Articles tagged with Breast Cancer
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Researchers at UNC Lineberger Comprehensive Cancer Center have found a way to overcome barriers limiting cancer immunotherapies. They discovered that activating the STING protein can increase regulatory B cells, which suppress anti-cancer immunity.
Researchers found that certain fungal species in tumors are linked to inflammation and reduced cell-to-cell adhesion, features associated with late-stage cancer spread. High levels of these fungi may serve as biomarkers for metastasis risk and lead to more effective treatment choices.
A recent study published in Acta Oncologica found that young women who have had cancer are at a higher risk of experiencing sexual problems, including loss of libido and intimacy issues. The study, which surveyed nearly 700 women, suggests that the type and intensity of cancer treatment can influence a patient's sex life.
A recent study published in Plastic and Reconstructive Surgery reports low rates of recurrent breast cancer after nipple-sparing mastectomy, with a 3.33% per patient rate over 10 years. The study suggests good long-term cancer control with this surgical option.
A USC-led team has found indications for an early breast cancer detection method using high-definition liquid biopsies. The test detected multiple cancer biomarkers, including 'oncosomes,' in the blood samples of most early-stage breast cancer patients.
Researchers are studying the interaction between obesity and nitric oxide synthase in triple-negative breast cancer, aiming to develop a new treatment strategy. Another team is investigating the role of NHE6 protein in multiple myeloma resistance to daratumumab treatment, with the goal of improving therapy outcomes for patients.
A study of 3,141 US counties found that counties with higher social vulnerability had lower rates of recommended breast, cervical, and colorectal cancer screenings. The findings suggest that addressing social determinants of health may be crucial for improving cancer screening rates.
A UTHealth Houston study found regional disparities in cancer screening rates tied to social vulnerability, with lower rates in more vulnerable counties. The study analyzed 3,141 US counties and discovered significant differences in breast, cervical, and colorectal cancer screenings.
Researchers have discovered immune cell types that could be targeted to develop specific immunotherapies in chemotherapy-resistant breast cancers. The study found that certain immune cells, such as neutrophils and natural killer cells, were unable to effectively fight cancer cells due to gene expression changes.
A potential new treatment for glioblastomas, a deadly form of brain tumor, is being researched using the medication letrozole. Studies have shown that letrozole can be effective in killing tumor cells and reaching target tissue safely.
Researchers at UT Southwestern Medical Center discovered that fat cells near breast tumors can transform into other cell types, creating a fertile ground for the disease. This transformation allows these cells to supply energy to neighboring tumor cells, contributing to their growth.
Research from UVA Cancer Center finds that an unhealthy gut microbiome can trigger changes in normal breast tissue, facilitating cancer's spread to other parts of the body. The study suggests that targeting the gut-mast cell relationship could help prevent breast cancer recurrence and metastasis.
The analysis found that inadequate margin widths may result in higher risks of distant recurrence and breast cancer mortality, as well as increased local recurrence. The researchers recommend a minimum tumour free distance of 1mm from the margin for optimal oncological outcomes.
Researchers at the University of Basel have successfully differentiated triple-negative breast cancer cells into normal-like cells, opening a new avenue for treatment. The breakthrough uses inhibitors of polo-like kinase 1 to induce estrogen receptor expression, leading to reduced cell growth and tumorigenicity.
A team of researchers has identified TSG101 as a crucial regulator of the PARP1 enzyme, which is responsible for repairing DNA damage. In cancer cells with BRCA mutations, TSG101 is essential for PARP1 activation, making it a promising target for cancer treatment.
Researchers discovered a type of triple-negative breast cancer cell that can trigger dormancy, evading therapies and allowing for efficient survival in distant organs. This finding highlights the need for more selective therapeutic strategies targeting both dividing and invasive dormant cells.
The Montefiore Einstein Cancer Center has received a $10 million grant from the National Cancer Institute to study lung metastasis in breast cancer. The research aims to understand the mechanisms of tumor cells seeding tumors in the lungs, a key site for triple-negative breast cancer metastasis.
A new study of over half a million people with type 2 diabetes found that smoking and low physical activity significantly increase the risk of premature death. Individuals with type 2 diabetes who develop cancer are more likely to die in seven years if they are smokers or physically inactive.
A novel imaging approach developed in mice may help detect early signs of cancer in dense breasts, which is essential for improved breast imaging and prognosis. Researchers created an analytic computer program that sorts mammary gland tissue into two assessments, resulting in better detection accuracy.
Researchers found that a specific sequence of drugs can reduce overall costs and improve the value of care for patients with metastatic breast cancer, while minimizing side effects. The study's results suggest that treatment sequencing approaches that minimize costs early may improve the value of care.
