Bone Diseases
Articles tagged with Bone Diseases
Your retina's biological age might indicate osteoporosis risk
A study found that accelerated retinal aging is associated with lower bone mineral density and an increased risk of fractures. The researchers developed a method to estimate biological age in the retina, which can predict incident osteoporosis.
Call for coordinated action to close Africa’s bone health gap
A new editorial by IOF members highlights the alarming high post-fracture mortality in Africa and emphasizes the need for a targeted, Africa-driven strategy. The authors propose five strategic priorities to build bone health into national health systems, education, and policy.
Shriners Children’s St. Louis researcher awarded $3 million grant to study providing treatment to strengthen bones while still in the womb
A $3.1 million R01 grant will fund research exploring how targeted therapy can strengthen bones in children with osteogenesis imperfecta while still in the womb. The goal is to develop a prenatal drug therapy that improves outcomes for both mothers and children.
Call for applications: Editor-in-Chief, Osteoporosis International (European office)
The International Osteoporosis Foundation is seeking an Editor-in-Chief for the European office of Osteoporosis International, a world-leading peer-reviewed journal focused on osteoporosis and metabolic bone diseases. The successful candidate will oversee content development, peer review, and strategic oversight of the journal.
Sticks and stones may break my bones but “hybrid” macrophages could heal me
Scientists created hybrid macrophages that can simultaneously promote blood vessel and bone growth, potentially improving outcomes for patients with bone fractures. The discovery could lead to new cell-derived therapies that speed up recovery and improve healing.
How bone marrow fat drives immune suppression and bone loss in obesity
Researchers reveal how expansion of bone marrow fat promotes immunosuppressive PD-L1 signaling, leading to enhanced osteoclast activity and accelerated bone loss. Reducing bone marrow fat improves bone structure.
Global survey reveals significant burden and inconsistent management of hypophosphataemic osteomalacia in adults
A new international survey reveals that adults with hypophosphataemic osteomalacia face a substantial disease burden, often under-recognised. The study calls for improved awareness, education, and coordinated care to ensure timely diagnosis and optimal treatment.
New genetic insights into developmental dysplasia of the hip
A large multiethnic study identifies genetic factors associated with developmental dysplasia of the hip (DDH) and its progression to osteoarthritis of the hip. Variations in COL11A2, CALN1, and TRPM7 genes were found to be common to both DDH and hip OA.
ESCEO-IOF Young Investigator Awards presented to researchers from 16 countries
Twenty-three young investigators from 16 countries received the ESCEO-IOF Young Investigator Awards for their outstanding abstracts submitted to the WCO-IOF-ESCEO 2026 Congress. The awards aim to support and attract young researchers to the field of musculoskeletal research.
Professor Roland Chapurlat receives IOF Olof Johnell Science Award
The International Osteoporosis Foundation has awarded Professor Roland Chapurlat the prestigious IOF Olof Johnell Science Award for his seminal contributions to understanding and managing osteoporosis, osteoarthritis, and skeletal rare bone diseases. He is recognized as one of the leading clinical academics in the field worldwide.
IOF CSA Medal of Achievement awarded to Professor Noriko Yoshimura
Professor Noriko Yoshimura has received the IOF CSA Medal of Achievement for her pioneering work on epidemiology and prevention of locomotive organ disorders and osteoporosis. Her research, including the ROAD Study, has significantly advanced understanding of musculoskeletal health.
PEPITEM ‘replacement therapy’ shows potential for early-stage inflammatory arthritis
Researchers have shown that PEPITEM supplementation can prevent or delay inflammatory arthritis by regulating the immune system. The study found that PEPITEM reduced arthritic joint swelling and inflammatory changes comparable to current standard care.
New research brings joint repair closer for millions with osteoarthritis
A team of researchers has achieved a major milestone in developing a new treatment aimed at helping the body repair damaged joints at the source. The experimental treatments have shown promising results in animal models, restoring joint tissue to near-normal levels and significantly reducing pain markers for long periods.
Can a new heart health metric identify fracture risk in postmenopausal women? New study finds link
A new study from Tulane University found that women with high predicted cardiovascular risk face nearly double the risk of hip fracture. The association was stronger in women under 65, and higher cardiovascular risk was linked to fractures in weakened bones in major areas.
Activation of hypoxia signaling pathway enhances bone health and metabolism in obesity
Activation of hypoxia signaling improved metabolism and limited fat accumulation in obese mice, while preserving vascular networks and bone health. The intervention also enhanced fracture healing and glucose tolerance, suggesting a dual beneficial effect on metabolism and bone integrity.
