Articles tagged with Breast Cancer
A small study at the University of Rochester Medical Center found that women with stage 4 breast cancer who followed a whole-foods plant-based diet experienced significant weight loss, improved cholesterol levels, and reduced fatigue. The diet also showed promise in reducing inflammation and changes in blood levels of amino acids.
Researchers found low rates of metastasis and lymph node involvement in post-menopausal patients with early-stage ER+ breast cancer. This suggests that clinical guidelines for de-escalating surgery may be safely extended to younger patients.
A study of nearly 5,000 mammograms found that AI algorithms produced false positive results more frequently in Black and older patients, while Asian patients and younger patients were less likely to be flagged as suspicious. Healthcare institutions should consider the patient population they serve before purchasing an AI algorithm.
The study evaluated a breast cancer pre-screening solution using a smartphone-based thermal imaging sensor and AI, achieving high sensitivity and specificity. The tool helped detect breast cancers earlier, particularly in settings where mammography is not available or accessible.
Researchers have developed a targeted therapy for triple negative breast cancer by linking an antibody to a cell-killing drug. This approach may reduce side effects and improve patient outcomes for women diagnosed with this aggressive form of the disease.
A novel therapy has been developed to reprogram macrophage immune cells, shifting their balance toward antitumor activity. The treatment, JHU083, blocks the use of glutamine in tumors, reducing growth and triggering cell death. It also boosts immune-activating macrophages, recruiting tumor-killing T-cells and natural killer cells.
Researchers found that endothelial cells in breast cancer tumors are two times more likely to interact with medicine-carrying nanoparticles than healthy endothelial cells. This discovery could lead to more efficient and targeted delivery of cancer nanomedicines.
A Phase III randomized, placebo-controlled trial found that donepezil did not improve memory or other cognitive functions in breast cancer survivors. Despite this, researchers emphasize the need for further trials with different approaches to address cancer-related cognitive impairment.
A study published in JAMA Surgery found that bariatric surgery significantly reduces the risk of breast cancer in women with obesity, particularly those with high blood insulin levels. The results show a 32% lower risk overall and a 52% lower risk for women with high insulin levels at the start of the study.
Researchers used D-FFOCT and deep learning to create an intraoperative diagnostic workflow for breast cancer patients. The approach achieved high accuracy and speed, reducing processing time by a factor of 10 compared to conventional histology.
Researchers found elevated expression of RPGRIP1L in invasive breast cancer specimens, correlating with shorter survival times and unfavorable clinicopathological features. The study identified 50 genes and 15 proteins related to RPGRIP1L expression, including those involved in immune response and metabolism.
Higher childhood body size may reduce breast cancer risk by forming less dense breast tissue, which is a known risk factor for the disease. The study found that over 50% of the protective effect is explained by changes in dense breast tissue.
New cancer projections highlight progress in reducing incidence rates for common cancers like lung, colorectal, and prostate, but also warn of rising rates for less common types such as liver, kidney, melanoma, and non-Hodgkin lymphoma.
A study published in Nature Genetics has identified genetic variants associated with an increased risk of breast cancer in women of African ancestry. The research found that nearly 8% of women carry all six risk variants, making them 4.2 times more likely to be diagnosed with triple-negative breast cancer.
A plant virus treatment, composed of cowpea mosaic virus nanoparticles, has shown remarkable success in improving survival rates and suppressing the growth of metastatic tumors across various cancer models. The treatment was effective even after surgical removal of tumors, indicating its potential to prevent metastasis.
A recent analysis of WHI findings indicates that MetS and obesity each have different associations with breast cancer subtypes and mortality risk. Women with higher MetS scores are at a higher risk of poor-prognosis, estrogen receptor-positive, progesterone receptor-negative breast cancers.
A UK Biobank study suggests that adults living with obesity who were underweight or average weight in childhood may be at increased risk of all-cause mortality. The study found that adult men and women who reported being thinner as children had higher mortality risks, with a 63% and 60% increase respectively.
A UCLA-led study reveals that chemotherapy for early-stage breast cancer in women over 65 can lead to a significant decline in physical function. The study found that 30% of older women who received chemotherapy experienced a substantial decline, with climbing stairs and walking being the most affected activities.
A cross-sectional study found racial and ethnic disparities in breast cancer treatment declination and overall survival. The study suggests that patient education on treatment benefits and improved communication between patients and clinicians can help reduce disparities and improve patient outcomes.
Researchers have developed a new imaging technique that rapidly and accurately identifies cancerous tissues in breast samples. The method uses machine learning algorithms trained on hyperspectral dark-field microscopy data to pinpoint regions of invasive ductal carcinoma and invasive mucinous carcinoma.
