Articles tagged with Bone Diseases
A new imaging technique developed by IU scientists allows for the visualization of 25 cellular markers in intact bone marrow tissue without disruption. This advancement could support future drug development and therapies for conditions involving bone marrow.
Dr Ambrish Mithal, an Indian endocrinologist, has been awarded the prestigious IOF CSA Medal of Achievement for his groundbreaking work in advancing the field of osteoporosis. His pioneering efforts have significantly increased understanding and awareness of osteoporosis globally.
AMMOM has been recognized by the IOF for its significant contributions to osteoporosis awareness and bone health in Mexico. The organization has collaborated extensively with the IOF on various initiatives, including joint scientific meetings and advocacy efforts.
Posterior fixation surgery suppresses infection by preventing bone destruction and weakening osteoclast activity. This treatment method increases bone stability, helping to control infection in pyogenic spondylodiscitis.
A new consensus paper emphasizes the role of bone turnover markers (BTMs) in diagnosing and managing osteoporosis. BTMs, such as procollagen type I N propeptide (PINP) and β-isomerized C-terminal telopeptide of type I collagen (β-CTX-I), are invaluable tools for predicting fracture risk and monitoring treatment adherence.
Researchers found that Shh significantly promotes BMP9-induced osteogenic differentiation of mesenchymal stem cells, leading to enhanced ectopic bone formation. The study suggests that Shh may augment BMP9-induced osteogenesis by activating essential transcription factors.
Researchers from Osaka University analyzed dental issues faced by Japanese patients with hypophosphatasia, finding two distinct groups: odonto-type disease (early tooth loss) and non-odonto-type disease (tooth misalignment and softening). The study aims to improve diagnosis and treatment for this often misunderstood disease.
Researchers at Saarland University have developed smart implants that can monitor and promote healing in fractured bones. The miniaturized technology, part of the EU-funded SmILE project, enables the use of thin intramedullary nails to support bone stability during healing.
A new study by Nemours Children's Health reveals that prenatal diagnosis of OI does not accurately predict mortality, and many babies can survive with medical interventions. The study found that 16 out of 18 infants with lethal OI diagnoses survived and achieved significant mobility milestones.
A new study reveals that heavy mechanical force can slow down orthodontic tooth movement by disrupting mitochondrial calcium levels. Blocking Piezo1 activity or enhancing STING signaling can restore osteoclast function and accelerate tooth movement under heavy force conditions.
This disorder has diverse etiologies, variable presentations, and different therapeutic responses. The proposed diagnostic algorithm can differentiate pediatric MF subtypes to improve patient outcomes.
Two comprehensive datasets from the Gabriella Miller Kids First Pediatric Research Program explore childhood cancers and congenital disorders. The new datasets aim to identify genetic causes and links between these diseases in children, ultimately supporting the development of improved treatments.
A new study adds weight to the safety and effectiveness of a gene therapy for hypophosphatasia, a rare inherited disorder that causes abnormal bone development. The treatment, AAV8-TNAP-D10, has shown promising results in mice models, with female mice achieving improvements in bone and teeth at lower doses.
The European Society for Paediatric Endocrinology and the European Society of Endocrinology will host the first-ever joint Congress on May 10-13, 2025. The event aims to bring together paediatric and adult endocrine specialists from across Europe and the world to collaborate and celebrate endocrinology.
Researchers found that pomalidomide enhances key immune cells, such as T cells and natural killer cells, which helps the body recognize and destroy cancer cells. This leads to improved immune profiles in patients with myeloma, resulting in longer progression-free survival periods.
A new pilot study sheds light on the numerous barriers to effective osteoporosis management, revealing profound knowledge gaps and misinformation. Key findings highlight the need for clear education and trust-building in osteoporosis care.
A new study identifies loss-translocation-amplification chromothripsis as a key mechanism driving osteosarcoma tumour development and evolution. This discovery has significant implications for treatment options and patient outcomes, highlighting the importance of investing in studies exploring cancer mechanisms.
A new bone regeneration scaffold, Qx-D, shows promise in treating infected bone defects by exhibiting broad-spectrum antibacterial activity against various bacteria. The scaffold also supports the adhesion and differentiation of key cell types involved in bone regeneration.
The study, published in Aging, introduces a new therapy for osteoarthritis that uses extracellular vesicles derived from fat tissue to repair damage caused by aging cells. The treatment showed strong therapeutic effects in both cellular and mouse preclinical studies, reducing inflammation and DNA damage markers in human joint cells.
A six-year study examining 38 clinical isolates of Cryptococcus found genes and gene alleles associated with disease severity. The research aims to develop new treatments targeting these genetic variations, predicting disease outcomes and improving patient care.