New research estimates the overall disease burden of genetic risk factors on healthy life years lost, prioritizing interventions using genetic information. The study found that common genetic variants for cardio-vascular diseases and Alzheimer’s disease have a substantial population-level impact.
A study found that trained radiographers perform as well as radiologists in key areas of double reading mammograms, improving cancer detection rates. The results suggest that focused training and experience are key factors in reader performance, not just medical degree or broad radiology education.
A study found that resiliency and family support play a crucial role in helping Hispanic breast cancer survivors manage lymphedema. Adaptations such as modifying work tasks and seeking support from family members enable survivors to maintain their quality of life.
A systematic review and meta-analysis of observational studies found a moderate association between antipsychotic use and an increased risk of breast cancer, estimated at over 30%. The study highlights the importance of risk-benefit assessment of antipsychotic prescription in high-risk patients.
Breast cancer recurrence and metastatic spread remain a significant challenge, with researchers identifying a metabolic signature that can predict patient outcomes. The signature could be used to develop new therapies targeting cancer metabolism.
A new study shows that the 'batwing' mastopexy technique can be safely performed simultaneously with immediate breast reconstruction, providing comparable complication rates and improved aesthetic outcomes. Women with larger breasts or ptosis can now consider nipple-sparing mastectomy without increased risk of complications.
A recent study found that background parenchymal enhancement (BPE) at surveillance breast MRI is independently associated with an increased risk of future second breast cancer. Women with dense breasts and minimal BPE may no longer need to undergo contrast-enhanced breast MRI every year if other risk factors are absent.
Researchers at LSU Health New Orleans have identified a critical immunosuppressive pathway and developed an experimental inhibitor to protect T-cells from weakening. The CBL-B inhibitors show great potential in enhancing the efficacy of cancer immunotherapy, making patients' T-cells more effective in killing cancer cells.
A new study suggests that the nuclear receptor TLX can inhibit the growth and progression of triple-negative breast cancer. TLX+ cells showed lower tumor growth, migration, and invasion rates compared to those without TLX expression.
A new treatment approach for triple-negative breast cancer is being developed using nitric oxide scavengers. The study found that converting nitric oxide into nitrogen centred free radicals inhibits the migration of cancer cells in the tumor environment, suggesting a potential use of modified hyaluronic acid as a key material.
A Swedish study of 1,275 women with breast cancer found no increased risk of disease recurrence or death after fertility preservation procedures. The research provides new hope for women who want to preserve their fertility after cancer treatment.
A study from Lund University found that Caveolin-1 protein levels in surrounding tumour tissue affect breast cancer prognosis. The study suggests that this protein could be used as a marker for precise prognosis and treatment choice.
A pilot study from UCLA researchers found that neurofeedback training significantly normalized brain wave frequencies and improved cognitive function in cancer patients with chemo brain. The study's results support further research into the effectiveness of neurofeedback as a treatment approach.
Recent evidence suggests hormone therapy at menopause does not significantly increase the risk of invasive breast cancer. However, estrogen combined with progesterone increases breast cancer risk for women with an intact uterus. Menopause experts offer reassurance to women and their healthcare providers about the safety of hormone ther...
A recent study found associations between socioeconomic stressors and specific N-glycosylation patterns in Black and White women, suggesting that molecular markers may be linked to socioeconomic status. The research also identified differences in glycosylation patterns in normal breast tissue based on body mass index (BMI) and ancestry.
Scientists at Baylor College of Medicine and the Broad Institute have identified biological markers associated with chemotherapy resistance in triple negative breast cancer. The study found that deletion on chromosome 19, specifically the LIG1 gene, is linked to resistance to treatment and poor clinical outcomes.
SUTD researchers leverage nanosecond electroporation to deliver cancer-related molecules into living cells with excellent viability. The platform enables pores to remain open for up to 720 minutes, paving the way for efficient drug delivery and other applications.
Researchers developed a method combining musical tests with EEG measurement to detect cognitive decline in old age. The study tested 50 elderly people who scored low on the mini-mental test, showing promising results in detecting mental deterioration.
Research suggests that cancer-related fatigue (CRF) contributes to balance problems in breast cancer survivors, even after chemotherapy. CRF predicts greater postural sway and changes in 'sit-to-stand' function, highlighting the need for rehabilitation professionals to consider CRF in exercise prescriptions.
A comprehensive analysis of interstitial lung disease diagnosis and treatment in patients who received an antibody drug conjugate known as T-DXd found that close monitoring and proactive management can reduce the risk of ILD. The study results suggest that patient awareness and ongoing education can aid in early detection.
