Articles tagged with Breast Cancer
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Breast cancer cells build molecular tunnels into nearby fat cells to release energy, blocking gap junctions stops tumor growth. The discovery provides a golden opportunity for developing effective strategies to treat the most aggressive forms of breast cancer.
Researchers at the University of Warwick have developed a handheld diamond magnetometer for cancer surgery, which uses magnetic tracer fluid to detect tumours. The device is ultra-sensitive and compact, offering a non-toxic alternative to traditional methods, such as radioactive tracers or blue dye.
Dr. Catheryn Yashar, a renowned radiation oncologist, has been appointed president-elect of the American Society for Radiation Oncology (ASTRO). She will champion innovative radiation therapies and advance health policy reform to improve cancer care outcomes.
A new AI hybrid reading strategy for screening mammography reduces radiologist workload by 38% while maintaining comparable cancer detection and recall rates. The strategy incorporates uncertainty quantification, allowing AI to provide certainty estimates for predictions.
A study at the Garvan Institute of Medical Research found that inactivation of a stress pathway makes ER+ breast cancer cells ignore stress signals, allowing them to evade treatment. The JNK pathway acts as a cellular alarm system, and its disruption leads to treatment resistance.
The International Osteoporosis Foundation has issued an updated joint position statement on managing aromatase inhibitor-associated bone loss in women with hormone-sensitive breast cancer. The guidelines incorporate recent clinical trials and systematic reviews to provide evidence-based treatment algorithms for assessing fracture risk ...
Researchers found that mitochondrial antioxidant glutathione enables tumors to break away from the primary tumor, travel through the body, and take root in new tissues. Elevated SLC25A39 expression was strongly correlated with poorer overall survival in breast cancer patients.
Breast cancer's reliance on lactate metabolism drives tumor progression, immune evasion, and metastasis. Researchers propose targeting lactate production and lactylation to develop more precise treatments with improved survival rates.
Researchers at Radboud University Medical Center found that AI detects breast cancer on mammograms more frequently than radiologists. The study analyzed 42,000 breast scans and showed that one radiologist working with AI detects more tumors than two radiologists alone.
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
Researchers discovered that PCAI-27 activates two major signaling pathways, MAPK and PI3K/AKT, leading to increased oxidative stress and apoptosis in AI-resistant breast cancer cells. The compound also disrupts cytoskeletal structure, making cancer cells more vulnerable.
Researchers evaluated over 1,500 AI algorithms for detecting breast cancers on mammography images, achieving median rates of 98.7% specificity and 27.6% sensitivity. Combining top-performing algorithms resulted in sensitivity boosts to 60.7% and 67.8%, comparable to average screening radiologists.
A study by George Mason University's Ali Weinstein found that breast cancer survivors who experienced higher levels of fatigue showed increased inflammation, particularly in TGF-β and eotaxin levels. Most participants did not experience significant changes in inflammation or fatigue after mentally or physically fatiguing tasks, suggest...
A new multi-institutional study confirmed that the NSD2 protein can be targeted with a new drug, blocking it effectively reprogrammed DNA structure, reversed and prevented cancer growth in preclinical models of KRAS-mutant lung and pancreatic cancers. Targeting the brain-liver pathway with electronic wearables could prevent cancer-asso...
A recent study found that policies aimed at increasing breast density screening coverage have limited effectiveness in improving early detection rates among Black women. The study suggests that these policies may not address the unique health needs of this population.
The symposium will feature talks by leading researchers on various aspects of cancer, including molecular discovery, clinical application, and population impact. Key findings include the exploration of genomic inequities and their impact on cancer disparities.
A new AI-based technology analyzes mammograms to predict a woman's five-year breast cancer risk, outperforming standard methods by 2.2 times. The system provides an absolute risk score comparable to national incidence rates, enabling targeted prevention and early detection.
A new AI algorithm has been shown to detect nearly one-third of interval breast cancers missed at screening using digital breast tomosynthesis (DBT), according to a study published in Radiology. The algorithm improved the performance of DBT, reducing interval cancers.
Researchers developed a software fueled by genomics to predict cancer cell behavior, combining genomics technologies with computational modeling. The new 'grammar' enables communication between biology and code, allowing scientists to build digital representations of multicellular biological systems and simulate diseases like cancer.
Researchers at Fox Chase Cancer Center have provided a detailed assessment of how fast breast cancers grow in patients and how surgical delays may affect breast cancer staging. The study found that upstaging rates associated with delays are relatively small and consistent with prior data.
A study published in iScience found that cells in breast tissues of women with African ancestry send cues promoting breast cancer growth. Researchers discovered that PZP cells activate epithelial cells, allowing them to invade surrounding tissue.