Researchers discovered that aggressive cancer cells pull more strongly on the extracellular matrix than on themselves, while noninvasive cells pull more strongly on themselves. The study found that the interplay between these contractility modes determines a cell's potential for escape and tumor aggressiveness.
A late University of Virginia School of Medicine scientist's research on the SAS1B protein could lead to new cancer treatments for multiple cancers. The discovery has the potential to selectively target cancer cells while sparing healthy tissue.
Researchers at Sylvester Comprehensive Cancer Center have developed a nanoparticle that can penetrate the blood-brain barrier, potentially targeting both primary breast cancer tumors and brain metastases in one treatment. The method shows early promise in preclinical models, where it shrinks breast and brain tumors.
Text messaging and bulk ordering can significantly increase mammogram completion rates for breast cancer screening outreach. The study found that these interventions are effective in improving adherence to recommended screening guidelines.
Researchers found that UTIs can provoke structural changes in breast tissue in mice, which are reversible once the infections are resolved. The study suggests a possible link between UTIs and abnormal breast cell growth, highlighting the importance of considering everyday occurrences on women's well-being.
Menopausal hormone therapy is appropriate to treat vasomotor symptoms in early menopause without contraindications. WHI evidence does not support routine supplementation with calcium plus vitamin D or a low-fat diet for preventing fractures and breast/colorectal cancer, respectively.
A new set of clinical practice standards and recommendations offers tailored and effective care for individuals with advanced and metastatic cancer. The initiative, backed by MASCC and ASCO, provides a critical resource to healthcare stakeholders.
A new study found that GPT-4 and Google Gemini performed poorly in breast imaging classification, with a high percentage of discordant assignments that could impact patient management. The researchers emphasize the need for regulation of these large language models in high-level medical scenarios.
The USPSTF updates its breast cancer screening recommendation to biennial mammography for women ages 40-74. However, the balance of benefits and harms is unclear for women over 75 or those with dense breasts. Breast cancer is a common cause of death among US women.
The US Preventive Services Task Force recommends biennial breast cancer screenings starting at age 40 for all women, aiming to enhance early detection and tackle disparities. However, challenges remain in ensuring equitable access to screening technologies and addressing gaps in evidence regarding AI-powered image interpretation.
A new study on aspirin's role in breast cancer treatment highlights critical issues related to health equity and aging, with implications for future disease intervention trials. The study found that aspirin did not decrease the risk of cancer recurrence or improve survival among breast cancer survivors.
Breast cancer study reveals seven pivotal genes are upregulated in tumor tissues, indicating critical role in disease progression and poorer patient prognosis. In vitro validation supports overexpression of these genes in breast cancer, emphasizing their importance as potential therapeutic targets.
A randomized clinical trial of 3,020 patients with high-risk nonmetastatic breast cancer found daily aspirin therapy had no effect on breast cancer recurrence or survival in early follow-up. Aspirin should not be recommended as an adjuvant breast cancer treatment despite its potential benefits and wide availability
A large-scale study of 572 Asian families with BRCA1 and BRCA2 mutations found increased breast cancer risk over time, with highest incidence at age 55. The study provides a new framework for estimating cancer risks in Asian carriers, supporting tailored clinical management approaches.
A study published in the Canadian Association of Radiologists Journal shows an increase in breast cancer diagnoses among females in their Twenties, Thirties, and Forties. Younger women are more likely to be diagnosed at later stages and with more aggressive cancer.
The ECOG-ACRIN Cancer Research Group will present late-breaking findings on prostate cancer, breast cancer, and pancreas cancer at ASCO 2024. These studies include optimal chemotherapy for Black women with breast cancer and results from the first randomized national trial in older adults with pancreas cancer.
Researchers identified elevated MALAT1 levels in various blood cancers, correlating with adverse outcomes. MALAT1 promotes cancer cell proliferation, migration, invasion, and metastasis through multiple mechanisms.
Research shows breast cancer survivors are at increased risk of developing second cancers, including endometrial and ovarian cancer for women, and prostate cancer for men. Socioeconomic deprivation is linked to a greater risk of second cancers among breast cancer survivors.
Women with germline BRCA pathogenic variants face increased risk of mortality from postpartum breast cancer, particularly those diagnosed under 10 years after giving birth. The study highlights the importance of genetic counseling and tailored prevention strategies for these high-risk individuals.
The innovative Integrated Virtual Care (IVC) program successfully connected residents with family physicians in Renfrew County, addressing the rural shortage of primary care providers. Over 2,800 unique patient appointments were conducted, with 70% done virtually, offering comprehensive team-based primary care.
