Articles tagged with Breast Cancer
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A new AI model has been developed to improve the accuracy of recurrence risk stratification in hormone receptor-positive, HER2-negative breast cancer. The model, called ICM+, uses a combination of clinical, molecular, and histopathological data to provide better prognostic information about cancer recurrence risk out to 15 years.
Researchers developed multimodal models integrating imaging, clinical, and molecular data from TAILORx tissue biorepository for early-stage breast cancer. The models demonstrated enhanced prognostic performance compared to existing methods, highlighting their potential for personalized treatment decision-making.
Researchers from Mount Sinai present new discoveries in breast cancer biology, treatment, and real-world patient outcomes. The institution's contributions span artificial intelligence, triple-negative breast cancer, geriatric oncology, and novel therapeutic approaches.
Researchers mapped NBCn1's structure-function properties to understand how breast cancer cells thrive in hostile environments. The study provides insights into the protein's dynamics and ion transport pathways, paving the way for designing drugs that target this transporter.
Researchers at CU Anschutz have discovered a novel therapy combination to offer new hope to ovarian cancer patients who do not respond to existing treatments. The combination of a PARP inhibitor and SM08502 boosts the effectiveness of treatment, even for patients resistant to PARP inhibitors.
The 48th San Antonio Breast Cancer Symposium brings together over 10,000 global experts to share cutting-edge research on breast cancer discovery, therapeutics, and standard of care. Key findings include the effectiveness of active monitoring for low-risk DCIS patients and a new estrogen-blocking pill that slows cancer progression.
Researchers at UCLA present several new studies on emerging blood-based surveillance tools, new approaches to predicting treatment response, and tailoring therapies across the disease spectrum for patients with breast cancer. The findings highlight the potential of precision medicine in improving quality of life.
A new study developed an antibody that blocks several ways TNBC cells survive, grow, and evade the immune system. The antibody suppressed primary tumor growth and reenergized cancer-fighting immune cells, including T-cells and macrophages, in preclinical models.
Researchers discovered breast cancer modifies lymphatic vessels to facilitate its spread. A specific protein, Matrix Gla protein (MPG), enables cancer cells to bind to lymphatic vessels, supporting metastasis. Understanding this process could lead to targeted therapies and improved patient outcomes.
A new study published in the Journal of the American College of Radiology found that targeted outreach can increase lung cancer screenings for eligible women who undergo mammograms. The CALM model, which coordinates lung screening with mammography, exceeded its target enrollment and demonstrated effectiveness in increasing uptake. By i...
A new study found that breast density notifications can lead to increased levels of confusion and anxiousness among women, contradicting the intended goal of empowering them. Women with denser breast tissue may require additional screening methods, which can result in higher out-of-pocket costs.
Researchers found that women notified of their dense breasts felt more anxious and confused about their breast health, with increased intentions to talk to their GP. The study suggests that population breast density notification should be carefully considered due to potential adverse outcomes.
Researchers found estrone hormone drives inflammatory activity in postmenopausal women with obesity, increasing risk of aggressive breast cancer. Lifestyle interventions may not be sustainable, but GLP-1 drugs show promise as a therapy.
Omomyc, a direct MYC inhibitor, causes DNA damage in cancer cells and potentiates antitumor response when combined with PARPi inhibitors. This synergy offers a new therapeutic opportunity to overcome PARPi resistance in triple-negative breast cancer.
A study of seven outpatient facilities found that 20-24% of all breast cancers diagnosed between 2014 and 2024 were in women aged 18-49. Invasive cancer cases accounted for 80.7%, often with aggressive types, challenging age-based screening cutoffs.
Serum markers such as NLR, PLR, ESR, LDH, ALP, creatine kinase-BB, SUA, CRP, and CA 15-3/27.29 have been linked to breast cancer diagnosis, prognosis, and therapeutic monitoring. These biomarkers offer affordable, non-invasive, and accessible diagnostic strategies for bridging the diagnostic gap in low-resource settings.
A new AI image-only model has been shown to provide stronger and more precise risk stratification for five-year breast cancer prediction than traditional breast density assessment. The model was trained on 421,499 mammograms and showed a fourfold higher cancer incidence in high-risk women compared to those with average risk.
The new system can reveal early cancers, lung disease, hidden material defects and changes in porosity without multiple exposures or complex mechanical movement. This method produces low-dose and faster images, lowering patients' radiation dose and making clinical translation feasible.
Researchers discovered that synthetic stress hormone dexamethasone can combat therapy-resistant breast cancer metastases in mice trials. The drug activates the glucocorticoid receptor, suppressing estrogen receptor production and slowing tumor growth. Further studies are needed to confirm these findings in patients with breast cancer.
Researchers at the LSU LCMC Health Cancer Center have identified key immune differences in triple-negative breast cancer, a leading cause of breast cancer deaths among Black women. The study provides new insights that could lead to more effective and personalized treatments for this aggressive form of cancer.
