Articles tagged with Breast Cancer
A polygenic risk score (PRS) can predict future breast cancer incidents in women diagnosed with ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS). PRS scores were associated with an increased risk of ipsilateral breast cancer, particularly in patients with a family history of breast cancer.
A groundbreaking study enrolls 465 AYA cancer patients to test if chatbot technology and digital education tools increase uptake of genetic counseling and improve patient outcomes. The trial aims to address longstanding gaps in genetic services for AYAs aged 18-39, who often receive care with limited access to genetic specialists.
The RadComp study found that both proton and photon radiation treatment options yielded excellent health-related quality of life (HRQOL) outcomes for women with non-metastatic breast cancer. The trial, which compared HRQOL tools, showed no significant differences between the two treatments at 6 months following treatment.
A phase III trial comparing proton and photon radiation therapy for breast cancer found that patients report equally strong health-related quality of life with either treatment. Patients treated with protons were more likely to say they would recommend or choose it again, but overall patient-reported outcomes were similar.
A study has identified KIMA, a genomic signature associated with a poor treatment response in HR+/HER2- breast cancer patients. The signature, composed of nine genes, can predict disease progression and overall survival, enabling personalized therapy selection.
A new study from Karolinska Institutet reveals that women who skip their first mammogram are more likely to be diagnosed with advanced breast cancer and die from the disease. The study found a 32% decline rate among women who missed their first screening, leading to poorer prognosis and higher mortality rates.
A new study published in Diabetes, Obesity and Metabolism found that weight loss treatments, including medication and surgical procedures, may help lower the risk of obesity-related cancers in people with obesity and type 2 diabetes. The study analyzed data from over 180,000 people and found a significant reduction in cancer incidence ...
A new study found that combining molecular breast imaging (MBI) and digital breast tomosynthesis (DBT) increases invasive cancer detection while moderately increasing recall rates. MBI detected an additional 6.7 cancers per 1,000 screenings in women with dense breasts.
A large-scale randomized trial will examine whether AI supports radiologists in interpreting mammograms more accurately, reducing unnecessary callbacks and anxiety. The PRISM Trial, led by UCLA, aims to inform future policy decisions and best practices in breast cancer screening.
The PRISM trial will examine the impact of AI on mammogram accuracy and patient experience, with hundreds of thousands of mammograms analyzed. The study aims to understand whether AI enhances cancer detection by radiologists or leads to more false alarms.
A new study from the University of California - Los Angeles Health Sciences suggests that regular mammograms may still offer significant benefits for women in their 80s. The study found that screened women were more likely to have surgery to remove the tumor and had a lower risk of cancer returning and dying compared to unscreened women.
A Lund University AI model analyzed mammograms to identify breast cancer patients at high risk of armpit metastasis, suggesting that 41.7% of axillary surgeries could be avoided. The study's findings have the potential to revolutionize breast cancer treatment by enabling more personalized care and reducing unnecessary surgeries.
Armida Labs will use the funding to advance preclinical studies of Targefrin, a potential clinical candidate for pancreatic and other cancers. The grant aims to develop an anti-metastatic agent that targets the EphA2 protein, which drives cancer cell invasion and metastasis.
The American Society for Radiation Oncology, American Society of Clinical Oncology, and Society of Surgical Oncology jointly published a guideline outlining when post-mastectomy radiation therapy (PMRT) is appropriate based on new evidence. PMRT reduces cancer recurrence risk in patients with node-positive disease or high-risk features.
Research by Angela Riedel and team identified fibroblastic reticulum cells as main players in reprogramming lymph nodes, corrupting monocytes and blocking T cell activity. Targeted TLR4 blockade combined with PD1 immunotherapy can restore T-cell activity and reduce distant metastasis.
This study analyzed differential expression of long non-coding RNAs in peripheral blood mononuclear cells of women with luminal A breast cancer. Differential expression was observed, particularly for LINC RNA 974 (LINC00974), which exhibited significant associations with other oncological disorders.
Research from Edith Cowan University found that both resistance training and high-intensity interval training (HIIT) reduced breast cancer cell growth by 22-25%. Both types of exercise also increased lean muscle and decreased body fat after 12 weeks of training.
Maria Jasin, a renowned developmental biologist, has been awarded the 2025 Pearl Meister Greengard Prize for her groundbreaking work on DNA repair. Her research has transformed our understanding of cancers linked to inherited gene mutations, and has led to significant advances in cancer treatment.
Researchers identified genes associated with breastfeeding disorders and postpartum breast cancer in the mammary gland, revealing potential new targets for investigation. The study provides a detailed atlas of genetic expression for the adult developmental cycle of the mammary gland.
