Breast Cancer
Articles tagged with Breast Cancer
When cells reveal their inner workings
UT MD Anderson shares latest research breakthroughs
Researchers identify the mechanism by which genome-doubled tumors evade the immune system in breast cancer
Study may help predict response to chemotherapy in triple-negative breast cancer
Stage IV breast cancer incidence and survival, 2010-2021
The study found that stage IV breast cancer incidence increased across ages and sexes, while overall survival improved despite the increase. Researchers highlight the need for further investigation into factors contributing to the rise in incidence, including potential changes in breast cancer screening and other conditions.
Slowly ticking breast cancer cells offer new clues to late relapse
Researchers have identified a hidden mechanism explaining why breast cancer can return years after successful treatment. Slow-growing breast cancer cells can form microscopic tumours that silently tick away in distant organs, evading detection for decades.
Survival and recurrence with GLP-1 receptor agonists in breast cancer
A cohort study found a potential association between GLP-1 RA use and improved survival rates among obese breast cancer patients with related metabolic conditions. Further evaluation of GLP-1 RA therapy in randomized clinical trials is warranted based on these findings.
Popular weight loss, diabetes drugs linked to improved breast cancer survival
A retrospective cohort study examining over 840,000 breast cancer patients found a potential link between GLP-1 RA use and improved outcomes among obese or diabetic patients. GLP-1 RAs were associated with lower risk of death and recurrence over a 10-year follow-up period.
National study examines genetic testing to inform follow-up care for cancer survivors
Scientists find blood-based biomarkers for inflammatory breast cancer
Researchers at the University of Texas MD Anderson Cancer Center have identified specific blood-based genomic biomarkers that distinguish inflammatory breast cancer from other subtypes. The study used an improved method of RNA sequencing, called TGIRT sequencing, which allowed for a more comprehensive overview of all RNA types and amou...
ASCO 2026 Tip Sheet - Sylvester Comprehensive Cancer Center
Researchers at the Sylvester Comprehensive Cancer Center presented several studies at ASCO 2026 exploring new treatment options for patients with advanced gastrointestinal stromal tumors (GISTs) and melanoma. These include velzatinib, a targeted therapy for GIST patients, and PRAME-directed T-cell receptor therapies for synovial sarcoma.
Mapping cancerous tissue with a hand-held probe
Researchers developed a hand-held device to differentiate tumors from healthy tissue using mechanical properties, reducing the need for future surgeries and delayed treatments. The wireless probe can aid surgeons in precise tumor removal during breast-conserving surgery.
Researchers find potential one-two punch against triple-negative breast cancer
A study published in Cell Reports Medicine found that inhibiting RNase H2 can cause significant damage to DNA and activate the innate immune system to produce signals that attract T cells to attack the tumor. This approach could lead to improved patient outcomes for patients with triple-negative breast cancer.
New treatment with fewer side effects reduces breast density
A new study from Karolinska Institutet shows that low doses of endoxifen reduce breast density to the same extent as tamoxifen without causing severe side effects. The results suggest a lower dose may be sufficient for therapeutic effect while being better tolerated.
JMIR News: AI mammograms and pocket CRISPR lead shift to proactive care
New technologies are shifting healthcare towards proactive care, using AI for early heart disease detection and miniaturized CRISPR-based diagnostics. These innovations enable seamless integration of existing medical screenings and provide laboratory-grade accuracy in a portable format.
NRG4 – the missing link connecting obesity and breast cancer
Researchers found that NRG4, an adipokine secreted by white adipose tissue, suppresses breast cancer metastasis via ERBB4-YAP1 signaling. The study also showed that higher NRG4 levels correlate with improved patient survival outcomes.
Liquid biopsy predicts response to breast cancer immunotherapy
A new liquid biopsy method has been developed to predict the response to immunotherapy in high-risk breast cancers. The study found that repeated blood sampling can assess and predict the evolving antitumor immune response to therapy, offering a potential tool for guiding immunotherapy decision-making.
Survey finds many women still believe mammograms should start at age 50—experts say age 40
A new survey found that nearly half of women incorrectly believe annual mammograms should start at age 50. Experts recommend yearly mammograms starting at age 40 for average-risk women. This delay can lead to cancers being found at a later stage, when treatment can be more complex.
