A study of over 56,000 patients found that new users of direct oral anticoagulants (DOACs) had lower risks for ischemic stroke or systemic embolism and major bleeding events compared to warfarin. DOACs were associated with greater effectiveness and fewer major bleeding events in adults with valvular atrial fibrillation.
A new study found that hysterectomies are used more frequently to treat significant postpartum bleeding than uterine artery embolization, a minimally invasive procedure. The procedure resulted in longer hospital stays and higher costs.
A large study found that people taking antidepressants were no more likely to have an intracerebral hemorrhage than those who didn't take such medications. Researchers analyzed data from over 127,000 stroke patients and found a slight decrease in risk associated with antidepressant use.
Researchers found that CD14+ macrophages and neutrophils change rapidly in the brain after hemorrhage, with signatures consistent in patients with good recovery. Inhibiting inflammation may improve patient outcomes, and targeting specific molecular circuits could unlock new treatment options for ICH.
Researchers have developed a new tool to address disseminated intravascular coagulation (DIC) by targeting blood clots with nanogel spheres loaded with tissue-type plasminogen activator. In vivo studies show promising results in rat models and in vitro tests using DIC patient blood plasma.
Researchers develop hydrogel dressings that can promote wound healing, absorb excess fluid, and prevent infection. These biodegradable dressings are better suited for irregular and deep wounds than traditional bandages.