Articles tagged with Breast Cancer
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A cohort study found that neighborhood deprivation is associated with increased breast cancer mortality in non-Hispanic white women, but not in non-Hispanic Black women. Factors beyond those explored may contribute to the disparity in breast cancer mortality among Black women.
A comparative study between FAPI and 18F-FDG PET/CT shows that FAPI PET/CT is more accurate in staging newly diagnosed breast cancer patients, with 19.8% being restaged due to its high sensitivity. This could lead to optimized management plans and improved patient outcomes.
A study led by researchers from the University of Arizona Cancer Center identified a biological mechanism that could lead to more effective treatments for breast cancer that has metastasized to the brain. By targeting the autophagy pathway, the researchers were able to disrupt breast cancer cells' ability to form brain metastases.
A recent study from the Women's Health Initiative found that both obesity and metabolic syndrome increase breast cancer risk, but in distinct ways for different subtypes. The research highlights the importance of controlling waist circumference and metabolic conditions to reduce breast cancer risk.
A study has shown that a potassium ion channel located in mitochondria rewires metabolism in breast cancer cells, promoting tumor growth. The channel, BKCa, is linked to the Warburg effect, a metabolic hallmark of cancer, by causing increased lactate secretion and hydrogen peroxide levels.
Researchers discovered that a mutation in the TREX1 gene causes catastrophic DNA damage, leading to premature aging and organ damage. The study found that targeting TREX1 could have broad implications for treating many human diseases linked to aging.
A study published in Radiology found that AI significantly improved breast cancer detection and reduced false-positive findings. The AI system detected more cancers while lowering the rate of unnecessary recalls, reducing radiologist workload by 33.4%.
Researchers found that tumor-associated macrophages respond to physical properties of fibrosis by synthesizing injury-associated collagens, resulting in metabolic changes that suppress CTL function. This provides an alternative explanation for why anti-tumor immunity is impaired in fibrotic solid tumors.
A study published in Frontiers in Oncology reveals breast cancer incidence has surged in oil-rich Gulf countries, with unique clinical and pathological features. The disease is attributed to a combination of menstrual cycle, hereditary factors, weaning children earlier than expected, hormonal treatment, obesity, and use of contraceptives.
Research links early menopause to higher risks of breast and ovarian cancer in women. Second-degree relatives also show increased risks for colon, prostate, and testicular cancers.
A quality improvement analysis found that many US residents live within 30 miles of a clinical trial site, highlighting disparities in access. The study highlights concerns about equity and fairness in healthcare resource distribution, particularly for marginalized communities.
A new study by Indiana University researchers found that Black patients with breast cancer who receive docetaxel instead of paclitaxel have significantly lower rates of taxane-induced peripheral neuropathy (TIPN). This toxicity can lead to debilitating numbness, tingling, and pain in the hands and feet, impacting chemotherapy doses.
A new study by ECOG-ACRIN Cancer Research Group aimed to address disparities in breast cancer care for Black patients. The trial found that tailoring research to the needs of underserved groups is effective, with docetaxel showing lower rates of peripheral neuropathy and dose reductions compared to paclitaxel.
A study found that nearly 20% of breast cancer survivors experience excess weight gain of more than 10% over six years. Factors associated with this weight gain include lower body weight, younger age, hormone-positive breast cancer, and certain genetic mutations.
Researchers at Dana-Farber Cancer Institute have reported encouraging results from three separate studies on treatments for central nervous system lymphoma, breast cancer, and glioblastoma. CAR T-cell therapy showed a 94% overall response rate in patients with CNS lymphoma, while an antibody-drug conjugate plus checkpoint inhibitor imp...
A Stanford Medicine study found that inherited gene sequences predict breast cancer type and mortality. The research challenges the dogma of random mutations, instead highlighting the role of germline genome factors in tumor development.
A team of researchers from Xi'an Jiaotong-Liverpool University has engineered a short sequence of artificial DNA to target the mutant protein p53-R175H, linked to lung, colorectal, and breast cancers. The new molecule, dp53m, inhibits cancer cell growth and increases sensitivity to chemotherapy agent cisplatin.
Researchers from Mass General Cancer Center are set to present key findings on palliative care delivery via telehealth versus in-person for patients with advanced lung cancer. The presentations also cover advances in colorectal and breast cancer treatments, as well as results from a phase 1b/2 study on a novel BRAF inhibitor.
Researchers discovered a previously unknown biological process through which breast tumor cells develop resistance to standard treatment. The study found that targeting the degradation of both HER2 and EGFR receptors can overcome drug resistance in HER2-positive breast cancer models.
Sharon Giordano and Richard Gorlick will be honored with Special Awards at the 2024 American Society of Clinical Oncology Annual Meeting for their dedication to improving cancer treatment and patient outcomes. Their research has made significant contributions to the field of oncology, with a focus on breast cancer and pediatric oncology.
