Articles tagged with Breast Cancer
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Early-onset cancer incidence rates among people under 50 increased significantly between 2010 and 2019, with breast cancer leading the number of cases. Gastrointestinal cancers showed the highest growth rate in this age group, highlighting the need for targeted surveillance strategies and funding priorities
Women with low-risk breast cancer aged 55 or older can be effectively treated without radiation after surgery, according to new research published in The New England Journal of Medicine. A total of 2.3% of patients experienced recurrence of cancer in the breast five years post-surgery.
Glutamine metabolism plays a crucial role in cancer cell growth and survival, with its inhibition shown to block cancer cell growth in vivo and in vitro. A recent editorial paper suggests that glutamine dysregulation may also impact the tumor microenvironment, potentially leading to increased oxidative stress and cancer cell death.
A computational genetic model has been developed to predict individual genetic risk of developing breast cancer based on a woman's genetic profile. The model uses data from a large-scale international study and identifies women at high risk, who may benefit from earlier and more frequent screening.
A Harvard T.H. Chan School of Public Health study found that chronic exposure to fine particulate air pollutants (PM2.5) and nitrogen dioxide (NO2) increases the risk of colorectal and prostate cancers in older adults. NO2 exposure was also associated with an increased risk of breast cancer, while PM2.5 exposure had mixed results.
A biomolecule has been engineered to selectively target and remove mucins from cancer cells, reducing tumor growth and increasing survival in lab-grown human cancer cells and mouse studies. This discovery could play a significant role in future therapies for cancer, as mucins are associated with many diseases.
A Kaiser Permanente study found that drinking alcohol after a breast cancer diagnosis does not impact a patient's prognosis. The research used data from over 4,500 women diagnosed with invasive breast cancer and tracked their lifestyle changes and outcomes over 11 years.
LSU Health researchers found combining an investigational oral drug with standard-of-care medications reverts hormone resistance and increases effectiveness in experimental models of ER+ and TNBC. The study's findings suggest a new approach for treating treatment-resistant breast cancers.
RAGE signaling maintains mesenchymal state of TNBC cells by enforcing SNAIL1 protein expression, promoting tumor cell proliferation and invasion. Inhibiting RAGE with a pharmacological antagonist reduces tumor cell plasticity and improves survival in xenograft mouse models.
A machine learning model found that background parenchymal enhancement (BPE) on breast MRI is an indicator of breast cancer risk in women with extremely dense breasts. Women with dense breasts are at a higher risk of developing breast cancer compared to those with fatty breasts.
A meta-analysis of multiple studies found no association between depression and anxiety and most types of cancer. However, the study found a link between depression and anxiety with a 6% higher risk of developing lung cancer and smoking-related cancers.
Researchers identified a mechanism regulating tumor growth in the skeleton, which decreases with age and can result from hormonal changes or chemotherapy. Mineralization of bone matrix reduces tumor cell growth and promotes genes associated with better patient prognosis.
A recent study published in Annals of Internal Medicine found that continued breast cancer screening after age 70 is associated with a greater incidence of cancer that likely would not have caused symptoms. Researchers estimate up to 47% of breast cancers found among women aged 74-84 were overdiagnosed.
A new study by the American Cancer Society reveals substantial racial and ethnic disparities among survivors of second primary cancers in the US. Non-Hispanic Black individuals experience higher cancer-related death rates, while Hispanic individuals face lower cardiovascular-related death rates compared to non-Hispanic White counterparts.
A new grant aims to decipher how diverse breast cancer tumors influence cancer cells' ability to resist treatment. By studying this phenomenon, researchers hope to uncover novel targets for more effective therapies.
A study by Harvard T.H. Chan School of Public Health found that chronic exposure to fine particulate air pollutants (PM2.5) and nitrogen dioxide (NO2) may increase non-lung cancer risk in older adults, with significant associations with colorectal and prostate cancers.
Researchers at Baylor College of Medicine have identified a novel strategy to control the growth of triple negative breast cancer and other cancers. By targeting the enzyme MAPK4, the team found that blocking both AKT and PDK1 can effectively suppress tumor growth, offering new options for treating this devastating disease.
Researchers found that age 50+, low education, and health insurance coverage are associated with non-participation. A risk score based on these factors can predict non-participation in the screening process. The study aims to identify women who are less likely to participate in breast cancer screening and encourage their participation.
A study found that breast cancer patients with higher body mass index (BMI) are more likely to experience heart damage, or cardiotoxicity, during chemotherapy. The study suggests that addressing obesity and considering the potential risk of cardiotoxicity requires a comprehensive approach.
A randomized trial involving over 80,000 Swedish women found AI-supported mammography analysis to be as accurate as two breast radiologists working together in detecting breast cancer. The technology also reduced the screen-reading workload by nearly half without increasing false positives.