Preclinical efficacy of experimental peptide therapy suggests a new target for metastatic breast cancer treatments, UTHealth Houston researchers find
Researchers at UTHealth Houston have discovered a new target for metastatic breast cancer treatments using experimental peptide therapy. The study found that the peptide BLMP6 targets fibulin-4, a protein expressed in high levels in metastatic breast cancers.
AI-assisted optical imaging could ease a major bottleneck in breast cancer surgery
A new study combines dynamic full-field optical coherence tomography with deep learning to generate real-time virtual pathology images of fresh lymph nodes during surgery. The approach achieved high accuracy and sensitivity, reducing tissue consumption and manual workload.
Dr. Dennis Slamon elected to Association of American Physicians
Dr. Dennis Slamon, a renowned breast cancer researcher, has been elected to the Association of American Physicians (AAP) for his pioneering work in HER2 gene discovery and targeted therapies. His research led to significant improvements in survival rates and established the principle of targeted cancer treatment.
Disparities in disease presentation and treatment initiation for de novo metastatic breast cancer
A cross-sectional study of patients with de novo metastatic breast cancer found racial and ethnic disparities in disease presentation. De novo metastatic breast cancer disproportionately contributes to breast cancer mortality in the U.S., emphasizing the need for tailored interventions to improve care delivery and outcomes.
Stiffer tumor tissue causes cancer to spread more quickly
Research from Lund University reveals that stiffer tumor tissue triggers a chain of molecular events driving cancer cells to invade surrounding tissue. The studies identified key proteins and pathways involved in this process, offering new insights into the mechanical properties of tumor microenvironments.
City of Hope and UC Berkeley researchers teach AI to spot cancer risk by squeezing individual breast cells
Researchers developed a microfluidic platform that squeezes individual breast epithelial cells to measure their mechanical age, revealing an unexpected insight: older cells are stiffer and at higher risk of cancer. The AI-powered platform provides a non-genetic test for women with unknown genetic risks.
Researchers identify novel vulnerability in breast cancer brain metastases and points to new therapeutic strategy
Breast cancer cells that spread to the brain rely on a specific metabolic pathway to survive. Targeting this pathway with ACSS2 inhibitors can induce ferroptosis and shrink tumors in preclinical models.
Candidate breast cancer drug overloads tumors with “surge” of toxic lipids
The experimental drug DH20931 targets triple-negative breast cancer by triggering a surge in fat-like molecules called ceramides, overwhelming cancer cells with toxic fats. In lab experiments, the drug made standard chemotherapy more effective, reducing the dose needed to kill cancer cells by about fivefold.
Dr. Aditya Bardia elected to American Society for Clinical Investigation
Dr. Aditya Bardia has been elected to the American Society for Clinical Investigation for his outstanding contributions to research and patient care in breast cancer treatment. He is advancing precision medicine therapies through antibody-drug conjugates and liquid biopsy technologies.
Mapping the hidden signals of breast cancer risk
Scientists at MUSC Hollings Cancer Center mapped the architecture of healthy breast tissue to uncover early biological changes linked to cancer risk. The study found that body weight and breast density shape the underlying structure of breast tissue, offering new clues about how cancer risk may develop long before tumors form.
Primary breast tumors already harbor cells with metastatic potential
Researchers have identified the Prrx1 gene as a key regulator of metastatic potential in breast cancer tumors. This discovery helps explain why highly invasive cells do not always give rise to metastases, and how cells combine invasiveness and proliferation to become the most dangerous from a clinical perspective.
Unveiling new targets in LAR triple-negative breast cancer: ERBB2 mutations and senescence
Researchers have discovered two therapeutic vulnerabilities in LAR triple-negative breast cancer: ERBB2 mutations and senescence. Targeting these weaknesses with next-generation TKIs and immunotherapy could improve patient outcomes.
New AI framework offers reliable, cost-effective prediction of PIK3CA mutations in breast cancer
A new AI framework combines digital pathology and structured clinical data to predict PIK3CA mutation status in breast cancer. The Multimodal PIK3CA Model outperformed single-modality models, achieving an AUC of 0.745, with strong performance across multiple clinical datasets.
