Articles tagged with Bone Diseases
The study found substantial international variability in laboratory testing for bone and mineral metabolism, limiting data sharing and clinical impact. The survey highlights the need for greater consistency in BSI testing to improve clinical utility and patient care.
Bone complications in sickle cell disease include early-onset osteoporosis, compression fractures, and avascular necrosis. Research aims to investigate how inflammation leads to bone complications and identify if bone cells drive musculoskeletal pain.
Researchers found that lower bone mineral density in the spine was associated with faster cognitive decline and accelerated age-related white matter injury. Lower bone density was also linked to specific brain regions, including the corpus callosum and the internal capsule, which support executive function.
Professors Etienne Cavalier and Roland Chapurlat assume leadership as Co-Editors-in-Chief, bringing complementary expertise in laboratory science, translational research, and clinical investigation. They aim to build on the journal's strong foundations and further enhance its role in musculoskeletal research.
A systematic review of 35 studies involving 2,108 patients found that patients who underwent posterior spinal fusion with posterior column osteotomies had similar overall correction compared to those who underwent PSF without PCOs. PCOs may be useful in select patients with larger or stiffer curves.
Professor Rizzoli brings extensive editorial experience to the role, along with a longstanding commitment to scientific excellence. He will work closely with the US Editor-in-Chief to advance scientific knowledge, inform clinical practice, and improve musculoskeletal health worldwide.
Researchers identified dormant progenitor cells in skeletal muscle that migrate to fracture sites and become bone-forming cells. Muscle is the main source of these regenerative cells, which can contribute to both normal fracture healing and heterotopic ossification.
A coral-inspired 3D-printed scaffold reprograms immune cells to promote angiogenesis and bone regeneration, shifting macrophages from inflammatory M1 state to reparative M2 state. The scaffold also enhances angiogenesis, new bone formation, and reconstruction of bone defects.
Researchers found that high-intensity sports involving explosive movements stimulated bone formation most effectively. Recreational football and handball were associated with increases in substances linked to bone formation, while walking and traditional gym-based exercises were less effective. This suggests that low-intensity exercise...
The IOF Musculoskeletal Rare Diseases Training Course bridges latest scientific advances with current clinical guidance, covering disorders-specific programs. Clinicians can access high-quality educational content at their own pace to deepen expertise in rare skeletal conditions diagnosis and management.
A new nationwide Austrian study found that bone fractures are often part of a complex pattern of multiple conditions, underscoring the need for consistent osteoporosis screening at the time of a fracture. Osteoporosis is not systematically documented for many fracture types, highlighting a diagnostic gap, especially in men.
A new position statement calls for systematic bone health optimization before joint replacement and spinal fusion surgery. Key findings include the progressive mechanical failure of bone-implant constructs resulting from compromised bone quality, particularly due to osteoporosis.
Researchers have successfully mapped the cells and genes that regulate bone formation and loss, revealing blood vessel cells play a critical role in bone health. The discovery has the potential to enable the development of new therapies to reverse bone loss and improve treatments for osteoporosis and other skeletal conditions.
A biomaterial scaffold has been developed to recreate a skull stem cell niche, reducing craniosynostosis-related deformities and promoting normal skull growth. The triphasic scaffold maintained skeletal stem cells while supporting bone formation and tissue regeneration.
A new study published in The Lancet found that a dual-mobility total hip replacement (DM THR) can reduce the risk of complications, including joint dislocations, by up to 70%. This breakthrough implant design consists of a small ball encased in a larger plastic ball, providing better stability and reducing surgical complications.
Researchers found that CAR3 coordinates bone formation and regeneration by forming a molecular complex with collagen type I alpha 1 and recruiting bone sialoprotein. The study identified CAR3 as a previously unrecognized regulator of osteoblast differentiation, highlighting its potential for treating bone disorders.
A retrospective cohort study found that menopausal hormone therapy significantly reduces the risk of low bone mineral density by 69% compared to non-users. This suggests that hormone therapy could be an effective way to prevent bone loss and lower fracture risks in women after menopause.
A new review highlights advances in preventing bone loss in people with rheumatoid arthritis, showing that modern antirheumatic therapies can significantly reduce both localized erosions and generalized bone loss. Emerging imaging technologies like HR-pQCT have been found to detect subtle bone erosions earlier and more sensitively.
A new review highlights that vitamin D deficiency is common and clinically important in patients with inflammatory rheumatic diseases, but the current evidence does not support a direct disease-modifying effect. Vitamin D supplementation shows modest benefits in some patients, particularly those with low baseline vitamin D levels.
