Articles tagged with Breast Cancer
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The COMET trial found that active monitoring is a viable option for some patients with low-risk ductal carcinoma in situ (DCIS), with similar two-year invasive ipsilateral breast cancer recurrence rates compared to usual care. Active monitoring involves close patient monitoring with surgery reserved for those who develop cancer.
Patients with low-risk ductal carcinoma in situ (DCIS) who underwent active monitoring reported comparable physical, emotional, and psychological outcomes to those who received upfront treatment. The study found no significant differences in health-related quality of life between the two groups over time.
For patients with 'good-risk' ductal carcinoma in situ (DCIS) who underwent breast-conserving surgery and did not receive radiotherapy, tamoxifen significantly decreased the risk of recurrence in the same breast. The estimated 15-year risk of ipsilateral recurrence was 11.4% for patients treated with tamoxifen.
The BIG 2-04 MRC SUPREMO clinical trial found no significant difference in overall survival between patients who received chest wall irradiation (CWI) and those who did not. CWI's impact was also shown to be clinically insignificant in reducing chest wall recurrence.
A randomized study found that active monitoring for low-risk ductal carcinoma in situ did not increase invasive cancer risk compared to guideline-concordant care. Women on active monitoring had comparable rates of disease recurrence and survival.
Artificial intelligence is enhancing breast cancer risk prediction through mammographic analysis, uncovering key features that predict breast cancer risk. These AI-generated features may inform personalized screening strategies, such as more frequent or less frequent screenings for women at high or low risk of breast cancer.
The PATINA study demonstrates that palbociclib improves progression-free survival (PFS) in patients with HR+, HER2+ metastatic breast cancer, with a median PFS of 44.3 months. This represents an extension in median PFS of over 15 months compared to anti-HER2 therapy and endocrine therapy alone.
Patients with germline BRCA mutations who underwent bilateral risk-reducing mastectomy and/or salpingo-oophorectomy had lower rates of recurrence, secondary malignancies, and death. Risk-reducing surgeries improved survival outcomes among young BRCA-mutation carriers with a prior history of early-onset breast cancer.
The OlympiA trial found that olaparib significantly improves survival outcomes in patients with high-risk, BRCA-positive breast cancer. After a median follow-up of 6.1 years, patients treated with olaparib showed better rates of invasive and distant disease-free survival compared to those who received placebo.
The EMBER-3 clinical trial showed that imlunestrant improved progression-free survival in patients with ER-positive, HER2-negative advanced breast cancer, particularly those with ESR1 mutations. The combination of imlunestrant and abemaciclib also demonstrated a significant reduction in risk of progression or death.
A study by Tulane University researchers found that tumors in female fruit flies grew 2.5 times larger than those in male fruit flies due to sex-based differences in immune response. The stronger innate immune response in females accelerated tumor growth.
The study found a significant increase in late-stage breast cancer diagnoses among U.S. women, with annual percentage increases of up to 2.9% between 2004 and 2021. The researchers attribute the trend to factors such as lack of national screening programs, inconsistent guidelines, and increasing obesity rates.
Researchers at UCLA Health presented several breakthroughs at the San Antonio Breast Cancer Symposium, including improved survival rates for advanced breast cancer patients who receive trastuzumab deruxtecan (T-DXd), a novel ADC. Additionally, new genomic testing and circulating tumor DNA analysis may help identify high-risk patients a...
The 47th San Antonio Breast Cancer Symposium is the world's largest breast cancer research conference, attracting over 11,000 attendees from 102 countries. The event showcases groundbreaking discoveries in drug development and advances care for underserved populations.
A study published in Cell found a common variant of the PCSK9 gene increases the risk of breast cancer metastasis by 22% compared to those without it. Researchers propose using an antibody targeting PCSK9 to suppress this variant and reduce metastatic disease.
Dr. Aditya Bardia's appointment as Editor-in-Chief of Breast Cancer Research and Treatment reflects his expertise in targeted therapies and innovative research. He aims to foster innovation and disseminate knowledge benefiting patients and the scientific community through this journal.
A study suggests that low doses of the commonly prescribed hair loss treatment minoxidil are safe and effective for regrowing hair in most breast cancer patients. The researchers found that all participants who took a low dose of oral minoxidil saw improvements in hair growth or stabilization within three to six months.
A University of Liverpool study uncovers a key mechanism driving breast cancer invasion and drug resistance, revealing a critical 'crosstalk' between HER2 and αVβ6 integrin molecules. The research highlights the importance of targeting the RAB5/RAB7A/GDI2 module to prevent or delay treatment resistance.
Scientists have created a living cell therapy that can navigate to specific organs using a
A new study improves breast cancer risk prediction by analyzing up to three years of previous mammograms, identifying individuals at high risk 2.3 times more accurately than the standard method. The AI method considers subtle changes in mammogram images and holds up well across diverse settings.
