Articles tagged with Breast Cancer
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Researchers found that online educational materials about breast surgery have a negative tone, exceed recommended reading levels, and are of poor quality. Studies assessed readability, bias, quality, and tone using validated tools, highlighting the need for accessible materials.
A new AI-based tool estimates patient-specific cancer survival rates using machine learning, offering personalized prognosis for patients with breast, thyroid, and pancreatic cancers. The Cancer Survival Calculator differs from existing estimators by incorporating multiple factors beyond disease stage.
A new cancer immunotherapy that targets two immune-evading tumor tactics has shown promising results in an early clinical trial. The drug, tebotelimab, blocks both PD-1 and LAG-3 proteins, leading to a double-digit response rate in patients with advanced solid tumors or blood cancers.
Researchers found that polygenic risk scores identify only 11% of individuals who develop disease and generate 5% false positives. The scores contribute little health benefit while adding cost and complexity to healthcare systems.
A team of researchers aims to develop drug therapies by targeting genes that affect metabolism in people with Down syndrome, potentially improving their quality of life. The project will focus on the protein SIM2, which has been linked to breast cancer and metabolic changes in individuals with the condition.
Researchers will study the impact of exercise, intermittent fasting, and their combination on fatigue, biomarkers of inflammation, and quality of life in women with advanced breast cancer. The trial aims to improve treatment tolerability and possibly life duration for these patients.
A team of researchers has developed a new visualization tool combining high-speed cameras and fluorescent injection to distinguish tumor tissue from normal tissue across cancer types. The technique, known as fluorescence lifetime (FLT) imaging, achieved an accuracy of over 97% in distinguishing tumor tissue from healthy tissue.
Researchers created a 3D printed tumor model using bioprinting and synthetic chips to better understand complex cancers. The model simulates the surrounding environment, addressing limitations of traditional 2D models.
Researchers developed a nanocapsule that reduces lactate levels and releases hydrogen peroxide, recruiting and activating immune cells to attack tumors. The approach increased immune cell activity by 2-5-fold, improving cancer immunotherapy success rates.
A University of Massachusetts Amherst team demonstrates a protein antigen from a childhood vaccine can be delivered into malignant tumor cells to refocus the immune system against cancer. The bacteria-based intracellular delivering system shows promise in treating pancreatic, liver, and metastatic breast tumors.
A multilevel primary care intervention, including electronic health record reminders and patient outreach, improved timely follow-up of overdue abnormal cancer screening test results for breast, cervical, colorectal, and lung cancer. The intervention was found to be effective in reducing missed screenings.
Researchers have pinpointed the molecular mechanism by which a large portion of BRCA1 mutations cause cancers in women. The study found that the E3 ligase activity of BRCA1 is crucial in several stages of DNA repair and tumor suppression, reinterpreting previous findings.
A recent study by UTHealth Houston found that the offspring of adolescent and young adult women with a history of cancer face a higher risk of birth defects. The study examined 6,882 offspring ages 12 months and younger and found an increased risk of specific types of defects in the offspring of women with a history of cancer.
Researchers discuss lurbinectedin as a method to treat neuroendocrine tumors (NETs), with encouraging results from phase II basket studies demonstrating activity in platinum-sensitive relapsed SCLC and other malignancies. Lurbinectedin's mechanism of action involves inhibiting oncogenic transcription, promoting apoptosis and cell death.
The study analyzed 10,000 gene expression signatures to assess their prognostic ability, finding that they lead to accurate patient prognosis in no more than 80% of cases. The researchers emphasize the need for a comprehensive approach incorporating molecular, clinical, histological, and other factors to ensure an accurate prognosis.
A new study by Columbia University Mailman School of Public Health found that women living in more walkable neighborhoods have a lower risk of obesity-related cancers, particularly postmenopausal breast cancer. Neighborhood walkability is associated with increased physical activity and reduced car-dependency.
Researchers discovered NKG2A receptors as potential targets to overcome immunotherapy resistance in breast cancer, offering a promising approach for treating immunotherapy-resistant triple-negative breast cancer patients.
Researchers at MedUni Vienna discovered that dormant tumor cells surviving chemotherapy can be targeted through the inhibition of P-glycoprotein, opening new possibilities for delaying relapse. This breakthrough could represent a step forward in treating aggressive triple-negative breast cancer, which has limited treatment options and ...
A randomized study shows that shorter radiation therapy courses are just as effective in preventing cancer return and reducing side effects for patients with breast reconstruction. The accelerated treatment regimen saved patients time, money, and experienced fewer treatment breaks.