A new study reveals that combining intermittent fasting with localized Wnt3a treatments can rejuvenate bone repair in older mice, suggesting a potential therapeutic approach to restore bone healing in aged animals. The treatment also showed promise in improving the repair and function of other aging tissues.
Researchers found that megakaryocyte conditioned media from younger mice was more effective at promoting blood vessel growth and improving healing. The study provides a potential approach for developing new therapies to speed up fracture recovery in older individuals, reducing pain and improving mobility.
Researchers at MD Anderson Cancer Center presented findings on novel treatments for MDS, including luspatercept, which significantly reduced the need for blood transfusions in lower-risk patients. Additionally, a triplet therapy regimen improved survival in older adults with FLT3-mutated AML.
Breast cancer cells can live for years in bone marrow after remission, leading to disease recurrence in approximately 40% of patients. A study found that mesenchymal stem cells support the cancer cells by donating essential proteins, making them more aggressive and drug-resistant.
This special issue of Calcified Tissue International presents a collection of critical reviews and original research articles on osteogenesis imperfecta (OI), covering essential aspects of the condition, including its nosology, genetics, and clinical presentation. The contributions also discuss treatment strategies for both children an...
Researchers mapped all cells and pathways involved in early skeletal development, shedding light on arthritis and skull growth conditions. The study identifies genetic mutations disrupting soft spots in the skull, potentially leading to congenital conditions.
The Center for Translational Exposomics Research (CTER) at USC aims to accelerate environmental health research and find practical solutions. CTER investigates how different exposures impact health across populations using population studies, lab experiments, and community engagement.
The International Osteoporosis Foundation's Capture the Fracture campaign highlights top-performing Fracture Liaison Services that deliver gold-standard care. These services prioritize continuous care, tailored treatment plans, and teamwork to reduce secondary fractures and improve patient outcomes.
Researchers used ex vivo lentiviral gene therapy to treat MPS IVA in mice, achieving partial correction of bone pathology and complete correction of heart pathology. The study suggests potential for novel therapies to treat patients with MPS IVA.
The Endocrine Society's new statement highlights research gaps on opioids' effects on the endocrine system, which can lead to conditions like male hypogonadism and secondary adrenal insufficiency. Clinicians need to monitor patients using opioids for signs of these health consequences.
A recent study employs zebrafish to model Nager syndrome, revealing the role of sf3b4 mutations in facial development and apoptosis. The research suggests that FGF8 plays a critical role in disease pathogenesis and provides a potential therapeutic strategy.
A new proteomics study explores the relationship between protein and transcript levels in young-adult and old mice bones. The research identifies key targets associated with bone mineral density and aging, shedding light on protein-specific changes that occur with age.
A recent study published in Knee Surgery, Sports Traumatology, Arthroscopy found that children who undergo surgery for discoid lateral meniscus are at higher risk of developing further knee injuries with age. Younger patients were particularly prone to relapse after surgery.
Researchers propose a better understanding of inflammation in rheumatoid arthritis, identifying an early pathogenic macrophage cell/gene signature that shapes the inflammatory environment. This discovery offers a unique opportunity for early diagnosis and therapeutic intervention, potentially leading to improved patient outcomes.
Scientists at Anglia Ruskin University are collaborating with Medannex to accelerate treatment for bone cancer in children, focusing on paediatric osteosarcoma. The first-in-class therapy MDX-124 has shown promising results in preclinical tests and is being evaluated in a clinical study.
A University of Virginia engineer developed a workflow to combine advanced imaging technologies for improved understanding of porous bone, which could inform disease detection. The method allows for three-dimensional rendering of bone structure across various length scales.
Researchers at Aston University have created a potential treatment for bone cancer using gallium-doped bioactive glasses, which has shown a 99% success rate in killing osteosarcoma cells. The therapy also promotes early stages of bone formation and regenerates diseased bones.
Research at the University of Tsukuba found high vertebral instability and diffuse low-signal changes in T2-weighted MRI observations to be risk factors for deteriorated ambulation status following different conservative treatments. These findings could help predict whether a patient's ability to walk will be affected by these treatments.
The International Space Station National Laboratory is collaborating with NASA to fund up to $4 million in research addressing significant diseases like cancer, cardiovascular disease, and neurodegenerative disease. The joint solicitation aims to leverage microgravity to improve existing or develop new technologies for health problems ...
Researchers found a significant association between the KIT M541L variant and mastocytosis diagnosis in patients with systemic and cutaneous mastocytosis. The variant was identified in 19 individuals, mostly diagnosed with systemic mastocytosis, but without significant differences in symptomatology.
