Articles tagged with Breast Cancer
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A study published in JAMA Oncology found that regular screening is not enough to prevent advanced breast cancer diagnoses, particularly among women of color who are overweight or obese. The researchers recommend primary prevention strategies to reduce the number of advanced cancer diagnoses.
A study found that patients with hormone receptor-positive breast cancer who paused endocrine therapy to conceive did not experience worse short-term recurrence rates. Cryopreserved embryo transfer was associated with higher pregnancy rates, and younger age and menstrual cycles returning after pausing therapy were linked to improved ou...
Researchers found correlations between flaxseed diets and changes in the gut microbiome and mammary gland miRNA profiles. Flaxseed lignans were shown to modify the relationship between the microbiota and miRNAs to be non-cancer causing.
A retrospective cohort study of 4,732 BRCA carriers found that pregnancy following breast cancer was not associated with decreased disease-free survival. 1 in 5 patients conceived within 10 years after diagnosis.
A phase III clinical trial found that neoadjuvant chemotherapy can downstage lymph node-positive breast cancer, allowing patients to safely omit adjuvant regional nodal irradiation. This treatment de-escalation strategy is an option for patients whose lymph nodes become cancer-free after neoadjuvant treatment.
A phase III trial found that tucatinib plus trastuzumab emtansine extended progression-free survival in patients with unresectable locally advanced or metastatic HER2-positive breast cancer, particularly those with brain metastases. The combination reduced the risk of disease progression or death by 24.1% and improved outcomes for pati...
The Susan G. Komen organization presents awards to four dedicated physician scientists and a pioneering research advocate for their contributions to advancing breast cancer research and transforming patient care. Dr. Olufunmilayo Olopade and Dr. Daniel Hayes are recognized for their work in basic science and clinical research, respecti...
A recent study published in Lancet Oncology has found that measuring blood hormone levels can identify post-menopausal women who are most likely to benefit from anastrozole, a medication used to prevent breast cancer. The study suggests that inexpensive blood tests could be used to personalize preventive therapy for these women.
Researchers developed a predictive model using baseline sociodemographic and financial measures to identify patients at high risk of stopping treatment with aromatase inhibitors. The model found four demographic and financial factors associated with increased non-adherence, including younger age and lower out-of-pocket costs.
A new AI-based risk model evaluates mammographic images to identify women at high risk of developing breast cancer. The study confirms that the method works well in different European populations, with 6.2% of women classified as high-risk having almost seven times the risk of developing breast cancer.
A new study found that a type of white blood cell called tumour-associated macrophages can promote the formation of lymphatic vessels, facilitating cancer cell transport to other organs. However, these cells also reduce breast cancer spread to the lungs while increasing it to the lymph nodes.
Researchers discovered that Osteopontin induces mitochondrial biogenesis in deadherent breast tumor cells, which aids metastatic success. The study suggests a possible mechanism and targets for treating cancer metastasis by increasing ATP levels and mitochondrial mass.
A study published at the Radiological Society of North America annual meeting found that attending regular mammograms can lower breast cancer mortality rates by up to 72%. Women who missed a scheduled mammogram had a significantly reduced survival rate, emphasizing the importance of adherence to screening schedules.
A deep learning AI model developed using mammographic images alone accurately predicted both ductal carcinoma in situ (DCIS) and invasive carcinoma, showing no bias across multiple races. The model outperformed traditional risk models in predicting breast cancer risk, providing a more accurate and equitable assessment.
A new AI tool combines cancerous and non-cancerous cell patterns to predict breast cancer outcomes, allowing for more precise treatment plans. This could lead to reduced chemotherapy duration and intensity for some patients.
Researchers identified 38 unique pathogenic variants in 57 patients, including novel variants specific to the Kazakh population. These variants were associated with an increased risk of triple-negative breast cancer and family history of breast cancer.
A study of 103,000 early-stage breast cancer patients reveals a significant racial disparity in chemosensitivity and survival rates. Black patients are more likely to experience residual disease after neoadjuvant chemotherapy, leading to a higher mortality risk.
Breast cancer incidence is higher in urban areas with poor environmental quality, especially at early stages. The study found a significant association between environmental exposure and breast cancer incidence, with varying levels of impact depending on the stage of cancer.
Researchers investigate nanoparticles for cancer treatment, hoping to reduce side effects and improve efficacy. La-Beck's lab aims to understand the body's interaction with nanoparticles and their impact on tumor growth and immune responses.
A study published in PLOS ONE found that 35% of women with breast cancer used self-discovered or peer-recommended techniques to enhance their sexual function. These techniques fell into four main domains: pain reduction, intimacy and relationship enhancement, desire and arousal enhancement, and emotional coping.
