Articles tagged with Breast Cancer
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Researchers found that necroptosis promotes metastasis in breast cancer models, and blocking it leads to inhibition of metastasis. Necroptosis may be a key factor in tumor progression, and targeting its regulators could be critical for mitigating metastasis.
A study of 5,000 patients with breast cancer found that women from disadvantaged neighborhoods had shorter breast cancer-specific survival rates compared to those from advantaged areas. The findings suggest potential unaccounted mechanisms, including social determinants of health and access to care.
Researchers at Indiana University School of Medicine have identified a new target for breast cancer treatment, the gene TONSL, which can make breast cells proliferate indefinitely. The study found that TONSL is amplified in about 20% of breast cancers and more than 30% of metastatic breast cancers.
A study of 415,000 US female breast cancer deaths from 2011 to 2020 found that Black women should start screening earlier than previously recommended. Health policy makers and clinicians may consider an alternative approach with race- and ethnicity-adapted age recommendations for breast cancer screening.
A study presented at the ARRS Annual Meeting reveals institutional variability in projection order and image acquisition timing for CEM protocol. Earlier-obtained recombined imaging is significantly preferred for cancer lesion characterization, with a trend towards prioritizing imaging the side of pathology.
A UK Biobank study found that cancer survivors may be at long-term increased risk of cardiovascular disease, regardless of traditional risk factors. Those with previous breast or blood cancers were found to have the greatest risk, with significant changes in heart size and function detected on MRI scans.
A team of researchers from the University of Rochester has discovered a molecule that guides T cells toward tumors, which could lead to improvements in CAR T-cell therapy for breast, lung, and brain cancers. The findings will help scientists develop a drug to manipulate this key protein, ST3GAL1, to ensure T cells hit their targets.
Patients with depression before or after a breast cancer diagnosis have lower survival rates compared to those without depression. Diagnosing and treating depression at the time of breast cancer diagnosis and beyond is crucial for improved patient care and survival.
A University of Colorado at Boulder research team has discovered a protein crucial for repairing DNA in cancer cells, which they found can be selectively targeted to kill cancer cells without harming healthy ones.
Researchers argue that current PPE provides inadequate protection to breast tissue, leaving it vulnerable to radiation exposure. Employers should invest in equipment that ensures the safety of all their staff, particularly female healthcare workers.
Scientists discovered that deleting a protein called sphingosine kinase 2 (SphK2) reprograms the tumor microenvironment, decreasing S1P levels and increasing p53 tumor suppressor gene accumulation. This creates an inhospitable environment for aggressive breast tumors.
Researchers found that patients with two or three separate areas of breast cancer in the same breast can opt for lumpectomies followed by whole-breast radiation therapy instead of mastectomies, resulting in better patient satisfaction and cosmetic outcomes. The study also showed that preoperative MRI scans reduced local recurrence rates.
A study published in Radiology found that digital breast tomosynthesis improved breast cancer screening performance and increased radiologists' interpretive accuracy compared to digital mammography. The results showed higher detection rates, sensitivity, and specificity for DBT, with 97.6% of assessed radiologists meeting recommended p...
Researchers at Mass General Cancer Center presented recent breakthroughs in cancer treatment, including a new mutant-selective drug that targets PI3Kα inhibitors, and innovations in whole-genome sequencing and imaging-based evaluation of cancer dependencies. These findings aim to improve the effectiveness of immunotherapy and personali...
Researchers discover loss of neurofibromin 1 (NF1) gene leads to resistance to alpelisib, a common treatment for advanced breast cancer. Dietary supplement N-acetylcysteine restores sensitivity to this treatment, offering new hope for improving treatment outcomes.
Researchers developed a chelator-free-radiolabeled polymersome capable of long-term multiday PET imaging in vivo. The nanovesicle meets key requirements for targeted cancer therapy, including precision targeting, stable radiotracer binding, and biocompatibility.
Recent studies have highlighted the importance of tumor microenvironment in developing and controlling triple negative breast cancer progression. Researchers suggest that technological advancements like genomics and epigenomics hold promise for overcoming TNBC's current limitations.
A new deep learning-based model estimates breast density with high precision, correlating it to cancer risk. The model's performance is comparable to that of human experts, but it can be trained faster and on smaller datasets.
Researchers discuss cortactin's impact on cancer progression by modulating the Wnt5a/ROR1 signaling pathway. Cortactin expression is found in various cancers, including breast and chronic lymphocytic leukemia, suggesting its potential role in promoting metastasis.
A study found that high deductible health plans may lead women to skip additional testing after an abnormal mammogram finding, particularly those with lower incomes and education levels. This can result in delays in diagnosis and treatment, worsening breast cancer outcomes.