A new position paper argues that single race-agnostic FRAX models would unfairly discriminate against Black, Asian, and Hispanic communities. The authors recommend retention of ethnic and race-specific FRAX models for the US with updated data on fracture and death hazards.
A new study from the University of Toledo found that individuals with diabetes are nearly three times more likely to experience non-union complications following spinal fusion surgery. Researchers also found that diabetic patients have weaker bone growth and healing, leading to increased degeneration in adjacent segments of the spine.
A research team from Osaka University identified a key osteoporosis-related gene, Men1, and developed a new animal model of the disease. The study found that inactivation of Men1 led to cellular senescence in osteoblasts, reducing bone formation activity and increasing bone resorption.
Researchers identify key proteins and signaling pathways for personalized treatment, enabling early detection of aggressive tumors. The study provides a crucial resource for developing new therapies and tests to guide treatment.
Researchers explore the feasibility of deep learning models in segmenting lesions on PET/CT images to improve salvage radiation therapy planning for prostate cancer. The study demonstrates promising potential to reduce inter- and intra-observer variations, leading to more accurate treatment outcomes.
A new Europe-wide clinical framework aims to collect high-quality biological samples from patients, enabling researchers and clinicians to understand the genetic, biological, and other factors involved in childhood bone cancer. This will guide the development of tailored treatments for each patient's cancer type.
A new global definition of sarcopenia is proposed, aiming to unify research and clinical practice. The definition may help identify low muscle mass or strength in older people, increasing the risk of poor outcomes such as fragility and disability.
A yearlong randomized controlled trial found that daily prune consumption slowed bone loss connected to osteoporosis. Participants who ate at least four to six prunes every day maintained bone density and bone strength.
The IOF position paper emphasizes the need for population-specific vitamin D approaches, considering factors like diet, skin pigmentation, and supplement use. The authors also highlight the importance of standardized measures of 25(OH)D in future studies.
Research presented at ENDO 2024 found that older women with low bone density are more likely to experience their first hip fracture in their 60s. A study analyzing NHANES data revealed a significant increase in osteoporosis, but surprisingly, a decrease in fragility hip fractures between 60-70 years.
A new study reveals how accumulation of IMAT drives diseases such as muscle loss, type 2 diabetes, and cardiovascular disease. Regular exercise and healthy diet can prevent and reverse IMAT accumulation.
Dr. Melissa Grunlan's team creates regenerative osteochondral plugs, a potential off-the-shelf device to treat OCDs and avoid total knee replacement surgery. The technology offers an alternative to autografting or total knee replacement, providing immediate support for joint function and potentially reducing post-operative complications.
A genomic study uncovers germline ARID1B and mitochondrial variants that may drive pediatric chordoma genesis, a rare and aggressive bone tumor. The study found aberrant indels and haywire mitochondria in 22% of pediatric chordoma samples.
Researchers discovered a link between high arm fat and low bone quality, particularly in the spine. Those with excess body fat, regardless of BMI, had lower bone quality and strength in their vertebrae.
The 5-year TAF treatment efficacy was high and similar to that of 3-year TDF followed by 2-year TAF in Chinese chronic hepatitis B patients. Favorable effects on bone and renal parameters were sustained with TAF treatment alone and were observed following the switch from TDF to TAF.
Researchers at NeuRA and UniSA found that early detection and comprehensive treatment can lead to significant recovery for most people with Complex Regional Pain Syndrome (CRPS) within 12-18 months. The study reviews the latest advances in CRPS epidemiology, pathophysiology, diagnosis, and treatment.
Professor Leith Zakraoui was awarded the 2024 IOF CNS Medal for his dedicated work in advancing musculoskeletal health at both national and international levels. He has been a key figure in strengthening IOF activities in Africa and promoting education and awareness within the region.
The International Osteoporosis Foundation (IOF) and ESCEO presented awards to 20 young investigators from 16 countries for their outstanding research abstracts. The awards recognize the researchers' contributions to the prevention, diagnosis, and treatment of osteoporosis and related musculoskeletal diseases.
The International Osteoporosis Foundation has presented the prestigious IOF President’s Award to Professor Peter Ebeling AO in recognition of his longstanding contributions to advancing the work of the IOF. He is an internationally renowned expert in bone health, with a total of over 536 peer-reviewed publications and a h-index of 93.
A comprehensive review examines the impact of osteoporosis on fracture healing and the effects of osteoporosis medications. The study concludes that there is no deleterious effect of osteoporosis medications on fracture healing, and prompt treatment can reduce the risk of secondary fractures.