Articles tagged with Bone Diseases
The new FRAXplus beta version offers a more user-friendly platform to refine risk factor information, allowing clinicians to explore the impact on individual patients. The tool provides helpful features such as saved data and export options to facilitate sharing.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
A new interactive online Fragility Fracture Decision Aid can help clinicians and patients visualize their individual risk of fracture. The Canadian Task Force on Preventive Health Care recommends a "risk assessment–first" screening process for women 65 years and older, centered around shared decision-making with primary care providers.
Professor Nicholas Harvey received the prestigious IOF Olof Johnell Science Award for his outstanding scientific contributions to osteoporosis. The award recognizes his work on fracture risk assessment tools and musculoskeletal research.
Bernard Cortet receives ESCEO-IOF Herbert Fleisch Medal for groundbreaking contributions to osteoporosis research, including publications on clinical recommendations and patient outcomes. He is recognized for his leadership roles in French Society of Rheumatology and Osteoporosis Research and Information Group.
The Build Better Bones platform provides practical guidance on strengthening bones through targeted exercises and bone-healthy nutrition. The platform also offers helpful information for caregivers, including support with daily tasks and medical specialty knowledge.
Researchers have identified 145 potential height genes linked to skeletal disorders and growth plate maturation. The study found that genetic changes affecting cartilage cell maturation may strongly influence adult height.
A new drug called CADD522 blocks a gene associated with driving bone cancer's spread, increasing survival rates by 50% in mice implanted with human bone cancer. The breakthrough treatment shows promise in all main bone cancer subtypes and has the potential to save lives and reduce disability.
A study published in PLOS ONE reveals that two elite brothers from Late Bronze Megiddo, Israel, had access to trephination, a rare brain surgery procedure, around 1500 BC. The brothers' tomb contained evidence of chronic disease and advanced bone lesions, suggesting they survived due to their wealth and status.
Scientists have successfully corrected limb length in a mouse model of FZD2-associated autosomal dominant Robinow Syndrome, a genetic disorder that affects skeletal growth and development. The treatment involves using a drug that stimulates the signalling pathway, resulting in significantly longer limbs than untreated mice.
A team of researchers discovered that a mutation in the HMGB1 protein causes a rare disorder with severe malformations, suggesting a link between protein droplets and genetic disease. The study's findings could have implications for understanding congenital malformations, common diseases, and cancer.
A new economic model estimates the health benefits and budget impact of Fracture Liaison Services, showing significant reductions in fragility fractures, hospital bed days, and social care costs. The model suggests that FLS implementation would lead to improved patient outcomes and cost-effectiveness.
Researchers discovered that bone marrow transplants can halt the development and progression of brain blood vessel disease in adults with sickle cell disease. The study found that receiving stem cell transplants led to positive changes in blood vessels, reducing the risk of stroke among patients with the condition.
Biomarkers of bone turnover are essential for diagnosing and treating metabolic musculoskeletal diseases. The International Osteoporosis Foundation, IFCC, and ESCEO have collaborated to publish authoritative reviews on the use and interpretation of these biomarkers.
Researchers have identified a key molecule, retinoic acid, that may be a promising new treatment for hand osteoarthritis. The study found that individuals with certain gene variants had lower levels of retinoic acid, which could lead to the development of disease-modifying drugs.
Researchers from Complexity Science Hub and Medical University of Vienna found that high doses of cholesterol-lowering statins impair bone quality in mice, with a significant increase in osteoporosis risk. The study confirms previous findings on the correlation between statin use and osteoporosis diagnosis in humans.
Researchers identified a link between skeletal muscle atrophy and the loss of two types of myosin. The study showed that mice lacking these proteins experienced severe muscle atrophy and died within four weeks, providing a potential animal model for treating human muscle-wasting disorders.
Researchers from Trinity College Dublin analyzed ancient DNA from two men with multiple osteochondromas, a rare genetic disease, and identified new mutations in the EXT1 gene. This study is the first to discover a new disease mutation in ancient genomic data.
Two studies found corticosteroid injections associated with osteoarthritis progression, while hyaluronic acid injections may slow down progression. Corticosteroids increase risk of disease progression, highlighting need for cautious use.
Researchers at UVA Cancer Center have identified interleukin-1 as a crucial contributor to the development of myelofibrosis, a potentially deadly bone marrow cancer. Targeting this cytokine could prevent myelofibrosis from progressing and spare bone marrow scarring.
Scientists from NTU Singapore have discovered that telomeres are stacked in columns like a spring, leaving DNA exposed to damage. This finding could improve understanding of how humans age and develop cancer, with potential treatments for diseases caused by dysfunctional telomeres.
