Articles tagged with Breast Cancer
Scientists have engineered a unique strain of probiotic bacteria to over-express a metal transporter that binds and concentrates copper, facilitating the delivery of radionuclide therapy to cancer cells. This approach targets tumors without relying on specific receptors, making it potentially effective against treatment-resistant cancers.
Cancer cells have been found to employ a strategy to evade the immune system's killer T cells by interacting with myeloid cells and suppressing type 1 interferon production. This natural pathway is crucial for recruiting killer T cells to combat cancer spread. Researchers hope to develop new therapeutic approaches, such as forcing tumo...
Researchers found significant decreases in the levels of KRAS, RHOA, RAC1, and CDC42 after PCAI treatment, implicating their role in cancer progression and metastasis. These findings support the potential of PCAIs as potent agents for developing new anticancer therapeutics.
Breast tumor microbes vary significantly among women of different ethnicities, with potential implications for personalized care and disease progression. Researchers identified distinct microbial biomarkers associated with genes involved in tumor aggressiveness and immune response.
A study published in Science Translational Medicine has identified immature Natural Killer (NK) cells as a key factor in promoting disease progression in triple-negative breast cancer. The researchers suggest that targeting these rogue NK cells could lead to new and more effective treatments for this aggressive form of breast cancer.
Researchers at Cold Spring Harbor Laboratory have created a method to safely synthesize the cancer-fighting molecule JA, which has shown promise in treating triple-negative breast cancer. The team found that JA inhibits metabolic activity in cancer cells, starves them of energy and building blocks, leading to cell death.
A new study published in PLOS Medicine found a similar association of progestogen-only and combined hormonal contraceptives with breast cancer risk. The analysis of almost 10,000 women under 50 years old showed a 20-30% relative increase in breast cancer risk associated with both types of contraceptives.
A new study found that women with BRCA1 or BRCA2 mutations who are obese may experience higher rates of DNA damage in their breast tissue, which could contribute to breast cancer development. The researchers suggest that weight management and medications like metformin may be important for preventive care.
A recent review article highlights the significant impact of cancer on Hispanic patients and their caregivers, citing communication barriers, financial difficulties, and sociocultural issues. The study estimates 126,000 new cancer cases diagnosed yearly in Hispanics, placing a substantial burden on family members and friends.
Researchers at Medical College of Georgia identified an increased prevalence of disease-causing genetic variants in females with unexplained infertility. The study found that 17% of these women had gene variants known to cause heart problems and cancer.
A comprehensive analysis of invasive ER+ breast cancers found macrophages as dominant immune cells infiltrating tumors. The study identified distinct immune cell 'neighborhoods' associated with good patient outcomes and highlights the need for tailored immunotherapies targeting macrophages.
A new study from McGill University reveals that every day Canadians are exposed to Bisphenol S (BPS) in fresh foods due to chemical migration from packaging materials. High concentrations of BPS were found on thermal food labels, exceeding the European Union's regulatory limit.
A large study of over 1 million women found DBT had a higher breast cancer detection rate and lower false positive rates compared to 2D digital mammography. The results suggest that DBT may be the more effective screening method for early breast cancer detection.
A recent study analyzed 7,301 metastatic breast cancer patients with MTAP loss, revealing younger age, higher TNBC cases, and BRCA1 mutations. The findings also suggest potential therapeutic agents targeting PRMT5 and MTA2 in MTAP-deficient cancers.
Researchers at Garvan Institute of Medical Research found that introducing bacteria to a tumor's microenvironment triggers an immune response, activating neutrophils to destroy tumors in animal models. This breakthrough therapy targets neutrophils to improve cancer treatment outcomes.
Researchers discovered that androgen therapy alters the organization of cells within breast tissue, reducing signs of estrogen influence and changing protein production. The findings could lead to new therapies for estrogen receptor-positive breast cancer.
A team of POSTECH researchers has developed a deep learning-based multimodal fusion network for segmentation and classification of breast cancers using B-mode and strain elastography ultrasound images. The method achieved high accuracy in distinguishing benign from malignant lesions, outperforming conventional methods.
Researchers identified a way to treat surrounding breast tumors that have spread to bone, making them vulnerable to the immune system's attack. Boosting T cells and macrophages eliminated metastatic breast tumors in mice, suggesting a new approach for treating bone-spreading breast cancers.
Researchers examine the effects of gender-affirming androgen therapy on breast tissue in transgender men with single-cell resolution. Gene expression is silenced, and male gene programs are activated. This work has implications for the treatment of breast cancer across all populations.
Axillary lymphadenopathy after a COVID-19 vaccine booster dose resolves at a mean of 102 days. Findings support follow-up intervals of at least 12 weeks to avoid delaying screening mammography for suspected vaccine-related lymphadenopathy.
