Articles tagged with Breast Cancer
A study published in the Journal of the National Comprehensive Cancer Network found that breast cancer survivorship has doubled among Canadian women, with 2.1% of adult females diagnosed with breast cancer and 86% surviving by 2022. The prevalence varies by age group, with senior women having a higher rate of survival.
A specialized triage algorithm, ROCA test, enables earlier stage diagnosis in women deferring preventive surgery, saving NHS costs. The approach results in fewer major surgical interventions and lower risk of wider disease spread.
A study reveals that interleukin 34 (IL-34) modulates the balance between two myeloid-derived suppressor cell populations, leading to immunosuppression and chemoresistance in triple-negative breast cancer. Neutralizing IL-34 with a drug reduces tumor growth and susceptibility to chemotherapy.
Researchers at Tokyo Medical and Dental University developed a new technique to detect breast cancer-related markers using transistors, offering a less invasive method for monitoring patients. The system successfully detected epidermal growth factor receptor expression on cancer cells.
Research at Linköping University suggests that dense breasts have unique biological characteristics that promote cancer growth, leading to a fivefold increased risk. The study used MRI and microdialysis techniques to measure proteins in breast tissue, finding elevated levels of inflammatory markers and growth factors.
Filopodia contribute to building a barrier surrounding breast tumours, blocking their escape. Cancer cells lacking Myosin-10 cannot maintain this barrier, making it easier for them to spread.
A Phase Ib clinical trial found that sequential administration of PARP inhibitor olaparib and WEE1 inhibitor adavosertib is safe and well-tolerated, with promising signs of anti-tumor activity in patients with advanced cancers driven by DNA damage response mutations. The combination showed durable responses in patients with resistant c...
A recent study published in BME Frontiers developed an AI-based approach that rapidly transforms autofluorescence images into virtual histological images for accurate HER2 assessment. This computational staining process takes only a few minutes per sample and does not require expensive facilities or toxic chemicals.
In a patient trial, the AKT inhibitor ipatasertib showed signs of effectiveness in treating advanced cancers. 22% of patients experienced tumor shrinkage, while 56% had stable disease. Further research is needed to understand why some patients responded and others did not.
Researchers at Baylor College of Medicine found that initiating bone repair triggers bone metastasis, with cancer cells 'riding' NG2-positive stem cells to tumor sites. This finding offers new directions for preventing tumor recurrence and controlling bone metastasis.
Researchers have developed a drug compound that stops cancer cell growth in mice with little effect on normal healthy cells, making it potentially nontoxic for patients. The therapy targets the epidermal growth factor receptor gene, which is overexpressed in about half of all triple-negative breast cancer cases.
Researchers at VCU Massey Cancer Center have identified a new therapeutic target for triple-negative breast cancer (TNBC), a more aggressive and deadly form of disease. Using CRISPR/CAS9 screening, scientists pinpointed the UBA1 enzyme as an ideal target, which can be inhibited by the novel drug TAK-243 to effectively kill cancer cells.
Researchers have found a drug that targets the key, cancer-causing gene MYC has been able to inhibit its function safely and effectively. Eight out of 12 patients showed stabilisation of disease after treatment with OMO-103, with one patient experiencing a reduction in tumour-derived DNA circulating in the blood stream.
A Phase III trial found that hypo-fractionated whole breast irradiation (WBI) with concurrent boost is not inferior to conventional WBI with a sequential boost following lumpectomy in patients with high-risk, early-stage breast cancer. The study showed comparable effectiveness and toxicity outcomes between the two treatment options.
A randomized phase III trial found that hypofractionated whole-breast radiation with concurrent boost is comparable to six weeks of treatment for patients with higher-risk disease, reducing tumor recurrence by 20-30%. The three-week course was non-inferior to the longer treatment in terms of tumor recurrence and cosmetic outcomes.
A large clinical trial data analysis found that rates of locoregional recurrence are low regardless of regional node irradiation use. The study suggests a randomized clinical trial is required to answer the question of whether favorable-risk patients can safely skip RNI.
A new study found that women with a first-degree family relative diagnosed with breast cancer may benefit from screening 5-8 years earlier than their relative's diagnosis age. This is equivalent to the recommended age for average-risk women of 50. The study analyzed data from over 300,000 women and found that increasing the age for ini...
A team of researchers has successfully 3D bioprinted breast cancer tumors, treated them with chemotherapy and CAR-T cells, and found promising results. The bioprinted tumor model enabled the testing of experimental therapies without animal experimentation, laying the foundation for precision fabrication of tumor models.
Researchers developed an antibody-based treatment that targets cadherins on circulating tumor cells, eliminating them in mouse models of breast and pancreatic cancer. The therapy shows promise in preventing cancer metastasis, a leading cause of cancer-related deaths.
