Articles tagged with Breast Cancer
A new MU study found that APRNs recognize the importance of breast cancer survivorship care and can benefit from standardized education. The findings suggest that formalizing education on breast cancer survivorship could lead to improved healthcare for patients, including symptom management, monitoring, and follow-up appointments.
A Brown University team developed a hydrogel-based delivery system that balances tumor acidity and increases doxorubicin's effectiveness against cancer cells. Initial lab tests show promising results, paving the way for pre-clinical trials.
Researchers found higher 5-year survival rates among Kaiser Permanente patients compared to National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) estimates. Improved screening rates, cancer treatment pathways, and coordinated care may have contributed to these higher survival rates.
Research suggests that women carrying disease-causing BRCA variants may face incorrect risk assessments of 60-80% for breast cancer, when in fact the true risk is less than 20%. This has led to unnecessary breast surgeries. The study aims to inform informed decision-making and responsible communication of genetic risks.
A recent study led by IBEC demonstrates that laminin, a protein present in healthy breast tissues, prevents the effects of stiffening, protecting cells against tumor growth. The researchers observed that cells seeded on laminin-rich gel exhibited a significantly less pronounced mechanical response to substrate stiffness.
Breast milk from breast cancer patients contains tumour DNA that can be detected through liquid biopsy, offering a potential new tool for early diagnosis. The study found that ctDNA was detectable in 13 of 15 breast milk samples collected from breast cancer patients, outperforming detection in blood samples.
A study of 2,176 US counties reveals that breast cancer mortality is influenced by local factors such as poverty, education, and access to healthcare. The findings suggest that geographically targeted interventions could lead to healthier communities and reduced mortality rates.
Researchers have discovered two FDA-approved and EMA-approved drugs that inhibit prmt5, a protein linked to promoting tumor growth in several cancers. These repurposed drugs show promise in reducing cancer cell proliferation and tumor growth.
Researchers identified distinct genomic characteristics that impact prognosis for patients with triple negative apocrine carcinoma. The study confirmed a five-year disease-free survival rate of 92.2% for these patients, significantly higher than those diagnosed with other types of TNBC.
Researchers discuss new drugs available for HER2-positive breast cancer patients with brain metastasis, showing improved outcomes and quality of life. The development of targeted therapies has led to better survival rates among these patients.
Researchers advocate for accessible breast cancer screening services for individuals with disabilities, highlighting physical barriers such as equipment accessibility and fragrance-free policies. They stress the need for social and procedural barriers removal through comprehensive training and resources.
The study found significant reductions in breast cancer screening volume and uptake globally during the 2020 COVID-19 pandemic. The analysis of 26 studies from 13 countries revealed a decline in screening volumes ranging from 13% to 61%, and screening uptake rates varying by up to 43.5%.
A recent study published in PLOS Biology suggests that chemotherapy injury to surrounding non-cancer cells can awaken dormant breast cancer cells, promoting cancer growth and recurrence. The researchers found that the release of specific cell signaling molecules, G-CSF and IL-6, by injured stromal cells drives this process.
A large-scale international study of childhood cancer survivors found that women who received high-dose doxorubicin chemotherapy without chest radiation have a significantly increased risk of breast cancer before age 40. The researchers are calling for broadening guidelines for breast cancer screening in these patients.
Researchers found a significant association between high particulate matter exposure and an 8% increase in breast cancer incidence among US women. The study, which considered historical air quality data, suggests that fine particulate matter may affect breast cancer through endocrine disruption.
Researchers found that African American women with ER-positive breast cancer have decreased levels of amino acids and increased levels of fatty acids compared to non-Hispanic white women. This study may help explain the higher mortality rates in African American women with the disease, suggesting potential new screening strategies.
A randomized trial published in The Lancet Oncology found that condensing prostate beam scanning proton therapy for breast cancer patients can result in similar control of the cancer while sparing surrounding normal tissue. The study demonstrated excellent outcomes, with reduced skin side effects and comparable complication rates.
Researchers discovered that a small subpopulation of AIB1-expressing cells in breast cancer enables invasion and metastasis. The study suggests that these subpopulations play a crucial role in tumor growth and spreading to distant sites.
Researchers found that an AI algorithm comparable to human readers demonstrated high sensitivity and specificity in detecting breast cancer. The study utilized a large dataset of mammographic exams and compared the performance of AI with human readers, finding no significant difference between the two.
Research published in BMJ Oncology reveals a global increase of 79% in new cancer cases among those under 50 between 1990 and 2019. Breast cancer accounted for the highest number of early onset cases, while cancers of the windpipe and prostate rose the fastest.