A new ASTRO clinical guideline recommends partial breast irradiation as a viable alternative to whole breast radiation for patients with early-stage invasive breast cancer or DCIS, based on evidence from large randomized trials. The guideline provides guidance on patient selection and best practices for delivering effective partial bre...
Researchers at UNC School of Medicine have pieced together the lesser-known DNA repair pathway, polymerase theta-mediated end joining (TMEJ), which is upregulated in patients with hereditary breast cancer, ovarian cancer, and prostate cancer. The discovery could lead to new therapies for cancer by targeting this pathway.
Researchers at Stanford University discovered that breast cancer cells use a collective, physical mechanism to break through the basement membrane barrier. In a 3D hydrogel model, cancer cells trapped within duct-like structures swelled and stretched, weakening the basement membrane and allowing escape.
A new study by Cleveland Clinic researchers reveals significant differences in cell communication between breast tissue with and without BRCA1/2 gene mutations. This discovery provides a foundation for personalized medicine approaches to prevent and treat breast cancer in mutation carriers.
A team of researchers developed a gel delivery system that overcomes challenges in intratumoral therapy. The gel contains an imaging agent and can hold a high concentration of drug for slow release. In preclinical models, the treatment induced tumor regression and improved survival in immunotherapy-resistant colon and breast cancer.
The Max Foundation has started treating three patients with advanced breast cancer, including a CDK4/6 inhibitor therapy, in Mozambique. This marks the first time this treatment is available in low-income countries and aims to improve outcomes for women living with advanced breast cancer.
Experts call for urgent measures to address discrimination against patients fleeing war or conflict zones, those with serious mental illnesses, and frail elderly patients. Guidelines for treating advanced breast cancer should prioritize patient preferences and involve multidisciplinary care teams.
Researchers identified key factors in DNA repair, revealing the 'proofreading' portion of polymerase epsilon helps prevent strand breakage. This knowledge arms scientists with ways to enhance anti-cancer drug effectiveness and develop new diagnostic methods.
Patients with breast cancer in conflict zones face significant barriers to treatment, including lack of standard procedures and funding for rebuilding capacity. This results in many patients being diagnosed with advanced breast cancer, often with limited palliative care options.
Researchers at IRB Barcelona have identified the mechanism by which the MAF protein promotes breast cancer metastasis, revealing a key interaction with the estrogen receptor. This finding opens up new therapeutic options for patients with high MAF levels, who may benefit from treatments aimed at preventing metastases.
The PhRMA Foundation awarded two $500,000 Frontier Awards to researchers William Padula and Surachat Ngorsuraches for their patient-centered value assessment models. Their studies will advance the field of value assessment by applying theoretical models in a real-world context and engaging with patients to ensure their voices are inclu...
Researchers discovered narrow-spectrum Wnt signaling inhibitors can suppress breast cancer tumors and reduce chemo-resistant cells in mice. The treatment, derived from a bacterial toxin, targets specific receptors to minimize bone density side effects.
Scientists at Nagoya University have discovered a reliable cancer marker, stromal cell-derived factor 4 (SDF-4), that detects gastric cancer with high accuracy. The protein is found in high levels even in patients with stage I gastric cancer, suggesting its potential for early detection.
Researchers found that breast cancer cells rely on vitamin B5 to grow and survive. In a study published in Nature Metabolism, scientists discovered that limiting vitamin B5 intake slowed the growth of breast cancer tumours in mice.
Researchers have found that simultaneously inhibiting two proteins, LOXL2 and BRD4, can help slow the growth of triple-negative breast cancer cells. This 'double strike' strategy shows promise in improving the prognosis of this aggressive disease, which is resistant to existing treatments.
A study finds that people with advanced breast cancer are more likely to stop working, leading to significant economic losses. The research estimates a loss of €28,676,754 in productivity over three years in Portugal.
Patients with HER2-positive breast cancer that has spread to other parts of the body survive for longer if treated with pyrotinib. The new drug targets proteins involved in HER2-positive breast cancer and shows a 22% reduction in risk of death compared to lapatinib.
Researchers at the University of Leicester have received a significant financial boost to advance their cancer treatment research. The team will investigate 'liquid biopsies' to reveal vital clues about cancer genetic makeup, aiming to predict how cancer changes and which treatment works best for individual patients.
New research suggests that vitamin D supplements can reduce the risk of peripheral neuropathy in patients undergoing paclitaxel treatment. The study found that patients with vitamin D deficiency were more likely to experience severe neuropathy, and that inducing vitamin D deficiency caused similar symptoms in a mice model study.