Eating more ultra-processed foods linked to poorer bone health, study finds
A study from Tulane University found that consuming more ultra-processed foods is linked to lower bone mineral density and a higher risk of hip fractures. The study involved over 160,000 participants and found that even small increases in ultra-processed food intake can increase the risk of hip fractures.
Altered copper metabolism is a crucial factor in inflammatory bone diseases
Copper metabolism plays a crucial role in inflammatory bone diseases, with copper overload suppressing glycogen synthesis and increasing inflammatory activity. Researchers found that cuproptosis, a form of programmed cell death, can lead to bone weakening and osteoclast formation, providing a potential new therapeutic target.
How periodontitis-linked bacteria accelerate osteoporosis-like bone loss through the gut
Research reveals that salivary bacteria from gum disease alter gut metabolism, driving osteoclast activity and systemic bone loss. Microbial metabolites like indole-3-lactic acid inhibit osteoclast differentiation and activity.
New record: Laser cuts bone deeper than before
Researchers at the University of Basel have developed a new laser profile that enables deeper and faster cuts in hard tissues like bone. The top hat profile distributes energy more evenly, overcoming limitations of traditional laser systems and enabling joint implants and custom-made 3D-printed implants.
ESE and ESPE launch joint transition of care guidance to improve outcomes for young people moving from child to adult endocrine care
The ESE and ESPE have launched a landmark Joint Clinical Practice Guidance to support structured and effective transition of young people with endocrine conditions. The Guidance provides practical, evidence-based recommendations to ensure continuity, safety and quality of care during this critical phase in a patient's life.
A non-invasive therapeutic strategy for improving bone healing in aged patients
Researchers identified ApoE as a systemic inhibitor of bone repair during aging, and showed that blocking its activity can restore bone regeneration and improve fracture healing. The study provides hope for therapies that actively restore regenerative capacity in older patients, reducing nonunion risk and improving recovery.
Why some broken bones fail to heal: scientists reveal a critical molecular trigger
Researchers discovered that Apex1 plays a crucial role in initiating and progressing bone healing after injury. The protein is required for activating the master regulatory gene Bmp2, which initiates healing by stimulating periosteal expansion and callus formation.
Universal method could transform the future of bone transplantation
Researchers at Lund University developed a universal method for creating cell-free cartilage structures that guide bone repair without triggering strong immune responses. The successful test in animal models paves the way for human trials and the potential to transform the future of bone transplantation.
Female athlete health, well-being focus of updated report
A new consensus statement provides evidence-based guidance for screening, diagnosis, treatment, and return-to-play protocols for female athletes. The updated report includes a first-of-its-kind adolescent model of the Female Athlete Triad, addressing energy deficiency in growing adolescents.
Schizophrenia and osteoporosis share 195 genetic loci, highlighting unexpected biological bridges between brain and bone
A comprehensive genetic investigation by Dr. Feng Liu and collaborators identifies shared genetic loci between schizophrenia and osteoporosis, suggesting overlapping biological pathways. The study found that psychiatric patients face elevated fracture risks due to these molecular connections.
Tackling the burden of osteoporosis and fragility fractures: The APCO-IOF Asia Pacific Regional Audit
The Asia Pacific Regional Audit highlights key trends, gaps, and opportunities in 22 countries and regions. The audit reveals a steep rise in fracture rates due to poor bone health and an ageing population, with China, Malaysia, and Australia experiencing significant increases.
9th IOF Asia-Pacific Bone Health Conference set to open in Tokyo
The 9th IOF Asia-Pacific Bone Health Conference will bring together healthcare professionals, researchers, and policymakers to exchange knowledge and shape the future of bone health across the region. The conference will feature keynote lectures, sponsored sessions, and a launch of the IOF Asia-Pacific Regional Audit 2025.
Researchers build bone marrow model entirely from human cells
Scientists have created a complex tissue model of human bone marrow using only human cells, replicating the cellular complexity of the body's 'blood factory'. This breakthrough reduces the need for animal experiments in blood cancer research and potentially enables personalized therapies.
PAI-1 deficiency protects aging female mice from muscle and bone loss
Researchers found that PAI-1 levels increase with age in both sexes, but only female mice lacking the gene experienced significant protection against age-related muscle and bone loss. Female mice maintained stronger grip strength and greater muscle mass, while showing less cortical bone loss.