The COVID-19 pandemic led to a decline in breast cancer screenings, particularly among older and racial minority women. A study analyzing real-world electronic health records found that follow-up screening rates decreased significantly during the pandemic, resulting in missed opportunities for early detection and treatment.
A recent study by Dr. Zhaohua Jiang successfully demonstrated VLNT's effectiveness in reconnecting the lymphatic system and improving patient outcomes. The procedure involves transplanting healthy lymph nodes into the affected area, promoting regeneration and reconnection of lymphatic vessels.
Researchers explore nanoparticle-based therapies to specifically target lymphatic metastasis in breast cancer, providing a promising solution for patient treatment. Nanoparticles deliver drugs directly to tumors, targeting cancer cells to destroy them or slow their growth, while also enhancing the immune response.
A study analyzing data from the National Cancer Database found that patients receiving care at minority-serving hospitals were 17% less likely to receive definitive treatment for breast cancer and up to 31% less likely for prostate, lung, and colon cancers. Improving treatment rates could lead to additional patient outcomes.
Researchers at Baylor College of Medicine identified PKMYT1, a protein kinase associated with resistance to endocrine therapy and CDK4/6 inhibitors in ER+ breast cancers. The study found that combining a PKMYT1 inhibitor with chemotherapy drug gemcitabine selectively reduced the viability of resistant cancer cells.
A recent study published by Dana-Farber Cancer Institute found that nearly 200 young women who tried to conceive after breast cancer treatment were able to become pregnant and have a live birth. Egg/embryo freezing before treatment was associated with a higher live birth rate, while older participants had lower rates.
SWOG Cancer Research Network will share results of their work in 30 presentations at the 2024 American Society of Clinical Oncology Annual Meeting, May 31 – June 4 in Chicago. The research focuses on improving cancer treatments and reducing devastating side effects.
Fred Hutch researchers present progress in treating metastatic cancer with novel therapies, including a Phase II study testing TNF-a inhibitors for castration-resistant prostate cancer. The center also explores improving hospice access and using machine learning with CAR T-cell therapy to enhance patient outcomes.
A small study at the University of Rochester Medical Center found that women with stage 4 breast cancer who followed a whole-foods plant-based diet experienced significant weight loss, improved cholesterol levels, and reduced fatigue. The diet also showed promise in reducing inflammation and changes in blood levels of amino acids.
Researchers found low rates of metastasis and lymph node involvement in post-menopausal patients with early-stage ER+ breast cancer. This suggests that clinical guidelines for de-escalating surgery may be safely extended to younger patients.
A study of nearly 5,000 mammograms found that AI algorithms produced false positive results more frequently in Black and older patients, while Asian patients and younger patients were less likely to be flagged as suspicious. Healthcare institutions should consider the patient population they serve before purchasing an AI algorithm.
The study evaluated a breast cancer pre-screening solution using a smartphone-based thermal imaging sensor and AI, achieving high sensitivity and specificity. The tool helped detect breast cancers earlier, particularly in settings where mammography is not available or accessible.
Researchers have developed a targeted therapy for triple negative breast cancer by linking an antibody to a cell-killing drug. This approach may reduce side effects and improve patient outcomes for women diagnosed with this aggressive form of the disease.
A novel therapy has been developed to reprogram macrophage immune cells, shifting their balance toward antitumor activity. The treatment, JHU083, blocks the use of glutamine in tumors, reducing growth and triggering cell death. It also boosts immune-activating macrophages, recruiting tumor-killing T-cells and natural killer cells.
Researchers found that endothelial cells in breast cancer tumors are two times more likely to interact with medicine-carrying nanoparticles than healthy endothelial cells. This discovery could lead to more efficient and targeted delivery of cancer nanomedicines.
A Phase III randomized, placebo-controlled trial found that donepezil did not improve memory or other cognitive functions in breast cancer survivors. Despite this, researchers emphasize the need for further trials with different approaches to address cancer-related cognitive impairment.
A study published in JAMA Surgery found that bariatric surgery significantly reduces the risk of breast cancer in women with obesity, particularly those with high blood insulin levels. The results show a 32% lower risk overall and a 52% lower risk for women with high insulin levels at the start of the study.
Researchers used D-FFOCT and deep learning to create an intraoperative diagnostic workflow for breast cancer patients. The approach achieved high accuracy and speed, reducing processing time by a factor of 10 compared to conventional histology.
Researchers found elevated expression of RPGRIP1L in invasive breast cancer specimens, correlating with shorter survival times and unfavorable clinicopathological features. The study identified 50 genes and 15 proteins related to RPGRIP1L expression, including those involved in immune response and metabolism.
