Articles tagged with Breast Cancer
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Residing in persistently impoverished neighborhoods is associated with poor breast cancer outcomes, including increased mortality. The study found that women from low-income areas had poorer tumor characteristics compared to those from higher-income areas.
Researchers have developed a nanodrug that targets miR-10b, a small noncoding RNA implicated in cancer cell invasion and proliferation. The study shows that inhibiting miR-10b reduces the stemness of breast cancer cells, supporting dedifferentiation as a potential therapeutic mechanism.
Researchers at Cold Spring Harbor Laboratory have discovered a strategy to kill breast cancer cells and shrink tumors by depriving them of two vital nutrients: glutamine and its backup supply, alpha-ketoglutarate. This approach was successful in lab experiments and effective in treating tumors in mice.
Researchers have found that natural killer cells instinctively recognize and attack the XPO1 protein, which drives cancer growth. By targeting this protein, scientists may be able to activate more killer cells to destroy cancer cells. The study suggests that this approach could lead to personalized cancer treatment with less side effects.
Researchers have discovered that sodium chloride can increase the efficiency of antitumoral T cells, leading to improved metabolic fitness and enhanced tumor killing capabilities. This finding has significant implications for adoptive T-cell therapy in cancer treatment.
Women with regular annual mammograms had higher overall survival and lower late-stage cancer rates than those screened less frequently. The study's findings contradict current guidelines, suggesting a significant benefit to annual screening for women over 40.
Researchers found that CHEK2 variants do not increase colorectal cancer risk compared to controls. Three low-risk missense variants were identified as potential drivers of breast cancer risk variability.
A new study reveals that cellular protein Gα13 acts as a tumour suppressor in oestrogen receptor-positive (ER+) breast cancer, potentially slowing or stopping cancer cell growth. Lower levels of Gα13 are associated with poorer patient survival outcomes.
Researchers have discovered that dialyl-sulfide and trans-chalcone can prevent breast cancer by targeting SULT1E1 and HIF1a-MMPs. These compounds neutralize oxidative stress and induce the expression of SULT1E1, leading to decreased HIF1a and MMP production.
Obesity-related cancer rates in China have risen sharply among young people, with an alarming 3.6% annual increase between 2007 and 2021. The trend is particularly pronounced among those aged 25-29, highlighting the urgent need for better public health policies to address China's growing overweight and obesity rates.
A new study by UCLA investigators found that Manuka honey contains compounds that can help reduce tumor growth in preclinical models. The research suggests that Manuka honey could potentially be developed into a natural supplement or standalone treatment for ER-positive breast cancer, which accounts for most breast cancer cases.
Researchers developed a nanobody that targets V-ATPase c subunit and inhibits tumor cell invasion and metastasis. The nanobody was tested on 4T1-12B mouse breast cancer cells implanted in mice, where it showed effectiveness in preventing lung metastasis.
Recent advances highlight PIK3CA mutation significance in determining targeted therapy efficacy, particularly in advanced breast cancer. Molecular signatures and genetic profiles drive personalized treatment strategies, with emerging therapies offering new hope for patients.
A Rice University-led team is developing an affordable system to improve tumor removal accuracy for breast and head and neck cancer. The AccessPath system enables rapid, automatic tumor margin classification, revolutionizing real-time surgical guidance.
A clinical trial in Denmark found that offering women further screening opportunities during breast cancer screenings significantly increased their participation and enabled early diagnosis of other cancers. The study used a cluster-randomized crossover design and involved over 27,000 participants.
A new study provides a detailed map of healthy breast cells, shedding light on how breast cancer develops and the genetic ancestry-dependent variability in breast tissue. The research aims to identify new treatment targets and improve understanding of breast cancer development.
A trial at UT Health San Antonio found that Sacituzumab Govitecan was well-tolerated and showed signs of effectiveness for patients with breast cancer who had progressed to brain tumors. The drug has been shown to deliver a topoisomerase inhibitor into tumors, providing promising clinical signals of efficacy.
A 30-year study suggests that radiotherapy can prevent breast cancer recurrence in the same location for up to 10 years after surgery, but survival rates remain similar. The study found fewer deaths from breast cancer among those who received radiotherapy compared to those who did not.
Researchers found that sensory neurons secrete a neuropeptide driving cancer growth and spread through a previously unknown neuro-cancer crosstalk. An FDA-approved drug may prevent metastasis in breast cancer instances. The study suggests targeting this pathway to stop breast cancer progression.
A large Danish study published in Diabetologia found no association between gestational diabetes and an increased risk of breast cancer. The study included over 708,000 women and followed them for a median of 11.9 years to examine the link between the two conditions.