Breast cancer survivors often struggle to take their life-extending medication due to side effects and high costs. A new study found that interventions such as cost-cutting policies, mobile apps, and psychological counseling can increase medication adherence by nearly 1.5 times. Addressing mental health issues, particularly depression,...
Researchers at UMass Amherst are investigating the connection between PFAS chemicals and breast cancer. They will examine data from postmenopausal women to determine if PFAS concentrations are associated with less breast tissue involution, which may increase breast cancer risk.
Researchers at Kyoto University have discovered the mechanism by which breast cancer forms in mammalian epithelial cells. The team found that approximately 20 mutations accumulate annually in each cell until menopause, after which the rate decreases significantly.
A new study finds that cost-cutting policy changes, mobile apps, and psychological strategies can increase medication adherence by nearly 1.5 times among breast cancer survivors. The study also highlights the importance of managing side effects through physical therapy, exercise, and behavioral counseling.
A study published in Radiology found that combining short- and long-term breast cancer risk models using artificial intelligence can improve cancer risk assessment. The combined model showed an overall improved risk assessment for both interval and long-term cancer detection, identifying women at high risk for breast cancer.
A team of KAUST researchers has found a critical protein that regulates cell division and proliferation in breast cancer and leukemia. Their work clears the way for the development of targeted drugs by refuting recent challenges to their approach.
A Swedish study revealed that including all eleven associated genes in the screening test doubled the proportion of women with genetically confirmed hereditary breast cancer. The study included 4759 individuals and found that around 85% of women investigated for suspected hereditary breast cancer had a genetic abnormality.
A statistician at Virginia Commonwealth University has been awarded a $1.7 million grant to investigate the long-term effects of neighborhood exposures and racial segregation on cancer risk. The researcher aims to better understand how geographic and socioeconomic factors contribute to disparities in cancer incidence and mortality.
Researchers have identified a neoplastic fusion transcript RAD51AP1-DYRK4 in luminal B breast cancer, associated with higher ki67 expression and aggressive clinical characteristics. MEK inhibitor trametinib may be effective in blocking the MEK-ERK signaling driven by this fusion.
Researchers have discovered that estrogen promotes tumor growth in ERα-negative cancers, such as triple-negative breast cancer. Anti-estrogenic therapies, when combined with immune checkpoint inhibitors, drastically suppress tumor progression in mice models.
A new study estimates that cancer screenings have saved the US at least $6.5 trillion and led to 12 million more years of life, with significant economic impact from breast, colon, cervical, and lung cancer screenings.
A large-scale international collaborative study has identified new genes associated with breast cancer, which could lead to better risk prediction and improved clinical management. The study found evidence for at least four new breast cancer risk genes, with many others showing suggestive evidence.
Early-onset cancer incidence rates among people under 50 increased significantly between 2010 and 2019, with breast cancer leading the number of cases. Gastrointestinal cancers showed the highest growth rate in this age group, highlighting the need for targeted surveillance strategies and funding priorities
Women with low-risk breast cancer aged 55 or older can be effectively treated without radiation after surgery, according to new research published in The New England Journal of Medicine. A total of 2.3% of patients experienced recurrence of cancer in the breast five years post-surgery.
Glutamine metabolism plays a crucial role in cancer cell growth and survival, with its inhibition shown to block cancer cell growth in vivo and in vitro. A recent editorial paper suggests that glutamine dysregulation may also impact the tumor microenvironment, potentially leading to increased oxidative stress and cancer cell death.
A computational genetic model has been developed to predict individual genetic risk of developing breast cancer based on a woman's genetic profile. The model uses data from a large-scale international study and identifies women at high risk, who may benefit from earlier and more frequent screening.
A Harvard T.H. Chan School of Public Health study found that chronic exposure to fine particulate air pollutants (PM2.5) and nitrogen dioxide (NO2) increases the risk of colorectal and prostate cancers in older adults. NO2 exposure was also associated with an increased risk of breast cancer, while PM2.5 exposure had mixed results.
A biomolecule has been engineered to selectively target and remove mucins from cancer cells, reducing tumor growth and increasing survival in lab-grown human cancer cells and mouse studies. This discovery could play a significant role in future therapies for cancer, as mucins are associated with many diseases.
A Kaiser Permanente study found that drinking alcohol after a breast cancer diagnosis does not impact a patient's prognosis. The research used data from over 4,500 women diagnosed with invasive breast cancer and tracked their lifestyle changes and outcomes over 11 years.
LSU Health researchers found combining an investigational oral drug with standard-of-care medications reverts hormone resistance and increases effectiveness in experimental models of ER+ and TNBC. The study's findings suggest a new approach for treating treatment-resistant breast cancers.
