Researchers identified a new kinase inhibitor that blocks a different path used by cancer, leading to improved treatment outcomes for chronic myelogenous leukemia (CML) and B-cell acute lymphoblastic leukemia (B-ALL). The study found that the inhibitor impaired proliferation of leukemic cells and prolonged survival in mice with B-ALL.
Researchers used SELDI-TOF mass spectrometry to analyze proteins in CSF of patients with known malignancies and non-cancerous conditions. They identified specific protein fingerprints that reliably distinguished between cancerous and non-cancerous disease, offering a promising diagnostic tool.
Researchers at Children's Hospital Boston have unraveled the biology behind chronic inflammatory anemia and propose new drug targets. They found a key regulator of hepcidin, a hormone controlling iron levels, and suggest that inhibiting it may improve treatment for patients with anemia of chronic disease.
A study found that men who consumed green and black tea for five days had slower-growing prostate cancer cells compared to those who drank diet or regular soda. The researchers discovered a significant negative correlation between total polyamine levels and tea polyphenol content in the tissue.
Researchers have found that blocking the action of the HFE gene can reduce anemia caused by chronic inflammation, providing a potential new treatment for patients. This breakthrough aims to alleviate the negative effects of withholding iron while preserving the body's natural defense mechanisms.
Scientists create microscision technique that uses gas to bombard skin with tiny crystals, creating invisible conduits for drug delivery. The new method is shown to be effective in administering local anaesthesia without causing pain, making it a promising alternative to traditional needles.
Researchers at Imperial College London have discovered a link between chromosome 'caps' and the prediction of rare bone marrow diseases. The study found that shorter telomeres in chromosomes can indicate an increased risk of disease severity and early onset, providing a potential new mechanism for understanding disease anticipation.
Researchers discovered a novel screening approach that identified a compound, GS4012, which suppresses a genetic mutation in zebrafish embryos. The compound promotes vascular growth and may have implications for diseases such as heart attack, stroke or injury.
Research reveals that stress triggers a hormonal response that modifies immune system function, leading to increased vulnerability to mental and physical diseases. Stress can create long-term damage by initiating an inflammatory state in the body, which can lead to chronic diseases such as depression and coronary artery disease.
Dr. Bissell's research reveals that the cellular microenvironment plays a crucial role in gene expression and cell behavior. She discovered that malignant cells can be reverted to a normal phenotype through manipulation of the extracellular matrix.
Researchers have discovered biomarkers for ALS in cerebrospinal fluid, which could enable rapid diagnosis and prompt treatment. These biomarkers have high sensitivity and specificity, and may be used to monitor drug effectiveness in clinical trials.