A CNIO group contributes to identifying which breast lesions will progress to cancer, thus helping avoid overtreatment
A study by the CNIO group has identified a genetic signature in precancerous breast lesions that can predict which ones will evolve into invasive tumours. This discovery could help avoid over-treatment of women diagnosed with ductal carcinoma in situ, a common precancerous lesion.
Key protein that drives the spread of aggressive breast cancer identified
A specific protein, PKC-eta, has been identified as a central driver of aggressive breast cancer cell migration and metastasis. Reducing PKC-eta activity significantly slows tumor growth and reduces metastatic spread in laboratory and animal models.
Global trial shows novel treatment for triple-negative breast cancer nearly doubles survival
A global, multicentre phase III trial demonstrates the potential of Dato-DXd as an effective new treatment option for triple-negative breast cancer. The novel antibody-drug conjugate (ADC) nearly doubles overall survival and improves progression-free survival in patients with untreated, advanced TNBC.
Breast cancer care: Merging global standards with regional adaptations
International guidelines must be tailored to address diverse biological behaviors of breast cancer subtypes and regional healthcare infrastructure limitations. Precision medicine, supported by molecular subtyping and AI, is refining these guidelines for personalized and effective care.
Cancer trends in Canada 2026
The study projects that cancer rates in Canada will be high in 2026, with declines seen in some cancers like colorectal and leukemia. However, death rates from pancreatic cancer are increasing.
Clinical trial aims to address vaginal complaints after breast cancer diagnosis
A clinical trial aims to evaluate whether laser therapy reduces vaginal dryness caused by breast cancer treatment. The study, REVITALIZE, plans to enroll approximately 250 women with a history of breast cancer who experience moderate to severe vaginal dryness.
Nanotechnology-based strategies in breast cancer diagnosis and therapy
Breast cancer diagnosis and treatment have been enhanced by nanotechnology, improving outcomes for patients. Various formulations such as lipid nanoparticles, nanoemulsions, polymeric nanoparticles, and metal-based nanoparticles offer improved bioavailability and overcome limitations of conventional therapies.
Exploring new pathways to monitor and treat the most aggressive and evasive forms of breast cancer
Researchers at ITQB NOVA and IPOLFG are developing a new project called BRIDGE to improve diagnosis and treatment of aggressive breast cancers. They aim to find new biomarkers to monitor cancer evolution and tailor treatment to individual patient needs.
Newly funded projects to develop more effective drugs with fewer side effects for hard-to-treat cancers
AACR: Targeted drug delivery for colorectal cancer, COVID-19’s impact on breast cancer outcomes, AI in cancer diagnosis and more
UCLA investigators present new research on targeted drug delivery for colorectal cancer, COVID-19's impact on breast cancer outcomes, and AI in cancer diagnosis. These studies offer insights into overcoming drug resistance, enhancing immune responses, and improving outcomes for patients with difficult-to-treat cancers.
Natural alkaloid gramine suppresses triple-negative breast cancer by inducing ferroptosis via the CUL3–MTDH axis
Gramine, a natural indole alkaloid, suppresses triple-negative breast cancer by inducing ferroptosis. It targets the CUL3–MTDH axis, reducing E3 ubiquitin ligase activity and downregulating ferroptosis inhibitors.
Are we seeing changes in the rates of secondary blood-related cancers that develop due to chemotherapy or radiation?
A study from Japan has revealed a gradual increase in tAML rates, especially after breast cancer treatment. The study analyzed data from the Osaka Cancer Registry and found that the annual incidence of tAML increased from 0.13 to 0.36 per 100,000 population between 1990 and 2020.
New evidence that fat promotes tumor growth in aggressive breast cancer
A study by Princeton University researchers found that high-fat diets contribute to aggressive breast cancer growth, with tumors fed fatty acids forming hollow appendages. The team's 3D model showed that a ketogenic diet did not provide the expected benefits for this type of cancer.
Women with diabetes less likely to receive preventive care and some screenings
A recent study published in the Journal of General Internal Medicine found that women with diabetes are less likely to receive recommended preventive care services such as conception counseling and breast/cervical cancer screening. This oversight puts them at risk for preventable medical conditions like pregnancy complications.