A self-pay, AI-enhanced breast cancer screening program was offered to patients across 10 clinical practices, resulting in a 43% higher cancer detection rate among enrolled women. The AI-powered program attributed 21% of the increase in cancer detection, with higher-risk patients choosing to enroll more frequently.
The study estimated that prevention, screening, and treatment efforts in the US led to an average of 8 out of 10 cancer deaths being avoided for breast, cervical, colorectal, lung, and prostate cancers combined. The total number of averted cancer deaths was approximately 5.94 million between 1975 and 2020.
A groundbreaking phase one clinical trial explores a novel cell-based immunotherapy for breast cancer, demonstrating significant shrinkage of tumors and minimal side effects. The treatment leverages dendritic cells to trigger an organized immune system attack on cancer, offering hope for replacing or reducing the need for chemotherapy.
A study published in Nature reveals that dietary fructose promotes tumor growth in animal models of melanoma, breast cancer, and cervical cancer. The liver converts fructose into usable nutrients for cancer cells, a finding that could lead to new treatment avenues.
A new study has solved a years-old mystery about which patients with aggressive breast cancer are helped by a targeted cancer treatment. The researchers found that low levels of the protein IGFBP7 can predict which patients will benefit from the treatment, providing hope for its continued development.
Breast cancer cells can live for years in bone marrow after remission, leading to disease recurrence in approximately 40% of patients. A study found that mesenchymal stem cells support the cancer cells by donating essential proteins, making them more aggressive and drug-resistant.
A study found that postmenopausal women with low-risk tumors experience a long-term benefit from anti-hormonal treatment of at least 20 years, while younger women do not. The researchers highlight the need for new markers to predict long-term risk and benefit in younger patients.
The American College of Surgeons' annual cancer report reveals that breast, bladder, and pancreatic cancers are increasingly treated with personalized therapies before surgery. Cancer stage at diagnosis remains a significant factor in determining patient survival rates.
A recent study develops a physicochemical approach to optical biosensing using 1DZnO nanostructures, enabling rapid CYFRA 21-1 testing within a 5-minute detection window. The developed biosensors have the potential to provide accurate and reliable results in complex matrices like saliva.
A series of five papers highlights critical public health challenges related to cancer control in eight SAARC countries and the Rohingya refugee population in Bangladesh. The studies identify barriers contributing to significant disparities in cancer outcomes and actionable solutions to address these challenges.
A new study suggests that addressing plastic pollution could play a critical role in lowering breast cancer rates. Researchers identified nearly half of the chemicals linked to breast cancer risk as being used in plastics, including 175 potential carcinogens that should be prioritized for regulatory action.
The SONIA trial found that delaying and shortening CDK4/6 inhibitor treatment in patients with hormone receptor-positive advanced breast cancer leads to similar survival outcomes while reducing toxicity and cost by €45 million per year. This innovative approach could reduce the burden on healthcare systems worldwide.
A new study has found that tamoxifen works better for some people due to their unique gut microbiota. Researchers discovered a specific enzyme, beta-glucuronidase, in certain bacteria that helps recycle the drug into its effective form. This finding may lead to tailored treatment interventions for breast cancer patients.
A new study suggests that a cancer peer support program called Stronger Together improved psychological outcomes, as well as overall quality of life, among patients with breast and gynecological cancers in Vietnam. The program showed promise for providing critical social support in low-resource settings.
A new study from the University of Texas M. D. Anderson Cancer Center found that at least 3% of normal breast tissue cells in healthy women contain chromosome abnormalities associated with invasive breast cancer, which may guide future approaches to early detection.
Researchers found nearly all women with breast cancer-like mutations carried the anomalies in luminal cells, which line the lobules and ducts. The study suggests that these rare genetic alterations could prime or predispose these cells to cancer development.
Sylvester researchers will present over 130 studies at ASH 2024, addressing disparities in gastric cancer. Frank J. Penedo's research highlights worse outcomes for patients with unmet supportive needs, while Shria Kumar's work seeks answers for disparities in gastric cancer among specific minorities.
A novel CAR T-cell therapy targeting p95HER2-expressing cells demonstrates complete and durable antitumor responses in a subset of HER2+ tumors, raising hopes for improved cancer treatment. The therapy also activates immune cells within the tumor microenvironment, showing promising results.
A new study by Silent Spring Institute has identified multiple chemical exposures in firefighters that increase their risk of developing breast cancer. The research found 12 hazardous substances, including benzene and flame retardants, that put female firefighters at increased risk for the disease.
