Articles tagged with Breast Cancer
Researchers from the UCLA Jonsson Comprehensive Cancer Center are presenting findings on combination therapies for breast cancer and a potential new treatment for patients with recurrent glioma. A phase 3 study evaluating vorasidenib versus placebo in patients with residual or recurrent grade 2 glioma with an IDH1/2 mutation is also be...
Researchers found that GPR141 enhances cell migration and proliferation in breast cancer by activating the p-mTOR/p53 signaling pathway. Silencing GPR141 restores p53 expression and attenuates tumor growth, suggesting its role in regulating breast cancer progression and metastasis.
Researchers from Rice University and Baylor College of Medicine are developing a new 'glyco-immune' checkpoint inhibitor to train the immune system to target and kill breast cancer metastasis in bones. The therapy has shown promise in preliminary tests, including eradicating cancer in some animals.
A study found that expert mammogram radiologists exhibit visual hindsight bias, leading to improved performance on blurry images after prior clear images were viewed. This bias can impact the detection of lesions and has implications for negligence lawsuits and patient outcomes.
A Baylor team created a molecular classifier test to identify patients with HER2-positive breast cancer who may benefit from anti-HER2 therapy alone without chemotherapy. The test accurately predicts the most likely response of a tumor to specific treatment regimens, allowing for personalized de-escalation approaches.
Harvard Medical School researchers have identified a molecular sparkplug that ignites cases of estrogen-driven breast cancer. The study suggests that as many as one-third of breast cancer cases may arise through this newly identified mechanism, which shows estrogen directly altering cell DNA and causing genomic rearrangements.
A new Northwestern Medicine study found young adult cancer survivors (18-39 years old) are 2.6 times more likely to develop heart failure when treated with anthracyclines. The incidence is highest among leukemia and other specific cancer types.
Researchers at Baylor College of Medicine have identified a targetable vulnerability in ESR1 fusion-driven breast cancer. Kinase inhibitor pralsetinib suppresses the growth of cancer cells, suggesting potential for treatment.
Increased expression of Musashi 1 on breast cancer cells has significant implications for understanding dormancy and survival in bone marrow. Msi 1 knockdown led to a reduction in cancer stem cells with undetectable PD-L1, suggesting a potential therapeutic target.
Researchers at Dartmouth Cancer Center found that alternating estrogen stimulation and anti-estrogen therapy is an effective treatment for patients with metastatic or advanced ER+ breast cancer. The POLLY trial showed that 42% of patients experienced tumor stabilization, while no patients discontinued treatment due to side effects.
Researchers discover that senescence-associated secretory phenotype (SASP) can induce neuroendocrine transdifferentiation (NED) in breast cancer epithelial cells, promoting tumor progression and aging-related features. SASP's dual role in cancer involves both antitumoral and tumorigenic effects.
A recent study published in PNAS reveals that succinate plays a critical role in enhancing cancer cell plasticity and identifies PLOD2 as a regulator of succinate during breast cancer progression. Targeting PLOD2 may be a promising strategy to suppress breast cancer metastasis and drug resistance.
SpaceMarkers, a new machine learning software, can identify molecular interactions among distinct cell types in and around tumors. By analyzing spatial transcriptomics data, it reveals genes overexpressed due to cell-to-cell interactions, providing new avenues for understanding cancer progression and treatment responses.
Researchers developed a virtual framework to investigate the effectiveness of optoacoustic tomography for breast cancer screening in people with darker skin. The results confirmed that tumors can be harder to locate in individuals with darker skin, highlighting the need to optimize imaging systems to mitigate racial bias.
A new study finds that one-time genomic screening of adults aged 20-60 for hereditary breast and ovarian cancer syndrome, Lynch syndrome, and familial hypercholesterolemia is cost-effective based on quality-adjusted life-year measures. The study suggests that this approach could improve disease management and reduce healthcare costs.
Researchers found that women with denser breasts who developed cancer had slower declining density over time. The study suggests using past history of density in addition to current estimates to better understand risk levels and potentially identify which breast is at risk.
Researchers review current treatment updates for systemic light chain (AL) amyloidosis, highlighting the need for early diagnosis and effective maintenance therapy. The article discusses the relationship between AL amyloidosis and monoclonal gammopathy of undetermined significance (MGUS), emphasizing the importance of regular monitoring.
Researchers found breast cancer tumors send signals to bone marrow altering its environment and suppressing anti-tumor response. After tumor removal, changes persist, reducing immunotherapy's success.
Researchers discovered that gamma delta T cells can effectively combat triple-negative breast cancer by targeting stress-induced molecules and phosphoantigens. Counteracting metabolic changes with zolendronate makes immunotherapy more efficient.