First-in-class dual HIF inhibitors eliminate breast, colorectal, melanoma, and prostate tumors in mice when combined with immunotherapy
Researchers developed first-in-class dual HIF inhibitors that, when combined with immunotherapy, can completely eliminate breast, colorectal, melanoma, and prostate tumors in mice. The drugs target HIF-1/2 transcription factors, which are key regulators of cancer progression.
Most detailed map to date of breast tissue changes reveals role of menopause in cancer susceptibility
The study created a detailed map of breast tissue changes over time, revealing that menopause triggers significant changes that create an environment where cancer cells thrive. The research found that all types of cells decrease in number and divide less often, leading to a more inflammatory immune environment.
Prioritizing potentially cancer-causing mutations in real-world cancer genomics
A framework has been developed to identify candidate pathogenic variants hidden among uncertain significance variants detected in comprehensive genomic profiling. The framework was tested using BRCA1 and BRCA2 genes, leading to the classification of a previously unknown variant as pathogenic.
San Antonio Breast Cancer Symposium® fuels $39.6 million impact and advances in cancer care
The San Antonio Breast Cancer Symposium generated nearly $40 million in economic impact and drew over 11,000 attendees from 104 countries. The symposium also produced $1.5 million in local tax revenue and supported more than 6,800 jobs.
Living in food deserts may affect complications after breast reconstruction
A study published in Plastic and Reconstructive Surgery suggests that residents in food deserts may experience increased risks of certain complications after breast reconstruction surgery. Patients living in these areas were more likely to experience overall complications and repeat surgery compared to those in non-food desert areas.
Research alert: New insights into breast cancer metastasis
A study by UC San Diego researchers reveals TYK2's role in preventing cancer spread and highlights need for enhanced screening in patients treated with TYK2 inhibitors. Understanding mechanotransduction can provide new avenues for treatment and improve breast cancer outcomes.
Genetic variants involved in rapid immune response linked to earlier breast cancer onset in BRCA1 carriers
Researchers have identified a link between genetic variants involved in innate immunity and earlier breast cancer onset in BRCA1 carriers. The study found that mutations in genes involved in natural killer cell activation were strongly associated with an increased risk, suggesting the need for more refined risk prediction models.
Lasting income costs of mental and physical illness
A study estimated income losses from individual perspectives in Denmark from 2000 to 2023 after hospital diagnoses of depression, alcohol use disorder, stroke, and breast cancer. The researchers found that income losses were largest for mental disorders, with average losses growing over time, particularly among younger individuals.
Technion researchers develop AI model to predict chemotherapy benefit in breast cancer
Researchers developed an AI model that analyzes routine pathology slides to predict breast cancer recurrence and chemotherapy benefit. The model was validated in a large clinical trial and demonstrates fast, accessible, and globally scalable diagnostic capabilities.
International Journal of Disease Reversal and Prevention publishes clinicians guide: Latest research on role of dietary interventions in cancer, menopause, Alzheimer’s disease, and others
A new clinician's guide has been published by the International Journal of Disease Reversal and Prevention, summarizing the latest research on dietary interventions for various diseases. The guide emphasizes the importance of plant-based diets and healthy lifestyle habits in disease prevention and treatment.
Early results from a trial of active surveillance for low-risk DCIS are ‘reassuring’
Researchers have reported early, reassuring results from the LORD trial on active surveillance for low-risk DCIS. The study found that patients with active surveillance did not experience worse early outcomes compared to those who underwent immediate surgery, and that many chose active surveillance over surgery.
Tumor DNA circulating in patients’ blood after pre-surgery treatments predicts whether breast cancer will return
A study found that tumor DNA in patients' blood can predict whether breast cancer will return, especially after neoadjuvant treatment. Patients with detectable DNA at the end of treatment were 3.5 times more likely to relapse during follow-up.
Immune response to cancer may cause brain disease
Researchers at Cold Spring Harbor Laboratory found that antibodies produced in response to cancer can attack the brain, causing autoimmune diseases like lupus and multiple sclerosis. The study suggests that these antibodies may be harnessed to develop new treatments for triple-negative breast cancer.
Breast cancer hijacks the lung repair system to fuel tumor growth, study finds
Researchers found that breast cancer cells trigger the lung's natural repair system, leading to chronic inflammation and promoting tumor growth. A repurposed drug, roflumilast, may slow this process by preventing the lung environment from aiding tumor growth.