Researchers have identified a biomarker that can select breast cancer patients who may benefit from denosumab treatment. The study found that tumors with high RANK protein expression are associated with poor prognosis and response to chemotherapy, suggesting that denosumab may be effective in hormone-receptor negative tumors.
New research analyzed data on 8,007 patients with stage I–III breast cancer to predict recurrence risk based on cancer stage and receptor status. Patients with certain receptor combinations had higher or lower risks of recurrence at different stages.
The HALP score, a novel immune-nutritional marker, has been linked to prognostic ability in different cancer types. It integrates indicators of immune status and nutritional status, showing promise as a cost-effective biomarker.
Lung cancer death rates are projected to decrease overall in the EU and UK in 2023, however, a concerning trend is observed among women in France, Italy, and Spain. Meanwhile, pancreatic cancer death rates are forecasted to rise among women due to continued smoking habits.
A new study found that high-risk Black women face significant barriers to breast cancer prevention, including a focus on spiritual well-being over risk management and limited access to specialists. Women in this group were less likely to prioritize preventive measures and more likely to report competing priorities in their lives.
A Tulane University study found that areas with paid sick leave mandates experienced significant increases in breast cancer (4%) and colorectal cancer (6-8%) screenings among private sector employees. The findings suggest that non-monetary barriers to healthcare access can have a meaningful impact on health outcomes.
A case series study of 373,000 patients found that time from diagnosis to surgery over eight weeks was associated with worse overall survival. This delay may be linked to disadvantageous social determinants of health, suggesting the importance of timely surgical interventions in breast cancer care.
A new study found that women with BRCA1 or BRCA2 mutations have a cumulative risk of 49% developing any type of cancer after age 50. Risk-reducing surgeries like mastectomies and BSOs can lower this risk, but many women opt out despite elevated risk. Genetic testing is crucial for accurate risk assessment and personalized care.
Researchers used materials science to analyze microcalcifications in breast tissue, revealing groups that reflect tissue type and malignancy. The study also found variations in mineral composition and trace metals in malignant calcifications.
Researchers have identified three novel pathogenic variants of the ATR gene as predisposing to male breast cancer. These variants were found in a cohort of individuals with early onset and familial breast cancers, using a combination of exome sequencing and functional investigations. The study suggests that extended genetic analysis ca...
A recent study suggests that routine evaluation of HER2 expression in ductal carcinoma in situ (DCIS) is crucial to avoid under or overtreatment. The research found a significant association between HER2 overexpression and a higher risk of recurrence, as well as improved radiotherapy outcomes.
A recent study published in JAMA Oncology found that Black women with early-stage, estrogen receptor-positive breast cancer are more likely to experience higher mortality rates due to both social determinants of health and tumor biology. The research analyzed data from 60,137 women between 2004-2015 and discovered that these factors co...
A new study suggests that radiotherapy does not improve survival rates in older breast cancer patients with early-stage breast cancer. The 10-year study found that adding radiotherapy to breast-conserving surgery and hormone therapy did not increase death rates among patients aged 65 or older.
A recent study found that breast cancer risk models can lead to vastly different recommendations for individual women, depending on the model used and threshold applied. The study highlighted the importance of considering both sensitivity and inaccurate classification when using these models.
A phase 2 trial found that talimogene laherparepvec combined with chemotherapy provided strong responses and immune cell activation in 45.9% of patients with early stage triple-negative breast cancer. Tumor samples showed high levels of tumor-fighting T cells, indicating a potential for improved outcomes.
The Cleveland Clinic has launched a phase 1b clinical trial to evaluate the safety and immune response of a preventive breast cancer vaccine in high-risk individuals who have undergone prophylactic mastectomy. The study aims to recruit 6-12 patients and is expected to be completed by the end of 2023.
Ultrafast MRI provides beneficial information for predicting DCIS upgrade to invasive cancer, including time to enhancement and lesion size. A study found that UF-MRI can accurately predict lesions diagnosed as DCIS at percutaneous biopsy that will be upgraded to invasive cancer at surgery.
Engineers at the University of Waterloo developed AI technology to predict breast cancer treatment effectiveness, allowing doctors to prescribe personalized treatments and reduce unnecessary side effects. The new algorithm uses synthetic correlated diffusion imaging images to forecast patient responses to chemotherapy.
Cancer screening rates for breast and lung cancers persisted despite initial pandemic surges, highlighting the need for targeted interventions. The study found that successful strategies to improve screening rates must address pandemic-related barriers.
Researchers discovered a new approach to treating ependymoma, a rare childhood brain tumor, by targeting YAP fusion proteins. The study found that blocking the function of BRD4 gene expression regulator can prevent tumors from forming.
