Articles tagged with Breast Cancer
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A new antibody drug conjugate (ADC) sacituzumab govitecan has been shown to improve progression-free survival in patients with advanced triple-negative breast cancer who are ineligible for immune checkpoint inhibitors. The ADC targets the protein Trop2 on TNBC cells and delivers a potent chemotherapy drug directly to tumor sites.
A new class of anti-cancer agents—antibody-drug conjugates (ADCs)—has unveiled compelling evidence that can dramatically improve outcomes for patients with early-stage HER2-positive breast cancer. The phase III DESTINY-Breast05 and DESTINY-Breast11 trials have shown superior efficacy and improved disease-free survival rates, positionin...
A phase 3 study found that giredestrant plus everolimus significantly improved progression-free survival in patients with ER-positive, HER-2-negative advanced breast cancer. The treatment combination reduced the risk of disease progression or death by 63% in patients with ESR1 mutations.
The study reveals geographic clusters of high and low screening for breast, cervical, and colorectal cancers in the US Northeast and Southwest. Future studies could examine county-level healthcare access to optimize cancer screening practices.
Recent studies from Sylvester have uncovered links between breast cancer, Superfund sites and social adversity. Researchers are also exploring the use of artificial intelligence (AI) in interpreting mammograms more accurately.
Researchers developed TAMENDOX to supplement (Z)-endoxifen in patients with CYP2D6 enzyme deficiency, improving drug concentration and effectiveness. The new therapy was well-tolerated, showing promise as an alternative to aromatase inhibitors for premenopausal women.
Researchers at MD Anderson have discovered a previously unknown mechanism that explains how bacteria can drive treatment resistance in patients with oral and colorectal cancer. The study also identifies a new biomarker for improved immunotherapy responses in solid tumors.
Researchers found high SIGLEC15 expression correlates with improved survival in breast cancer patients. SIGLEC15 suppresses EMT progression and metastatic potential by down-regulating ZEB1, N-cadherin, and vimentin levels. It also shows vulnerability to the MDM2 inhibitor Nutlin-3a, suggesting a potential therapeutic strategy.
A study by Huntsman Cancer Institute found that triple-negative breast cancer is fueled by lipids and that these fatty acids promote tumor growth. The research suggests that breast cancer patients and survivors with obesity could benefit from lipid-lowering therapies.
A cohort study reveals a significant association between social adversity and increased incidence of triple-negative breast cancer in Black women. The findings suggest potential social genomic and gene-environment interactions that contribute to disparities in breast cancer survival.
Prognosia, a biotech startup founded by WashU Medicine researchers, has been acquired by Lunit. The company's AI-based software analyzes mammograms to predict breast cancer risk, showing more than twice the accuracy of standard methods.
Dana-Farber researchers present promising phase 3 trial results for breast, lung, and bladder cancers, including improved quality of life for metastatic breast cancer patients. The trials also explore new approaches to kidney cancer treatment and real-world data analysis for metastatic breast cancer.
Researchers developed a latex-based tissue adhesive to prevent seroma formation and prolonged lymphorrhea after axillary dissection. The study found that the adhesive significantly reduced wound exudate volume and allowed patients to be discharged earlier, with no complications reported.
Women living close to Superfund sites in Florida face higher risks of developing aggressive breast cancers, including triple-negative subtype. A growing body of evidence suggests that environmental degradation and pollution are associated with poor health outcomes.
Researchers at UMass Amherst have developed a nanoparticle-based vaccine that prevents melanoma, pancreatic and triple-negative breast cancer in mice. The vaccine achieved remarkable survival rates, with up to 88% of vaccinated mice remaining tumor-free.
Researchers found that 27% of breast cancer cases have genetic features guiding personalized treatment immediately. The study identified over 8,300 cases suitable for future research, providing insights into prognosis and potential new treatments.
Research found that inflammatory markers are linked to different aspects of cancer-related fatigue, with some effects persisting after treatment. The study suggests targeting inflammation for developing treatments to alleviate this debilitating symptom.
The NCCN Guidelines Navigator now covers treatment for over a dozen cancer types, including hereditary risk assessment, providing seamless navigation and search capabilities. The new format aims to improve treatment decision-making based on the latest evidence and expert-consensus.
A new study shows that a multi-step effort to reduce unneeded pre-operative testing, using a tailored program for each hospital, can lead to significant reductions in wasteful tests. The findings have already spurred an expansion of the program to 16 more Michigan hospitals.
Women undergoing mastectomy may experience emotional and physical challenges, including worse psychosocial outcomes and a lack of standardized approach to assess quality of life. Researchers emphasize the importance of developing a validated screening tool to prepare women for surgery.
