Articles tagged with Breast Cancer
A new PET radiotracer effectively visualizes Nectin-4, a biomarker found in triple-negative breast cancer (TNBC), with the potential to improve clinical outcomes. Researchers developed a series of Nectin-4-targeted radiotracers and evaluated their efficacy in detecting TNBC.
A study of nearly 2,500 postmenopausal women found that taking more daily steps and engaging in moderate-to-vigorous physical activity were associated with a significantly reduced risk of death from cardiovascular disease. Even walking fewer than 5,000 steps per day showed a risk reduction.
Breast cancer mortality rates have stopped decreasing in two age groups: women under 40 and those over 74. This shift is attributed to an increase in stage IV breast cancers at diagnosis, leading to poor prognoses.
A new study by Boston University researchers reveals that insulin resistance increases the aggressiveness and brain metastasis of triple-negative breast cancer. The findings highlight the need for personalized treatments and monitoring for patients with obesity-driven diabetes and aggressive breast cancer.
Researchers have discovered a new mechanism of how anticancer drugs attack and destroy BRCA mutant cancer cells, including drug-resistant breast cancer cells. The study found that small DNA nicks can expand into large single-stranded DNA gaps, leading to cell death.
A recent study by Professor Mamas highlights the significant risk of cardiovascular diseases (CVD) in patients with cancer, particularly in aging populations. The review emphasizes the need for early diagnosis and regular monitoring to improve quality of life.
Researchers are conducting a clinical trial to find the optimal combination of pain management tools for patients undergoing mastectomy procedures. The study will enroll approximately 100 patients and examine various combinations of pectoralis nerve blocks, non-opioid analgesics, and administration methods.
Researchers create microfluidic device to sort tumor cells based on adhesive strength, revealing potential method to predict aggressive cancer behavior. The study's findings offer a promising approach for personalizing treatment plans and identifying high-risk patients.
Researchers found that aspirin prevents cancers from spreading by decreasing a clotting factor called thromboxane A2 and releasing T cells from suppression. This discovery could lead to the development of targeted treatments to prevent cancer metastasis, making aspirin potentially less expensive than antibody-based therapies.
Breast and colorectal cancer screening rates have recovered from pandemic-related declines, surpassing pre-pandemic estimates. Cervical cancer screening rates remain below pre-pandemic levels, indicating a persistent trend of declining early-stage diagnoses.
The Damon Runyon Cancer Research Foundation has named 13 new Fellows, awarding them $300,000 each to investigate cancer causes and mechanisms. Five recipients of the Dale F. Frey Award for Breakthrough Scientists will also receive an additional $100,000 investment to catapult their research careers.
Researchers at Sanford Burnham Prebys have discovered a way to target the energy supply chain of cancer cells. By understanding how enzymes like ubiquitous mitochondrial creatine kinase (uMtCK) function, scientists can design new treatments that slow or stop tumor growth.
A new study published in the European Journal of Preventive Cardiology found that a type of diabetes medication called SGLT2 inhibitors can significantly lower the risk of heart failure and hospital visits related to heart failure in cancer patients. The benefits were particularly promising for breast cancer patients receiving anthracy...
A new federal mandate aims to improve patient awareness about breast density, which affects cancer detection and risk. Women with dense breasts may need supplemental screening, such as MRI, to detect breast cancer earlier, but this comes with potential downsides.
Researchers at MD Anderson Cancer Center have identified biomarkers for predicting treatment response in metastatic breast cancer and found a potential target for tumor progression in pancreatic cancer. Additionally, they discovered that abnormal chromosome changes predict survival in patients with secondary acute myeloid leukemia.
A study published in Plastic and Reconstructive Surgery reports that women who undergo breast-conserving therapy (BCT) experience improved sexual well-being compared to those who receive post-mastectomy breast reconstruction (PMBR). Scores on a sexual well-being subscale were consistently higher for BCT patients, with average scores 7....
Insilico Medicine has discovered a potent and selective CDK12/13 dual inhibitor, compound 12b, using AI-powered platforms. The compound shows significant efficacy in breast cancer and AML models without inducing side effects, paving the way for further therapeutic development.
Researchers introduce a dual threshold classifier to interpret circulating tumor DNA levels, enabling earlier detection of disease progression and personalized treatment. The study confirms that ctDNA levels are superior to traditional biomarkers like CA15-3.
Researchers at Tufts University have developed a cancer vaccine that amplifies the visibility of tumor antigens to the immune system, leading to potent responses and lasting immunological memory. The vaccine works against multiple solid tumors in animal models, including melanoma, triple-negative breast cancer, and ovarian cancer.
Researchers have created a new imaging technique that uses the nanostructures found on butterfly wings to analyze cancerous tissues, providing a simpler and more accessible tool for cancer diagnosis. The method has shown comparable results to conventional staining methods and advanced imaging techniques, offering a stain-free alternative.