A study published in Radiology found that ultrasound is an effective standalone diagnostic method for patients with focal breast complaints. The analysis showed that ultrasound alone led to accurate diagnosis in 90% of patients, with over 80% of complaints being benign findings.
A new study by the University of Maryland School of Medicine found that ChatGPT provides correct information on breast cancer screening for most questions. However, inconsistencies and outdated information were detected in some responses. The researchers recommend relying on doctors for advice due to the limitations of ChatGPT.
A new study reveals the mechanism of BRCA2's DNA repair function, understanding its role in breast and ovarian cancer development. The findings also provide insights into developing targeted cancer therapies by inhibiting DNA repair mechanisms.
The LSU Health New Orleans Louisiana Tumor Registry released the sixth report of statewide cancer incidence rates by census tract, finding that 81% of tracts met criteria for all cancers combined. Census tracts with statistically higher incidence rates were found in parishes including Orleans, Lafourche, and St. Bernard.
Researchers used microfluidic devices to track what happens to cancer cells as they migrate and take root in the brain. They found that Dkk-1 triggers cancer cell migration, and reducing its levels near tumor cells may disrupt crosstalk between brain niche cells and cancer cells.
A study found that the change in guidelines led to a decline in mammography screening rates, particularly among women ages 50-74, an unintended consequence known as spillover. This effect resulted in 2.4 million fewer women being up-to-date with screening mammography between 2009 and 2018.
This study of 690 patients with early-stage breast cancer found racial disparities in pathological complete response to neoadjuvant chemotherapy, affecting survival outcomes. Racial disparities varied across different breast cancer subtypes and highlight the importance of understanding tumor biology.
Research outlines actionable steps to address longstanding health disparities in breast cancer screening and treatment options. Surgeons can drive change by maintaining awareness of existing disparities and providing additional resources to patients.
Scientists have engineered a unique strain of probiotic bacteria to over-express a metal transporter that binds and concentrates copper, facilitating the delivery of radionuclide therapy to cancer cells. This approach targets tumors without relying on specific receptors, making it potentially effective against treatment-resistant cancers.
Cancer cells have been found to employ a strategy to evade the immune system's killer T cells by interacting with myeloid cells and suppressing type 1 interferon production. This natural pathway is crucial for recruiting killer T cells to combat cancer spread. Researchers hope to develop new therapeutic approaches, such as forcing tumo...
Researchers found significant decreases in the levels of KRAS, RHOA, RAC1, and CDC42 after PCAI treatment, implicating their role in cancer progression and metastasis. These findings support the potential of PCAIs as potent agents for developing new anticancer therapeutics.
Breast tumor microbes vary significantly among women of different ethnicities, with potential implications for personalized care and disease progression. Researchers identified distinct microbial biomarkers associated with genes involved in tumor aggressiveness and immune response.
A study published in Science Translational Medicine has identified immature Natural Killer (NK) cells as a key factor in promoting disease progression in triple-negative breast cancer. The researchers suggest that targeting these rogue NK cells could lead to new and more effective treatments for this aggressive form of breast cancer.
Researchers at Cold Spring Harbor Laboratory have created a method to safely synthesize the cancer-fighting molecule JA, which has shown promise in treating triple-negative breast cancer. The team found that JA inhibits metabolic activity in cancer cells, starves them of energy and building blocks, leading to cell death.
A new study published in PLOS Medicine found a similar association of progestogen-only and combined hormonal contraceptives with breast cancer risk. The analysis of almost 10,000 women under 50 years old showed a 20-30% relative increase in breast cancer risk associated with both types of contraceptives.
A new study found that women with BRCA1 or BRCA2 mutations who are obese may experience higher rates of DNA damage in their breast tissue, which could contribute to breast cancer development. The researchers suggest that weight management and medications like metformin may be important for preventive care.
A recent review article highlights the significant impact of cancer on Hispanic patients and their caregivers, citing communication barriers, financial difficulties, and sociocultural issues. The study estimates 126,000 new cancer cases diagnosed yearly in Hispanics, placing a substantial burden on family members and friends.
Researchers at Medical College of Georgia identified an increased prevalence of disease-causing genetic variants in females with unexplained infertility. The study found that 17% of these women had gene variants known to cause heart problems and cancer.
A comprehensive analysis of invasive ER+ breast cancers found macrophages as dominant immune cells infiltrating tumors. The study identified distinct immune cell 'neighborhoods' associated with good patient outcomes and highlights the need for tailored immunotherapies targeting macrophages.
A new study from McGill University reveals that every day Canadians are exposed to Bisphenol S (BPS) in fresh foods due to chemical migration from packaging materials. High concentrations of BPS were found on thermal food labels, exceeding the European Union's regulatory limit.
