Deepak Srivastava, MD, is recognized for his organizational leadership and scientific innovation at Gladstone Institutes. His lab has made significant discoveries in treating heart disease and repairing heart damage.
The Center for Translational Exposomics Research (CTER) at USC aims to accelerate environmental health research and find practical solutions. CTER investigates how different exposures impact health across populations using population studies, lab experiments, and community engagement.
Epigenetic changes, driven by oxidative stress, facilitate tumor metastasis through EMT, ECM remodeling, and CTCs survival. Novel therapeutic strategies combining oxidative stress modulators and epigenetic drugs show promise in combating metastasis.
A large-scale clinical trial found that intravenous infusion of exenatide during heart surgeries involving bypass did not significantly reduce the risk of death, stroke, or organ failure. The study included approximately 1,400 adults and a randomized, double-blind, placebo-controlled design.
A study found that pharmacists who received feedback about their heart failure patients increased the frequency of their patient interactions and prescribed more medication adjustments. The intervention, which provided educational resources and monthly audit and feedback emails, led to a significant increase in heart failure management.
A clinical trial found that combining two commonly recommended medications into a single pill lowered blood pressure and was safe among Indian adults. The study's results have significant meaning for South Asian adults, including those living in the US.
In patients with mildly reduced ejection fraction, finerenone resulted in more frequent hyperkalemia but maintained clinical benefit when dose-adjusted. With protocol-directed surveillance, finerenone showed improved clinical outcomes compared to placebo, even at high potassium levels.
The study reveals that atomic resolution SE imaging can distinguish between surface atomic arrangements with high sensitivity, identifying honeycomb-like structures composed of molybdenum and sulfur atoms. The method's depth sensitivity is also demonstrated by the absorption or scattering of SEs from the second layer.
Research highlights edoxaban's effectiveness in reducing stroke and blood clots for patients after bioprosthetic heart valve replacement. Edoxaban was found to be equally or more effective than warfarin, with a predictable pharmacokinetic profile and reduced burden on patients.
The Finerenone Trial found finerenone to be effective in reducing the primary end point in both women and men with heart failure. Finerenone, a mineralocorticoid receptor antagonist, showed similar tolerability in women and men.
A new AI program, PanEcho, has been developed to interpret echocardiography videos independently, reducing wait times and improving timely medical care. The program demonstrated accuracy in estimating continuous echocardiographic parameters and quantifying left ventricle dimensions and function.
Research challenges clonal evolution theory, presenting evidence that tumors can emerge from multiple cells. Single-cell phylogenies were analyzed using DNA barcoding system, revealing striking patterns of parallel clonal expansions within individual lesions.
A new thermochromic hydrogel design can regulate both solar transmission and rapid visible-light stealth at any temperature, with potential applications in energy-efficient windows, military equipment, and anti-counterfeiting. The innovation enables fast response times of just 1 second.
Researchers used Intermountain Risk Score to predict major cardiac events in patients being evaluated for kidney transplant, with a five-year follow-up period showing 171 patients experiencing cardiac events. The study's findings suggest the potential use of calculating such a score in people undergoing kidney transplant evaluation.
A randomized trial found reconditioned pacemakers comparable to new devices in terms of safety and effectiveness up to 90 days after implantation. However, longer-term follow-up is necessary to confirm the safety and efficacy of reconditioned devices.
Researchers developed a dual-function molecule (LXW7)2-SILY to remodel native extracellular matrix at ischemic sites, enhancing endothelial cell adhesion and survival. This approach improved vascularization, blood perfusion, and tissue regeneration in mouse hindlimb ischemia models.
A new study introduces the PWAS Hub, a powerful tool that explores gene-disease connections across 99 common diseases. The platform identifies genes linked to specific conditions and provides valuable genetic insights for clinicians and researchers.
A study found that 64% of clinical trials for the top 30 highest-revenue medicines had their data accessible to researchers, a significant improvement over prior assessments. Companies using independent platforms achieved higher eligibility rates than those relying on internal processes.
Research found that spironolactone reduced the likelihood of heart failure after a heart attack, but did not significantly reduce deaths or other severe heart-related events. The study included over 7,000 adults in 14 countries who had experienced a severe heart attack.
Path planning is vital for navigating micro-/nanorobots in complex and dynamic environments. Micro-/nanorobots play a significant role in advancing medical and biological applications, enabling targeted drug delivery and minimally invasive surgery.
Patients with transthyretin amyloid cardiomyopathy experience frequent decline in kidney function, associated with higher mortality risk. eGFR decline is an independent marker of disease progression guiding treatment optimization.
Research published in European Heart Journal reveals that taking an NSAID with anticoagulant medication increases the risk of internal bleeding. The study found a significant increase in bleeding risks for various organs, including gut, brain, lungs, and bladder.
Researchers aim to harness sunlight into laser beams using photosynthetic structures from bacteria, enabling efficient and sustainable power transmission in space. The project's goal is to provide reliable energy for lunar bases, Mars missions, and terrestrial wireless power transmission.
A recent study published in Journal of Interprofessional Care highlights the importance of strong teamwork and face-to-face communication in improving patient care within hospitals. The research, conducted by researchers at the University of Colorado Anschutz Medical Campus, found that frequent in-person interactions between healthcare...
A randomized clinical trial found partial cardiac denervation effective in preventing postoperative atrial fibrillation after isolated coronary artery bypass grafting without additional complications. This suggests partial cardiac denervation as a viable option for preventing postoperative atrial fibrillation after CABG.
A recent study found that electronic letter reminders highlighting the cardiovascular benefits of influenza vaccines increased vaccination rates among over 2 million adults in Denmark. The strategy showed a greater impact on those who have had a heart attack, improving flu shot rates by potentially being cardioprotective. The research ...
Researchers have developed a mindfulness therapy tailored to teenagers to combat increasing levels of depression and mental health problems. The ATTEND programme teaches participants to manage negative thought patterns and focus on the present moment, offering a family-centred approach to tackling depression.