A new NIH study found that frequent use of hair straightening products was associated with a higher risk of uterine cancer, particularly among Black women. The researchers estimated that women who used these products frequently were more than twice as likely to develop uterine cancer compared to those who did not use them.
Researchers at LSU Health New Orleans have identified a new drug target for triple-negative breast cancer, which lacks estrogen and progesterone receptors. The novel small molecule inhibitor NSC33353 works synergistically with doxorubicin to suppress the growth of TNBC cells.
A team of researchers at Baylor College of Medicine has investigated how breast cancer cells lose their ER expression, revealing a mechanism that explains the process and offers possibilities to overcome it. The study found that over-expressing 14-3-3τ in cancer cells leads to ER loss, with other molecular players such as AKT and GATA3...
A new therapy has been discovered to overcome treatment resistance in aggressive breast cancer by targeting fibroblasts and enhancing the immune response. The therapy, FAP-IL2v, binds to fibroblast-expressed molecules, allowing the immune system to break through the tumor's protective microenvironment and eliminate cancer cells.
A large multi-center study analyzing patient records from three major cancer centers found that ILC is detected later and has worse outcomes than IDC. The research highlights the need for new imaging technologies to improve early detection of ILC, which often spreads beyond breast tissue before diagnosis.
Invasive breast cancer rates declined in childhood cancer survivors under age 40, largely due to reduced chest radiation therapy. Concurrent changes in other therapies may have tempered this trend, according to a study of 11,550 female survivors diagnosed between 1970 and 1999
A study published in the Journal of Medical Screening found that pre-booked appointments increased breast cancer screening attendance by 53.1%, compared to 60.6% for timed appointments in London between September 2020 and March 2021.
Interdisciplinary researchers at the Beckman Institute have received a four-year, $2M award from the National Institutes of Health to develop a device that can instantly enable real-time 3D ultrasound imaging. The device, named FASTER, is designed to improve high-quality medical imaging accessibility in diverse communities.
A study of over 4 million claims found that Black women had less access to new mammography technology, even when receiving mammograms at the same institution. The disparities in digital breast tomosynthesis use among Black and white women began to subside after 2016.
Research reveals that individuals with inflammatory breast cancer are at a higher risk of brain metastases, which can lead to improved survival rates and quality of life. The study suggests that patients with triple-negative breast cancer face an even higher risk, emphasizing the need for earlier detection and more aggressive treatment.
Geoffrey M. Wahl and Norman Wolmark will receive the Brinker Award for their groundbreaking contributions to cancer genetics, research methodology, and transformative approaches to patient care.
Italian scientists have discovered a new mechanism of drug resistance in breast cancer that leads to the formation of cancer stem cells. The research found that tumor cells release alarmins during chemotherapy, which can reprogram residual cancer cells into stem cells with high invasive potential.
Researchers developed a low-cost, simple imaging system using tumor-targeting fluorescent molecules to determine tumor depth. The portable system provides quantitative information about the depth of tumor cells in the body, helping surgeons remove healthy tissue around tumors for better outcomes.
Researchers at UNC Lineberger Comprehensive Cancer Center have found a way to overcome barriers limiting cancer immunotherapies. They discovered that activating the STING protein can increase regulatory B cells, which suppress anti-cancer immunity.
Researchers found that certain fungal species in tumors are linked to inflammation and reduced cell-to-cell adhesion, features associated with late-stage cancer spread. High levels of these fungi may serve as biomarkers for metastasis risk and lead to more effective treatment choices.
A recent study published in Acta Oncologica found that young women who have had cancer are at a higher risk of experiencing sexual problems, including loss of libido and intimacy issues. The study, which surveyed nearly 700 women, suggests that the type and intensity of cancer treatment can influence a patient's sex life.
A recent study published in Plastic and Reconstructive Surgery reports low rates of recurrent breast cancer after nipple-sparing mastectomy, with a 3.33% per patient rate over 10 years. The study suggests good long-term cancer control with this surgical option.
A USC-led team has found indications for an early breast cancer detection method using high-definition liquid biopsies. The test detected multiple cancer biomarkers, including 'oncosomes,' in the blood samples of most early-stage breast cancer patients.
Researchers are studying the interaction between obesity and nitric oxide synthase in triple-negative breast cancer, aiming to develop a new treatment strategy. Another team is investigating the role of NHE6 protein in multiple myeloma resistance to daratumumab treatment, with the goal of improving therapy outcomes for patients.
A study of 3,141 US counties found that counties with higher social vulnerability had lower rates of recommended breast, cervical, and colorectal cancer screenings. The findings suggest that addressing social determinants of health may be crucial for improving cancer screening rates.