Understanding jaw growth: Key gene axis controls postnatal condyle development
Researchers investigated the role of PLAGL1 in postnatal condyle development and found that it regulates osteogenesis through the IGF2 pathway. The study reveals a critical driver of jaw bone formation, offering opportunities for therapeutic exploration and a deeper understanding of craniofacial biology.
New EndoCompass Research Roadmap calls for coordinated investment to tackle Europe’s hormone health challenge
The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.
Alliance Global study challenges age-based treatment decisions in leukemia
A recent study published in Leukemia found that age-based classifications in acute myeloid leukemia (AML) treatment may be outdated. The research analyzed data from 2,823 adult AML patients, revealing nuanced age-related trends in genetic mutations and survival outcomes.
Cracking the code: Shared genes connect osteoporosis and rotator cuff tears
A large-scale study uncovered a strong connection between osteoporosis and rotator cuff tears, finding that individuals with osteoporosis are 1.56 times more likely to suffer an RCT. The study also identified common genetic variants influencing both conditions, suggesting a possible biological explanation for the link.
Unfolded Protein Response pathway offers new targets to treat bone weakness in cancer patients
Researchers identify three primary UPR pathways and their downstream cascades, which play a crucial role in the differentiation of osteoblasts and osteoclasts. Targeting these pathways with emerging drugs may alleviate bone-related events and kill tumors localized in bones.
MiR-378: A prognostic marker and therapeutic target for osteoporosis
Researchers found miR-378 suppresses bone marrow stromal cell osteogenesis and hinders fracture healing in an OVX-induced osteoporosis model. MiR-378 overexpression increased osteoclastogenesis by activating NF-κB signaling pathways, impairing bone formation.
Microplastics may affect bone health
Brazilian researchers analyzed over 60 scientific articles on microplastics and their impact on bone health. They found that the materials can impair bone marrow stem cells, accelerate cell aging, and promote inflammation, leading to potential bone weakening and fractures.
A new perspective in bone metabolism: Targeting the lysosome–iron–mitochondria axis for osteoclast regulation
Research focuses on lysosome, iron, and mitochondria connections in osteoclasts. Lysosomes regulate intracellular iron mobilization and mitochondria rely on iron for energy metabolism.
Closing the care gap: IOF position paper identifies barriers and solutions to global undertreatment of osteoporosis
The International Osteoporosis Foundation identifies critical global barriers to osteoporosis care, including limited DXA scanning and outdated treatment criteria. The IOF advocates for a paradigm shift in bone health management worldwide, recognizing high fracture risk as a valid criterion for treatment and reimbursement.
Therapeutic potential for PEPITEM in osteoporosis
Researchers from the University of Birmingham identified bioactive peptide sequences in PEPITEM that counteract key changes caused by osteoporosis. The study shows the full PEPITEM molecule reduces bone resorption, increases bone formation, and promotes angiogenesis in bone.
Nucleic acid aptamers for advancing targeted therapies for bone diseases
Researchers explore the benefits of nucleic acid aptamers in targeted therapies for bone tissue regeneration, revealing their potential in managing orthopedic conditions. Aptamers can modulate key molecular pathways involved in bone repair, advancing the standard of care for fractures and various types of bone diseases.
Dr. Matthew Greenblatt awarded Paul-Gallin Trailblazer Prize for bone stem cell discoveries
Dr. Greenblatt's discovery of distinct types of bone-building stem cells has opened new areas of research into targeted therapies for bone cancer, osteoporosis, and rare bone conditions. His work has identified potential therapeutic targets to block spine metastases in breast and prostate cancer.
The aging blueprint: Understanding the cellular mechanisms of skeletal aging
Aging cells disrupt bone renewal and repair processes, leading to weak bones and joint degeneration. Cellular senescence and inflammation are major drivers of skeletal decline, while senolytics and emerging therapies offer promising new paths for treatment.
Genetically engineered mouse model provides insights on genetic bone disorders
Researchers developed a genetically modified mouse model to study osteogenesis imperfecta (OI), a rare genetic bone disorder. The study found that the Sp7 R342C mutation affects bone mineral density, trabecular bone volume fraction, and cortical porosity, leading to impaired bone remodeling.
Finding the hidden link between diabetic nerve damage and bone loss
Research reveals a direct connection between diabetic peripheral neuropathy and skeletal health, linking nerve damage to reduced cell signaling. The study shows that diabetic mice with nerve damage had weakened bones due to impaired nerve-bone communication.
Osteoporosis treatment benefits people older than 80
A recent study published by The Endocrine Society found that osteoporosis treatment after a fracture can decrease both hospitalization and mortality in people older than 80. Researchers analyzed data from 88,676 patients aged 80 and older who suffered a fracture due to bone deterioration or weakness caused by osteoporosis.