Researchers found a shorter course of radiation therapy provides equivalent protection against breast cancer recurrence and physical side-effects, but reduces life disruption and financial burden. Patients reported less burden on their time and finances, with improved quality of life.
Researchers have made significant progress in using immunotherapies prior to surgery, leading to better biomarkers and more effective combination therapies. This approach has shown promise in various cancer types, including lung cancer, triple-negative breast cancer, melanoma, and gastrointestinal cancers.
Cancer cells exploit enhancer DNA to accelerate tumor growth, according to researchers at the University of Toronto. The study found that specific proteins regulate this process, suggesting potential treatments through FOXA1 or NFIB suppression.
A new poll found that 62% of people aged 50-80 disagree with using life expectancy as a factor in determining cancer screening guidelines. The majority also believes that some older adults should still receive cancer screenings even if guidelines don't recommend them.
A new imaging agent, 68Ga-ABY-025, can predict early metabolic response to HER2-targeted treatment in HER2-positive metastatic breast cancer patients. Whole-body PET/CT enables quantification of HER2 expression and predicts metabolic response, potentially sparing patients from unnecessary side effects.
A new report highlights the significant impact of gender inequality on women's experiences with cancer, including unequal access to prevention, diagnosis, and treatment. The Commission calls for a more inclusive and responsive health system to address these disparities.
Researchers found that adding dendritic cell boosting therapy to radiation and CTLA4 inhibitor combination produced synergistic effect, eliciting tumor regression. This approach resulted in complete or almost complete elimination of targeted tumors.
A new clinical and research partnership has created an AI model that can predict whether cancerous tissue has been fully removed from the body during breast cancer surgery. The model performed as well as humans in identifying positive margins, especially in patients with higher breast density.
A study found that 80.3% of patients with metastatic breast cancer who received standard care treatment with alpelisib developed hyperglycemia, with 40.2% experiencing serious hyperglycemia. Lifestyle interventions and medication may help improve blood sugar levels and reduce the risk of needing to discontinue the drug.
A new MU study found that APRNs recognize the importance of breast cancer survivorship care and can benefit from standardized education. The findings suggest that formalizing education on breast cancer survivorship could lead to improved healthcare for patients, including symptom management, monitoring, and follow-up appointments.
A Brown University team developed a hydrogel-based delivery system that balances tumor acidity and increases doxorubicin's effectiveness against cancer cells. Initial lab tests show promising results, paving the way for pre-clinical trials.
Researchers found higher 5-year survival rates among Kaiser Permanente patients compared to National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) estimates. Improved screening rates, cancer treatment pathways, and coordinated care may have contributed to these higher survival rates.
Research suggests that women carrying disease-causing BRCA variants may face incorrect risk assessments of 60-80% for breast cancer, when in fact the true risk is less than 20%. This has led to unnecessary breast surgeries. The study aims to inform informed decision-making and responsible communication of genetic risks.
A recent study led by IBEC demonstrates that laminin, a protein present in healthy breast tissues, prevents the effects of stiffening, protecting cells against tumor growth. The researchers observed that cells seeded on laminin-rich gel exhibited a significantly less pronounced mechanical response to substrate stiffness.
Breast milk from breast cancer patients contains tumour DNA that can be detected through liquid biopsy, offering a potential new tool for early diagnosis. The study found that ctDNA was detectable in 13 of 15 breast milk samples collected from breast cancer patients, outperforming detection in blood samples.
A study of 2,176 US counties reveals that breast cancer mortality is influenced by local factors such as poverty, education, and access to healthcare. The findings suggest that geographically targeted interventions could lead to healthier communities and reduced mortality rates.
Researchers have discovered two FDA-approved and EMA-approved drugs that inhibit prmt5, a protein linked to promoting tumor growth in several cancers. These repurposed drugs show promise in reducing cancer cell proliferation and tumor growth.
Researchers identified distinct genomic characteristics that impact prognosis for patients with triple negative apocrine carcinoma. The study confirmed a five-year disease-free survival rate of 92.2% for these patients, significantly higher than those diagnosed with other types of TNBC.
Researchers discuss new drugs available for HER2-positive breast cancer patients with brain metastasis, showing improved outcomes and quality of life. The development of targeted therapies has led to better survival rates among these patients.
Researchers advocate for accessible breast cancer screening services for individuals with disabilities, highlighting physical barriers such as equipment accessibility and fragrance-free policies. They stress the need for social and procedural barriers removal through comprehensive training and resources.
The study found significant reductions in breast cancer screening volume and uptake globally during the 2020 COVID-19 pandemic. The analysis of 26 studies from 13 countries revealed a decline in screening volumes ranging from 13% to 61%, and screening uptake rates varying by up to 43.5%.