A study published in Oncotarget reveals that HER2 mutant alleles play a crucial role in determining treatment response to neratinib and poziotinib. Researchers found that individual HER2 mutant alleles have distinct effects on therapeutic efficacy, suggesting new targets for breast cancer therapy.
A study of 185 women found that high neighborhood deprivation was associated with changes in DNA methylation and gene expression in Black women with breast cancer. This suggests a potential link between environmental factors and biological susceptibility to chronic diseases.
Researchers use 3D human breast organoids to study cellular and molecular processes of lactogenesis, milk production, and involution. The models form structures characteristic of human breast tissue, maintain various cell subtypes, and respond to hormone or drug treatments.
Researchers at MUSC Hollings Cancer Center have identified new targets for treating breast cancer that has become resistant to hormone therapy and CDK4/6 inhibitors. By understanding the molecular mechanisms of resistance, the team has found potential solutions using epidermal growth factor receptors and PARP inhibitors.
A recent study published in JAMA Oncology found that false-positive mammography results may significantly increase the risk of developing breast cancer. The risk varies depending on individual characteristics and follow-up, highlighting the need for personalized screening strategies after a false-positive result.
Mutations in the PIK3CA gene lead to elevated production of the PI3Ka protein, found in approximately 40% of hormone receptor-positive breast cancers. Next-generation PI3Kalpha inhibitors targeting a different region of the mutant protein show promise in overcoming resistance.
Researchers found a significant long-term increased risk of breast cancer among women with false-positive mammography results. The risk is highest in women aged 60-75 and those with low breast density, facing a 60% increased risk over the subsequent 20 years.
A successful approach that eliminated Delaware's racial disparities in colorectal cancer can now be applied to breast cancer. The 'village' model focuses on building community partnerships and increasing access to care to reduce disparities.
Researchers found that FAAH inhibition reduced breast cancer growth in immunodeficient mice and induced apoptosis of breast cancer cells. The combination of FAAH inhibitors and endocannabinoids was the most effective treatment approach.
A new study by NUS provides insights into how BRCA2 mutations impact breast tissue cells, leading to early breast cancer development. The research found that healthy mammary glands are not predisposed to form lesions, but HR- luminal cells with BRCA2 mutations exhibit enhanced organoid formation and survival under replication stress.
Researchers at the University of Cincinnati Cancer Center found that SmartClips, a wireless localization method for breast tumors, is safe and effective. The devices reduce patient discomfort and improve surgery efficiency by allowing surgeons to locate tumors more accurately.
Researchers have found that targeting protein eIF4A with the small molecule drug Zotatifin can suppress tumor cell proliferation and remodel the immune microenvironment in triple-negative breast cancer. The promising findings support pursuing clinical trials to assess the potential patient benefits of this approach.
A new antibody created by Cold Spring Harbor Laboratory researchers may offer an effective treatment for some breast cancers. The antibody targets the PTPRD enzyme, which is overabundant in certain breast cancers and helps them spread.
The TMIST breast cancer screening trial is expanding to Thailand, aiming to improve outcomes for Black and Hispanic women. The trial, led by the ECOG-ACRIN Cancer Research Group, is comparing 3-D and 2-D mammography in 128,905 women to better inform tailored future screenings.
Researchers have discovered that a motor protein called dynein powers the movement of breast cancer cells in soft tissue models, offering a potential target for treatment. This finding could fundamentally change how cancer is treated by paralyzing cancer cells rather than killing them.
Researchers found that an adaptive memory tracking training program can improve cognitive function, particularly attention and working memory, in women treated for breast cancer. The training showed lasting gains after just 12 hours of practice.
A study of 9,479 participants identified racial and ethnic disparities in breast cancer survival, highlighting the need for targeted interventions to improve outcomes for at-risk subgroups. The findings suggest that focused care approaches can address these disparities and promote more equitable treatment.
Researchers have discovered that genetic ancestry influences the biology of normal breast tissue and how it factors into the development of aggressive breast cancers. PZP cells, naturally higher in Black women, can influence cancer cell behavior and growth.
The partnership aims to reduce disparities in cancer research and drug development through collaborations, resources, and training programs. Key projects will focus on breast and pancreatic cancers, particularly luminal B breast cancers disproportionately affecting women of African descent.
A research team from the University of California - Davis Health has identified a crucial epitope on the CD95 receptor that can trigger programmed cell death in cancer cells. This finding could lead to improved cancer treatments and potentially enhance CAR T-cell therapy for solid tumors like ovarian cancer.
Researchers at Penn Medicine have received a $10 million grant to develop a new strategy for preventing breast cancer recurrence by targeting dormant tumor cells. In a phase II clinical trial, the team successfully cleared dormant cells from over 80% of patients, offering a promising proof-of-concept for this approach.