A recent study published in The Journal of Clinical Endocrinology and Metabolism found that women who underwent menopause before age 46 were nearly twice as likely to develop breast cancer as other women of similar ages. Relatives of these women were also more likely to have breast, prostate, or colon cancer.
A new AI protocol called DeepHRD enables accurate, instantaneous detection of cancer genomic biomarkers directly from tumor biopsy slides. This breakthrough technology saves weeks and thousands of dollars from clinical oncology treatment workflows, providing access and equity in cancer care for resource-constrained settings.
A new study uses artificial intelligence to predict which breast cancer patients are most at risk for developing chronic pain, with anxiety and depression being leading factors. The AI model was built with detailed data on over 1,000 breast cancer patients and correctly predicted chronic pain more than 80% of the time.
Researchers found that abnormal results from routine blood tests were linked to a higher risk of being diagnosed with cancer within a year. The study estimated that taking these results into account could lead to an extra six people with undiagnosed cancer being urgently referred for treatment.
A new study finds that combining an inhibitor of a metabolic pathway with chemotherapy could improve treatment outcomes in triple negative breast cancer brain metastases. Inhibiting fatty acid synthase, an enzyme critical for cancer cell survival, shows promise in improving chemotherapy efficacy.
Women with bilateral mastectomy have a greatly diminished risk of contralateral breast cancer, yet experience similar mortality rates as patients treated with lumpectomy or unilateral mastectomy. The study highlights the importance of considering long-term risks and benefits in breast cancer treatment decisions.
A randomized controlled trial found that structured exercise programs significantly improved the quality of life and reduced fatigue in women with metastatic breast cancer. The program, which included twice-weekly training sessions, also showed improvements in pain, shortness of breath, and social participation.
Researchers discovered that sodium channels allow cancer cells to grow and spread by increasing energy production and producing lactic acid, which breaks down the extracellular matrix. Blocking these channels may be an effective way to slow cancer growth and prevent metastasis in breast cancer patients.
A new AI model can identify certain stages of ductal carcinoma in situ (DCIS), a type of pre-invasive breast cancer, that are likely to progress to invasive cancer. The model uses imaging and machine learning to analyze tissue samples and determine the stage of DCIS based on cell arrangement and organization.
Researchers analyzed collision-type mixed ductal-lobular breast cancers and found that IDC and ILC regions had distinct gene expression profiles. The study reveals tremendous variation within this already highly variable disease, highlighting the need for personalized treatments.
The study reveals that non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, play a crucial role in regulating the Notch signaling pathway in breast cancer. These molecules can modulate gene expression and affect cancer cell proliferation, invasion, and metastasis.
A new compound developed by researchers at MUSC Hollings Cancer Center has shown promise in improving response to chemotherapy in preclinical models. The compound inhibits the protein lysyl oxidase, preventing it from producing a stiff environment around tumors and allowing drugs to penetrate better.
The UVA School of Engineering and Applied Science has been awarded a collective $10 million in research grants by Susan G. Komen, including a $100,000 grant for doctoral student Catalina Alvarez Yela's work on triple negative breast cancer.
Researchers from Drexel University have identified two compounds, AD-5584 and AD-8007, that selectively kill cancer cells and block tumor growth by targeting a key metabolic enzyme in cancer cells. These findings show early success in shrinking breast cancer tumors in brain metastases and offer hope for more effective therapies.
A new study found that an electronic health record (EHR)-based nudge intervention significantly decreased low-value axillary surgery in older women with clinically node-negative, HR+/HER2− breast cancer. The user-friendly intervention could be beneficial for other practice settings or patient populations.
Researchers developed an electronic health record nudge to remind surgeons about the risks of lymphedema and potential overtreatment. The intervention led to a 49.3% reduction in sentinel lymph node biopsy procedures among eligible patients.
A Mayo Clinic study reveals that current genetic screening protocols fail to detect notable numbers of people carrying hereditary breast and ovarian cancer syndrome and Lynch syndrome mutations. The study identified 550 carriers of these mutations, with half being previously unaware of their risk.
A retrospective cohort study found hormone-modulating therapy protected against Alzheimer's disease and related dementias in postmenopausal women with breast cancer. The protective effect varied by age and race, with greater benefit for Black women under 75.
A new study from the University of Michigan Health Rogel Cancer Center found that nearly three-quarters of patients who were eligible for genetic testing at diagnosis received it over the study period. Those who got testing and found they had a genetic variant were most likely to talk with their family about the results.
A new study published in JAMA Network Open found that hormone modulating therapy (HMT) used to treat breast cancer was associated with a 7% lower risk of developing Alzheimer's disease and related dementias. The protective effect of HMT decreased with age, particularly for women over 80.
Researchers discuss HER2 in breast cancer, highlighting the prognostic and predictive factors. They found an independent positive prognostic effect of HER2-low compared to HER2-zero in early breast cancer, challenging the long-held view that HER2-negative tumors do not benefit from trastuzumab-based therapy.