Researchers developed a new photoacoustic imaging technique that addresses skin tone bias in breast cancer detection. The technique, combined with specific wavelengths and beamforming methods, enhances target visibility across all skin tones, providing clearer images with improved signal-to-noise ratios.
A small clinical trial found a vaccine designed to prevent recurrence of tumors in patients with triple-negative breast cancer to be well-tolerated and stimulate the immune system. After three years, 16 out of 18 patients remained cancer-free.
Researchers developed a new AI-powered diagnostic system, FastGlioma, which reveals invisible cancerous tissue in brain tumor surgery. The technique may delay or prevent recurrence of high-grade tumors and improve patient survival.
Researchers have discovered that metabolic enzymes play a crucial role in maintaining the integrity of the human genome by orchestrating critical functions like cell division and DNA repair. This discovery could lead to new cancer therapies, particularly for triple-negative breast cancer, by exploiting its metabolic vulnerabilities.
Researchers found that a single defective copy of the BRCA1 gene can accelerate tumor growth in breast cells, contradicting the traditional two-hit model. The study suggests new possibilities for cancer prevention and therapy targeting the reprogramming effect inside cells.
A new genetic breast cancer model developed by MSU researcher could help scientists better understand why and where cancer metastasizes. The model uses a genetically engineered mouse to study the E2F5 gene's role in breast cancer development, revealing altered regulation of Cyclin D1 and tumor formation.
Researchers at Cleveland Clinic have made significant progress in their novel vaccine aimed at preventing triple-negative breast cancer. The study found that the investigational vaccine was generally well-tolerated and produced an immune response in most patients, with the highest tolerated dose to date identified.
Researchers developed a 36-gene predictive score that surpasses conventional methods in predicting tamoxifen treatment resistance. The polygenic score UAB36 has potential as a tool for personalized medicine, helping identify patients at higher risk of poor survival and suggesting alternative treatment strategies.
A new study published in The British Journal of Cancer found that whole genome sequencing can help identify treatment recommendations for cancer patients. The study evaluated the regional implementation of the 100,000 Genomes Project and found that different types of cancer were associated with varying rates of recommended actions.
A collaborative study led by Dr. Julie St-Pierre at the University of Ottawa found that promoting mitochondrial elongation in cancer cells hobbles their ability to metastasize. The research team identified a common signature that could help determine which pathways lead to decreased metastasis.
Scientists at Johns Hopkins Medicine identified 16 genes that breast cancer cells use to survive in the bloodstream, including MUC1, which is already in clinical trials. The research showed that hypoxic cells are able to migrate to higher oxygen levels and form metastasis in the body, leading to a worse prognosis.
Recent studies by MSK researchers show that the innate immune system helps maintain genome stability during DNA replication, and chronic activation can contribute to tumor development. The findings also suggest that problems with a protein complex called Mre11 can create an environment where cancer is more likely to occur.
A new study has found that Canadian women who did not identify as White have an earlier peak age of breast cancer diagnosis and higher proportions of cases diagnosed under age 50. They also experience an earlier peak age of death, with a 7-year gap in mortality rates compared to their White counterparts.
A comprehensive study analyzed diverse methods to investigate breast cancer metastases, providing new insights into their biology. The researchers found connections between clinical characteristics and malignant expression phenotypes, as well as clues about immune escape processes.
Researchers at The Jackson Laboratory have developed a new combination of imaging and computational methods to study immune cell interactions. The approach reveals that interactions between immune cells in the vicinity of breast cancer or melanoma can predict immune responses and patient outcomes.
Researchers discovered that tumor dormancy in breast cancer can be triggered by specific signaling changes within small cell clusters, called tumor emboli. Key mechanisms include reduced activity of mTOR and structural shifts in E-cadherin, which are regulated by the PI3K pathway.
Researchers at MIT have designed tiny particles that can be implanted at a tumor site, delivering heat and chemotherapy to treat cancer. The treatment approach has been shown to completely eliminate tumors in most mice and prolong their survival.
Researchers developed a method to assess which patients with metastatic triple-negative breast cancer can benefit from immunotherapy. The tool uses predictive biomarkers and machine learning-based approaches to identify patients who are likely to respond to treatment.
Researchers have identified a new therapeutic strategy to enhance the sensitivity of aggressive breast cancer cells to hormonal therapies. By inhibiting the HDAC6 protein, they were able to boost progesterone receptor levels and potentially reverse resistance to hormonal treatments.
Researchers have uncovered a mechanism by which the BRCA1 gene influences fertility, leading to genetic errors that can cause infertility. This breakthrough discovery enables potential therapeutic avenues for correcting or treating fertility issues in BRCA1 patients.
Researchers are analyzing RNA and DNA amplification in breast cancer cases to identify potential biomarkers. Funding will support the study from September 2024 to March 2025.