A low-cost antibacterial regimen can prevent acute radiation dermatitis, a common skin problem affecting up to 95% of radiation therapy patients. The treatment involves using chlorhexidine and mupirocin nasal ointment twice daily, with no adverse effects or severe cases reported.
A study of 1,340 women with high-risk breast cancer found that strongest collective adherence to lifestyle recommendations was associated with significant reductions in disease recurrence and mortality. Education strategies to help patients adhere to cancer prevention recommendations are warranted.
The American College of Radiology (ACR) has introduced new guidelines recommending earlier and more intensive breast cancer screening for high-risk women, including Black women. According to the ACR, risk assessment by age 25 is necessary to determine if screening should start before age 40.
Researchers developed a method to predict DCIS progression to invasive breast cancer using mice with human DCIS cells. The study found molecular similarities between humans and mice, including the presence of HER2 protein increasing breast cancer risk.
A clinical trial of 406 patients found that a fluorescent agent allowed surgeons to identify and remove residual tumor tissue with favorable results. The technique showed promising results in detecting tumor tissue missed by standard lumpectomy procedures, potentially avoiding second surgeries for positive margins.
A new study suggests combining digital cancer risk assessment with point-of-care genetic testing can help overcome clinical workflow challenges that prevent at-risk patients from accessing genetic testing. The approach more than doubled the average uptake of genetic testing, showing promise for cancer prevention and detection.
Researchers discuss the importance of biomarkers in breast lump management, enabling patients to make informed decisions between proactive treatment and watchful waiting. The development of biomarkers could provide personalized risk assessments and guide treatment strategies for women with breast lumps.
New Finnish studies show that short bouts of light or moderate exercise can increase the number of immune cells capable of destroying cancer cells in cancer patients. The exercises were enough as short as 10 minutes to boost the immune system, with a positive impact on quality of life and prognosis.
A study published in Radiology found that AI can analyze breast mass images from low-cost portable ultrasound machines and accurately identify cancer. The technology showed great promise for improving breast health care in low-resource settings, reducing delays in diagnosis and potentially saving lives.
A research tool developed at the Garvan Institute has uncovered unprecedented detail about pancreatic cancer drug response and resistance. The molecule AKT, a key driver of cancer growth and spread, is activated in distinct parts of the tumour, including areas of low oxygen supply where it forms pockets of resistance to therapy.
A new study found that remote outreach involving interactive education and follow-up support via telephone increased breast, cervical, and colorectal cancer screening rates among rural women. The combination of a remotely delivered interactive DVD and patient navigation services resulted in a six-fold increase in screenings.
A research team from the Medical University of South Carolina identified a protein called TACC3 that enables cancer cells to successfully divide despite an abnormality that should lead to their death. This discovery offers new hope for developing targeted therapies to selectively kill cancer cells while leaving normal cells intact.
Researchers investigated the roles of STAT3α and STAT3β in aggressive breast cancer and found that differential silencing of these isoforms leads to changes in STAT3 activation. This study emphasizes the importance of distinguishing between STAT3 isoforms for accurate cancer diagnosis and therapy.
Researchers found that necroptosis promotes metastasis in breast cancer models, and blocking it leads to inhibition of metastasis. Necroptosis may be a key factor in tumor progression, and targeting its regulators could be critical for mitigating metastasis.
A study of 5,000 patients with breast cancer found that women from disadvantaged neighborhoods had shorter breast cancer-specific survival rates compared to those from advantaged areas. The findings suggest potential unaccounted mechanisms, including social determinants of health and access to care.
Researchers at Indiana University School of Medicine have identified a new target for breast cancer treatment, the gene TONSL, which can make breast cells proliferate indefinitely. The study found that TONSL is amplified in about 20% of breast cancers and more than 30% of metastatic breast cancers.
A study of 415,000 US female breast cancer deaths from 2011 to 2020 found that Black women should start screening earlier than previously recommended. Health policy makers and clinicians may consider an alternative approach with race- and ethnicity-adapted age recommendations for breast cancer screening.
A study presented at the ARRS Annual Meeting reveals institutional variability in projection order and image acquisition timing for CEM protocol. Earlier-obtained recombined imaging is significantly preferred for cancer lesion characterization, with a trend towards prioritizing imaging the side of pathology.
A UK Biobank study found that cancer survivors may be at long-term increased risk of cardiovascular disease, regardless of traditional risk factors. Those with previous breast or blood cancers were found to have the greatest risk, with significant changes in heart size and function detected on MRI scans.
A team of researchers from the University of Rochester has discovered a molecule that guides T cells toward tumors, which could lead to improvements in CAR T-cell therapy for breast, lung, and brain cancers. The findings will help scientists develop a drug to manipulate this key protein, ST3GAL1, to ensure T cells hit their targets.