A national cohort study found that neighborhood disadvantage was independently associated with shorter breast cancer–specific survival. The study suggests potential unaccounted-for mechanisms, including both nonbiologic and biologic factors, and highlights the need for further research.
Researchers at the University of Toronto have discovered a DNA repair mechanism that uses nuclear metamorphosis to fix double-strand breaks in human cells. This discovery has significant implications for cancer treatment and premature aging, and may lead to new therapeutic avenues.
A new study published in JNCI Cancer Spectrum found that following a healthy diet, such as the DASH diet, lowers the risk of cardiovascular disease in breast cancer survivors. Women whose diets were most similar to DASH had a 47% lower risk of heart failure and other cardiovascular-related events.
A study by the University of Gothenburg found that women with triple-negative breast cancer and high immune cell levels have a lower relapse risk after surgery. This suggests that these patients may not need chemotherapy, despite having faster-growing tumors and higher relapse rates than other breast cancers.
The new Lancet Commission on Breast Cancer warns that people with metastatic breast cancer have been often forgotten, highlighting key barriers and inequities in healthcare. The report advocates for six crucial areas for change, including improving early diagnosis programs and communication with patients.
Researchers at Insilico Medicine have identified a new class of Polθ inhibitors featuring central scaffolding rings, designed using Chemistry42, with significant enzymatic and cellular potency. The discovery showcases the potential of AI in medicinal chemistry for precise molecular modifications.
A new Lancet Commission reveals that many people with breast cancer are being systematically left behind due to inaction on inequities and hidden suffering. The commission highlights the need for better patient support, including improved communication between patients and healthcare professionals.
Researchers have discovered how softer tumor environments prime cancer cells to better survive metastasis. The study found that soft environments alter the cancer cells' preference for 'fuel', equipping them with a more resilient energy pathway.
Young breast cancer survivors without germline pathogenic variants are at lower risk for developing a second primary breast cancer within the first decade after diagnosis. This study informs treatment decision-making and follow-up care considerations in this population.
Researchers developed an AI algorithm to identify normal mammograms and ran a simulation on patient data, revealing that AI can reduce unnecessary testing while maintaining cancer detection rates. The study suggests that AI can help doctors focus on more questionable scans, reducing false positives and improving workflows.
A new study found that survival rates after hip or spine fractures are comparable to or worse than those seen in patients with certain types of cancer. The study, which analyzed data from over 100,000 Canadians aged 65 and older, highlights the urgent need for secondary prevention interventions before hospital discharge.
Saruparib, a selective PARP1 inhibitor, demonstrates clinical benefit in patients with HRR-deficient breast cancers. The objective response rate was 48.4%, and progression-free survival was 9.1 months. The drug's favorable safety profile enables patients to stay on treatment for longer durations.
A Phase I/II trial led by the University of Texas M. D. Anderson Cancer Center found saruparib effective against HRR-deficient breast cancers, demonstrating a favorable safety profile and high response rate. The drug's low dose-reduction rate compared to approved PARP inhibitors may enable longer treatment duration.
MD Anderson researchers presented studies on combination therapies for AML and lung cancer, tumor microbiomes in immunity, and improved HPV screening. Genetic markers predict extended survival with KRAS inhibitors and may identify patients who benefit from novel combinations.
Cold Spring Harbor Laboratory researchers developed Accelerated SuFEx Click Chemistry to create over 150 new molecular compounds, including derivatives of complex natural molecules. These compounds show promise as leads for developing antibiotics and cancer therapies.
A large trial enrolling nearly 2,800 patients from five countries has clarified the situation for patients with larger metastases. The study found that leaving most of the lymph nodes intact resulted in similar recurrence rates as completion axillary dissection, but with fewer arm-related complications.
Researchers at the University of Cincinnati Cancer Center presented abstracts on new potential drugs and targets for treating various types of cancer. A study found that a brain-permeable drug called AM-101 sensitizes brain metastatic tumors to radiation, improving survival in preclinical animal models.
Research highlights socioecologic factors contributing to racial disparities in breast cancer prognostic scores, emphasizing the impact of structural racism on health outcomes. Additional research is needed to better understand the influence of social determinants on breast cancer biology among disadvantaged communities.
Researchers from the University of Southern Denmark have identified specific groups of cells driving resistance to chemotherapy in TNBC, offering new biomarkers and alternative treatment options. The studies shed light on the mechanisms behind chemoresistance and its epigenetic control.
Researchers at Tel Aviv University developed a novel therapeutic strategy using existing medications to inhibit bone metastasis in breast cancer patients. The combination of drugs improved survival rates and reduced bone metastases in animal models and human tissue samples.