Researchers discovered that an enzyme called EZH2 drives triple negative breast cancer cells to divide abnormally, enabling them to spread. Inhibiting EZH2 with drugs like tazemetostat restored order to dividing cells and thwarted the spread of TNBC cells.
Researchers at Cold Spring Harbor Laboratory have created a tool called MaGNet to analyze the branching structure of mouse mammary glands. The system enables precise comparison of stained images and quantifies data with ease, allowing for earlier detection of breast cancer and investigation into hormonal changes and treatments.
A recent study published in Radiology found that adding molecular breast imaging to a 3D mammogram improved the ability to detect cancer in dense breast tissue. The combined test detected more cancerous tissue than either technique alone, increasing cancer finds by over double.
Researchers at King's College London have developed a genetic test that can predict which women with abnormal breast cells are most likely to develop invasive breast cancer. The test uses a genetic risk score to estimate a person's inherited likelihood of developing the disease, allowing for more personalized treatment options.
A polygenic risk score (PRS) can predict future breast cancer incidents in women diagnosed with ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS). PRS scores were associated with an increased risk of ipsilateral breast cancer, particularly in patients with a family history of breast cancer.
A groundbreaking study enrolls 465 AYA cancer patients to test if chatbot technology and digital education tools increase uptake of genetic counseling and improve patient outcomes. The trial aims to address longstanding gaps in genetic services for AYAs aged 18-39, who often receive care with limited access to genetic specialists.
The RadComp study found that both proton and photon radiation treatment options yielded excellent health-related quality of life (HRQOL) outcomes for women with non-metastatic breast cancer. The trial, which compared HRQOL tools, showed no significant differences between the two treatments at 6 months following treatment.
A phase III trial comparing proton and photon radiation therapy for breast cancer found that patients report equally strong health-related quality of life with either treatment. Patients treated with protons were more likely to say they would recommend or choose it again, but overall patient-reported outcomes were similar.
A study has identified KIMA, a genomic signature associated with a poor treatment response in HR+/HER2- breast cancer patients. The signature, composed of nine genes, can predict disease progression and overall survival, enabling personalized therapy selection.
A new study from Karolinska Institutet reveals that women who skip their first mammogram are more likely to be diagnosed with advanced breast cancer and die from the disease. The study found a 32% decline rate among women who missed their first screening, leading to poorer prognosis and higher mortality rates.
A new study published in Diabetes, Obesity and Metabolism found that weight loss treatments, including medication and surgical procedures, may help lower the risk of obesity-related cancers in people with obesity and type 2 diabetes. The study analyzed data from over 180,000 people and found a significant reduction in cancer incidence ...
A new study found that combining molecular breast imaging (MBI) and digital breast tomosynthesis (DBT) increases invasive cancer detection while moderately increasing recall rates. MBI detected an additional 6.7 cancers per 1,000 screenings in women with dense breasts.
A large-scale randomized trial will examine whether AI supports radiologists in interpreting mammograms more accurately, reducing unnecessary callbacks and anxiety. The PRISM Trial, led by UCLA, aims to inform future policy decisions and best practices in breast cancer screening.
The PRISM trial will examine the impact of AI on mammogram accuracy and patient experience, with hundreds of thousands of mammograms analyzed. The study aims to understand whether AI enhances cancer detection by radiologists or leads to more false alarms.
A new study from the University of California - Los Angeles Health Sciences suggests that regular mammograms may still offer significant benefits for women in their 80s. The study found that screened women were more likely to have surgery to remove the tumor and had a lower risk of cancer returning and dying compared to unscreened women.
A Lund University AI model analyzed mammograms to identify breast cancer patients at high risk of armpit metastasis, suggesting that 41.7% of axillary surgeries could be avoided. The study's findings have the potential to revolutionize breast cancer treatment by enabling more personalized care and reducing unnecessary surgeries.
Armida Labs will use the funding to advance preclinical studies of Targefrin, a potential clinical candidate for pancreatic and other cancers. The grant aims to develop an anti-metastatic agent that targets the EphA2 protein, which drives cancer cell invasion and metastasis.
The American Society for Radiation Oncology, American Society of Clinical Oncology, and Society of Surgical Oncology jointly published a guideline outlining when post-mastectomy radiation therapy (PMRT) is appropriate based on new evidence. PMRT reduces cancer recurrence risk in patients with node-positive disease or high-risk features.
Research by Angela Riedel and team identified fibroblastic reticulum cells as main players in reprogramming lymph nodes, corrupting monocytes and blocking T cell activity. Targeted TLR4 blockade combined with PD1 immunotherapy can restore T-cell activity and reduce distant metastasis.
This study analyzed differential expression of long non-coding RNAs in peripheral blood mononuclear cells of women with luminal A breast cancer. Differential expression was observed, particularly for LINC RNA 974 (LINC00974), which exhibited significant associations with other oncological disorders.
