Articles tagged with Breast Cancer
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Researchers found that early pregnancy reduces the buildup of abnormal cells in breast tissue, which can lead to breast cancer. Pregnancy prevents these 'confused' cells from accumulating and triggers a 'cellular reset button,' maintaining tissue lineage integrity.
Researchers created a miniaturized ultrasound system that can be used at home or in doctors' offices to scan people at high risk of breast cancer. The new system detects tumors earlier, increasing the chances of successful treatment.
Researchers developed polygenic risk score models to predict breast cancer risk in women of African ancestry, improving accuracy and performance compared to existing models. The new tools could lead to earlier screening, tailored care, and increased survival rates for high-risk women.
Researchers developed an AI tool called ONCO-ACS to predict the risk of secondary heart attacks in cancer patients after a heart attack. The tool combines cancer-related factors with standard clinical data to provide reliable information for doctors to balance treatment benefits and harms.
The PATINA trial demonstrates a significant progression-free survival benefit with palbociclib in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-positive (HER2+) metastatic breast cancer. The study showed a median progression-free survival of 44.3 months, compared to 29.1 months in the control arm.
The study found a 12% reduction in interval cancers diagnosed after screening, as well as fewer aggressive sub-type cancers detected. AI-supported mammography also increased cancer detection without an increase in false positives.
Researchers identified a targetable driver of brain metastases in inflammatory breast cancer, promoting tumor invasion and triggering brain inflammation via the CXCR2 signaling pathway. Targeting sEcad or the CXCR2 pathway may treat or prevent brain metastasis.
The G protein-coupled estrogen receptor (GPER) is a key regulator of endocrine resistance in breast cancer, promoting tumor survival and proliferation. Elevated GPER expression is associated with poor therapeutic response and disease recurrence, highlighting its role as a coordinator of tumor-stroma interactions.
A cohort study found that Medicaid expansion under the Affordable Care Act was associated with lower overall mortality among women with breast cancer aged 40-64. The benefits of expanded coverage were uneven, highlighting persistent disparities in healthcare access for certain populations.
A Purdue University team led by Kyle Cottrell has discovered a new therapeutic target for triple-negative breast cancer, a deadly form of breast cancer lacking targeted therapies. The researchers identified dsRNA-binding proteins, specifically PACT, which suppress another protein called RNA-activated protein kinase (PKR).
Researchers found that combining selective CDK2 inhibitor BLU-222 with CDK4/6 inhibitors produces strong, durable anti-tumor effects across preclinical models of breast cancer. This approach targets cancer cells' reliance on CDK proteins and restores control over the cell cycle in resistant tumors.
Cancer mortality rates have decreased for breast cancer and leukemia, despite increasing incidence, while colorectal cancer has become the leading cause of death among US young adults. Colorectal cancer surpasses lung, breast, and prostate cancers as the leading cancer-related death in people under 50 years old.
A study published by the National Institutes for Quantum Science and Technology found that carbon-ion radiotherapy provided durable tumor control with minimal side effects while preserving breast appearance in carefully selected patients who were unable or unwilling to undergo surgery. The treatment resulted in excellent local control ...
The University of Texas MD Anderson Cancer Center has made significant advancements in cancer care through its collaborative efforts between clinicians and scientists. These breakthroughs include an immune-targeting vaccine that shows promise in intercepting cancer in patients with Lynch Syndrome, a novel immunotherapy that demonstrate...
A new imaging technique using ultrasound-guided diffuse optical tomography can reduce unnecessary benign breast biopsies by nearly 25%, according to a recent study. The technology uses near-infrared light to create 3D pictures of tissues, revealing functional differences between normal and cancerous tissue.
Population risk-based screening using 5-year invasive breast cancer risk is associated with similar or greater benefits than age-based screening, as well as reduced false-positive recalls. As personalized medicine advances, risk-based screening is poised to become a cornerstone of breast cancer prevention.
Predictions for lung cancer death rates among EU and UK women indicate stabilization of mortality rates at 12.5 deaths per 100,000 in 2026. Lung cancer remains the leading cause of cancer death for both sexes in the EU, with mortality rates continuing to decline among men.
Researchers developed an innovative noninvasive technique that combines ultrasound and photoacoustic imaging to capture images of both tissue and blood vessels. The technology has the potential to address current gaps in medical imaging, providing faster and more comprehensive imaging at meaningful depths.
Fine particulate matter and ozone exposure independently associated with poorer cardiac health outcomes in breast cancer patients treated with cardiotoxic therapy. Environmental exposure modifications are crucial to mitigate cardiovascular disease risk.
A new study from Columbia University finds that recreational physical activity is associated with lower breast density and stress biomarker changes in adolescent girls. The research suggests a potential link between physical activity during adolescence and reduced breast cancer risk later in life.