A recent study found that a 5 mg dose of olanzapine taken after chemotherapy significantly reduced nausea and vomiting in breast cancer patients, with fewer side effects compared to the standard 10 mg dose. The low-dose regimen was effective for both immediate and delayed symptoms, making it an attractive alternative for patients.
A new analysis suggests that preventive mastectomy is a cost-effective way to reduce the likelihood of developing breast cancer compared to breast screening and medication. Women aged 30 or above with a lifetime breast cancer risk of 35% or more may benefit from this treatment option.
A new study finds that risk-reducing mastectomy is cost-effective for women aged 30-55 with a lifetime breast cancer risk of 35% or higher. The findings have significant clinical implications, suggesting that RRM could expand access to the procedure beyond BRCA1/BRCA2/PALB2 pathogenic variant carriers.
Researchers at the University of Illinois found that benign and cancerous breast calcifications have unique structures and formation processes. The study provides a new classification scheme and opens the possibility of treating benign calcifications using certain drugs.
A contemporary cohort study found a low risk of isolated locoregional recurrence (5.6%) at 10.1 years follow-up for young women diagnosed with breast cancer under 40. Surgical decision-making should not be influenced by concerns about long-term risk.
City of Hope research demonstrates a new drug combination that slows advanced prostate cancer growth without improving overall survival. A novel AI conversation tool helps scientists uncover gene-disease connections without programming expertise.
A study documents elite-level strength training during active breast cancer treatment, showing rare retention of squat strength despite chemotherapy. LaShae Rolle, a competitive powerlifter and breast cancer survivor, completed the first-of-its-kind study, demonstrating the feasibility of high-intensity training when carefully managed.
A combination of two approved cancer medications may slow or reverse Alzheimer's symptoms by reversing gene expression changes in neurons and brain cells. Researchers analyzed public data from deceased donors and found a link between these drugs and reduced risk of developing the disease.
A new study published in JAMA Network Open found no statistical relationship between pathologic complete response (pCR) and overall survival in rectal cancer patients. This challenges the FDA's use of pCR as a surrogate endpoint for drug approval, which may lead to treatments being fast-tracked without evidence of improved long-term su...
Researchers found that tirzepatide reduced body weight and body fat by approximately 20% in mice, resulting in a significant reduction of tumor volume. The study suggests that this new anti-obesity drug may have a beneficial impact on breast cancer outcomes.
Researchers identified RTK dependent and independent mechanisms of resistance to EGFR targeted therapies in breast and head and neck cancers, highlighting opportunities for combination therapies and biomarker identification.
A recent analysis of 16 years of data on Japanese adults reveals a strong association between socioeconomic status and the incidence of five common cancers. Communities with low employment rates or low incomes show higher cancer rates compared to those with higher socioeconomic status.
Researchers at Boston University have found that exosomes released by obese tissues can turn slow-moving TNBC cells into highly mobile and invasive ones. This discovery could lead to the development of non-invasive biomarkers for metastatic risk and new drug targets like Rho-protein inhibitors.
The interplay between exosomes and metabolic reprogramming shapes breast cancer progression and resistance. Targeting this axis offers novel diagnostic and therapeutic strategies, including exosome-based liquid biopsy techniques and combination therapies.
A study published in Radiology found that AI decision support systems improve breast cancer detection accuracy and visual search patterns among radiologists. With AI assistance, radiologists spend more time examining regions with actual lesions, leading to better performance and efficiency.
A study of 168,547 postmenopausal women found that excess weight is associated with a 31% higher risk of breast cancer in those with cardiovascular disease. Higher BMI also increases the risk in women without cardiovascular disease, although to a lesser extent.
Researchers discovered that breast cancer responds to CDK4/6 inhibitors by forming an immunosuppressive microenvironment, which can be mitigated with radiation therapy or immune-modulating drugs. The study also found a potential biomarker to predict treatment response in patients.
Researchers have discovered a hidden switch in breast cancer that uncovers PHGDH's role as both a metabolic and transcriptional regulator. PHGDH suppresses genes vital for immune cell function, steering macrophages toward tumor-fighting behavior. The study offers promising new strategies for reprogramming the tumor microenvironment.
A novel nanocarrier system utilizing metal-polyphenols enables precise intracellular delivery of therapeutic antibodies into cancer cells. This technology overcomes endosomal entrapment, resulting in suppressed tumor growth and enhanced anti-cancer activity.
A recent survey by the Annenberg Public Policy Center found that nearly half of Americans believe women should begin regular mammograms at age 40, while younger women are less certain. Women aged 18-29 were most likely to choose an incorrect age, with 27% selecting 30 years old as the start age.