Awareness of breast density increases perceived risk and uncertainties about screening choices in Spanish-speaking women. However, these effects are short-term and do not persist over time, suggesting that educational outreach may help clarify implications for personal risk and screening decisions.
Researchers from HKUMed discovered that somatic deletion of AKTIP promotes luminal breast cancer development and resistance to endocrine therapy. Blocking the alternative escape pathway with a JAK2/STAT3 inhibitor can overcome this resistance, offering new therapeutic possibilities for patients with AKTIP gene deletion.
Researchers developed a novel CRISPR system to detect small amounts of cancer-related molecules in exosomes in plasma, effectively distinguishing between malignant and benign samples. The method has the potential to make cancer diagnosis and monitoring quicker and easier by analyzing blood samples.
Patients living in Southern states with expanded Medicaid were more likely to receive early treatment for invasive breast cancer. Despite this, the proportion of patients undergoing treatments actually decreased across all states.
Researchers analyzed over 500,000 patient records and found that patients diagnosed at age 70 were nearly twice as likely to be passed over for post-surgical radiation therapy. This significant gap in treatment recommendations suggests that cognitive heuristics play a major role in physician decision-making.
A new study suggests that higher consumption of ultra-processed foods may be linked to an increased risk of developing and dying from cancer. The study found that each 10% increase in ultra-processed food consumption was associated with a 2% increase in cancer incidence, as well as a 6% increase in mortality from cancer.
The SWOG S1416 clinical trial demonstrated the efficacy of PARP inhibitor veliparib in patients with triple-negative breast cancer and a 'BRCA-like' phenotype. Patients treated with veliparib experienced longer progression-free survival times compared to those receiving chemotherapy alone, with median PFS of 5.9 months versus 4.2 months.
A meta-analysis of 22 studies found that breast MRI was superior to other supplemental screening methods in detecting breast cancer in women with dense breasts. This is because breast MRI can detect even the smallest of cancers, making it a valuable tool for identifying high-risk patients.
Researchers at Rice University have discovered a new way protein structures communicate with each other to regulate hormone activity. This finding could lead to improved therapies for breast cancer and other diseases.
Researchers from UTSA and UT Health San Antonio are developing compounds that target the estrogen receptor-beta, which suppresses cancer growth. The goal is to identify a novel ER-beta agonist with potential as a therapeutic strategy for treating GBM in patients.
A UK study found that people with type 2 diabetes have substantially higher cancer mortality rates than the general population. Breast cancer mortality in younger women with T2D is rising, highlighting the need for extended screening, better management of diabetes and its complications, and improved cancer treatments.
A study of women ages 40 to 76 found that family history was the greatest perceived risk factor for breast cancer, with few considering breast density a risk. Comprehensive education is needed to address these misconceptions and reduce breast cancer risk.
A study of breast cancer patients in North Carolina found that Black patients experienced longer treatment delays than non-Black patients, with those living in higher-risk regions facing twice the risk. The researchers suggest that healthcare system structure, rather than patient characteristics, may be to blame for these delays.
A new study led by Mayo Clinic researchers found that women carrying specific genetic changes, such as BRCA1 and BRCA2, have a twofold increased risk of developing contralateral breast cancer. Premenopausal women with these mutations are more likely to develop cancer in both breasts.
Researchers found a protein called Rac1 that triggers milk production in breast cells when lactation stops and the breast returns to its pre-pregnancy state. This process involves cell death and autophagy, but can be reversed upon suckling, providing a fail-safe mechanism for mammalian survival.
Researchers at Bar-Ilan University have discovered a new molecular blocker that successfully halted breast cancer metastasis by targeting the Pyk2 and cortactin interaction. The study's findings provide significant hope for fighting breast cancer, as the blocker inhibited metastasis formation in breast cancer-bearing mice.
The study found that methylation of the HLA-A gene and focal deletions resulted in reduced immune cell activity against cancer cells, leading to fewer immune cells being available to attack cancer cells. The researchers also discovered differences in immune cell response between various sites of metastasis.
Researchers at Rice University and St. Jude Children’s Research Hospital discovered the structural basis of DNA polymerase theta-mediated microhomology-mediated end joining, a process complementary to homologous recombination and non-homologous end joining. This mechanism could be a promising target for precision cancer therapy.
Researchers found that MMTV-NeuT/ATTAC mice treated with anti-PD-1 therapy developed increased tumor-associated macrophages, EMT, fibroblast proliferation, and enhanced extracellular matrix. These findings suggest potential therapeutic avenues to enhance PD-1 immune checkpoint sensitivity.
A new study found that measuring activation of immune-system B cells may be better than measuring either T-cell activation or total number of immune cells in and around a tumor. The findings suggest that six signatures of immune cell gene activation from B cells were associated with higher elimination rates and better survival outcomes.