A recent study published in PLOS Biology suggests that chemotherapy injury to surrounding non-cancer cells can awaken dormant breast cancer cells, promoting cancer growth and recurrence. The researchers found that the release of specific cell signaling molecules, G-CSF and IL-6, by injured stromal cells drives this process.
A large-scale international study of childhood cancer survivors found that women who received high-dose doxorubicin chemotherapy without chest radiation have a significantly increased risk of breast cancer before age 40. The researchers are calling for broadening guidelines for breast cancer screening in these patients.
Researchers found a significant association between high particulate matter exposure and an 8% increase in breast cancer incidence among US women. The study, which considered historical air quality data, suggests that fine particulate matter may affect breast cancer through endocrine disruption.
Researchers found that African American women with ER-positive breast cancer have decreased levels of amino acids and increased levels of fatty acids compared to non-Hispanic white women. This study may help explain the higher mortality rates in African American women with the disease, suggesting potential new screening strategies.
A randomized trial published in The Lancet Oncology found that condensing prostate beam scanning proton therapy for breast cancer patients can result in similar control of the cancer while sparing surrounding normal tissue. The study demonstrated excellent outcomes, with reduced skin side effects and comparable complication rates.
Researchers discovered that a small subpopulation of AIB1-expressing cells in breast cancer enables invasion and metastasis. The study suggests that these subpopulations play a crucial role in tumor growth and spreading to distant sites.
Researchers found that an AI algorithm comparable to human readers demonstrated high sensitivity and specificity in detecting breast cancer. The study utilized a large dataset of mammographic exams and compared the performance of AI with human readers, finding no significant difference between the two.
Research published in BMJ Oncology reveals a global increase of 79% in new cancer cases among those under 50 between 1990 and 2019. Breast cancer accounted for the highest number of early onset cases, while cancers of the windpipe and prostate rose the fastest.
Breast cancer survivors often struggle to take their life-extending medication due to side effects and high costs. A new study found that interventions such as cost-cutting policies, mobile apps, and psychological counseling can increase medication adherence by nearly 1.5 times. Addressing mental health issues, particularly depression,...
Researchers at UMass Amherst are investigating the connection between PFAS chemicals and breast cancer. They will examine data from postmenopausal women to determine if PFAS concentrations are associated with less breast tissue involution, which may increase breast cancer risk.
Researchers at Kyoto University have discovered the mechanism by which breast cancer forms in mammalian epithelial cells. The team found that approximately 20 mutations accumulate annually in each cell until menopause, after which the rate decreases significantly.
A new study finds that cost-cutting policy changes, mobile apps, and psychological strategies can increase medication adherence by nearly 1.5 times among breast cancer survivors. The study also highlights the importance of managing side effects through physical therapy, exercise, and behavioral counseling.
A study published in Radiology found that combining short- and long-term breast cancer risk models using artificial intelligence can improve cancer risk assessment. The combined model showed an overall improved risk assessment for both interval and long-term cancer detection, identifying women at high risk for breast cancer.
A team of KAUST researchers has found a critical protein that regulates cell division and proliferation in breast cancer and leukemia. Their work clears the way for the development of targeted drugs by refuting recent challenges to their approach.
A Swedish study revealed that including all eleven associated genes in the screening test doubled the proportion of women with genetically confirmed hereditary breast cancer. The study included 4759 individuals and found that around 85% of women investigated for suspected hereditary breast cancer had a genetic abnormality.
A statistician at Virginia Commonwealth University has been awarded a $1.7 million grant to investigate the long-term effects of neighborhood exposures and racial segregation on cancer risk. The researcher aims to better understand how geographic and socioeconomic factors contribute to disparities in cancer incidence and mortality.
Researchers have identified a neoplastic fusion transcript RAD51AP1-DYRK4 in luminal B breast cancer, associated with higher ki67 expression and aggressive clinical characteristics. MEK inhibitor trametinib may be effective in blocking the MEK-ERK signaling driven by this fusion.
Researchers have discovered that estrogen promotes tumor growth in ERα-negative cancers, such as triple-negative breast cancer. Anti-estrogenic therapies, when combined with immune checkpoint inhibitors, drastically suppress tumor progression in mice models.
A new study estimates that cancer screenings have saved the US at least $6.5 trillion and led to 12 million more years of life, with significant economic impact from breast, colon, cervical, and lung cancer screenings.
A large-scale international collaborative study has identified new genes associated with breast cancer, which could lead to better risk prediction and improved clinical management. The study found evidence for at least four new breast cancer risk genes, with many others showing suggestive evidence.