Researchers at Lund University found AI-supported mammography screening to be safe and effective, detecting 20% more cancers than standard double reading without increasing false positives. The study also reduced radiologists' screen-reading workload by 44%, saving approximately five months of time.
A new study shows that estrogen receptor (ER) expression in ductal carcinoma in situ (DCIS) is multi-clonal, meaning it varies across different cells. This finding has significant clinical implications, as it may help avoid overtreatment and undertreatment in DCIS patients.
Researchers discovered a protein called TRPM4 that strongly signals the immune system to target and clean up dying cancer cells. This finding may enhance immunotherapies against solid tumors by promoting necrosis, a type of cell death that activates immune cells.
A commercial AI tool did not provide additional benefit to mammography with supplementary ultrasound in patients with dense breasts. Mammography with supplementary ultrasound showed higher accuracy, specificity, and lower recall rate compared to AI alone or combined with US.
Researchers at MIT developed a wearable ultrasound device that can detect breast cancer in early stages, reducing the risk of late-stage diagnosis. The device, attached to a bra, allows users to image breast tissue from different angles and is portable, easy to use, and provides real-time monitoring.
New prediction models developed at MSK effectively identify patients at higher risk of developing lymphedema, allowing for interventions to reduce risk before surgery and closer follow-up. The models take racial differences in disease incidence into consideration, improving accuracy.
A study by Cold Spring Harbor Laboratory researchers found that breast cancer cells trick the immune system using a molecule called MHC-II, allowing them to spread faster and evade treatment. Targeting this molecule may lead to new therapeutics and improve patient outcomes.
Researchers found that Syrian refugees with breast cancer were more likely to be younger than Jordanian women and diagnosed with late-stage cancers. The trauma associated with displacement was also a contributing factor to the disparities in treatment gaps for refugees.
A new clinical practice resource provides valuable information for healthcare professionals caring for individuals with pathogenic variants in the CHEK2 gene. The resource assesses personalized risk estimates based on family history, specific variant, and other factors.
Researchers developed a strategy to predict chemotherapy response in triple negative breast cancer (TNBC) using the Kinase Inhibitor Pulldown Assay (KIPA). The study identified a seven-purine-binding protein signature that predicted chemotherapy sensitivity and favorable clinical outcomes.
Researchers have created a biomedical compound that can block the interaction of metastasis-inducing protein S100A4 with its target inside the cell. The compound inhibits properties associated with metastasis at very low doses, showing potential therapeutic role in breast cancer treatment.
A new study by researchers at the National Institutes of Health found that women diagnosed and treated for breast cancer have increased biological aging compared to those who remain free of breast cancer. Radiation therapy showed the strongest association with faster biological aging, while surgery had no effect.
Researchers found that breast cancer survivors experience a faster rate of biological aging, with higher rates of age-related diseases and physical cognitive decline. Radiation therapy was found to be particularly impactful on aging rates, contributing to the conversation on how to best treat and care for breast cancer survivors.
Researchers at NUS developed a new photodynamic therapy that selectively kills breast cancer cells without damaging surrounding tissues. The treatment uses a biocompatible silicone implant loaded with nanoparticles activated by near-infrared light, reducing the risk of toxicity and improving tumour control.
Rice University chemist Han Xiao has won a $3.2 million research grant from the National Cancer Institute to develop an epigenetic inhibitor targeting bone metastasis. The drug, based on existing bisphosphonates, aims to prevent cancer cells from spreading to other organs without affecting normal tissues.
Researchers have discovered a mechanism leading to resistance in luminal breast cancer and propose using the approved osteoporosis drug denosumab to block RANK protein, promoting effectiveness of CDK4/6 inhibitors. This could lead to new treatment options for patients with metastatic breast cancer.
Researchers at Georgetown University Medical Center discovered the biological mechanism of TTP488, an experimental drug that impairs aggressive triple-negative breast cancer from metastasizing. The finding enables clinical trials to explore the drug's effectiveness in preventing TNBCs from spreading, offering new hope for patients with...
Researchers found that healthy breast adipocytes secrete IGFBP2, which acts as a barrier against invasive breast cancer progression. Lower IGFBP2 levels with age may contribute to increased breast cancer risk.
A new study led by Sandra Casimiro and Luís Costa found a promising molecular target, the RANK signaling pathway, that could be used in combination with standard care to avoid resistance to treatment in metastatic breast cancer. High levels of RANK in cancer cells are associated with resistance to treatment with CDK4/6 inhibitors.
A new study by researchers at Dartmouth Cancer Center shows that a combination of estrogen and PARP inhibitors can effectively treat advanced ER+ breast cancer by damaging cancer cells and preventing DNA repair. The treatment strategy has been shown to be effective regardless of BRCA1 or BRCA2 genetic mutations.