A nationally representative US survey found that women aged 39-49 who received a decision aid describing the benefits and harms of breast cancer screening were more likely to delay or forego screening. The study suggests that providing accurate information may change intention to screen for some women, particularly those with higher br...
Researchers at Linköping University created a tool to predict risk of persistent side effects in breast cancer patients treated with taxane drugs. The model uses genetic characteristics to forecast the risk of nerve damage, which can be used to adapt treatment and improve patient outcomes.
Researchers have identified a shared molecular mechanism between pregnancy and cancer that suppresses the immune system. Progesterone was found to play a key role in this process, with blocking its signaling slowing down cancer growth in mice and activating the immune response.
A new Finnish study from University of Turku shows that already a 30-minute exercise can increase the proportion of tumor-killing white blood cells in the bloodstream of breast cancer patients. The amount of several different white blood cell types increased during exercise, with cytotoxic T cells and natural killer cells rising the most.
A recent study published in Plastic and Reconstructive Surgery found that American Indian/Alaska Native women have consistently lower rates of breast reconstruction after mastectomy compared to non-Hispanic White women. The disparity persists despite an upward trend in reconstruction rates, with AI/AN women being nearly half less likel...
A new study has identified potential cancer drivers hidden in so-called 'junk' regions of DNA, which could lead to early diagnosis and new treatments. The discovery reveals mutations in previously overlooked regions of the genome that may contribute to the formation and progression of at least 12 different cancers.
Researchers at Osaka University have developed molecules that can correct improper splicing of a vital tumor suppressor gene in neuroendocrine cancers. The study demonstrates that these splice-switching oligonucleotides can significantly reduce viable cancer cells and tumor size in mice, suggesting a novel therapeutic approach for intr...
Researchers at Karolinska Institutet developed nanorobots that target and kill cancer cells using a 'kill switch' activated in low pH environments. The study achieved a 70% reduction in tumour growth in mice, paving the way for further investigation into its potential as a cancer treatment.
Researchers have discovered compounds that convert the Bcl-2 protein, which protects cancer cells, into a tumor killer. The findings open the door to promising therapies for breast cancer and other malignancies that rely on Bcl-2 to evade treatment and develop drug resistance.
A clinical trial found that trastuzumab emtansine (T-DM1) is highly effective in preventing stage 1 HER2-positive breast cancer from recurring in patients. The treatment significantly reduced the risk of recurrence and improved patient-reported outcomes compared to chemotherapy and trastuzumab.
A new study from the University of Copenhagen reveals that AI has helped detect significantly more cases of breast cancer and reduce radiologist workloads. The AI system has been used to analyze tens of thousands of X-rays every year, resulting in a 12% increase in detected cases, including more small tumours of one centimetre or less.
Research by UCLA Health confirms that Tai Chi reduces inflammation and improves anti-viral defenses in breast cancer survivors, while cognitive behavioral therapy shows greater increases in anti-viral gene transcripts. The study found significant reductions in inflammatory biomarkers among Tai Chi participants.
A study by Ohio State University researchers found that chemotherapy disrupts the gut microbiome in breast cancer patients, leading to cognitive decline and increased inflammation. The research suggests that targeting the gut microbiome may improve behavioral side effects of chemotherapy.
A novel inhibitor HVH-2930 targeting heat shock protein 90 (HSP90) demonstrates efficacy against drug-resistant breast cancer cells. It selectively downregulates HER2 signaling, crucial for breast cancer progression, without triggering the heat shock response.
A pooled analysis of three randomized trials found that acupuncture significantly reduced hot flashes and hormonal side effects in women with stage 0-III breast cancer. The study showed that 64% of participants experienced improvements in hot flashes, and acupuncture also improved quality of life.
A study published in Journal of Clinical Oncology found that socioeconomic status significantly impacts the quality of life of women diagnosed with breast cancer. Women from lower socioeconomic backgrounds experience more pronounced physical and psychological side effects, despite similar medical treatment.
Finnish researchers found that blocking the DUSP6 protein can significantly improve treatment outcomes in experimental models by preventing dormant breast cancer cells from waking up. This discovery provides new insights into breast cancer recurrence and offers a potential basis for effective combination therapy.
Families with germline CDH1 P/LP variants show a cumulative risk of gastric cancer between 7-10% and breast cancer in female carriers at 37%
Researchers at Weill Cornell Medicine developed an artificial intelligence-powered method for detecting tumor DNA in blood, showing high sensitivity and accuracy in predicting cancer recurrence. The technology, called MRD-EDGE, can detect subtle patterns in sequencing data to distinguish between cancer and non-cancerous signals.