New artificial intelligence–based test detects early signs of osteoporosis from X-ray images
Researchers have developed an AI-assisted diagnostic system that can estimate bone mineral density in the lumbar spine and femur with high sensitivity and specificity. The system has the potential to transform routine clinical X-rays into a powerful tool for opportunistic screening, enabling earlier detection of osteoporosis.
Researchers identify protein essential for balancing bone tissue
A team of researchers from the University of São Paulo identified agrin as a crucial protein in maintaining bone mass and quality. The study found that osteocytes produce agrin, which plays an essential role in preserving bone health. Without agrin, bone tissue becomes less dense and more fragile, making bones susceptible to fractures.
Breaking the silence about men breaking bones
A new survey conducted by Ohio State University Wexner Medical Center found that only 1% of men are concerned about bone density, with cancer and heart disease being top concerns. Men can build back bone density through exercise, nutrition, and lifestyle changes, and early intervention can prevent deadly fractures.
New study reveals how RUNX2 regulates skull development
Researchers uncover how RUNX2 regulates cranial base growth by controlling chondrocyte differentiation, proliferation, and organization. The study provides fundamental insights into the complex interplay between RUNX2 and FGFR3, shedding light on novel therapeutic targets for craniofacial defects.
New review highlights impact of diabetes on bone health and fracture risk
A landmark review highlights how diabetes alters bone microarchitecture and increases fracture risk in people with type 2 diabetes, despite normal or elevated bone mineral density. The authors advocate for updated diagnostic tools, including a revised TBS algorithm, to more accurately reflect bone quality in individuals with central ob...
Aging disrupts osteocyte networks and bone structure, with greater impact in males
Researchers used a premature aging mouse model to study the effects of age and sex on osteocyte networks and bone structure. Aged PolgA mice showed accelerated skeletal aging, reduced osteocyte connectivity, and increased frailty, with males exhibiting more pronounced changes.
Cracking the spatial code: A new chapter in bone and muscle research
A new review highlights the emerging applications of spatial transcriptomics in musculoskeletal research, enabling discoveries in arthritis mechanisms and limb development. Researchers can now explore how cellular environments influence development, disease, and healing with unprecedented resolution.
Missing gene regulator accelerates disc aging and spinal degeneration
Researchers found that removing SIRT6 from disc cells led to early-onset degeneration, characterized by DNA damage, disorganized collagen fibers, and heightened inflammatory activity. Enhancing SIRT6 activity could offer a new path for non-invasive treatments to delay or prevent age-related spinal degeneration.
Firmicutes gut bacteria boost metabolism and bone health, study found
A recent study found that individuals with a specific type of gut bacteria (Firmicutes) had higher bone mineral density and better metabolic health. The researchers suggest that promoting the growth of butyrate-producing bacteria could be an effective strategy for maintaining bone mass and preventing osteoporosis.
Fine-tuning osteoclast development: a targeted approach to bone disease
Researchers developed a tetravalent peptide that specifically inhibits the recruitment of MKK3 to TRAF6, preventing late-stage osteoclast activation and reducing side effects. In mice models, the peptide effectively prevented bone loss with minimal impact on osteoblast function.
Enhance your clinical expertise with the new IOF Advanced Course on Osteoporosis
The IOF Advanced Course on Osteoporosis is a comprehensive, 18-hour online training programme designed to equip healthcare professionals with the latest knowledge in osteoporosis prevention, diagnosis, and management. The course aims to promote timely diagnosis and treatment, reduce patient burden, and improve global outcomes.
Long-term survival rates of some Acute Myeloid Leukaemia patients could double with sensitive bone marrow test
A highly sensitive bone marrow test has shown to double survival rates for patients with AML mutations in NPM1 and FLT3 genes, allowing for early detection of potential relapse. This trial indicates that regular molecular testing can improve long-term survival rates by restarting treatment earlier.
Largest osteoarthritis genetic study uncovers pathways to new therapies and repurposed drugs
A global research initiative analyzing data from nearly 2 million people in diverse populations worldwide has uncovered multiple new genes associated with osteoarthritis. The study also identified key genetic pathways and 69 genes whose protein products are targeted by approved drugs, paving the way for repurposed treatments.
IU scientists develop new bone marrow imaging technique
A new imaging technique developed by IU scientists allows for the visualization of 25 cellular markers in intact bone marrow tissue without disruption. This advancement could support future drug development and therapies for conditions involving bone marrow.