A large study of over 1 million women found DBT had a higher breast cancer detection rate and lower false positive rates compared to 2D digital mammography. The results suggest that DBT may be the more effective screening method for early breast cancer detection.
A recent study analyzed 7,301 metastatic breast cancer patients with MTAP loss, revealing younger age, higher TNBC cases, and BRCA1 mutations. The findings also suggest potential therapeutic agents targeting PRMT5 and MTA2 in MTAP-deficient cancers.
Researchers at Garvan Institute of Medical Research found that introducing bacteria to a tumor's microenvironment triggers an immune response, activating neutrophils to destroy tumors in animal models. This breakthrough therapy targets neutrophils to improve cancer treatment outcomes.
Researchers discovered that androgen therapy alters the organization of cells within breast tissue, reducing signs of estrogen influence and changing protein production. The findings could lead to new therapies for estrogen receptor-positive breast cancer.
A team of POSTECH researchers has developed a deep learning-based multimodal fusion network for segmentation and classification of breast cancers using B-mode and strain elastography ultrasound images. The method achieved high accuracy in distinguishing benign from malignant lesions, outperforming conventional methods.
Researchers identified a way to treat surrounding breast tumors that have spread to bone, making them vulnerable to the immune system's attack. Boosting T cells and macrophages eliminated metastatic breast tumors in mice, suggesting a new approach for treating bone-spreading breast cancers.
Researchers examine the effects of gender-affirming androgen therapy on breast tissue in transgender men with single-cell resolution. Gene expression is silenced, and male gene programs are activated. This work has implications for the treatment of breast cancer across all populations.
Axillary lymphadenopathy after a COVID-19 vaccine booster dose resolves at a mean of 102 days. Findings support follow-up intervals of at least 12 weeks to avoid delaying screening mammography for suspected vaccine-related lymphadenopathy.
Researchers have identified a biomarker that can select breast cancer patients who may benefit from denosumab treatment. The study found that tumors with high RANK protein expression are associated with poor prognosis and response to chemotherapy, suggesting that denosumab may be effective in hormone-receptor negative tumors.
New research analyzed data on 8,007 patients with stage I–III breast cancer to predict recurrence risk based on cancer stage and receptor status. Patients with certain receptor combinations had higher or lower risks of recurrence at different stages.
The HALP score, a novel immune-nutritional marker, has been linked to prognostic ability in different cancer types. It integrates indicators of immune status and nutritional status, showing promise as a cost-effective biomarker.
Lung cancer death rates are projected to decrease overall in the EU and UK in 2023, however, a concerning trend is observed among women in France, Italy, and Spain. Meanwhile, pancreatic cancer death rates are forecasted to rise among women due to continued smoking habits.
A new study found that high-risk Black women face significant barriers to breast cancer prevention, including a focus on spiritual well-being over risk management and limited access to specialists. Women in this group were less likely to prioritize preventive measures and more likely to report competing priorities in their lives.
A Tulane University study found that areas with paid sick leave mandates experienced significant increases in breast cancer (4%) and colorectal cancer (6-8%) screenings among private sector employees. The findings suggest that non-monetary barriers to healthcare access can have a meaningful impact on health outcomes.
A case series study of 373,000 patients found that time from diagnosis to surgery over eight weeks was associated with worse overall survival. This delay may be linked to disadvantageous social determinants of health, suggesting the importance of timely surgical interventions in breast cancer care.
A new study found that women with BRCA1 or BRCA2 mutations have a cumulative risk of 49% developing any type of cancer after age 50. Risk-reducing surgeries like mastectomies and BSOs can lower this risk, but many women opt out despite elevated risk. Genetic testing is crucial for accurate risk assessment and personalized care.
Researchers used materials science to analyze microcalcifications in breast tissue, revealing groups that reflect tissue type and malignancy. The study also found variations in mineral composition and trace metals in malignant calcifications.
Researchers have identified three novel pathogenic variants of the ATR gene as predisposing to male breast cancer. These variants were found in a cohort of individuals with early onset and familial breast cancers, using a combination of exome sequencing and functional investigations. The study suggests that extended genetic analysis ca...
A recent study suggests that routine evaluation of HER2 expression in ductal carcinoma in situ (DCIS) is crucial to avoid under or overtreatment. The research found a significant association between HER2 overexpression and a higher risk of recurrence, as well as improved radiotherapy outcomes.
A recent study published in JAMA Oncology found that Black women with early-stage, estrogen receptor-positive breast cancer are more likely to experience higher mortality rates due to both social determinants of health and tumor biology. The research analyzed data from 60,137 women between 2004-2015 and discovered that these factors co...