Articles tagged with Bone Diseases
The project aims to catalog the HLA gene complex and explore its differences among populations worldwide. The goal is to create a searchable database linking multiple interacting genes with function, ethnicity, and disease.
An international team is accelerating the investigation of immune-related genes to improve organ transplant matches and develop vaccines for specific diseases. The Human Leukocyte Antigen (HLA) gene complex holds clues to many medical questions.
Two new Phase III studies published in Neurology show that Reminyl (galantamine) significantly improves cognition, global function, and behavioral symptoms of Alzheimer's disease over a period of 12 months. The treatment also maintains activities of daily functioning for patients with mild to moderate Alzheimer's disease.
A new UC Francisco study reveals a link between chronic use of protease inhibitors and the development of avascular necrosis (AVN) of the femoral head in HIV/AIDS patients. Early diagnosis can lead to effective treatment, but high-risk hip replacement surgery is associated with infection risk for these patients.
A new study shows Bexxar produced tumor shrinkage in 97% of patients with advanced-stage, low-grade non-Hodgkins lymphoma. Most patients achieved complete remission, with no sign of cancer, and molecular remissions lasting up to three years.
A new study suggests Reminyl, a treatment for Alzheimer's disease, provides significant cognitive and functional improvements in patients. The medication has been shown to delay the emergence of behavioral symptoms and maintain daily functioning for up to a year.
A recent study found that the genetic marker associated with periodontal disease in people of European heritage is barely present in Chinese populations. This suggests that oral hygiene habits, smoking, and other risk factors may be more important in explaining the high prevalence of periodontal disease in Chinese populations.
Researchers identified a link between genetic mutations in the cathepsin C gene and severe gum disease and periodontitis. The study found that individuals with normal functioning of the cathepsin C gene tend to have healthy gums, suggesting dietary, bacterial, and other genetic factors can compromise its function.
Researchers successfully demonstrated the effectiveness of a new oral form of ganciclovir to treat CMV retinitis, a blinding disorder that affects AIDS patients. The experimental valganciclovir offers a simpler treatment option with fewer pills needed per day.
A study using polymerase chain reaction detects MRD in long-term CML survivors, finding that approximately 25% of patients had evidence of disease at some time after transplant. The team aims to identify patients who appear cured but may still harbor disease and benefit from early therapeutic intervention.
A recent University of Iowa Health Care study calls into question the reliability of a classification system used to evaluate treatment outcomes in children with Legg-Calve-Perthes Disease. The Stulberg Classification System, developed in 1981, predicts long-term patient outcomes but has poor reliability among surgeons.
Researchers used embryonic stem cells to repair damaged nerve fibers in a rat model of Pelizaeus-Merzbacher disease. The study showed that transplanted cells can promote myelin sheath growth, potentially leading to improved function and clinical applications.
Researchers developed a transgenic mouse model of chronic liver disease caused by hepatitis B virus (HBV), enabling the study of immune responses and drug development. The model opens opportunities for scientists to test drugs in the liver and understand how HBV causes liver disease.
The Rosalind Russell New Arthritis Treatment Program at UCSF is testing innovative therapies targeting specific cells that promote inflammation and joint damage. Current clinical trials focus on rheumatoid arthritis and systemic lupus erythematosus, with promising results expected to lead to nationwide approval.
Researchers have successfully replicated human bone disorder McCune-Albright syndrome in mice using a novel animal model. The model utilizes a combination of normal and mutant stromal cells, which are mixed together before transplantation into immune-compromised mice.
A study of 228 diseased heart valves found organized, hard-bone tissue in 30 valves, suggesting an active process of calcification. The discovery could lead to the development of treatments to prevent or treat heart-valve disease and provide insights into rare disorders like fibrodysplasia ossificans progressiva.
Thomas Jefferson researchers discovered that lower levels of the tumor suppressor gene Rb2/p130 correlate with increased risk of returning disease and higher mortality in women with endometrial cancer. The study suggests a potential diagnostic test to guide treatment and improve patient outcomes.
Researchers discovered a genetic defect in ALL1 gene duplication that signals poor prognosis and shorter survival time in AML patients. Patients with this defect require aggressive treatment, including allogenic bone marrow transplant, to improve survival rates.
A nationwide effort to find genes that determine susceptibility to rheumatoid arthritis has been launched, with researchers collecting medical information and genetic material from 1,000 families. The project aims to identify genetic regions shared by affected siblings, which may contain genes involved in the disease.
Researchers have identified the genetic link to Griscelli disease, a rare autosomal recessive disorder characterized by partial albinism and immunologic abnormalities. The gene responsible for the condition is myosin-5a, which plays a crucial role in organelle transport within cells.