Women with a genetic predisposition to higher body mass index are at increased risk of all-cause mortality after breast cancer diagnosis. Targeted lifestyle recommendations can mitigate this risk.
Aggressive triple-negative breast cancer fine-tunes its protein production through a previously unknown mechanism discovered by Umea University researchers. The study reveals that fibrillarin collaborates with RPS28 to create specialized ribosomes, leading to imbalance in protein production and driving cancer development.
Researchers at UC San Diego have discovered a previously unrecognized treatment target for triple-negative breast cancer (TNBC). Disrupting the activity of PUF60 causes widespread errors in gene processing, resulting in DNA damage and tumor cell death.
Researchers at MD Anderson have made significant advancements in cancer treatment, demonstrating the effectiveness of immunotherapy before and after surgery in improving lung cancer patient outcomes. Additionally, a new study shows promise in using CAR T cell therapy to treat large B-cell lymphoma, reducing relapse rates.
Melanie Rutkowski's pioneering research may lead to novel immunotherapy treatments for ovarian cancer by understanding how faulty cellular signaling interacts with the microbiome. The grant aims to enhance immune system's ability to kill cancer cells and improve patient outcomes.
Researchers found that pitavastatin directly inhibits the anti-apoptotic protein Mcl-1, a key driver of survival and resistance in TNBC cells. The study showed pitavastatin effectively eliminates cancer stem-like cell populations and reduces tumor growth, angiogenesis, and lung metastasis.
The Global Centre for Asian Women’s Health has partnered with NUS Medicine to host the Women’s Health Impact Tracking (WHIT) platform, which measures progress on closing the women’s health gap across a set of conditions and countries. The platform provides clear, comparative insights to support decision-making and inform policies.
A new study found that a drug mimicking the hormone progesterone, megestrol, has anti-cancer activity when used with conventional anti-oestrogen treatment for women with breast cancer. This combination showed a greater decrease in tumour growth rates compared to those treated with an anti-oestrogen only.
A large-scale international study has deciphered a mechanism enabling breast cancer to metastasize to the brain. Researchers identified a specific chromosomal alteration predicting high likelihood of brain metastases and found that the absence of functional p53 gene impairs brain environment adaptation.
Researchers discover breast cancer cells hijack the immune system's alarm pathway, inducing chronic pro-tumor inflammation. This shift creates a vulnerability that can be targeted by existing immunotherapies.
A survey study found that exposure to medical misinformation was common among breast cancer patients, yet fear of recurrence was not associated. Further research on how patients process medical misinformation is essential to improve survivorship communication and reduce misinformation spread.
Researchers at OHSU discovered a promising new drug combination that may help people with acute myeloid leukemia (AML) overcome treatment resistance by pairing venetoclax, a standard AML drug, with palbociclib, a cell-cycle inhibitor approved for breast cancer. The study found that this combination produced significantly stronger and m...
Researchers highlight how minimal residual disease detection is changing breast cancer management by capturing molecular traces of cancer at extremely low levels. CTDNA-based monitoring reveals relapse risk months ahead of clinical symptoms, enabling clinicians to identify high-risk patients and adjust treatment strategies in real time.
Researchers have identified Rb1 as a predictive biomarker for a new therapeutic strategy in some breast cancers. The study found that simultaneous inhibition of ATR and PKMYT1 triggers cell death in Rb1-deficient breast cancer models, leading to tumor shrinkage and improved survival.
A new study from Texas A&M University reveals that circadian disruptions change the structure of mammary glands, weaken immune defenses, and fuel aggressive breast cancer. Disabling an immune checkpoint molecule called LILRB4 helps restore the immune system's ability to fight back.
A deep learning framework called PRTS accurately predicts single-cell-resolution spatial transcriptomics from H&E-stained histology images. The model identifies 21 cell subtypes in mouse brain and maintains prediction accuracy in human breast and lung cancer tissues.
UT Health San Antonio received $3 million in CPRIT grants to expand access to preventive salpingectomy, test novel methods to prevent liver cancer, and advance treatment for therapy-resistant metastatic breast cancer. These projects aim to improve cancer prevention, diagnosis, and treatment in South Texas.
A new study has found that radioactive seed localization (RSL) is an effective and comfortable alternative to traditional wire localization for breast cancer surgery. Patients who received RSL reported less pain and anxiety, while surgeons rated the technique as more convenient and satisfying to perform.
Proton therapy has been shown to provide a significant survival benefit for patients with head and neck cancers. In another study, researchers have identified a promising target for treating pancreatic cancer by inhibiting the mitochondrial enzyme GFER. Additionally, diagnostic breast MRI may be unnecessary for some patients with early...
A study from Rutgers Cancer Institute researchers found that Black women with breast cancer who ate the most ultra-processed foods before diagnosis were 36-40% more likely to die from their cancers or other causes of death. The researchers followed 1,733 Black women diagnosed with breast cancer in New Jersey between 2005 and 2019.