A new study reveals that European moles reduce their brains by 11% in winter and regrow them by 4% in summer to conserve energy. This phenomenon, known as Dehnel's phenomenon, is driven by cold conditions rather than food shortage alone.
Researchers at MUSC found that extracting and isolating Treg cells and transplanting them back into the same system successfully treats osteogenesis imperfecta for a year. The treatment results in stronger bones, increased osteoblast numbers, and decreased osteoclast numbers.
A new study shows that photon-counting detector CT with AI-based noise reduction detects more lesions in multiple myeloma patients than conventional CT. The technology offers superior image quality at lower radiation doses, potentially impacting therapy choice and patient outcomes.
A team of researchers at Mount Sinai discovered a molecular mechanism involving carbohydrate response-element binding protein (ChREBP) that plays a key role in glucose toxicity and beta-cell death. Increasing expression of an alternate form of ChREBP or activating nuclear factor-erythroid factor 2 can preserve beta-cell mass.
Researchers discovered that vitamin K acts as an antioxidant, inhibiting ferroptotic cell death and identifying FSP1 as the warfarin-insensitive enzyme responsible. This finding has implications for treating Alzheimer's disease and acute organ injuries.
A KAUST-developed nanotechnology platform uses tiny iron wires that bend in response to magnetic fields to accelerate bone cell formation. Bone-forming stem cells grown on the moving substrate transform into mature bone much faster than usual, potentially paving the way for more efficient regeneration of bone.
The International Osteoporosis Foundation proposes a screening strategy to identify women at high risk of hip fracture, which could lead to a reduction in treatment gaps and improved identification of fractures. The approach combines low-cost assessment with targeted intervention using low-cost generic treatments.
A review of scientific evidence concludes that diet has little impact on the progression of osteoarthritis and rheumatoid arthritis. While a healthy diet brings other health benefits, the impact on these diseases is small and not clinically meaningful.
The UK National Osteoporosis Guideline Group has published a new guideline for the prevention and treatment of osteoporosis, which includes updated recommendations for vertebral fracture detection and anabolic treatment options. The guidance aims to improve service provision in both primary and secondary care settings.
The International Osteoporosis Foundation awarded Professor Thierry Thomas the IOF Committee of Scientific Advisors (CSA) Medal of Achievement for his outstanding scientific contributions to osteoporosis. The award recognizes his work on secondary fracture prevention and post-fracture care coordination programs.
The IOF Skeletal Rare Diseases Academy has awarded grants to six young researchers for their outstanding work on rare skeletal disorders. The awards recognize the importance of advancing knowledge and diagnosis for these conditions.
Professor René Rizzoli has been recognized for his significant and longstanding contribution to the advancement of osteoporosis research through his work on bone metabolism and mineralization. He is a respected researcher, clinician, and leader in the field of osteoporosis, with a strong focus on prevention and treatment.
Chronic liver injury triggers bone loss through the liver-bone axis, characterized by an imbalance of PP2Ac® and LCAT. This study reveals the molecular mechanisms behind HOD disease progression.
The American Roentgen Ray Society recognizes Drs. Nguyen, Beheshtian, Harfouch, and Hashiba for their outstanding research and education contributions to the field of radiology. The awards honor the candidates' scientific merit and potential impact on imaging and allied sciences research.
Survival rates for adult patients with relapsed acute lymphoblastic leukemia (ALL) after hematopoietic cell transplantation have increased significantly over the past two decades. The two-year overall survival rate rose from 27.8% in 2000-2004 to 54.8% in 2015-2019, despite a significant increase in patient age at relapse.
Researchers develop ice-inspired lubricant that enhances lubrication and reduces friction and inflammation in a rat model of osteoarthritis. The treatment, which uses microfluidic technology to create drug-loaded particles, shows promise as a potential solution for joint pain and degeneration.
A new study by researchers at Mount Sinai found that a specific gene, HHIP, helps regulate the development of the coronal suture, a fibrous joint that connects the front and middle bone plates. The study showed that embryos with a missing HHIP gene had misshapen skulls and fewer mesenchymal cells separating the bones.
Researchers at Hospital Gregorio Marañón and UC3M developed a navigation system combining surgical navigation, three-dimensional photography, and augmented reality to estimate bone fragment positions during surgery. This system has been used on 7 patients with optimal results, reducing dependency on surgeons' experience.
Researchers used next-generation DNA sequencing to detect residual disease in patients treated with CAR-T therapy for acute lymphoblastic leukemia. The study found that DNA sequencing was more sensitive and accurate than flow cytometry in predicting relapse, enabling earlier intervention.