Researchers developed a mineralized DNA hydrogel that coordinates immune regulation and sustained bone regeneration. The material promotes healing-friendly macrophage activity while supporting bone-forming stem cells, accelerating bone repair and improving tissue mineralization.
Researchers found that traumatic occlusion combined with periodontitis leads to significant bone loss due to upregulated inflammatory pathways. The study suggests that excessive bite force does not directly cause damage but exacerbates existing dysregulation, making clinical applications of occlusal adjustment in treatment more relevant.
Researchers identified a vitamin K-dependent GAS6 pathway that controls osteoclast maturation and bone resorption in mice. Osteoblasts use Vitamin K signals to regulate osteoclast fusion via the GAS6 pathway.
A phase 2 clinical trial found that burosumab safely restored normal phosphate levels and improved physical function in patients with severe fibrous dysplasia. Key findings include reduced pain, fatigue, and mobility impairment, as well as significant improvements in children's mobility and independence.
Researchers developed a novel mouse model that mirrors the human disease, revealing molecular mechanisms underlying geleophysic dysplasia. The model replicates severe symptoms, including short stature, heart valve alterations, and early lethality, facilitating the identification of potential therapeutic targets.
International experts in laboratory medicine, osteoporosis, and chronic kidney disease recommend ending routine reporting of albumin-adjusted ('corrected') calcium. The practice may misclassify patients and compromise care due to unreliable correction formulas and variability in local measurements.
A large clinical trial found that increasing bone density in patients with brittle bone disease does not prevent fractures. The study suggests treatment strategies should focus on improving bone quality instead of relying solely on bone density treatments.
A study found that accelerated retinal aging is associated with lower bone mineral density and an increased risk of fractures. The researchers developed a method to estimate biological age in the retina, which can predict incident osteoporosis.
A new editorial by IOF members highlights the alarming high post-fracture mortality in Africa and emphasizes the need for a targeted, Africa-driven strategy. The authors propose five strategic priorities to build bone health into national health systems, education, and policy.
A $3.1 million R01 grant will fund research exploring how targeted therapy can strengthen bones in children with osteogenesis imperfecta while still in the womb. The goal is to develop a prenatal drug therapy that improves outcomes for both mothers and children.
The International Osteoporosis Foundation is seeking an Editor-in-Chief for the European office of Osteoporosis International, a world-leading peer-reviewed journal focused on osteoporosis and metabolic bone diseases. The successful candidate will oversee content development, peer review, and strategic oversight of the journal.
Scientists created hybrid macrophages that can simultaneously promote blood vessel and bone growth, potentially improving outcomes for patients with bone fractures. The discovery could lead to new cell-derived therapies that speed up recovery and improve healing.
Researchers reveal how expansion of bone marrow fat promotes immunosuppressive PD-L1 signaling, leading to enhanced osteoclast activity and accelerated bone loss. Reducing bone marrow fat improves bone structure.
A new international survey reveals that adults with hypophosphataemic osteomalacia face a substantial disease burden, often under-recognised. The study calls for improved awareness, education, and coordinated care to ensure timely diagnosis and optimal treatment.
A large multiethnic study identifies genetic factors associated with developmental dysplasia of the hip (DDH) and its progression to osteoarthritis of the hip. Variations in COL11A2, CALN1, and TRPM7 genes were found to be common to both DDH and hip OA.
Twenty-three young investigators from 16 countries received the ESCEO-IOF Young Investigator Awards for their outstanding abstracts submitted to the WCO-IOF-ESCEO 2026 Congress. The awards aim to support and attract young researchers to the field of musculoskeletal research.
The International Osteoporosis Foundation has awarded Professor Roland Chapurlat the prestigious IOF Olof Johnell Science Award for his seminal contributions to understanding and managing osteoporosis, osteoarthritis, and skeletal rare bone diseases. He is recognized as one of the leading clinical academics in the field worldwide.
Professor Noriko Yoshimura has received the IOF CSA Medal of Achievement for her pioneering work on epidemiology and prevention of locomotive organ disorders and osteoporosis. Her research, including the ROAD Study, has significantly advanced understanding of musculoskeletal health.
Researchers have shown that PEPITEM supplementation can prevent or delay inflammatory arthritis by regulating the immune system. The study found that PEPITEM reduced arthritic joint swelling and inflammatory changes comparable to current standard care.
A team of researchers has achieved a major milestone in developing a new treatment aimed at helping the body repair damaged joints at the source. The experimental treatments have shown promising results in animal models, restoring joint tissue to near-normal levels and significantly reducing pain markers for long periods.
A new study from Tulane University found that women with high predicted cardiovascular risk face nearly double the risk of hip fracture. The association was stronger in women under 65, and higher cardiovascular risk was linked to fractures in weakened bones in major areas.