A randomized controlled pilot study investigates the effects of Baduanjin exercise on menopausal symptoms in breast cancer patients taking aromatase inhibitors. The study reveals that Baduanjin alleviates hot flash severity and improves quality of life for these women.
Studies show that patients with advanced ovarian and metastatic breast cancer dedicate approximately 7 hours per week to cancer-related tasks. Most participants report performing these tasks daily, impacting their time burden. The use of a mobile app facilitated the collection of detailed time-use data.
Research found that breast cancer flattens corticosterone release in mice, reducing quality of life and increasing mortality. Disruptions to diurnal rhythms have been linked to stress responses like insomnia and anxiety in cancer patients.
Dr Aldona Mzyk's project uses quantum sensors to track how immune cells interact with tumours, enabling the development of improved patient-tailored cancer therapies and earlier diagnosis tools. The research aims to overcome current cancer immunotherapies' failure in solid tumours by controlling metabolic changes.
A matched prospective analysis of 676 women found that menopausal hormone therapy was not associated with an increased risk of breast cancer in those with BRCA mutations. This suggests a personalized approach to menopause management for these women, balancing the risks and benefits of MHT use.
Breast cancer survivors experienced significant improvement in perceived cognitive impairment with real acupuncture, outperforming sham acupuncture and usual care. Real acupuncture also showed benefits in objective cognitive function, particularly when compared to sham acupuncture.
A mobile health intervention, Young, Empowered & Strong (YES), improved quality of life and symptoms in adolescent and young adult breast cancer survivors. The study found significant reductions in general and cancer-specific quality of life scores after six months.
The WISDOM randomized clinical trial found risk-based breast cancer screening to be equally effective as annual screening in detecting advanced cancers. However, it did not reduce breast biopsy rates. The study suggests a safer and more efficient approach to breast cancer screening.
A secondary analysis of the WISDOM trial found a substantial number of women with clinically actionable genetic variants, many not qualifying for current guidelines. This study supports broader access to genetic testing for personalized breast cancer risk assessment.
Maher El-Kady's work on sustainable energy storage technologies aims to create a cleaner, more accessible future. Dr. Dennis Slamon's breakthroughs in breast cancer treatment have benefited millions worldwide, highlighting the impact of UCLA researchers on global health and innovation.
A recent study found that preoperative breast MRI did not significantly impact five-year recurrence rates or overall survival in patients with stage 1 or 2, hormone receptor-negative breast cancer. The trial involved 319 patients and showed similar results between those who underwent MRI and those who did not.
A phase II clinical trial found that preoperative radiation improved T-cell infiltration and treatment responses in hormone receptor-positive, HER2-negative breast cancer patients. Radiation doses of 24 Gy showed the greatest increase in TCI and tumor clearance, suggesting a potential new strategy for immunotherapy.
Research from Florida Atlantic University strengthens evidence that alcohol consumption increases cancer risk, particularly for breast, colorectal, and liver cancers. Higher intake and specific groups, such as African Americans and those with obesity or diabetes, are found to be more vulnerable to the risks.
A recent study found that omitting sentinel lymph node biopsy (SLNB) in clinically node-negative, HR-positive, HER2-negative early-stage breast cancer patients did not compromise regional control or survival after a median five years of follow-up. The recurrence of the cancer in the lymph nodes surrounding the primary tumor was observe...
A prospective multicenter trial validated an improved method for predicting treatment benefits in hormone receptor-positive metastatic breast cancer with bone metastases. Metabolic change assessed by FDG-PET/CT accurately predicted progression-free survival as early as 12 weeks after treatment initiation.
The study found that the investigational vaccine produced an immune response in 74% of participants and was safe and well-tolerated. A Phase 2 study is planned to evaluate the vaccine's efficacy, offering new hope for triple-negative breast cancer treatment.
A new oral endocrine therapy, giredestrant, has been shown to significantly lower the risk of breast cancer recurrence in early-stage HR-positive/HER2-negative patients. In a large clinical trial, patients treated with giredestrant were 30% less likely to have invasive disease recur or progress.
The addition of tucatinib to first-line maintenance therapy with trastuzumab and pertuzumab delayed disease progression in HER2-positive metastatic breast cancer patients, particularly those with brain metastasis. This delay allowed for prolonged time off chemotherapy and maintained disease control.
For patients with HR-positive, HER2-negative advanced breast cancers who have received endocrine therapy, sacituzumab govitecan-hziy offers comparable progression-free survival rates as standard chemotherapy. The study also found higher response rates and longer response durations for patients treated with sacituzumab govitecan-hziy.
The phase III lidERA trial found that giredestrant improved invasive disease-free survival compared to standard-of-care endocrine therapy. Patients who received giredestrant were 30% less likely to develop invasive disease progression and had a clinically meaningful superiority to currently established endocrine agents.