A new study using magnetoelectric nanoparticles successfully shrinks pancreatic tumors in preclinical models, extending survival. The Sylvester Cancer Institute has also launched its Survivorship and Supportive Care Institute to provide evidence-based care for cancer patients.
Researchers have discovered a new class of BRCA1 mutations that can be targeted by HSP90 inhibitors, potentially improving treatment outcomes for patients with breast cancer. The study found that these mutations are more resistant to PARP inhibitor treatment but can be overcome with low-dose HSP90 inhibition.
Researchers at UC San Diego School of Medicine have identified a promising new therapy for triple-negative breast cancer (TNBC), employing an antibody-drug conjugate to deliver chemotherapy directly into cancer cells. Targeting tumor-initiating cells through FZD7 may offer a path forward for patients with aggressive TNBC that fails to ...
Dr. Sedrak receives King Hussein Cancer Research Award for innovative work on accelerated aging in cancer survivors, with a focus on developing new strategies to prevent or reverse age-related effects. His research aims to improve health span and quality of life for cancer patients, holding promise for other age-related diseases.
Rockefeller researchers found a molecular switch in breast cancer cells that reprograms gene expression towards tumor growth and stress resistance. This switch is mediated by the MED1 subunit of RNA polymerase II and can be activated under stressful conditions, leading to faster-growing and more stress-resistant tumors.
This study develops an interpretable machine learning model that integrates proteomics and clinical data to predict 5-year survival in breast cancer. The model uses SHAP and KAN to identify key predictive factors, achieving high accuracy and robust predictive capability.
A recent study using UK Biobank data found that greener environments may reduce the risk of postmenopausal breast cancer associated with air pollution. The researchers analyzed data from over 500,000 women to investigate the relationship between green spaces and air pollution on breast cancer risk.
Researchers discovered a cellular protein, FGD3, that enhances the effectiveness of breast cancer chemotherapy and immunotherapies. FGD3 weakens cancer cells when attacked by drugs like ErSO or doxorubicin, causing them to rupture and alert the immune system.
Researchers identified a cholesterol metabolite called hydroxycholesterol that suppresses the immune system's ability to attack cancer, leading to increased metastasis. The team discovered a line of communication used by immune cells and cancer cells that stimulates breast cancer progression.
Researchers at the University of Notre Dame developed a modular, computational pipeline to predict pH-sensitive protein structures. The new process enables screening hundreds of proteins in a few days, which can help design treatments for diseases like cancer, Alzheimer's, and Huntington's.
Researchers found that the leptin-SCD pathway fuels breast cancer growth and motility, leading to poorer recurrence-free survival. Selectively blocking SCD activity can counteract pro-tumorigenic effects driven by leptin, revealing a potential therapeutic target for obese patients.
Experts warn that new drugs for advanced breast cancer are unaffordable and may lead to unequal treatment access worldwide. The consensus panel recommended prioritizing most effective treatments and using next-generation sequencing for personalized medicine.
A new radioimmunotherapy approach has been developed to treat HER2-positive breast cancer, resulting in complete and histologic cures with minimal toxicities. The treatment uses a pretargeted approach to directly target tumors, reducing the risk of radiation toxicity to healthy tissues.
Researchers at OHSU develop a promising drug SU212 to treat intractable cases of triple-negative breast cancer. The molecule binds to and degrades the enzyme enolase 1, suppressing tumor growth and metastasis in humanized mouse models.
Triple-negative breast cancer often responds well to treatment, but 'persister' cells can reform a tumour, leading to relapse. A shared transcriptional programme determines which genes are active or not, with the FOSL1 protein playing a central role in resistance.
The study found that a nine-month programme of supervised exercise improved muscle mass and strength, particularly in the arms and legs, and physical performance in patients with breast cancer that had spread to other parts of the body. Muscle mass increased by an average of 0.79 kg after three months and 0.32 kg after six months compa...
Researchers at University of Miami Miller School of Medicine have developed a new combination therapy that shrinks tumors, reduces cancer stem cells and reprograms immune environment to combat hormone-resistant breast cancer. The triple therapy approach targets tumor-associated macrophages, which act like bodyguards for cancer cells.
A new case report describes the successful treatment of a 37-year-old woman with HER2-positive breast cancer that had spread to the membranes surrounding the brain and spinal cord. Trastuzumab deruxtecan, an antibody-drug conjugate, improved the patient's neurological symptoms and reduced cancer growth.
A new study found that patients with early-stage breast cancer who underwent a mastectomy and anti-cancer drugs had similar 10-year survival rates whether or not they received chest wall radiotherapy. The research team concludes that radiotherapy may no longer be necessary for these patients, reducing treatment burden and potential sid...
A global survey of nearly 4,000 young women with advanced breast cancer found that nearly half have children under 18 and face significant hardship. The study also revealed delays in seeking care, unmet psychosocial needs, and limited access to precision diagnostics.