Researchers at the University of Alberta have discovered a correlation between chemotherapy-induced changes to gut bacteria and unhealthy weight gain in breast cancer patients. The study found that these patients gained abdominal fat and experienced inflammation, with significant changes to their gut microbiome.
A new study reveals that preoperative hydroxyprogesterone administration can improve disease-free and overall survival in patients with node-positive breast cancer by modulating cellular stress response and negative regulation of inflammation. Non-coding RNAs, such as DSCAM-AS1, play a regulatory role in this process.
An epigenetic study of over 18,000 people in Scotland identified associations between certain DNA modifications and increased risks of breast cancer, type II diabetes, and chronic obstructive pulmonary disease (COPD). The findings provide new insights into the underlying mechanisms of these diseases.
Inflammatory breast cancer is a rare and aggressive form of breast cancer with poor outcomes. Research highlights the role of ERβ as a mediator of estrogen signaling, demonstrating its tumor suppressive effects in preclinical models. ERβ's antimetastatic activity may hold promise for improving treatment options for IBC.
A study found that certain genetic mutations are associated with treatment-resistant breast cancer in young women, but not older women. The research proposes a new paradigm for classifying and studying all types of cancer.
A new study has created the world's largest map of normal breast tissue, highlighting 12 major cell types and 58 biological cell states. The atlas also identifies differences based on ethnicity, age, and menopause status, providing a powerful resource for researchers studying breast cancer and other diseases.
A newly discovered radionuclide-based agent (CB-2PA-NT) has shown high tumor uptake, sustained retention, and contrast in preclinical models. Targeting neurotensin receptors, CB-2PA-NT expands precision medicine for cancer diagnosis and treatment.
Researchers have developed a new technique to generically treat several kinds of cancer, showing tumors grew almost three times less and survival rates reached 100% after just one injection. The method targets cancer cells with alpha radiation, sparing healthy tissue.
Researchers at the University of Malaga develop a new therapy using manual techniques and stretching to reduce pain and improve mobility in women with axillary web syndrome after breast cancer. The therapy, consisting of 15 sessions, has shown significant results in reducing evolution time of lymphatic thrombi.
Researchers found that ChatGPT 4 can accurately identify appropriate imaging services for breast cancer screening and breast pain. The AI model outperformed its predecessor, ChatGPT 3.5, in providing evidence-backed guidelines for radiologists.
A new study reveals how breast cancer cells suppress anti-cancer immune responses in the lymph nodes to survive and spread. Researchers found that some cancer cells exhibit elevated expression of MHC class II proteins, which are involved in initiating immune responses.
A new study reveals that the protein complex BCDX2 plays a critical role in DNA repair, suggesting mutations in this complex could lead to cancer. The research also highlights the importance of screening for mutations in people with a family history of breast and ovarian cancers.
A team of researchers at the University of Tennessee Health Science Center has received a $3.07 million grant from the National Cancer Institute to develop new drugs targeting microtubules for breast cancer treatment. The goal is to improve overall survival and quality of life for patients with metastatic breast cancer.
A UMass Amherst biostatistician is developing statistical tools to better predict breast cancer survival rates and survival time after recurrence. The methods, funded by an NIH grant, will also have a broad application for other chronic diseases, such as those involving hormones and biomarkers.
A new study published in the Journal of the American College of Surgeons found that people who live in historically redlined areas are less likely to be screened for breast, colorectal, and cervical cancer. The legacy of redlining continues to contribute to significant disparities in cancer screening rates.
Research suggests that aromatase inhibitors can limit the effectiveness of weight loss medications in breast cancer survivors. Studies have shown that these medications are less effective in women taking aromatase inhibitors, leading to reduced weight loss and increased risk of health complications.
Researchers developed tiny nano-sized pores that can detect specific proteins in complex biological fluids, such as blood. The breakthrough enables fast and accurate disease diagnosis, potentially leading to earlier interventions and improved treatment outcomes.
A recent study has found that impaired histone inheritance accelerates breast cancer growth and metastasis by disrupting the epigenetic state of cells. This disruption leads to the reactivation of genes associated with development, promoting tumor progression.
A new review paper suggests ACSL4 status as a biomarker for breast cancer subtype classification and predictor of response to hormone-based therapies. The enzyme may also serve as a target for developing new treatment modalities in quadruple negative breast cancer.
Researchers from Medical College of Wisconsin found that older breast cancer survivors, particularly those exposed to chemotherapy, showed greater epigenetic aging than their same-aged peers without cancer. This acceleration in biological aging may be associated with worse functional outcomes and quality of life for these patients.