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Science News for April 1, 1998


First Trimester Screening For Down Syndrome Possible, NICHD-Funded Study Finds

Researchers developed a new blood test that can detect Down syndrome in the first trimester with accuracy rates exceeding 60%. The test combines measurements of human chorionic gonadotropin and pregnancy-associated protein A to identify women at higher risk of carrying a fetus with the condition.

Study Shows Unrelated Marrow Transplantation Offers Hope Of Cure For People Diagnosed With Chronic Myeloid Leukemia

Researchers at Fred Hutchinson Cancer Center found that HLA-matched unrelated marrow transplants can be safe and effective for CML patients in chronic phase. The study showed a 57% overall survival rate, with younger patients having a higher rate of 74%, comparable to those with matched sibling donors.

SourceFred Hutchinson Cancer Center·JournalNew England Journal of Medicine·DateApr 1, 1998

Human Metabolite Of Taxol Synthesized In The Laboratory

Researchers have synthesized the major human metabolite of Taxol, 6-alpha-hydroxypaclitaxel, for the first time in a laboratory setting. This breakthrough will enable easier identification and quantification of the metabolite in complex mixtures, crucial for maximizing the clinical effectiveness of paclitaxel.

Kaposi's Sarcoma Caused By Virus Usually Transmitted Through Homosexual Sex, According To UCSF Study

A UC San Francisco study published in the New England Journal of Medicine found that HHV-8 is a direct cause of Kaposi's sarcoma in HIV-positive homosexual men, with transmission through sexual contact playing a major role. The study showed that infection with HHV-8 increases the risk of developing Kaposi's sarcoma within 10 years.

SourceUniversity of California - San Francisco·JournalNew England Journal of Medicine·DateApr 1, 1998