A study by Tokyo University of Science researchers identifies a novel regulatory axis targeting dendritic cell activity, suppressing autoimmune disease symptoms and bone loss. They discovered DCIR binds to glycoproteins on macrophages and osteoclasts, reducing inflammation and immune responses.
Research suggests that obesity triggers inflammation, leading to an increase in myeloid-derived suppressor cells, which break down bone tissue. This can result in gum disease and tooth loss. The study found a significant link between high-fat diets and increased osteoclasts and alveolar bone destruction.
The study provides a unique genomic blueprint for understanding the complex mechanisms linking obesity with comorbidities like type 2 diabetes and cardiovascular diseases. The Ossabaw pig's genome is highly relevant to humans, making it an ideal model for studying human obesity.
Researchers at Universitat Autonoma de Barcelona develop gene therapy that fully corrects severe whole-body alterations in Morquio A disease, a rare condition caused by GALNS enzyme deficiency. The therapy, administered via intravenous viral vector, prevents bone malformations and life-threatening complications.
A study published in Current Rheumatology Reviews found that rehabilitation exercises significantly improved functional strength and reduced weight in knee osteoarthritis patients. The researchers also noted an increase in exercise adherence among the rehabilitation group compared to the control group.
Researchers created the first detailed cell-by-cell description of how the coronal suture develops, identifying new genes and cell types involved in generating stem cells that grow skull bones. The study aims to advance new interventions for patients with craniosynostosis.
Scientists have discovered a way to replace mutated osteoblasts with healthy ones, leading to improved collagen production and potentially paving the way for a cure for brittle bone disease. The breakthrough could be translated to other forms of OI and bone diseases in the future.
A preclinical study supports AAV8-TNAP-D10 as a single-dose treatment for hypophosphatasia, extending the life span of mice with minimal side effects. The therapy may provide an alternative to current medication injections, benefiting patients with severe skeletal and dental abnormalities.
Scientists have created a miniature 3D bone marrow model that can predict patient responses to Eltrombopag therapy for platelet disorders. The model uses silk protein scaffolding and patient-derived cells to recreate human bone marrow conditions.
Researchers found that people with periodontitis are at higher risk of experiencing major cardiovascular events due to associated inflammation. Active gum disease was predictive of arterial inflammation, leading to heart attacks, strokes, and other cardiovascular complications.
Scientists regenerate parts of the skull using stem cells, correcting skull shape and reversing learning and memory deficits in young mice with craniosynostosis. The study holds great potential for less invasive therapies for children with this common birth defect.
Researchers identified a non-hereditary mutation in blood cells from a patient with GATA2 deficiency that may have prevented bone marrow failure and other clinical manifestations. The mutation acted as a kind of natural gene therapy, protecting the patient from developing typical symptoms.
Researchers at Uppsala University used synchrotron X-rays to study the organ of balance and surrounding blood vessels. The discovery of a drainage system may improve understanding of how Ménière's disease arises from fluid accumulation in the inner ear.
Researchers have identified a new gene, SMAD3, associated with melorheostosis, a rare condition causing excessive bone tissue growth. The study provides a breakthrough in understanding the disease's causes and may lead to the development of treatments.
A study published in the Journal of the Endocrine Society found that exercising women with menstrual disorders can start menstruating again by consuming an additional 300-400 calories a day. This strategy is easy to implement with the help of a nutritionist and avoids complications from drug therapy.
Researchers have found that Saussurea extract has antimicrobial properties and can speed up bone tissue regeneration. The study suggests using Saussurea to treat bacterial bone infections, which are resistant to antibiotics.
A 289-million-year-old lizard-like animal exhibited a bone condition similar to Paget's disease, indicating early susceptibility to the disorder. The study provides evidence of an ancient case of a bone metabolic disorder, shedding light on the evolution of diseases in early life forms.
Researchers have described a new treatment that could cope with Heterotopic Ossification and Fibrodysplasia Ossificans Progressiva using a PI3-kinase inhibitor. The study shows promising results in preclinical models, potentially leading to improved treatment options for patients.
A collaboration of researchers from Oregon State University, University of Oxford, and Erasmus University discovered a genetic mutation causing craniosynostosis, a condition where skull bones fuse prematurely. This finding may lead to the prevention of the disorder and a better understanding of its effects on other organ systems.
Recent advances in focal and sclerotic bone diseases have led to a clearer characterization of conditions like Paget's disease, fibrous dysplasia, and Camurati-Engelmann disease. This improved understanding has enabled the development of new therapeutic approaches for these disorders.