Researchers at MD Anderson have made significant advancements in treating kidney cancer, including the use of metastasis-directed targeted radiation therapy to delay systemic treatments. Additionally, preliminary data from an ELI-002 vaccine trial showed promise in delaying relapse of KRAS-mutated pancreatic and colorectal cancers.
The ASTRO's 2025 Annual Meeting will feature pivotal studies in radiation medicine, highlighting advances in radiopharmaceutical therapy and new indications for low-dose radiation therapy. The meeting will also explore cutting-edge techniques for prostate, breast, lung, and other common cancers.
This study reveals that GPNMB modifies the tumor microenvironment by repurposing macrophages into immunosuppressive tumor-associated macrophages. The interaction between GPNMB and Siglec-9 enables this reprogramming, leading to increased cancer cell motility and invasiveness.
Researchers discovered that breast cancer cells co-opt iron-recycling immune cells in bone marrow to acquire essential minerals, disrupting red blood cell production. This adaptation enables cancer cells to survive in low-oxygen environments and proliferate, ultimately leading to anemia and poor patient outcomes.
Researchers at the University of Mississippi have developed a new method to deliver cancer therapies directly to triple-negative breast cancer cells. The sugar-coated nanoparticles effectively target this aggressive cancer, which affects young women and disproportionately impacts Black women. The discovery holds promise for treating no...
A study led by Yibin Kang and Yujiao Han reveals that cancer cells hijack a specialized cell to recycle iron, depriving red blood cells of necessary iron and causing anemia. The discovery aims to slow down bone metastasis and alleviate complications.
A clinical trial has identified breast cancer survivors at high risk of recurrence due to dormant cells and successfully treated them with existing drugs. The study shows a 90% survival rate without disease recurrence in patients who received one drug and 100% for those who received both, offering new hope for breast cancer prevention.
A recent study published in Radiology found that AI-assisted mammography catches most advanced breast cancers, but still misses 14% of invasive cases. The AI missed more cases in younger women with tumors 2 cm or smaller, and those with low histologic grade, fewer lymph node metastases, and non-glandular locations.
Researchers at Lund University identify genetic toolkit to program dendritic cell subtypes for targeted cancer treatment. The discovery could lead to more precise and powerful immunotherapies by supplying patients with tailored dendritic cells.
The study found that risk of complications is the top driver of preferences for breast reconstruction, with an average relative importance of 26% on ACBC analysis. Autologous reconstruction was preferred by 15% of patients, who were willing to accept increased risks in exchange for a more natural appearance.
The foundation provides $300,000 total funding over four years to investigate cancer causes, mechanisms, therapies, and prevention. This support fosters interdisciplinary research and encourages innovative projects that push boundaries and make breakthroughs.
A study published in The BMJ found that women diagnosed with early breast cancer have a low long-term risk of developing a second primary cancer, with risks varying by age and treatment. Researchers used data from the National Cancer Registration and Analysis Service to estimate these risks.
Researchers found tamoxifen encourages uterine cell growth and increases risk of secondary uterine cancer in breast cancer patients. The study suggests that blocking the PIK3 pathway could reduce this risk and potentially save lives.
Kristi Funk, MD, a renowned breast cancer surgeon and founder of the Pink Lotus Breast Center, has received the Benjamin Spock Award for Compassion in Medicine. Dr. Funk's tireless advocacy focuses on empowering women with life-saving information about using nutrition and lifestyle to reduce cancer risk and improve survival.
Researchers envision AI-powered systems that identify patients at risk of mental health struggles, provide continuous psychological monitoring and tailor interventions. AI can also overcome barriers to mental health care by delivering support exactly where and when it's needed, including rural areas.
Researchers at Mount Sinai Hospital discovered that adding everolimus to standard chemotherapy improves outcomes for patients with advanced triple-negative breast cancer. The combination therapy reduces the risk of disease progression or death by 52%.
A telephone-based weight loss intervention significantly reduced weight in breast cancer patients with overweight and obesity. The study suggests that this intervention may improve disease outcomes, warranting further investigation in future trials.
Breast cancer cells build molecular tunnels into nearby fat cells to release energy, blocking gap junctions stops tumor growth. The discovery provides a golden opportunity for developing effective strategies to treat the most aggressive forms of breast cancer.
Researchers at the University of Warwick have developed a handheld diamond magnetometer for cancer surgery, which uses magnetic tracer fluid to detect tumours. The device is ultra-sensitive and compact, offering a non-toxic alternative to traditional methods, such as radioactive tracers or blue dye.
Dr. Catheryn Yashar, a renowned radiation oncologist, has been appointed president-elect of the American Society for Radiation Oncology (ASTRO). She will champion innovative radiation therapies and advance health policy reform to improve cancer care outcomes.