A new study found that breast cancer incidence in US women under 40 varies significantly across different states and regions, with the Western region experiencing the highest rate of increase from 2001 to 2020.
Cancer cells work together to source nutrients from their environment, a cooperative process that can be targeted for treating cancer. Researchers identified key enzymes and mechanisms behind this cooperation, including the enzyme CNDP2, which can be inhibited by the drug bestatin.
A study found racial and ethnic minorities are less likely to receive standard-of-care diagnostic imaging after abnormal screening mammograms compared to white patients. Minority groups were also less likely to have access to same-day biopsy services, despite similar availability of most diagnostic services.
A new study reveals encouraging results for circulating tumor DNA (ctDNA) testing in advanced breast cancer, detecting genetic mutations and influencing treatment decisions. The non-invasive method offers real-time genetic insights, enabling precision medicine to tailor therapies to individual patients.
Researchers at H. Lee Moffitt Cancer Center & Research Institute have identified a specific immune response that can prevent the spread of breast cancer cells within the body. Activating certain immune cells can stop dormant cancer cells from growing into new tumors, potentially leading to long-term survival.
Researchers found that Black women with triple-negative breast cancer are less likely to receive immunotherapy treatment, even when accounting for socioeconomic factors. The study analyzed data from over 10,000 patients and found a significant disparity in immunotherapy response between racial groups.
The 2024 Chinese Society of Clinical Oncology Breast Cancer (CSCO BC) guidelines offer a comprehensive approach to managing breast cancer, informed by high-quality clinical studies and real-world data from China. The updated guidelines prioritize precision medicine, recommending tailored treatment approaches for various subtypes of bre...
A cross-sectional study found that perceived stress, inadequate social support, racial discrimination, and neighborhood deprivation negatively impacted systemic and tumor immunity in Black women. These findings may inform prevention and public health interventions for cancer health disparities.
Researchers found a biomarker, RNA Polymerase II (RNAPII), associated with tumor aggressiveness and recurrence in meningioma and breast cancers. The study developed a novel profiling technology, Cleavage Under Targeted Accessible Chromatin (CUTAC), to measure gene transcription activity from DNA, which predicted cancer outcomes.
A new review study found significant gaps in existing research on breast cancer within the Black community and barriers preventing eligible but non-participating women from screenings. The study highlights the need for culturally sensitive research to address emotional and psycho-social barriers faced by Black women.
Researchers at The Jackson Laboratory have created an atlas of how healthy breast tissue ages, revealing key cellular and molecular changes that may contribute to breast cancer development. The study found that epithelial cells lose their job descriptions, becoming more prone to malignancy, while stromal cells lose their specialized id...
Donald Patrick McDonnell, a professor at Duke University School of Medicine, has been awarded the Endocrine Society's John D. Baxter Prize for his research on hormone therapies for treating breast and prostate cancers. His work led to the discovery of novel treatments for these cancers and has improved patient care.
A team of researchers at Queen Mary University of London discovered that disrupting a single amino acid in the vimentin protein makes breast cancer cells behave like stem cells. This mutation promotes tumour growth and increases cancer stemness in an oestrogen-independent manner.
A preclinical study reveals that tumors drive clot formation by releasing chemokines, prompting immune cells to release small vesicles that attach to cell fragments, forming life-threatening clots. The findings may lead to diagnostic tests and safer therapies to target the root of blood clotting risk.
New cyanine-carborane salts show promise in eradicating metastatic breast cancer tumors with minimal side effects. The therapy targets specific proteins in cancer cells, allowing for precise killing of diseased cells while sparing healthy tissue.
Researchers at University of Melbourne and Pfizer discover new insights into a dual-target drug that may supercharge cancer-fighting immune cells, potentially leading to improved outcomes for breast cancer patients. The study found that this approach can enhance anti-tumor immunity by intratumoral CD8+ T cells.
Researchers at MD Anderson Cancer Center have made significant advancements in treating oligometastatic prostate cancer, advanced urothelial cancer, and triple-negative breast cancer. Personalized risk-based screening is also being explored as a tool to reduce cancer deaths.
Researchers at Stanford Medicine classified breast cancers into three main groups based on structural variations in their DNA, including repeats of oncogenes and small DNA circles. Understanding these variations could aid physicians in making decisions and point to new targeted therapeutic interventions.
A new study reveals that breast cancer survivors face significant psychosocial challenges due to fear of recurrence, affecting various aspects of their lives. The study found that nearly all affected domains were impacted by the fear, with those having greater fear experiencing more frequent disruptions.
In Japan, breast cancer screening participation rates dropped significantly during the pandemic, affecting specific subgroups such as those aged 45-49 and living in towns/villages. The overall rate declined from 48.3% to 47.1%, with municipalities seeing a decrease but worksites an increase.