A UTHealth Houston study found regional disparities in cancer screening rates tied to social vulnerability, with lower rates in more vulnerable counties. The study analyzed 3,141 US counties and discovered significant differences in breast, cervical, and colorectal cancer screenings.
Researchers have discovered immune cell types that could be targeted to develop specific immunotherapies in chemotherapy-resistant breast cancers. The study found that certain immune cells, such as neutrophils and natural killer cells, were unable to effectively fight cancer cells due to gene expression changes.
A potential new treatment for glioblastomas, a deadly form of brain tumor, is being researched using the medication letrozole. Studies have shown that letrozole can be effective in killing tumor cells and reaching target tissue safely.
Researchers at UT Southwestern Medical Center discovered that fat cells near breast tumors can transform into other cell types, creating a fertile ground for the disease. This transformation allows these cells to supply energy to neighboring tumor cells, contributing to their growth.
Research from UVA Cancer Center finds that an unhealthy gut microbiome can trigger changes in normal breast tissue, facilitating cancer's spread to other parts of the body. The study suggests that targeting the gut-mast cell relationship could help prevent breast cancer recurrence and metastasis.
The analysis found that inadequate margin widths may result in higher risks of distant recurrence and breast cancer mortality, as well as increased local recurrence. The researchers recommend a minimum tumour free distance of 1mm from the margin for optimal oncological outcomes.
Researchers at the University of Basel have successfully differentiated triple-negative breast cancer cells into normal-like cells, opening a new avenue for treatment. The breakthrough uses inhibitors of polo-like kinase 1 to induce estrogen receptor expression, leading to reduced cell growth and tumorigenicity.
A team of researchers has identified TSG101 as a crucial regulator of the PARP1 enzyme, which is responsible for repairing DNA damage. In cancer cells with BRCA mutations, TSG101 is essential for PARP1 activation, making it a promising target for cancer treatment.
Researchers discovered a type of triple-negative breast cancer cell that can trigger dormancy, evading therapies and allowing for efficient survival in distant organs. This finding highlights the need for more selective therapeutic strategies targeting both dividing and invasive dormant cells.
The Montefiore Einstein Cancer Center has received a $10 million grant from the National Cancer Institute to study lung metastasis in breast cancer. The research aims to understand the mechanisms of tumor cells seeding tumors in the lungs, a key site for triple-negative breast cancer metastasis.
A new study of over half a million people with type 2 diabetes found that smoking and low physical activity significantly increase the risk of premature death. Individuals with type 2 diabetes who develop cancer are more likely to die in seven years if they are smokers or physically inactive.
A novel imaging approach developed in mice may help detect early signs of cancer in dense breasts, which is essential for improved breast imaging and prognosis. Researchers created an analytic computer program that sorts mammary gland tissue into two assessments, resulting in better detection accuracy.
Researchers found that a specific sequence of drugs can reduce overall costs and improve the value of care for patients with metastatic breast cancer, while minimizing side effects. The study's results suggest that treatment sequencing approaches that minimize costs early may improve the value of care.
New research estimates the overall disease burden of genetic risk factors on healthy life years lost, prioritizing interventions using genetic information. The study found that common genetic variants for cardio-vascular diseases and Alzheimer’s disease have a substantial population-level impact.
A study found that trained radiographers perform as well as radiologists in key areas of double reading mammograms, improving cancer detection rates. The results suggest that focused training and experience are key factors in reader performance, not just medical degree or broad radiology education.
A study found that resiliency and family support play a crucial role in helping Hispanic breast cancer survivors manage lymphedema. Adaptations such as modifying work tasks and seeking support from family members enable survivors to maintain their quality of life.
A systematic review and meta-analysis of observational studies found a moderate association between antipsychotic use and an increased risk of breast cancer, estimated at over 30%. The study highlights the importance of risk-benefit assessment of antipsychotic prescription in high-risk patients.
Breast cancer recurrence and metastatic spread remain a significant challenge, with researchers identifying a metabolic signature that can predict patient outcomes. The signature could be used to develop new therapies targeting cancer metabolism.
A new study shows that the 'batwing' mastopexy technique can be safely performed simultaneously with immediate breast reconstruction, providing comparable complication rates and improved aesthetic outcomes. Women with larger breasts or ptosis can now consider nipple-sparing mastectomy without increased risk of complications.
A recent study found that background parenchymal enhancement (BPE) at surveillance breast MRI is independently associated with an increased risk of future second breast cancer. Women with dense breasts and minimal BPE may no longer need to undergo contrast-enhanced breast MRI every year if other risk factors are absent.
Researchers at LSU Health New Orleans have identified a critical immunosuppressive pathway and developed an experimental inhibitor to protect T-cells from weakening. The CBL-B inhibitors show great potential in enhancing the efficacy of cancer immunotherapy, making patients' T-cells more effective in killing cancer cells.