Higher childhood body size may reduce breast cancer risk by forming less dense breast tissue, which is a known risk factor for the disease. The study found that over 50% of the protective effect is explained by changes in dense breast tissue.
New cancer projections highlight progress in reducing incidence rates for common cancers like lung, colorectal, and prostate, but also warn of rising rates for less common types such as liver, kidney, melanoma, and non-Hodgkin lymphoma.
A study published in Nature Genetics has identified genetic variants associated with an increased risk of breast cancer in women of African ancestry. The research found that nearly 8% of women carry all six risk variants, making them 4.2 times more likely to be diagnosed with triple-negative breast cancer.
A plant virus treatment, composed of cowpea mosaic virus nanoparticles, has shown remarkable success in improving survival rates and suppressing the growth of metastatic tumors across various cancer models. The treatment was effective even after surgical removal of tumors, indicating its potential to prevent metastasis.
A recent analysis of WHI findings indicates that MetS and obesity each have different associations with breast cancer subtypes and mortality risk. Women with higher MetS scores are at a higher risk of poor-prognosis, estrogen receptor-positive, progesterone receptor-negative breast cancers.
A UK Biobank study suggests that adults living with obesity who were underweight or average weight in childhood may be at increased risk of all-cause mortality. The study found that adult men and women who reported being thinner as children had higher mortality risks, with a 63% and 60% increase respectively.
A UCLA-led study reveals that chemotherapy for early-stage breast cancer in women over 65 can lead to a significant decline in physical function. The study found that 30% of older women who received chemotherapy experienced a substantial decline, with climbing stairs and walking being the most affected activities.
A cross-sectional study found racial and ethnic disparities in breast cancer treatment declination and overall survival. The study suggests that patient education on treatment benefits and improved communication between patients and clinicians can help reduce disparities and improve patient outcomes.
Researchers have developed a new imaging technique that rapidly and accurately identifies cancerous tissues in breast samples. The method uses machine learning algorithms trained on hyperspectral dark-field microscopy data to pinpoint regions of invasive ductal carcinoma and invasive mucinous carcinoma.
Researchers discovered that aggressive cancer cells pull more strongly on the extracellular matrix than on themselves, while noninvasive cells pull more strongly on themselves. The study found that the interplay between these contractility modes determines a cell's potential for escape and tumor aggressiveness.
A late University of Virginia School of Medicine scientist's research on the SAS1B protein could lead to new cancer treatments for multiple cancers. The discovery has the potential to selectively target cancer cells while sparing healthy tissue.
Researchers at Sylvester Comprehensive Cancer Center have developed a nanoparticle that can penetrate the blood-brain barrier, potentially targeting both primary breast cancer tumors and brain metastases in one treatment. The method shows early promise in preclinical models, where it shrinks breast and brain tumors.
Text messaging and bulk ordering can significantly increase mammogram completion rates for breast cancer screening outreach. The study found that these interventions are effective in improving adherence to recommended screening guidelines.
Researchers found that UTIs can provoke structural changes in breast tissue in mice, which are reversible once the infections are resolved. The study suggests a possible link between UTIs and abnormal breast cell growth, highlighting the importance of considering everyday occurrences on women's well-being.
Menopausal hormone therapy is appropriate to treat vasomotor symptoms in early menopause without contraindications. WHI evidence does not support routine supplementation with calcium plus vitamin D or a low-fat diet for preventing fractures and breast/colorectal cancer, respectively.
A new set of clinical practice standards and recommendations offers tailored and effective care for individuals with advanced and metastatic cancer. The initiative, backed by MASCC and ASCO, provides a critical resource to healthcare stakeholders.
A new study found that GPT-4 and Google Gemini performed poorly in breast imaging classification, with a high percentage of discordant assignments that could impact patient management. The researchers emphasize the need for regulation of these large language models in high-level medical scenarios.
The USPSTF updates its breast cancer screening recommendation to biennial mammography for women ages 40-74. However, the balance of benefits and harms is unclear for women over 75 or those with dense breasts. Breast cancer is a common cause of death among US women.
The US Preventive Services Task Force recommends biennial breast cancer screenings starting at age 40 for all women, aiming to enhance early detection and tackle disparities. However, challenges remain in ensuring equitable access to screening technologies and addressing gaps in evidence regarding AI-powered image interpretation.
A new study on aspirin's role in breast cancer treatment highlights critical issues related to health equity and aging, with implications for future disease intervention trials. The study found that aspirin did not decrease the risk of cancer recurrence or improve survival among breast cancer survivors.
Breast cancer study reveals seven pivotal genes are upregulated in tumor tissues, indicating critical role in disease progression and poorer patient prognosis. In vitro validation supports overexpression of these genes in breast cancer, emphasizing their importance as potential therapeutic targets.