The Micro Immune Response On chip (MIRO) replicates tumours and their environment, allowing researchers to study the efficacy of immunotherapy treatments. This technology has been tested with breast cancer samples and shows promise in understanding how the immune system interacts with tumours.
The ACC Advancing the Cardiovascular Care of the Oncology Patient conference will provide clinicians with tools to improve cardiovascular care of cancer patients. Key sessions will include discussions on pulmonary tumor thrombotic microangiopathy, AI and technology in cardio-oncology.
A new tool named retriever extracts disease-specific drug response signatures to predict cancer treatment combinations, improving personalized treatment strategies. The tool refines predictions using single-cell RNA sequencing data and demonstrates its potential in identifying effective treatments for triple-negative breast cancer.
Researchers at UCSF used CRISPR gene editing technology to transform ordinary white fat cells into 'beige' fat cells that voraciously consume calories to make heat. Implanted near tumors, these cells outcompeted cancer cells for nutrients, beating back five types of cancer in lab experiments.
A new study published in The Lancet Digital Health found that AI-supported breast cancer screening increased the detection of early-stage invasive cancers by 24% compared to traditional screening. AI also identified pre-cancerous lesions with a 51% higher rate, without increasing false positives.
A study from the University of Surrey reveals that delays in cancer diagnosis for pregnant women are often due to misattributed symptoms as normal pregnancy changes. Women experiencing more specific symptoms, such as breast lumps, are more likely to receive quicker diagnoses and referrals.
The study analyzed 63 tumor samples from 10 common malignancies, revealing how malignant cells specialize in growing tumors and non-cancer cells contribute to the immune system's suppression. The findings suggest a hierarchical structure of tumors with specific hallmark expression patterns.
The foundation has awarded eight recipients of the 2025 Damon Runyon-Rachleff Innovation Award, including five early-career researchers with initial grants of $400,000 over two years. The awardees aim to develop novel cancer therapies using innovative approaches such as engineered skin bacteria and small molecule-boosted drug delivery.
A new study published in Nature Medicine shows a promising approach to preventing metastases in breast cancer patients. Researchers found that administering digoxin reduced circulating tumour cell clusters by an average of 2.2 cells, significantly decreasing the risk of metastasis.
A cognitive science professor at UC Merced proposes a suite of video games to accelerate cancer research using artificial intelligence and gamified citizen science. The 'Cancer Wars' initiative aims to harness the collective problem-solving power of millions of gamers to tackle complex scientific problems.
A new combination therapy combining systemic interferon-I with local imiquimod application showed promising results in treating melanoma and breast cancer. The therapy activated the adaptive immune system to fight distant metastases, reducing tumor relapses and increasing sensitivity to checkpoint inhibitors.
A new approach to cancer therapy is being developed by inhibiting mechanotransduction, a process that regulates processes such as tumour progression and wound healing. The INTROPY project aims to validate the potential of six molecules in blocking this process, offering a new strategy for cancer treatment.
The RSClin Tool N+ provides more accurate estimates of recurrence risk and individual chemotherapy benefit in node-positive breast cancer. The tool combines clinical and pathologic factors with the 21-gene Oncotype DX Breast Recurrence Score to predict patient-level prognosis and treatment benefit.
Researchers have developed a novel small molecule that completely eliminates breast cancer tumors and shrinks large tumors in mice with a single dose, with minimal side effects. This compound shows promise as a transformative treatment option for estrogen receptor-positive (ER+) breast cancer.
Researchers explore HER2-low breast cancer, a new clinical subtype that benefits from novel treatments and personalized care. Current testing methods are not always accurate, calling for better detection methods to correctly identify patients who can benefit from these new therapies.
A study demonstrates the effectiveness of telephone-delivered acceptance and commitment therapy in reducing fatigue's interference with functioning and improving quality of life for metastatic breast cancer survivors. The remote intervention showed promise in reducing sleep interference, leading to improved sleep quality and a greater ...
A study found that a simple blood test could predict breast cancer risk in older women by measuring biological aging via DNA methylation changes. Lifestyle factors, such as obesity and hormone replacement therapy, also influenced epigenetic aging and breast cancer risk.
The new NCCN Guidelines for Patients: Genetic Testing for Hereditary Breast, Ovarian, Pancreatic, and Prostate Cancer provide evidence-based recommendations for assessing and testing for inherited genetic mutations. The resource aims to inform individuals about their cancer risks based on personal or family history.
Researchers at UMass Amherst have developed a non-toxic bacterial therapy, BacID, to deliver cancer-fighting drugs directly into tumors. The therapy uses genetically engineered strains of Salmonella that can target tumors and control the release of cancer-fighting drugs inside cancer cells.
The phase 3 KATHERINE clinical trial found trastuzumab emtansine to be an effective adjuvant treatment for high-risk HER2-positive breast cancer patients, reducing the risk of death or invasive disease by 46% and improving survival. The study showed consistent benefits across patient subgroups, supporting T-DM1 as a new standard of care.