A new AI hybrid reading strategy for screening mammography reduces radiologist workload by 38% while maintaining comparable cancer detection and recall rates. The strategy incorporates uncertainty quantification, allowing AI to provide certainty estimates for predictions.
A study at the Garvan Institute of Medical Research found that inactivation of a stress pathway makes ER+ breast cancer cells ignore stress signals, allowing them to evade treatment. The JNK pathway acts as a cellular alarm system, and its disruption leads to treatment resistance.
The International Osteoporosis Foundation has issued an updated joint position statement on managing aromatase inhibitor-associated bone loss in women with hormone-sensitive breast cancer. The guidelines incorporate recent clinical trials and systematic reviews to provide evidence-based treatment algorithms for assessing fracture risk ...
Researchers found that mitochondrial antioxidant glutathione enables tumors to break away from the primary tumor, travel through the body, and take root in new tissues. Elevated SLC25A39 expression was strongly correlated with poorer overall survival in breast cancer patients.
Breast cancer's reliance on lactate metabolism drives tumor progression, immune evasion, and metastasis. Researchers propose targeting lactate production and lactylation to develop more precise treatments with improved survival rates.
Researchers at Radboud University Medical Center found that AI detects breast cancer on mammograms more frequently than radiologists. The study analyzed 42,000 breast scans and showed that one radiologist working with AI detects more tumors than two radiologists alone.
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
Researchers discovered that PCAI-27 activates two major signaling pathways, MAPK and PI3K/AKT, leading to increased oxidative stress and apoptosis in AI-resistant breast cancer cells. The compound also disrupts cytoskeletal structure, making cancer cells more vulnerable.
Researchers evaluated over 1,500 AI algorithms for detecting breast cancers on mammography images, achieving median rates of 98.7% specificity and 27.6% sensitivity. Combining top-performing algorithms resulted in sensitivity boosts to 60.7% and 67.8%, comparable to average screening radiologists.
A study by George Mason University's Ali Weinstein found that breast cancer survivors who experienced higher levels of fatigue showed increased inflammation, particularly in TGF-β and eotaxin levels. Most participants did not experience significant changes in inflammation or fatigue after mentally or physically fatiguing tasks, suggest...
A new multi-institutional study confirmed that the NSD2 protein can be targeted with a new drug, blocking it effectively reprogrammed DNA structure, reversed and prevented cancer growth in preclinical models of KRAS-mutant lung and pancreatic cancers. Targeting the brain-liver pathway with electronic wearables could prevent cancer-asso...
A recent study found that policies aimed at increasing breast density screening coverage have limited effectiveness in improving early detection rates among Black women. The study suggests that these policies may not address the unique health needs of this population.
The symposium will feature talks by leading researchers on various aspects of cancer, including molecular discovery, clinical application, and population impact. Key findings include the exploration of genomic inequities and their impact on cancer disparities.
A new AI-based technology analyzes mammograms to predict a woman's five-year breast cancer risk, outperforming standard methods by 2.2 times. The system provides an absolute risk score comparable to national incidence rates, enabling targeted prevention and early detection.
A new AI algorithm has been shown to detect nearly one-third of interval breast cancers missed at screening using digital breast tomosynthesis (DBT), according to a study published in Radiology. The algorithm improved the performance of DBT, reducing interval cancers.
Researchers developed a software fueled by genomics to predict cancer cell behavior, combining genomics technologies with computational modeling. The new 'grammar' enables communication between biology and code, allowing scientists to build digital representations of multicellular biological systems and simulate diseases like cancer.
Researchers at Fox Chase Cancer Center have provided a detailed assessment of how fast breast cancers grow in patients and how surgical delays may affect breast cancer staging. The study found that upstaging rates associated with delays are relatively small and consistent with prior data.
A study published in iScience found that cells in breast tissues of women with African ancestry send cues promoting breast cancer growth. Researchers discovered that PZP cells activate epithelial cells, allowing them to invade surrounding tissue.
A recent study found that a 5 mg dose of olanzapine taken after chemotherapy significantly reduced nausea and vomiting in breast cancer patients, with fewer side effects compared to the standard 10 mg dose. The low-dose regimen was effective for both immediate and delayed symptoms, making it an attractive alternative for patients.
A new analysis suggests that preventive mastectomy is a cost-effective way to reduce the likelihood of developing breast cancer compared to breast screening and medication. Women aged 30 or above with a lifetime breast cancer risk of 35% or more may benefit from this treatment option.
A new study finds that risk-reducing mastectomy is cost-effective for women aged 30-55 with a lifetime breast cancer risk of 35% or higher. The findings have significant clinical implications, suggesting that RRM could expand access to the procedure beyond BRCA1/BRCA2/PALB2 pathogenic variant carriers.