Activation of hypoxia signaling improved metabolism and limited fat accumulation in obese mice, while preserving vascular networks and bone health. The intervention also enhanced fracture healing and glucose tolerance, suggesting a dual beneficial effect on metabolism and bone integrity.
A study from Tulane University found that consuming more ultra-processed foods is linked to lower bone mineral density and a higher risk of hip fractures. The study involved over 160,000 participants and found that even small increases in ultra-processed food intake can increase the risk of hip fractures.
Copper metabolism plays a crucial role in inflammatory bone diseases, with copper overload suppressing glycogen synthesis and increasing inflammatory activity. Researchers found that cuproptosis, a form of programmed cell death, can lead to bone weakening and osteoclast formation, providing a potential new therapeutic target.
Research reveals that salivary bacteria from gum disease alter gut metabolism, driving osteoclast activity and systemic bone loss. Microbial metabolites like indole-3-lactic acid inhibit osteoclast differentiation and activity.
Researchers at the University of Basel have developed a new laser profile that enables deeper and faster cuts in hard tissues like bone. The top hat profile distributes energy more evenly, overcoming limitations of traditional laser systems and enabling joint implants and custom-made 3D-printed implants.
The ESE and ESPE have launched a landmark Joint Clinical Practice Guidance to support structured and effective transition of young people with endocrine conditions. The Guidance provides practical, evidence-based recommendations to ensure continuity, safety and quality of care during this critical phase in a patient's life.
Researchers identified ApoE as a systemic inhibitor of bone repair during aging, and showed that blocking its activity can restore bone regeneration and improve fracture healing. The study provides hope for therapies that actively restore regenerative capacity in older patients, reducing nonunion risk and improving recovery.
Researchers discovered that Apex1 plays a crucial role in initiating and progressing bone healing after injury. The protein is required for activating the master regulatory gene Bmp2, which initiates healing by stimulating periosteal expansion and callus formation.
Researchers at Lund University developed a universal method for creating cell-free cartilage structures that guide bone repair without triggering strong immune responses. The successful test in animal models paves the way for human trials and the potential to transform the future of bone transplantation.
A new consensus statement provides evidence-based guidance for screening, diagnosis, treatment, and return-to-play protocols for female athletes. The updated report includes a first-of-its-kind adolescent model of the Female Athlete Triad, addressing energy deficiency in growing adolescents.
A comprehensive genetic investigation by Dr. Feng Liu and collaborators identifies shared genetic loci between schizophrenia and osteoporosis, suggesting overlapping biological pathways. The study found that psychiatric patients face elevated fracture risks due to these molecular connections.
The Asia Pacific Regional Audit highlights key trends, gaps, and opportunities in 22 countries and regions. The audit reveals a steep rise in fracture rates due to poor bone health and an ageing population, with China, Malaysia, and Australia experiencing significant increases.
The 9th IOF Asia-Pacific Bone Health Conference will bring together healthcare professionals, researchers, and policymakers to exchange knowledge and shape the future of bone health across the region. The conference will feature keynote lectures, sponsored sessions, and a launch of the IOF Asia-Pacific Regional Audit 2025.
Scientists have created a complex tissue model of human bone marrow using only human cells, replicating the cellular complexity of the body's 'blood factory'. This breakthrough reduces the need for animal experiments in blood cancer research and potentially enables personalized therapies.
Researchers found that PAI-1 levels increase with age in both sexes, but only female mice lacking the gene experienced significant protection against age-related muscle and bone loss. Female mice maintained stronger grip strength and greater muscle mass, while showing less cortical bone loss.
Researchers investigated the role of PLAGL1 in postnatal condyle development and found that it regulates osteogenesis through the IGF2 pathway. The study reveals a critical driver of jaw bone formation, offering opportunities for therapeutic exploration and a deeper understanding of craniofacial biology.
The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.
A recent study published in Leukemia found that age-based classifications in acute myeloid leukemia (AML) treatment may be outdated. The research analyzed data from 2,823 adult AML patients, revealing nuanced age-related trends in genetic mutations and survival outcomes.
A large-scale study uncovered a strong connection between osteoporosis and rotator cuff tears, finding that individuals with osteoporosis are 1.56 times more likely to suffer an RCT. The study also identified common genetic variants influencing both conditions, suggesting a possible biological explanation for the link.
Researchers identify three primary UPR pathways and their downstream cascades, which play a crucial role in the differentiation of osteoblasts and osteoclasts. Targeting these pathways with emerging drugs may alleviate bone-related events and kill tumors localized in bones.