Patients with depression before or after a breast cancer diagnosis have lower survival rates compared to those without depression. Diagnosing and treating depression at the time of breast cancer diagnosis and beyond is crucial for improved patient care and survival.
A University of Colorado at Boulder research team has discovered a protein crucial for repairing DNA in cancer cells, which they found can be selectively targeted to kill cancer cells without harming healthy ones.
Researchers argue that current PPE provides inadequate protection to breast tissue, leaving it vulnerable to radiation exposure. Employers should invest in equipment that ensures the safety of all their staff, particularly female healthcare workers.
Scientists discovered that deleting a protein called sphingosine kinase 2 (SphK2) reprograms the tumor microenvironment, decreasing S1P levels and increasing p53 tumor suppressor gene accumulation. This creates an inhospitable environment for aggressive breast tumors.
Researchers found that patients with two or three separate areas of breast cancer in the same breast can opt for lumpectomies followed by whole-breast radiation therapy instead of mastectomies, resulting in better patient satisfaction and cosmetic outcomes. The study also showed that preoperative MRI scans reduced local recurrence rates.
A study published in Radiology found that digital breast tomosynthesis improved breast cancer screening performance and increased radiologists' interpretive accuracy compared to digital mammography. The results showed higher detection rates, sensitivity, and specificity for DBT, with 97.6% of assessed radiologists meeting recommended p...
Researchers at Mass General Cancer Center presented recent breakthroughs in cancer treatment, including a new mutant-selective drug that targets PI3Kα inhibitors, and innovations in whole-genome sequencing and imaging-based evaluation of cancer dependencies. These findings aim to improve the effectiveness of immunotherapy and personali...
Researchers discover loss of neurofibromin 1 (NF1) gene leads to resistance to alpelisib, a common treatment for advanced breast cancer. Dietary supplement N-acetylcysteine restores sensitivity to this treatment, offering new hope for improving treatment outcomes.
Researchers developed a chelator-free-radiolabeled polymersome capable of long-term multiday PET imaging in vivo. The nanovesicle meets key requirements for targeted cancer therapy, including precision targeting, stable radiotracer binding, and biocompatibility.
Recent studies have highlighted the importance of tumor microenvironment in developing and controlling triple negative breast cancer progression. Researchers suggest that technological advancements like genomics and epigenomics hold promise for overcoming TNBC's current limitations.
A new deep learning-based model estimates breast density with high precision, correlating it to cancer risk. The model's performance is comparable to that of human experts, but it can be trained faster and on smaller datasets.
Researchers discuss cortactin's impact on cancer progression by modulating the Wnt5a/ROR1 signaling pathway. Cortactin expression is found in various cancers, including breast and chronic lymphocytic leukemia, suggesting its potential role in promoting metastasis.
A study found that high deductible health plans may lead women to skip additional testing after an abnormal mammogram finding, particularly those with lower incomes and education levels. This can result in delays in diagnosis and treatment, worsening breast cancer outcomes.
A study published in Radiology found that ultrasound is an effective standalone diagnostic method for patients with focal breast complaints. The analysis showed that ultrasound alone led to accurate diagnosis in 90% of patients, with over 80% of complaints being benign findings.
A new study by the University of Maryland School of Medicine found that ChatGPT provides correct information on breast cancer screening for most questions. However, inconsistencies and outdated information were detected in some responses. The researchers recommend relying on doctors for advice due to the limitations of ChatGPT.
A new study reveals the mechanism of BRCA2's DNA repair function, understanding its role in breast and ovarian cancer development. The findings also provide insights into developing targeted cancer therapies by inhibiting DNA repair mechanisms.
The LSU Health New Orleans Louisiana Tumor Registry released the sixth report of statewide cancer incidence rates by census tract, finding that 81% of tracts met criteria for all cancers combined. Census tracts with statistically higher incidence rates were found in parishes including Orleans, Lafourche, and St. Bernard.
Researchers used microfluidic devices to track what happens to cancer cells as they migrate and take root in the brain. They found that Dkk-1 triggers cancer cell migration, and reducing its levels near tumor cells may disrupt crosstalk between brain niche cells and cancer cells.
A study found that the change in guidelines led to a decline in mammography screening rates, particularly among women ages 50-74, an unintended consequence known as spillover. This effect resulted in 2.4 million fewer women being up-to-date with screening mammography between 2009 and 2018.
This study of 690 patients with early-stage breast cancer found racial disparities in pathological complete response to neoadjuvant chemotherapy, affecting survival outcomes. Racial disparities varied across different breast cancer subtypes and highlight the importance of understanding tumor biology.
Research outlines actionable steps to address longstanding health disparities in breast cancer screening and treatment options. Surgeons can drive change by maintaining awareness of existing disparities and providing additional resources to patients.