The ABC Global Decade Report 2015-2025 reveals significant advances in breast cancer care for some patients globally. However, persistent inequalities leave many behind. The report's findings drive the creation of the ABC Global Charter 2025-2035, aiming to improve equitable progress and transform care for everyone with ABC.
A study of over 60,000 US patients with advanced breast cancer found average survival times increased by six to seven months since 2011. Researchers attribute the improvement to more effective treatments, wider diagnosis, and quality of care advancements.
A new editorial highlights the importance of primary care in preventing heart disease in breast cancer survivors. The study found that most women do not go on to develop serious cardiac disease, but those with higher-risk chemotherapy, older age, or multiple cardiovascular risk factors may benefit from closer monitoring.
A large global study of 23,000 people found that proton pump inhibitors (PPIs) used for indigestion and heartburn were associated with poorer overall survival and a higher risk of severe side effects in patients with breast cancer. Statins and metformin showed no significant impact on either survival or adverse events.
Researchers developed nanomachines that can function stably within living organisms, enabling starvation therapy to treat refractory pancreatic cancer. This approach improved treatment outcomes by depleting essential nutrients for cancer cell growth.
The DEFEND study aims to assess whether virtual exercise sessions can be successfully delivered to patients with cancer receiving chemotherapy. Researchers will evaluate the impact on physical function, fatigue, and disability.
Researchers outline biological mechanisms of breast cancer brain metastasis, highlighting key molecular pathways and the role of the brain microenvironment. The review also discusses emerging therapeutic approaches and calls for cross-disciplinary collaboration to improve outcomes.
A new study from Memorial Sloan Kettering Cancer Center identifies unique genetic signatures in cancer patients of non-European ancestry and finds adding immunotherapy can boost effectiveness for hard-to-treat follicular lymphomas. Additionally, researchers discover a web-based system to report head-and-neck cancer concerns, leading to...
A new Swedish study found that breast cancer risk varies depending on the type of hormone in hormonal contraceptives. Desogestrel was linked to a higher risk, while levonorgestrel products showed a lower risk, indicating that some contraceptives may be safer options for women with a higher baseline risk.
A new study suggests that collecting and testing cancer cells in patients' blood could help doctors choose the right breast cancer treatment. The 'labyrinth chip' technology separates cancer cells from other blood cells, allowing researchers to identify biomarkers that distinguish aggressive treatments from less invasive ones.
Researchers developed an AI tool to identify women at higher risk of developing interval breast cancers, which have a worse prognosis. The tool predicted 42.4% of interval cancers for women with the top 20% scores, suggesting it could optimize breast cancer screening programs by identifying those who need supplemental imaging.
A multiyear analysis of over 400,000 women and 28,000 breast cancer cases found a strong association between outdoor air pollution and increased breast cancer incidence. The study suggests that reducing car traffic and promoting alternative transportation can help mitigate this risk.
Recent discoveries in breast cancer biology highlight the potential of targeted therapies and molecularly guided treatment approaches. The review discusses various treatments, including monoclonal antibodies and immunotherapies, as well as challenges in treating triple-negative and HER2-positive breast cancers.
A new study led by Mayo Clinic researchers found that abemaciclib improves survival for people with high-risk, early-stage breast cancer. The drug reduced the risk of death by 15.8% compared to endocrine therapy alone among patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative breast cancer.
Scientists at King's College London have developed a potential antibody therapy strategy that restricts the growth of treatment-resistant breast cancers. The 'triple-engineered antibody' harnesses the body's immune defences to attack tumour cells and activates immune cells to kill cancer cells.
A new study led by Silent Spring Institute examines how job-related chemical exposures contribute to breast cancer risk among foreign-born workers. Immigrant women are overrepresented in high-risk jobs with fewer health and safety protections, facing unique barriers to avoiding toxic exposures at work.
Researchers at the Mayo Clinic have found that platelet-rich plasma (PRP) treatment can significantly improve genitourinary syndrome of menopause (GSM) symptoms in breast cancer survivors. After six months, GSM symptoms such as sexual function, urinary symptoms and quality of life improved, even among those taking estrogen blockers.
Researchers at UCLA have developed CAR-NKT cell therapy, which can attack tumors from multiple fronts while dismantling their protective shields. The therapy uses engineered immune cells that can be mass-produced from donated blood stem cells and stored ready-to-use, offering a potentially life-changing treatment option.
A major study of breast, cervical, and ovarian cancers found significant inequalities in global care, with many low- and middle-income countries (LMICs) diagnosing cancer at a later stage. Surgery was offered consistently, but treatment consistency varied, with LMICs often choosing mastectomy over breast-conserving surgery.
Biologists at Cold Spring Harbor Laboratory have made a significant discovery that could lead to better patient outcomes for ER+ breast cancer patients. Inhibiting the BPTF protein in mice can slow cancer metastasis and restore tumors' susceptibility to hormone therapy, offering new hope for treating resistant forms of the disease.