A recent study published in Cancer Research identified a unique vulnerability in certain high-risk cancers that can be exploited for targeted therapy. Researchers found that cancer cells with alternative lengthening of telomeres (ALT) have a common weakness, leading to resistance to DNA-damaging agents and chemotherapy.
Researchers found lower stages of breast cancer in women aged 40-49 compared to those aged 50-59, with a significant decrease in stage 4 cases. This suggests that early detection through regular mammograms can lead to better health outcomes and survival rates.
Scientists have found a potential link between follicle stimulating hormone (FSH) levels and postmenopausal obesity, which increases the risk of breast cancer. The study will analyze data from the Women's Health Initiative to understand the relationship between FSH and abdominal obesity.
Researchers discovered that high levels of collagen type XII can trigger breast cancer cells to spread from the tumour to other parts of the body. The study suggests that measuring collagen XII levels in a patient's tumour biopsy could be used as an additional screening tool to identify aggressive breast cancers.
Researchers have identified key molecular differences between cancer cells that cling to initial tumors and those that spread to distant sites. The study found unique properties in cells that gain migratory ability and survival advantages, leading to the development of new treatment targets.
Researchers at Dartmouth Cancer Center developed a new approach for detecting and quantifying tumor heterogeneity in breast cancer. High levels of heterogeneity are linked to poor patient outcomes, while specific proteins regulate its extent. The study aims to utilize this approach in therapeutic decision-making.
Researchers at Queen's University Belfast have secured a £228,900 grant to develop an mRNA vaccine targeting protein p53 in triple negative breast cancer. The project aims to improve treatment options for patients with this aggressive form of the disease.
Researchers analyzed genomic data from 44 women with germline PTEN mutations who developed breast cancer and compared it to sporadic breast cancers. They found that PTEN and PIK3CA were the most frequently somatically mutated genes in PHTS-associated breast cancers, indicating that somatic mutations in PTEN drive these cancers.
A study found that cold temperatures activate brown adipose tissue that competes with tumors for glucose, inhibiting tumor growth and prolonging survival. Researchers suggest that cold therapy could be a promising approach to cancer therapy.
Researchers at NUS Medicine have successfully used a plant-derived nutrient supplement to shrink breast cancer tumors in preclinical models. The treatment, which uses nanotechnology to convert the natural component into chemotherapy only at the tumor site, shows promise for reducing side effects and increasing patient lifespan.
A new study by CU Anschutz researchers found that over 70% of breast cancer patients experience changes in their sexual health during and after treatment. Patients desire early education and counseling from medical teams to address these issues, which are often overlooked.
A researcher studied the 'black box' phenomenon in breast cancer survivorship care, revealing communication gaps between women and their providers. She found that black boxing can hide service access complexities, emphasizing the need for improved information pathways to address post-treatment needs.
A phase I/II clinical trial found that treatment outcomes were similar between Black and non-Black patients with triple-negative breast cancer who received neoadjuvant durvalumab plus chemotherapy. The study's results suggest that improving healthcare access and delivery could mitigate some of the existing disparities in healthcare.
A new study found an inverse association between breast cancer risk and n-3 PUFA consumption, especially in premenopausal women who are obese. Higher intake of marine n-3 PUFAs and total n-3 PUFAs was associated with a lower risk of breast cancer.
A new study found that over half of adult cancer survivors experience significant hearing problems after chemotherapy treatment. The researchers also discovered that platinum and taxane drugs, commonly used to treat the majority of cancers, are linked to high rates of hearing loss and tinnitus.
A study found that informing children about their mother's genetic cancer risk has no impact on their lifestyle or quality of life. Children of mothers with BRCA gene mutations were more concerned and knowledgeable about cancer, but this did not influence their behavior.
A large cohort study found that hormone replacement therapy for breast cancer survivors is not associated with an increased risk of recurrence. The study included over 8,400 Danish postmenopausal women and found no link between vaginal estrogen or menopausal hormone therapy and breast cancer reoccurrence.
The NHS Breast Screening Programme is associated with modest overdiagnosis of breast cancer, estimated at 3.7% of screen detected cancers. However, the benefits of screening in preventing deaths from breast cancer outweigh this risk, according to a recent study.
A systematic review and meta-analysis of 39 publications found a global association between COVID-19 measures and reduced breast, colorectal, and cervical cancer screenings. This could lead to an increase in avoidable cancer deaths.
A $3.1 million grant will enable researchers to collaborate on a prospective study investigating early signs of heart vessel damage in young, pre-menopausal breast cancer survivors. The CROWN study aims to identify biomarkers that correlate with cardiovascular risk and develop strategies to lower the risk of irreversible heart disease.