Research from Edith Cowan University found that both resistance training and high-intensity interval training (HIIT) reduced breast cancer cell growth by 22-25%. Both types of exercise also increased lean muscle and decreased body fat after 12 weeks of training.
Maria Jasin, a renowned developmental biologist, has been awarded the 2025 Pearl Meister Greengard Prize for her groundbreaking work on DNA repair. Her research has transformed our understanding of cancers linked to inherited gene mutations, and has led to significant advances in cancer treatment.
Researchers identified genes associated with breastfeeding disorders and postpartum breast cancer in the mammary gland, revealing potential new targets for investigation. The study provides a detailed atlas of genetic expression for the adult developmental cycle of the mammary gland.
Researchers at MD Anderson have made significant advancements in treating kidney cancer, including the use of metastasis-directed targeted radiation therapy to delay systemic treatments. Additionally, preliminary data from an ELI-002 vaccine trial showed promise in delaying relapse of KRAS-mutated pancreatic and colorectal cancers.
The ASTRO's 2025 Annual Meeting will feature pivotal studies in radiation medicine, highlighting advances in radiopharmaceutical therapy and new indications for low-dose radiation therapy. The meeting will also explore cutting-edge techniques for prostate, breast, lung, and other common cancers.
This study reveals that GPNMB modifies the tumor microenvironment by repurposing macrophages into immunosuppressive tumor-associated macrophages. The interaction between GPNMB and Siglec-9 enables this reprogramming, leading to increased cancer cell motility and invasiveness.
Researchers discovered that breast cancer cells co-opt iron-recycling immune cells in bone marrow to acquire essential minerals, disrupting red blood cell production. This adaptation enables cancer cells to survive in low-oxygen environments and proliferate, ultimately leading to anemia and poor patient outcomes.
Researchers at the University of Mississippi have developed a new method to deliver cancer therapies directly to triple-negative breast cancer cells. The sugar-coated nanoparticles effectively target this aggressive cancer, which affects young women and disproportionately impacts Black women. The discovery holds promise for treating no...
A study led by Yibin Kang and Yujiao Han reveals that cancer cells hijack a specialized cell to recycle iron, depriving red blood cells of necessary iron and causing anemia. The discovery aims to slow down bone metastasis and alleviate complications.
A clinical trial has identified breast cancer survivors at high risk of recurrence due to dormant cells and successfully treated them with existing drugs. The study shows a 90% survival rate without disease recurrence in patients who received one drug and 100% for those who received both, offering new hope for breast cancer prevention.
A recent study published in Radiology found that AI-assisted mammography catches most advanced breast cancers, but still misses 14% of invasive cases. The AI missed more cases in younger women with tumors 2 cm or smaller, and those with low histologic grade, fewer lymph node metastases, and non-glandular locations.
Researchers at Lund University identify genetic toolkit to program dendritic cell subtypes for targeted cancer treatment. The discovery could lead to more precise and powerful immunotherapies by supplying patients with tailored dendritic cells.
The study found that risk of complications is the top driver of preferences for breast reconstruction, with an average relative importance of 26% on ACBC analysis. Autologous reconstruction was preferred by 15% of patients, who were willing to accept increased risks in exchange for a more natural appearance.
The foundation provides $300,000 total funding over four years to investigate cancer causes, mechanisms, therapies, and prevention. This support fosters interdisciplinary research and encourages innovative projects that push boundaries and make breakthroughs.
A study published in The BMJ found that women diagnosed with early breast cancer have a low long-term risk of developing a second primary cancer, with risks varying by age and treatment. Researchers used data from the National Cancer Registration and Analysis Service to estimate these risks.
Researchers found tamoxifen encourages uterine cell growth and increases risk of secondary uterine cancer in breast cancer patients. The study suggests that blocking the PIK3 pathway could reduce this risk and potentially save lives.
Kristi Funk, MD, a renowned breast cancer surgeon and founder of the Pink Lotus Breast Center, has received the Benjamin Spock Award for Compassion in Medicine. Dr. Funk's tireless advocacy focuses on empowering women with life-saving information about using nutrition and lifestyle to reduce cancer risk and improve survival.
Researchers envision AI-powered systems that identify patients at risk of mental health struggles, provide continuous psychological monitoring and tailor interventions. AI can also overcome barriers to mental health care by delivering support exactly where and when it's needed, including rural areas.
Researchers at Mount Sinai Hospital discovered that adding everolimus to standard chemotherapy improves outcomes for patients with advanced triple-negative breast cancer. The combination therapy reduces the risk of disease progression or death by 52%.
A telephone-based weight loss intervention significantly reduced weight in breast cancer patients with overweight and obesity. The study suggests that this intervention may improve disease outcomes, warranting further investigation in future trials.