RAGE signaling maintains mesenchymal state of TNBC cells by enforcing SNAIL1 protein expression, promoting tumor cell proliferation and invasion. Inhibiting RAGE with a pharmacological antagonist reduces tumor cell plasticity and improves survival in xenograft mouse models.
A machine learning model found that background parenchymal enhancement (BPE) on breast MRI is an indicator of breast cancer risk in women with extremely dense breasts. Women with dense breasts are at a higher risk of developing breast cancer compared to those with fatty breasts.
A meta-analysis of multiple studies found no association between depression and anxiety and most types of cancer. However, the study found a link between depression and anxiety with a 6% higher risk of developing lung cancer and smoking-related cancers.
Researchers identified a mechanism regulating tumor growth in the skeleton, which decreases with age and can result from hormonal changes or chemotherapy. Mineralization of bone matrix reduces tumor cell growth and promotes genes associated with better patient prognosis.
A recent study published in Annals of Internal Medicine found that continued breast cancer screening after age 70 is associated with a greater incidence of cancer that likely would not have caused symptoms. Researchers estimate up to 47% of breast cancers found among women aged 74-84 were overdiagnosed.
A new study by the American Cancer Society reveals substantial racial and ethnic disparities among survivors of second primary cancers in the US. Non-Hispanic Black individuals experience higher cancer-related death rates, while Hispanic individuals face lower cardiovascular-related death rates compared to non-Hispanic White counterparts.
A new grant aims to decipher how diverse breast cancer tumors influence cancer cells' ability to resist treatment. By studying this phenomenon, researchers hope to uncover novel targets for more effective therapies.
A study by Harvard T.H. Chan School of Public Health found that chronic exposure to fine particulate air pollutants (PM2.5) and nitrogen dioxide (NO2) may increase non-lung cancer risk in older adults, with significant associations with colorectal and prostate cancers.
Researchers at Baylor College of Medicine have identified a novel strategy to control the growth of triple negative breast cancer and other cancers. By targeting the enzyme MAPK4, the team found that blocking both AKT and PDK1 can effectively suppress tumor growth, offering new options for treating this devastating disease.
Researchers found that age 50+, low education, and health insurance coverage are associated with non-participation. A risk score based on these factors can predict non-participation in the screening process. The study aims to identify women who are less likely to participate in breast cancer screening and encourage their participation.
A study found that breast cancer patients with higher body mass index (BMI) are more likely to experience heart damage, or cardiotoxicity, during chemotherapy. The study suggests that addressing obesity and considering the potential risk of cardiotoxicity requires a comprehensive approach.
A randomized trial involving over 80,000 Swedish women found AI-supported mammography analysis to be as accurate as two breast radiologists working together in detecting breast cancer. The technology also reduced the screen-reading workload by nearly half without increasing false positives.
Researchers at Lund University found AI-supported mammography screening to be safe and effective, detecting 20% more cancers than standard double reading without increasing false positives. The study also reduced radiologists' screen-reading workload by 44%, saving approximately five months of time.
A new study shows that estrogen receptor (ER) expression in ductal carcinoma in situ (DCIS) is multi-clonal, meaning it varies across different cells. This finding has significant clinical implications, as it may help avoid overtreatment and undertreatment in DCIS patients.
Researchers discovered a protein called TRPM4 that strongly signals the immune system to target and clean up dying cancer cells. This finding may enhance immunotherapies against solid tumors by promoting necrosis, a type of cell death that activates immune cells.
A commercial AI tool did not provide additional benefit to mammography with supplementary ultrasound in patients with dense breasts. Mammography with supplementary ultrasound showed higher accuracy, specificity, and lower recall rate compared to AI alone or combined with US.
Researchers at MIT developed a wearable ultrasound device that can detect breast cancer in early stages, reducing the risk of late-stage diagnosis. The device, attached to a bra, allows users to image breast tissue from different angles and is portable, easy to use, and provides real-time monitoring.
New prediction models developed at MSK effectively identify patients at higher risk of developing lymphedema, allowing for interventions to reduce risk before surgery and closer follow-up. The models take racial differences in disease incidence into consideration, improving accuracy.
A study by Cold Spring Harbor Laboratory researchers found that breast cancer cells trick the immune system using a molecule called MHC-II, allowing them to spread faster and evade treatment. Targeting this molecule may lead to new therapeutics and improve patient outcomes.
Researchers found that Syrian refugees with breast cancer were more likely to be younger than Jordanian women and diagnosed with late-stage cancers. The trauma associated with displacement was also a contributing factor to the disparities in treatment gaps for refugees.