A computational study found amygdalin to be a promising therapeutic agent for HER2-positive breast cancer. The compound shows favorable binding energies and induces structural changes in the HER2 protein, suggesting its potential to suppress cancer-promoting activity.
A new study by the NIH found that hormone therapy may alter breast cancer risk in women under 55. Women treated with unopposed estrogen hormone therapy were less likely to develop breast cancer, while those using estrogen plus progestin hormone therapy were more likely to develop the disease.
A new AI-assisted technique called PACT has been developed to help differentiate between suspicious and healthy tissue in breast imaging. The method, which combines light and sound into a single modality, performs as well as or better than conventional techniques like mammography and MRI.
Researchers have identified LINC01235 as a crucial regulator of NFIB expression and NOTCH pathway in TNBC, suggesting potential therapeutic targets for this aggressive form of breast cancer. The study provides new insights into the role of non-coding RNAs in cancer progression.
Breast cancer metastasis relies heavily on mitochondrial oxidative metabolism, with adaptations including lipid metabolism and oxidative phosphorylation. Targeting mitochondrial fission, fusion, and mitophagy shows promise in preclinical models, while challenges remain due to heterogeneity and drug resistance.
This study examines breast cancer incidence trends in older US women by racial and ethnic groups, geographic location, and cancer stage. The analysis reveals differing patterns across age groups, highlighting the importance of considering screening guidelines when analyzing breast cancer incidence rates.
The Association for Molecular Pathology publishes guidelines for detecting homologous recombination deficiency (HRD) in cancer. The report includes recommendations for clinical laboratories, addressing technical aspects of genomic instability and HRD analysis.
Researchers developed an AI tool called AAnet to characterize cancer cell diversity, identifying five distinct cell groups with different gene expression profiles. This could lead to more targeted therapies and improved patient outcomes.
The BRACELET-1 trial demonstrated a 20% objective response rate and 12.1-month progression-free survival for patients with unresectable HR+ HER2- tumors, suggesting that adding pelareorep to paclitaxel chemotherapy warrants further investigation in metastatic breast cancer.
Researchers developed nanomachines that can efficiently deliver antisense oligonucleotides to sentinel lymph nodes, reducing TGF-β1 levels and reactivating depleted CD8-positive T cells. This enhances cancer treatment outcomes for advanced breast cancers with no effective treatments.
A cohort study found breast cancer survivors have a lower risk of Alzheimer's dementia compared to cancer-free controls. Certain cancer treatments may confer benefits for reducing AD risk in this population.
A comprehensive review highlights the impact of anti-cancer treatments on bone health, increasing the risk of fractures and bone fragility. The International Osteoporosis Foundation advocates for a multidisciplinary approach to early screening and proactive bone-protective strategies.
Researchers developed a tool to monitor treatment response in patients with solid tumours using circulating tumour DNA analysis, anticipating clinical relapses up to 68 months before symptoms become apparent. The technology is minimally invasive and can be tailored to each tumour type, reducing unnecessary treatments and costs.
Scientists at MSK found that certain metabolites play a key role in driving differentiation in stem cells, potentially leading to improved tissue regeneration and healing for conditions involving chronic inflammation. APOBEC3 enzymes were linked to breast cancer resistance and growth, with implications for treatment.
The UNC Lineberger Comprehensive Cancer Center has developed an adaptive clinical trial for metastatic breast cancer, leveraging $28 million in funding from the Advanced Research Projects Agency for Health (ARPA-H). The study aims to adapt treatment plans in near real-time using tumor biopsies, blood samples, and biomarkers.
A new dual-laser strategy revolutionizes breast cancer photothermal therapy by minimizing damage to surrounding tissues while effectively ablating tumors. The approach uses near-infrared photothermal agents with aggregation-induced emission properties and achieves precise targeting through second NIR-II fluorescence imaging technology.
A new study of 591 women with early-stage breast cancer found that nearly two-thirds opted for continued endocrine therapy beyond the initial five years. Patients with higher-risk stage 2 disease were more likely to continue treatment, highlighting potential benefits in extending hormone-based therapy for these patients.
A newly developed molecular imaging technique can identify multiple subtypes of triple-negative breast cancer, improving diagnostic capacity. The approach targets extra domain A of fibronectin, a stable protein in the tumor stromal environment abundantly expressed in breast cancer.
MOME achieves expert-level accuracy in classifying tumor malignancy and reduces unnecessary biopsies by identifying benign cases. The AI model also predicts treatment responses and subtypes triple-negative breast cancer.